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Journals Toxicological Sciences : An Of...

Toxicological Sciences : An Official Journal of the Society of Toxicology

https://read.qxmd.com/read/38015832/a-network-based-transcriptomic-landscape-of-hepg2-cells-uncovering-causal-gene-cytotoxicity-interactions-underlying-drug-induced-liver-injury
#1
JOURNAL ARTICLE
Lukas S Wijaya, Attila Gabor, Iris E Pot, Luca van de Have, Julio Saez-Rodriguez, James L Stevens, Sylvia E Le Dévédec, Giulia Callegaro, Bob van de Water
Drug-induced liver injury (DILI) remains the main reason for drug development attritions largely due to poor mechanistic understanding. Toxicogenomic to interrogate the mechanism of DILI has been broadly performed. Gene co-regulation network-based transcriptome analysis is a bioinformatics approach that potentially contributes to improve mechanistic interpretation of toxicogenomic data. Here we performed an extensive concentration time course response-toxicogenomic study in the HepG2 cell line exposed to 20 DILI compounds, 7 reference compounds for stress response pathways, and 10 agonists for cytokines and growth factor receptors...
November 28, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/38011675/long-lasting-developmental-effects-in-rat-offspring-after-maternal-exposure-to-acetamiprid-in-the-drinking-water-during-gestation
#2
JOURNAL ARTICLE
V Longoni, P C Kandel Gambarte, L Rueda, J S Fuchs, M G Rovedatti, M J Wolansky
Neonicotinoids (NNTs) are a class of insecticides proposed to be safe for pest control in urban, suburban and agricultural applications. However, little is known about their developmental effects after repeated low-dose exposures during gestation. Here, we tested a dose considered subthreshold for maternal toxicity in rats (6 mg/kg/day) by assessing several morphological, biochemical and neurobehavioral features in pre-term fetuses and developing pups after maternal administration of the NTT acetamiprid (ACP) dissolved in the drinking water during gestational days (GD) 2-19...
November 27, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37978862/correction-to-crypt-and-villus-transcriptomic-responses-in-mouse-small-intestine-following-oral-exposure-to-hexavalent-chromium
#3
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37952249/naturally-occurring-autoimmune-disease-in-nzb-x-nzw-f1-mice-is-correlated-with-suppression-of-mz-b-cell-development-due-to-aberrant-b-cell-receptor-bcr-signaling-which-is-exacerbated-by-exposure-to-inorganic-mercury
#4
JOURNAL ARTICLE
Randall F Gill, Patricia A Mathieu, Lawrence H Lash, Allen J Rosenspire
Autoimmune diseases are multifactorial and include environmental as well as genetic drivers. Although much progress has been made in understanding the nature of genetic underpinnings of autoimmune disease, by comparison much less is understood regarding how environmental factors interact with genetics in the development of autoimmunity and autoimmune disease. In this report, we utilize the (NZB X NZW) F1 mouse model of Systemic Lupus Erythematosus (SLE). Mercury is a xenobiotic that is environmentally ubiquitous and is epidemiologically linked with the development of autoimmunity...
November 11, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37952247/investigating-the-replacement-of-carboxylates-with-carboxamides-to-modulate-the-safety-and-efficacy-of-platinum-ii-thioether-cyanide-scavengers
#5
JOURNAL ARTICLE
Matthew M Behymer, Huaping Mo, Naoaki Fujii, Vallabh Suresh, Ari S Arzumanian, Adriano Chan, Anjali K Nath, Robyn McCain, Calum A MacRae, Randall Peterson, Gerry R Boss, Vincent Jo Davisson, Gregory T Knipp
Cyanide represents a persistent threat for accidental or malicious misuse due to easy conversion into a toxic gas and access to large quantities through several industries. The high safety index of hydroxocobalamin is a cornerstone quality as a cyanide scavenger. Unfortunately, intravenous infusion of hydroxocobalamin limits the utility in a mass casualty setting. We previously reported platinum(II) [Pt(II)] complexes with trans-directing sulfur ligands as an efficacious alternative to hydroxocobalamin when delivered by a bolus intramuscular injection in mice and rabbits...
November 11, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37941503/mechanistic-toxicology-in-light-of-genetic-compensation
#6
JOURNAL ARTICLE
Mary Jane Elizalde, Daniel A Gorelick
Mechanistic toxicology seeks to identify the molecular and cellular mechanisms by which toxicants exert their deleterious effects. One powerful approach is to generate mutations in genes that respond to a particular toxicant, and then test how such mutations change the effects of the toxicant. CRISPR is a rapid and versatile approach to generate mutations in cultured cells and in animal models. Many studies use CRISPR to generate short insertions or deletions in a target gene and then assume that the resulting mutation, such as a premature termination codon, causes a loss of functional protein...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37941498/mono-2-ethylhexyl-phthalate-mehp-reversibly-disrupts-the-blood-testis-barrier-btb-in-pubertal-rats
#7
JOURNAL ARTICLE
Richa Tiwary, John H Richburg
The blood-testis barrier (BTB) is constituted by tight junctions between adjacent Sertoli cells (SC) that create a specialized adluminal microenvironment to foster the development of spermatocytes and spermatids. The BTB is a well-studied target of numerous environmental toxicants, including di-(2-ethylhexyl) phthalate (DEHP), a compound widely used in various consumer products. MEHP is the active toxic metabolite of DEHP that has long been recognized in postnatal rodents to disrupt SC function. This study evaluates the impact of MEHP on the integrity of the BTB in both pubertal and adult rats and the signal transduction pathways known to be involved in the disruption of the BTB...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37941476/toxicological-mechanisms-and-potencies-of-organophosphate-esters-in-kgn-human-ovarian-granulosa-cells-as-revealed-by-high-throughput-transcriptomics
#8
JOURNAL ARTICLE
Xiaotong Wang, Andrea Rowan-Carroll, Matthew J Meier, Andrew Williams, Carole L Yauk, Barbara F Hales, Bernard Robaire
Despite the growing number of studies reporting potential risks associated with exposure to organophosphate esters (OPEs), their molecular mechanisms of action remain poorly defined. We used the high-throughput TempO-Seq™ platform to investigate the effects of frequently detected OPEs on the expression of ∼3000 environmentally responsive genes in KGN human ovarian granulosa cells. Cells were exposed for 48 h to one of five OPEs (0.1 to 50 μM): tris(methylphenyl) phosphate (TMPP), isopropylated triphenyl phosphate (IPPP), tert-butylphenyl diphenyl phosphate (BPDP), triphenyl phosphate (TPHP), or tris(2-butoxyethyl) phosphate (TBOEP)...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37941452/metabolic-reprograming-and-increased-inflammation-by-cadmium-exposure-following-early-life-respiratory-syncytial-virus-infection-the-involvement-of-protein-s-palmitoylation
#9
JOURNAL ARTICLE
Zachery R Jarrell, Choon-Myung Lee, Ki-Hye Kim, Xiaojia He, Matthew R Smith, Jannatul R Raha, Noopur Bhatnagasr, Michael Orr, Sang-Moo Kang, Yan Chen, Dean P Jones, Young-Mi Go
Early-life respiratory syncytial virus (RSV) infection (eRSV) is one of the leading causes of serious pulmonary disease in children. eRSV is associated with higher risk of developing asthma and compromised lung function later in life. Cadmium (Cd) is a toxic metal, widely present in the environment and in food. We recently showed that eRSV re-programs metabolism and potentiates Cd toxicity in the lung, and our transcriptome-metabolome-wide study showed strong associations between S-palmitoyl transferase expression and Cd-stimulated lung inflammation and fibrosis signaling...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37941438/fetoplacental-disposition-and-toxicity-of-cadmium-in-mice-lacking-the-bcrp-transporter
#10
JOURNAL ARTICLE
Danielle Kozlosky, Cathleen Doherty, Brian Buckley, Michael J Goedken, Richard K Miller, Dan Dongeun Huh, Emily S Barrett, Lauren M Aleksunes
The environmental toxicant cadmium (Cd) impairs the growth of rodents and humans in utero which in turn heightens susceptibility to diseases later in life. We previously demonstrated that the maternal-facing efflux transporter, breast cancer resistance protein (human BCRP/ABCG2, mouse Bcrp/Abcg2) confers resistance against Cd toxicity in human trophoblasts. In the current study, we sought to determine whether the absence of Bcrp alters the fetoplacental disposition and toxicity of Cd in mice. Pregnant female wild-type (WT) and Bcrp-null mice (n = 9-10/group) were administered a single injection of saline (5 ml/kg) or CdCl2 (5 mg/kg) on gestational day (GD) 9...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37941435/rat-deconvolution-as-knowledge-miner-for-immune-cell-trafficking-from-toxicogenomics-databases
#11
JOURNAL ARTICLE
Katsuhisa Morita, Tadahaya Mizuno, Iori Azuma, Yutaka Suzuki, Hiroyuki Kusuhara
Toxicogenomics databases are useful for understanding biological responses in individuals because they include a diverse spectrum of biological responses. Although these databases contain no information regarding immune cells in the liver, which are important in the progression of liver injury, deconvolution that estimates cell-type proportions from bulk transcriptome could extend immune information. However, deconvolution has been mainly applied to humans and mice and less often to rats, which are the main target of toxicogenomics databases...
November 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37931227/correction-to-reducing-uncertainties-in-quantitative-adverse-outcome-pathways-by-analysis-of-thyroid-hormone-in-the-neonatal-rat-brain
#12
(no author information available yet)
No abstract text is available yet for this article.
November 1, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37875026/correction-to-deletion-of-il-1%C3%AE-exacerbates-acrylamide-induced-neurotoxicity-in-mice
#13
(no author information available yet)
No abstract text is available yet for this article.
October 24, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37875019/correction-to-role-of-nrf2-in-1-2-dichloropropane-induced-cell-proliferation-and-dna-damage-in-the-mouse-liver
#14
(no author information available yet)
No abstract text is available yet for this article.
October 24, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37851381/extracellular-vesicles-altered-by-a-per-and-polyfluoroalkyl-substance-mixture-in-vitro-dose-dependent-release-chemical-content-and-microrna-signatures-involved-in-liver-health
#15
JOURNAL ARTICLE
Celeste K Carberry, Jacqueline Bangma, Lauren Koval, Deepak Keshava, Hadley J Hartwell, Marina Sokolsky, Rebecca C Fry, Julia E Rager
Per- and polyfluoroalkyl substances (PFAS) have emerged as high priority contaminants due to their ubiquity and pervasiveness in the environment. Numerous PFAS co-occur across sources of drinking water, including areas of North Carolina (NC) with some detected concentrations above the Environmental Protection Agency's health advisory levels. While evidence demonstrates PFAS exposure induces harmful effects in the liver, the involvement of extracellular vesicles (EVs) as potential mediators of these effects has yet to be evaluated...
October 18, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37831906/the-lncrna-h19-mir-29a-3p-snip1-c-myc-regulatory-axis-is-involved-in-pulmonary-fibrosis-induced-by-nd2o3
#16
JOURNAL ARTICLE
Bu Ning, Wang Shurui, Ma Yupeng, Xia Haibo, Zhao Yuhang, Shi Xuemin, Liu Qizhan, Suhua Wang, Gao Yanrong
Some rare earth elements are occupational and environmental toxicants and can cause organ and systemic damage; therefore, they have attracted global attention. Neodymium oxide (Nd2O3) is a rare earth element that is refined and significantly utilized in China. The long non-coding RNA (lncRNA) H19 is encoded by the H19/IGF2 imprinted gene cluster located on human chromosome 11p15.5. H19 has become a research focus due to its ectopic expression leading to the promotion of fibrosis. However, the mechanisms by which it causes pulmonary fibrosis are elusive...
October 13, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37824398/correction-to-from-classical-toxicology-to-tox21-some-critical-conceptual-and-technological-advances-in-the-molecular-understanding-of-the-toxic-response-beginning-from-the-last-quarter-of-the-20th-century
#17
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37812252/evidence-for-the-cardiodepressive-effects-of-the-plasticizer-di-2-ethylhexylphthalate-dehp
#18
JOURNAL ARTICLE
Luther M Swift, Anysja Roberts, Jenna Pressman, Devon Guerrelli, Samuel Allen, Kazi T Haq, Julie A Reisz, Angelo D'Alessandro, Nikki Gillum Posnack
Di-2-ethylhexylphthalate (DEHP) is commonly used in the manufacturing of plastic materials, including intravenous bags, blood storage bags, and medical-grade tubing. DEHP can leach from plastic medical products, which can result in inadvertent patient exposure. DEHP concentrations were measured in red blood cell (RBC) units stored between 7-42 days (17-119 μg/mL). Using these concentrations as a guide, Langendorff-perfused rat heart preparations were acutely exposed to DEHP. Sinus activity remained stable with lower doses of DEHP (25-50 μg/mL), but sinus rate declined by 43% and sinus node recovery time prolonged by 56...
October 9, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37792503/hepatocyte-specific-deletion-of-small-heterodimer-partner-protects-mice-against-acetaminophen-induced-hepatotoxicity-via-activation-of-nrf2
#19
JOURNAL ARTICLE
Priyanka Ghosh, Nancy Magee, Jephte Y Akakpo, Forkan Ahamed, Natalie Eppler, Elizabeth Jones, Yifan Yu, Lily He, Margitta Lebofsky, Hongyan Dai, Hartmut Jaeschke, Wen-Xing Ding, Yuxia Zhang
Acetaminophen (APAP) overdose stands as the primary cause of acute liver failure in the United States. APAP hepatotoxicity involves hepatic glutathione (GSH) depletion and mitochondrial damage. To counteract the toxicity of APAP, the nuclear factor erythroid 2 like 2 (Nrf2) activates the expression of genes responsible for drug detoxification and GSH synthesis. In this study, we present evidence that the elimination of hepatocyte small heterodimer partner (Shp), a critical transcriptional repressor for liver metabolism, results in Nrf2 activation and protects mice from APAP-induced acute liver injury...
October 4, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/37788138/the-involvement-of-hepatic-cytochrome-p450s-in-the-cytotoxicity-of-lapatinib
#20
JOURNAL ARTICLE
Si Chen, Xilin Li, Yuxi Li, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo
Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells...
October 3, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
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