Jason J Ong, Aaron Lim, Catriona Bradshaw, David Taylor-Robinson, Magnus Unemo, Paddy J Horner, Peter Vickerman, Lei Zhang
OBJECTIVES: Mycoplasma genitalium (MG) disproportionately affects men who have sex with men (MSM). We determined the cost-effectiveness of different testing strategies for MG in MSM, taking a healthcare provider perspective. METHODS: We used inputs from a dynamic transmission model of MG among MSM living in Australia in a decision tree model to evaluate the impact of four testing scenarios on MG incidence: (1) no one tested; (2) symptomatic MSM; (3) symptomatic and high-risk asymptomatic MSM; (4) all MSM...
March 23, 2023: Sexually Transmitted Infections
Anissa Desmoulin, Elisa Joly, Phuong Tran, Christian Derancourt, Antoine Bertolotti
INTRODUCTION: Anogenital warts (AGWs) are among the most common STDs. Many therapy options are available but are not codified. Systematic reviews (SRs) and meta-analyses (MAs) are helpful to elaborate recommendations on the management of AGWs. The objective of our study was to assess the quality and consistency of SRs for the local management of AGWs using three international tools. METHODS: Seven electronic databases were searched from inception to 10 January 2022 for this SR...
March 22, 2023: Sexually Transmitted Infections
Audrey Courdurié, Matthieu Buscot, Géraldine Gonfrier, Johan Courjon, Constantin Oncioiu, Elisa Demonchy, Michel Carles
We describe a rare case of severe disseminated monkeypox (MPox) virus infection complicated by peritonitis in a 44-year-old man living with well-controlled HIV. The patient was successfully treated with tecovirimat without requiring surgery. MPox should be considered in the differential diagnosis of non-bacterial peritonitis in patients at risk of infection.
March 16, 2023: Sexually Transmitted Infections
Sinead Delany-Moretlwe, Nyaradzo Mgodi, Linda-Gail Bekker, Jared M Baeten, Chuwen Li, Deborah Donnell, Yaw Agyei, Denni Lennon, Scott M Rose, Marcia Mokgatle, Sheetal Kassim, Shorai Mukaka, Adeola Adeyeye, Connie Celum
INTRODUCTION: We investigated the prevalence, incidence and factors associated with sexually transmitted infections (STIs) among young African women seeking HIV pre-exposure prophylaxis (PrEP). METHODS: HPTN 082 was a prospective, open-label PrEP study enrolling HIV-negative sexually active women aged 16-25 years in Cape Town and Johannesburg, South Africa, and Harare, Zimbabwe. Endocervical swabs from enrolment, months 6 and 12 were tested for Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) by nucleic acid amplification, and Trichomonas vaginalis (TV) by a rapid test...
March 8, 2023: Sexually Transmitted Infections
Shir Azrielant, Amichai Sheffy, Fahim Kanani, Israel Nissan, Amos Adler, Michal Dekel
Perihepatitis (Fitz-Hugh-Curtis syndrome) is a rare complication of sexually transmitted infections, mostly seen in women. Only 12 male cases have been reported to date, of which Chlamydia trachomatis was confirmed in 2. We report a case of chlamydial perihepatitis in a male patient, occurring 1 month after Mpox and associated with the unusual LGV ST23 strain. Our case suggests that rectal Mpox lesions may facilitate chlamydial dissemination.
March 7, 2023: Sexually Transmitted Infections
Bethany Young Holt, Anke Hemmerling, Susanna Moore, Katherine Yang
BACKGROUND: Continued high incidence of HIV and other STIs, paired with rising antibiotic resistance to a number of existing treatments, warrants the development of new pharmaceutical approaches for STI prevention. Multipurpose prevention technologies (MPTs) offer an innovative approach for expanding HIV/STI prevention. The majority of MPT product candidates currently in development include HIV prevention, while only half include compounds active against non-HIV STIs. METHODS: This narrative review focuses on compounds in preclinical development (in vitro and in vivo) through phase 3 clinical trials with activity against one or more of the following infections: HIV, HSV-1, HSV-2 , Chlamydia trachomatis , Neisseria gonorrhoeae , Treponema pallidum , and Trichomonas vaginalis...
March 6, 2023: Sexually Transmitted Infections
Daniel Teixeira da Silva, Spandana Makeneni, Hannah Wall, José A Bauermeister, Sarah Wood
OBJECTIVES: Engagement in guideline-recommended sexually transmitted infection (STI) care is fundamental to ending the STI epidemic in the USA. However, the US 2021-2025 STI National Strategic Plan and STI surveillance reports do not include a framework to measure quality STI care delivery. This study developed and applied an STI Care Continuum that can be used across settings to improve STI care quality, assess adherence to guideline-recommended care and standardise the measurement of progress towards National Strategic goals...
March 3, 2023: Sexually Transmitted Infections
Jack Rg Brown, David Reid, Alison R Howarth, Hamish Mohammed, John Saunders, Caisey V Pulford, Dana Ogaz, Gwenda Hughes, Catherine H Mercer
OBJECTIVES: We examined sexual behaviour, sexually transmitted infection (STI) and HIV testing and testing need, and identified associated factors, among gay, bisexual and other men who have sex with men (GBMSM) in the UK after COVID-19 restrictions ended, and compared these with 'pre-pandemic' estimates. METHODS: We analysed survey data from GBMSM (N=1039) recruited via social media and Grindr in November-December 2021. We then compared Grindr-recruited 2021 participants (N=437) with those from an equivalent survey fielded in March-May 2017 (N=1902)...
March 1, 2023: Sexually Transmitted Infections
(no author information available yet)
No abstract text is available yet for this article.
February 23, 2023: Sexually Transmitted Infections
Angelo Roberto Raccagni, Elena Bruzzesi, Benedetta Trentacapilli, Maria Francesca Lucente, Antonella Castagna, Silvia Nozza
No abstract text is available yet for this article.
February 23, 2023: Sexually Transmitted Infections
Marguerite Dalmau, Robert Ware, Emma Field, Emma Sanguineti, Damin Si, Stephen Lambert
OBJECTIVE: To investigate trends in testing and notifications of chlamydia and gonorrhoea during the COVID-19 pandemic in Queensland, Australia. METHODS: Statewide disease notification and testing data between 1 January 2015 and 31 December 2021 were modelled using interrupted time series. A segmented regression model estimated the pre-pandemic trend and observed effect of the COVID-19 pandemic response on weekly chlamydia notifications, monthly gonorrhoea notifications and monthly testing figures...
February 23, 2023: Sexually Transmitted Infections
Annie Russell, Sarah Tasker, Kayleigh Nichols, Marc Tweed, Mary Darking, Jennifer Whetham, Daniel Richardson
No abstract text is available yet for this article.
February 23, 2023: Sexually Transmitted Infections
Dwayne-Wilson Hunt, Rageshri Dhairyawan, Annabel Sowemimo, Tom Nadarzynski, Uzochi Nwaosu, Shardia Briscoe-Palmer, Joseph Heskin, Frances Lander, Taslima Rashid
No abstract text is available yet for this article.
February 22, 2023: Sexually Transmitted Infections
Paulo Roberto Sokoll, Celina Borges Migliavaca, Uwe Siebert, Daniela Schmid, Marjan Arvandi
OBJECTIVES: To summarise the prevalence of Mycoplasma genitalium (MG) and antibiotic-resistant MG infection among HIV pre-exposure prophylaxis (PrEP) users. METHODS: We searched MEDLINE, Embase, Web of Science and Global Index Medicus up to 30 September 2022. We included studies reporting the prevalence of MG and/or antibiotic-resistant MG infection among PrEP users. Two reviewers independently searched for studies and extracted data. A systematic review with random-effects meta-analysis was performed to quantitatively summarise the results of included studies...
February 9, 2023: Sexually Transmitted Infections
Jane Babiarz, Chad D Nix, Sean Bowden, Rachel Roberts
OBJECTIVES: To assess HIV pre-exposure prophylaxis (PrEP) prescribing habits by primary care providers and the number of patients at risk of HIV acquisition at a single medical centre in the Northwestern USA from 1 July 2018 to 31 June 2020. METHODS: An electronic cross-sectional survey was administered in April and May 2021 to providers in family medicine, internal medicine, adolescent and young adult health, student health and women's health clinics affiliated with the medical centre with questions pertaining to PrEP prescribing practices...
February 9, 2023: Sexually Transmitted Infections
Amber Savary-Trathen, Richard Cooper, Colin Fitzpatrick, Deborah Williams, Daniel Richardson
No abstract text is available yet for this article.
February 8, 2023: Sexually Transmitted Infections
Jonathan Joseph Goodfellow, Stephen Hughes, Jo Smith, Rachael Jones, Luke S P Moore, Michael Rayment
We describe the novel use of oral chloramphenicol for treatment-resistant Mycoplasma genitalium (M. genitalium ) infection in a 20-year-old heterosexual cisgender male presenting with recurrent symptomatic non-gonococcal urethritis. M. genitalium urethritis is an increasingly common clinical conundrum in sexual health clinics and in cases of second-line treatment failure (such as moxifloxacin), UK and international guidelines struggle to make recommendations for third-line treatments. As shown in our case, the evidence base for third-line treatments is lacking, with poor success rates, and may be poorly tolerated...
January 30, 2023: Sexually Transmitted Infections
John Golden, Lindsey Harryman, Megan Crofts, Peter Muir, Matthew Donati, Sophie Gillett, Charles Irish
We present an apparent second episode of mpox (monkeypox) genital ulcerative disease in a non-immunosuppressed MSM (man who has sex with men) patient who had completely recovered from a primary mpox infection 4 months previously. The patient had also received a complete two-dose course of smallpox vaccination between the two presentations. This case highlights the importance of continuing to include mpox in the differential diagnoses for individuals presenting with genital or mucosal ulceration, regardless of assumed immunity derived from prior infection or vaccination...
January 27, 2023: Sexually Transmitted Infections
Emily Rowlinson, James P Hughes, Christine M Khosropour, Lisa E Manhart, Matthew R Golden, Lindley A Barbee
OBJECTIVES: Epidemiological treatment of persons who are sexual contacts to partners with Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) often results in treatment of uninfected persons, which may increase the risk of antibiotic-resistant infections. We sought to identify the predictors of NG and/or CT infections to develop a risk score that could be used to limit epidemiological treatment to persons most likely to have these infections. METHODS: We included visits to the Public Health - Seattle & King County Sexual Health Clinic by asymptomatic cisgender men who have sex with men (MSM) aged ≥18 who presented as a sexual contact to partner(s) with CT or NG infection between 2011 and 2019...
January 6, 2023: Sexually Transmitted Infections
Simisola Agunbiade, Felicity Burton, Jessica Muirhead, Gary George Whitlock, Nicolò Girometti
INTRODUCTION: A key part of the response to the mpox (monkeypox) epidemic has been the vaccination campaign targeted at gay, bisexual and other men who have sex with men (GBM), including people living with HIV (PLWH). METHODS: We undertook a single-site, retrospective analysis of individuals who received a single dose of modified vaccinia Ankara (MVA-BN) prior to the onset of mpox symptoms. Demographics, clinical characteristics and patient management were analysed...
January 3, 2023: Sexually Transmitted Infections
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