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Sexually Transmitted Infections

Brendan Maughan-Brown, Gavin George, Sean Beckett, Meredith Evans, Lara Lewis, Cherie Cawood, David Khanyile, Ayesha B M Kharsany
OBJECTIVE: There is an urgent need to understand high HIV-infection rates among young women in sub-Saharan Africa. While age-disparate partnerships have been characterised with high-risk sexual behaviours, the mechanisms through which these partnerships may increase HIV-risk are not fully understood. This study assessed the association between age-disparate partnerships and herpes simplex virus type-2 (HSV-2) infection, a factor known to increase HIV-infection risk. METHODS: Cross-sectional face-to-face questionnaire data, and laboratory HSV-2 and HIV antibody data were collected among a representative sample in the 2014/2015 household survey of the HIV Incidence Provincial Surveillance System in KwaZulu-Natal, South Africa...
February 8, 2019: Sexually Transmitted Infections
Jeanne A M C Dirks, Christian J P A Hoebe, Geneviève A F S van Liere, Nicole H T M Dukers-Muijrers, Petra F G Wolffs
OBJECTIVES: Pathogen load has been linked to disease severity in patients infected with HIV, resulting in international standards to adequately and reproducibly quantify load. Chlamydia trachomatis (CT) load has been inconsistently linked to disease severity since extensive differences exist in quantification methods (14 methods in 28 articles). Differences include normalisation for human cell load due to CT's intracellular nature, despite the inability to distinguish inflammatory cells from epithelial cells with molecular techniques...
February 7, 2019: Sexually Transmitted Infections
Eric Richardson, Kelli A Komro, Esaa Samarah, Stephanie A S Staras
OBJECTIVES: We evaluated the feasibility of conducting a 9-week long sexually transmitted infection (STI) prevention intervention, Angels in Action, within an alternative disciplinary school for adolescent girls. METHODS: All girls who were 16-18 years old, enrolled in the school and did not have plans to transfer from the school were eligible to participate. We measured process feasibility with recruitment, retention and participant enjoyment. Using a pretest-post-test design with a double post-test, we used χ² tests to estimate the intervention effect on participants' sexual partner risk knowledge, intentions to reduce partner risk and sexual activities in the past 60 days with three behavioural surveys: prior to, immediately following and 3 months after the intervention...
February 7, 2019: Sexually Transmitted Infections
Marta Checchi, David Mesher, Hamish Mohammed, Kate Soldan
OBJECTIVES: In 2008, a national human papillomavirus (HPV) vaccination programme for females was introduced in England using the bivalent vaccine (HPV16 and 18 only). In 2012, the programme changed to offer the quadrivalent vaccine that includes protection against the two HPV types that cause the majority of anogenital warts (AGW; HPV6 and 11). We present data reporting AGW diagnoses in sexual health clinics (SHCs) in England to the end of 2017, including diagnoses among birth cohorts offered the quadrivalent vaccine...
February 5, 2019: Sexually Transmitted Infections
Pam Sonnenberg, Clare Tanton, David Mesher, Eleanor King, Simon Beddows, Nigel Field, Catherine H Mercer, Kate Soldan, Anne M Johnson
OBJECTIVES: To estimate the prevalence of, and describe risk factors for, genital warts (GWs) in the British population, following the introduction of the bivalent (human papillomavirus (HPV)-16/18) vaccination programme in girls, and prior to the switch to quadrivalent (HPV-6/11/16/18) vaccine (offering direct protection against GWs) and compare this with GW diagnoses in the prevaccination era. METHODS: Natsal-3, a probability sample survey in Britain, conducted in 2010-2012, interviewed 9902 men and women aged 16-44...
February 5, 2019: Sexually Transmitted Infections
Carol Strong, Huachun Zou, Nai-Ying Ko, Ya-Lun Liang, Wen-Wei Ku, Chia-Wen Lee
OBJECTIVES: Men who have sex with men (MSM) are a highly neglected population in the current recommendation of girls-only human papillomavirus (HPV) vaccination programmes in many countries. To better assess the cost effectiveness of HPV vaccination among men requires data on the prevalence of HPV infection in MSM using a community sample, which is still sparse in several regions. We examined the prevalence of and factors associated with anogenital HPV infection among MSM in Taiwan. METHODS: MSM 20 years of age and older were recruited from the community and social media in Taiwan in 2015-2016 and screened for HPV infection to detect 37 genotypes...
January 29, 2019: Sexually Transmitted Infections
Erica M Lokken, Griffins Odhiambo Manguro, Amina Abdallah, Caroline Ngacha, Juma Shafi, James Kiarie, Walter Jaoko, Sujatha Srinivasan, Tina L Fiedler, Matthew M Munch, David N Fredricks, R Scott McClelland, Jennifer E Balkus
OBJECTIVES: Vaginal washing has been associated with reductions in cultivable Lactobacillus and an increased risk of both bacterial vaginosis (BV) and HIV infection. The effect of vaginal washing on the quantity of individual Lactobacillus species is not well characterised. This analysis tested the hypothesis that vaginal washing would be associated with a lower likelihood of Lactobacillus spp. detected by both culture and quantitative PCR (qPCR). METHODS: We conducted a cross-sectional study of 272 HIV-seronegative women enrolled in an open-cohort study in Mombasa, Kenya...
January 29, 2019: Sexually Transmitted Infections
Maximo Robert Prescott, Glenn-Milo Santos, Sean Arayasirikul, Erin Wilson
OBJECTIVES: Little is known about the sexual networks of young transwomen, leaving a major gap in what we know about transmission dynamics and the elevated rates of HIV in this population. The objective of this study was to understand partnership-level factors associated with condomless anal sex among young transwomen. METHODS: A secondary data analysis of the sexual partnerships of young transwomen was conducted using baseline data from the SHINE study. Generalised estimating equation logistic regressions were used to assess for partnership-level associations between partnership type, age, injection drug use and racial concordance, HIV seroconcordance, sexual role and condomless receptive (CRAI) and insertive anal intercourse (CIAI)...
January 25, 2019: Sexually Transmitted Infections
Axel Jeremias Schmidt, Ekkehardt Altpeter
OBJECTIVES: There is no estimate of the current number of men who have sex with men (MSM) in Switzerland, or of their geographical distribution. We aimed to (1) estimate MSM concentration factors and population sizes for 83 Swiss postal code areas (PCA), including the nine largest Swiss cities, and (2) calculate MSM-specific local HIV prevalence and yearly rates of diagnosed HIV, hepatitis C virus (HCV), syphilis and gonorrhoea. METHODS: We triangulated data from general population estimates, MSM online surveys, published data on HIV prevalence and Swiss notification data for HIV and STDs...
January 24, 2019: Sexually Transmitted Infections
Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Jae-Kwan Lee, Kyung-Jin Min, Moran Ki
OBJECTIVE: We aimed to evaluate trends in the prevalence of human papillomavirus (HPV)-related diseases in the era before the introduction of organised HPV vaccination programmes in the Republic of Korea. METHODS: This cross-sectional study used National Health Insurance Service data from 2002 to 2015 and included participants who were diagnosed with the following HPV-related diseases (codes from the International Classification of Diseases, 10th Revision): genital warts (A63...
January 24, 2019: Sexually Transmitted Infections
Laia Cayuelas Redondo, Marina Ruíz, Belchin Kostov, Ethel Sequeira, Pablo Noguera, Maria Alba Herrero, Ignacio Menacho, Olga Barba, Thaïs Clusa, Benet Rifa, Eva María González de la Fuente, Eva González Redondo, Felipe García, Antoni Sisó Almirall, Agathe León
OBJECTIVE: Indicator condition (IC)-guided HIV testing is a strategy for the diagnosis of patients with HIV. The aim of this study was to assess the impact on the proportion of HIV tests requested after the introduction of an electronic prompt instructing primary healthcare (PHC) physicians to request an HIV test when diagnosing predefined IC. METHODS: A prospective interventional study was conducted in 2015 in three PHC centres in Barcelona to assess the number of HIV test requests made during the implementation of an electronic prompt...
January 24, 2019: Sexually Transmitted Infections
Chantal den Daas, Bob Sukel, Hanna Bos, Ingrid van den Broek
OBJECTIVES: Online testing for STIs might complement regular care provided by general practitioners or STI clinics. Two types of online testing can be distinguished, self-testing and self-sampling (sending sample to a laboratory for diagnosis). Online testing can occur without consultation with a healthcare professional, therefore information given by providers is essential for informed decision-making. We aimed to enumerate online test providers in the Netherlands focusing on chlamydia tests, to evaluate information using quality indicators and to gain insight on the proportion of online testing in the STI testing arena...
January 22, 2019: Sexually Transmitted Infections
Ross Liam Cameron, Kate Cuschieri, Kevin G J Pollock
OBJECTIVES: A human papillomavirus (HPV) vaccination programme targeted towards men who have sex with men who are disproportionately affected by HPV anogenital infection and related disease was established in Scotland in July 2017. We aimed to establish a baseline HPV prevalence to assess the potential impact of the programme. METHODS: Residual rectal swabs taken in a sexual health clinic (n=1 248) were tested for the presence of HPV and HPV-type prevalence was collated and stratified by age...
January 13, 2019: Sexually Transmitted Infections
Catherine F Houlihan, Kathy Baisley, Ignacio G Bravo, Miguel A Pavón, John Changalucha, Saidi Kapiga, Silvia De Sanjosé, David A Ross, Richard J Hayes, Deborah Watson-Jones
OBJECTIVE: Human papillomavirus (HPV) DNA has been detected in vaginal samples from adolescent girls who report no previous sex and, in high-income settings, from fingertips, raising the possibility of non-sexual transmission. No such studies originate from East Africa which bears among the highest cervical cancer incidence and HPV prevalence worldwide. HPV-related oral cancer incidence is increasing, but oral HPV prevalence data from East Africa are limited. We aimed to describe the HPV DNA prevalence in genital and non-genital sites and in the bathroom of unvaccinated adolescent girls, and examine genotype concordance between sites...
January 13, 2019: Sexually Transmitted Infections
Travis Salway, Kimberly Thomson, Darlene Taylor, Devon Haag, Elizabeth Elliot, Tom Wong, Christopher K Fairley, Troy Grennan, Jean Shoveller, Gina Ogilvie, Mark Gilbert
OBJECTIVE: Internet-based HIV testing offers the potential to address privacy-related barriers to testing and increase frequency of testing but may result in missed opportunities related to sexual health education and prevention that typically occur in face-to-face encounters. In this study, we assessed the HIV test knowledge and sexual risk behaviour of clients testing for HIV through GetCheckedOnline , an internet-based sexually transmitted and bloodborne infection testing platform inclusive of HIV testing, in comparison to clients testing through a large sexual health clinic...
January 13, 2019: Sexually Transmitted Infections
Rod Eric Knight, Cathy Chabot, Anna Carson, Kimberly Thomson, Devon Haag, Mark Gilbert, Jean Shoveller
OBJECTIVES: To describe the factors that influence gay, bisexual and other men who have sex with men's (gbMSM) experiences with (GCO) in British Columbia (BC), Canada. GCO clients complete an internet-based risk assessment and print a laboratory test requisition form for HIV and other STIs to take to a private laboratory for diagnostic services. METHODS: Drawing on a purposive stratified sampling framework, we conducted 37 in-depth semistructured interviews with gbMSM who had used GCO at least once between 2015 and 2017...
January 13, 2019: Sexually Transmitted Infections
Adam Bourne, Beatrice Alba, Alex Garner, Gianfranco Spiteri, Anastasia Pharris, Teymur Noori
OBJECTIVE: Currently, seven European countries provide HIV pre-exposure prophylaxis (PrEP) through public health services, although there are numerous reports of off-licence use. The objective of this study was to examine current use of PrEP, likelihood of future use and indicators of potential PrEP candidacy among an opportunistic sample of men who have sex with men in Europe and Central Asia. METHODS: A survey was sent out in eight languages to users of the Hornet gay networking application in July and August 2017...
January 5, 2019: Sexually Transmitted Infections
Bernice M Hoenderboom, Birgit H B van Benthem, Jan E A M van Bergen, Nicole H T M Dukers-Muijrers, Hannelore M Götz, Christian J P A Hoebe, Arjan A Hogewoning, Jolande A Land, Marianne A B van der Sande, Servaas A Morré, Ingrid V F van den Broek
OBJECTIVES: A better understanding of Chlamydia trachomatis infection (chlamydia)-related sequelae can provide a framework for effective chlamydia control strategies. The objective of this study was to estimate risks and risk factors of pelvic inflammatory disease (PID), ectopic pregnancy and tubal factor infertility (TFI) with a follow-up time of up until 8 years in women previously tested for chlamydia in the Chlamydia Screening Implementation study (CSI) and participating in the Netherlands Chlamydia Cohort Study (NECCST)...
January 3, 2019: Sexually Transmitted Infections
Céline Langendorf, Céline Lastrucci, Isabelle Sanou-Bicaba, Kara Blackburn, Marie-Hortense Koudika, Tania Crucitti
OBJECTIVES: In resource-limited settings, screening pregnant women for syphilis using rapid diagnostic tests (RDTs) is a key tool in the prevention of congenital syphilis. However, most syphilis RDTs detect only treponemal antibodies (T-RDT), meaning antibiotics may be provided unnecessarily to previously treated pregnant women, particularly in non-venereal treponematoses endemic regions. We estimated the potential reduction in overtreatment when comparing T-RDT (SD Bioline) to a newer rapid test (Dual Path Platform (DPP) Screen and Confirm Assay, Chembio) detecting both treponemal and non-treponemal antibodies...
December 22, 2018: Sexually Transmitted Infections
Duygu Durukan, Christopher K Fairley, Catriona S Bradshaw, Tim R H Read, Julian Druce, Michael Catton, Leon Caly, Eric P F Chow
OBJECTIVES: Reports of rising herpes simplex virus type 1 (HSV-1) genital infections relative to HSV-2 have been published up to 2006 in Australia. These changes have been attributed to declining childhood immunity to HSV-1. We described the temporal trends of HSV-1 and HSV-2 up to 2017 in Melbourne, Australia, to determine if the earlier trend is continuing. METHODS: We conducted a retrospective review of the medical records of 4517 patients who were diagnosed with first episode of anogenital HSV infection at the Melbourne Sexual Health Centre, Australia, between January 2004 and December 2017...
December 15, 2018: Sexually Transmitted Infections
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