journal
Journals Toxicological Sciences : An Of...

Toxicological Sciences : An Official Journal of the Society of Toxicology

https://read.qxmd.com/read/36951524/triazole-fungicides-induce-adipogenesis-and-repress-osteoblastogenesis-in-zebrafish
#1
JOURNAL ARTICLE
Savini Thrikawala, Fahmi Mesmar, Beas Bhattacharya, Maram Muhsen, Srijita Mukhopadhyay, Sara Flores, Sanat Upadhyay, Leoncio Vergara, Jan-Åke Gustafsson, Cecilia Williams, Maria Bondesson
Triazoles are a major group of azole fungicides commonly used in agriculture, veterinary, and human medicine. Maternal exposure to certain triazole anti-fungal medication causes congenital malformations, including skeletal malformations. We hypothesized that triazoles used as pesticides in agriculture also pose a risk of causing skeletal malformations in developing embryos. In this study, teratogenic effects of three commonly used triazoles, cyproconazole, paclobutrazol, and triadimenol, were investigated in zebrafish, Danio rerio...
March 23, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36946286/profiling-mechanisms-that-drive-acute-oral-toxicity-in-mammals-and-its-prediction-via-machine-learning
#2
JOURNAL ARTICLE
Sanjeeva J Wijeyesakere, Tyler Auernhammer, Amanda Parks, Dan Wilson
We present a mechanistic machine-learning quantitative structure-activity relationship (QSAR) model to predict mammalian acute oral toxicity. We trained our model using a rat acute toxicity database compiled by the US National Toxicology Program. We profiled the database using new and published profilers and identified the most plausible mechanisms that drive high acute toxicity (LD50 ≤ 50 mg/kg; GHS categories 1 or 2). Our QSAR model assigns primary mechanisms to compounds, followed by predicting their acute oral LD50 using a random-forest machine-learning model...
March 22, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36929940/long-term-exposure-to-di-2-ethylhexyl-phthalate-diisononyl-phthalate-and-a-mixture-of-phthalates-alters-estrous-cyclicity-and-or-impairs-gestational-index-and-birth-rate-in-mice
#3
JOURNAL ARTICLE
Mary J Laws, Daryl D Meling, Ashley R K Deviney, Ramsés Santacruz-Márquez, Jodi A Flaws
Phthalates are found in plastic food containers, medical plastics, and personal care products. However, the effects of long-term phthalate exposure on female reproduction are unknown. Thus, this study investigated the effects of long-term, dietary phthalate exposure on estrous cyclicity and fertility in female mice. Adult female CD-1 mice were fed chow containing vehicle control (corn oil) or 0.15 ppm-1500 ppm of di(2- ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP), or a mixture of phthalates (Mix) containing DEHP, DiNP, benzyl butyl phthalate, di-n-butyl phthalate, diisobutyl phthalate, and diethyl phthalate...
March 17, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36916757/behavior-and-brain-size-of-larval-zebrafish-exposed-to-environmentally-relevant-concentrations-of-beta-methylamino-l-alanine-bmaa
#4
JOURNAL ARTICLE
Amanda M Reside, Sana Gavarikar, Frédéric Laberge, Nicholas J Bernier
Harmful algal blooms (HABs) release toxic compounds in water and are increasing in frequency worldwide. The neurotoxin β-methylamino-L-alanine (BMAA) is released by HABs and has garnered much attention over the past twenty years due to its association with human neurodegenerative disorders, but its effects on wildlife are still largely unknown. This study characterized the effects of chronic exposure to environmentally relevant concentrations of BMAA on the behavior and brain size of developing zebrafish (Danio rerio)...
March 14, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36912754/adolescent-exposure-to-low-dose-%C3%AE-9-tetrahydrocannabinol-thc-depletes-the-ovarian-reserve-in-female-mice
#5
JOURNAL ARTICLE
Jinhwan Lim, Hye-Lim Lee, Julie Nguyen, Joyce Shin, Samantha Getze, Caitlin Quach, Erica Squire, Kwang-Mook Jung, Stephen V Mahler, Ken Mackie, Daniele Piomelli, Ulrike Luderer
Cannabis use by adolescents is widespread, but its effects on the ovaries remain largely unknown. Δ9-tetrahydrocannabinol (THC) exerts its pharmacological effects by activating, and in some conditions hijacking, cannabinoid receptors (CBRs). We hypothesized that adolescent exposure to THC affects ovarian function in adulthood. Peripubertal female C57BL/6N mice were given THC (5 mg/kg) or its vehicle, once daily by intraperitoneal injection. Mice either received THC from postnatal day (PND) 30-33 and ovaries were harvested PND34 or mice received THC from PND30-43, and ovaries were harvested PND70...
March 13, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36912747/updating-the-biologically-based-dose-response-model-for-the-nasal-carcinogenicity-of-inhaled-formaldehyde-in-the-f344-rat
#6
JOURNAL ARTICLE
Rory B Conolly, Jeffry Schroeter, Julia S Kimbell, Harvey Clewell, Melvin E Andersen, P Robinan Gentry
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including dose-response and time course data for SCC, mechanistic endpoints, and nasal dosimetry. Conolly et al. (Toxicol. Sci. 75, 432-447, 2003) used these resources to develop a biologically based dose-response (BBDR) model for SCC in F344 rats. This model, scaled up to humans, has informed dose-response conclusions reached by several international regulatory agencies. However, USEPA concluded that uncertainties precluded its use for cancer risk assessment...
March 13, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36912746/pulmonary-and-neurological-health-effects-associated-with-exposure-to-representative-composite-manufacturing-emissions-and-corresponding-alterations-in-circulating-metabolite-profiles
#7
JOURNAL ARTICLE
Li Xia, Yoorae Noh, Andrew J Whelton, Brandon E Boor, Bruce Cooper, Nathanael I Lichti, Jae Hong Park, Jonathan H Shannahan
Cured-in-place pipe (CIPP) technology is increasingly being utilized to repair aging and damaged pipes, however, there are concerns associated with the public health hazards of emissions. CIPP installation involves the manufacture of a new plastic composite pipe at the worksite and includes multiple variable components including resin material, curing methods, and operational conditions. We hypothesize styrene-based composite manufacturing emissions (CMEs) will induce greater pulmonary inflammatory responses and oxidative stress, as well as neurological toxicity compared to non-styrene CMEs...
March 13, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36892438/vinyl-chloride-enhances-high-fat-diet-induced-proteome-alterations-in-the-mouse-pancreas-related-to-metabolic-dysfunction
#8
JOURNAL ARTICLE
Yue Ge, Maribel Bruno, Maliha S Nash, Najwa Haykal Coates, Brian N Chorley, Matthew C Cave, Juliane I Beier
Alterations in physiological processes in pancreas have been associated with various metabolic dysfunctions and can result from environmental exposures, such as chemicals and diet. It was reported that environmental vinyl chloride exposure, a common industrial organochlorine and environmental pollutant, significantly exacerbated metabolic-related phenotypes in mice fed concurrently fed high-fat diet but not low-fat diet. However, little is known about the role of the pancreas in this interplay, especially at a proteomic level...
March 9, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36881996/photoaging-of-polystyrene-microspheres-causes-oxidative-alterations-to-surface-physicochemistry-and-enhances-airway-epithelial-toxicity
#9
JOURNAL ARTICLE
Eliane El Hayek, Eliseo Castillo, Julie G In, Marcus Garcia, Jose Cerrato, Adrian Brearley, Jorge Gonzalez-Estrella, Guy Herbert, Barry Bleske, Angelica Benavidez, Hsuan Hsiao, Lei Yin, Matthew J Campen, Xiaozhong Yu
Microplastics represent an emerging environmental contaminant, with large gaps in our understanding of human health impacts. Furthermore, environmental factors may modify the plastic chemistry, further altering the toxic potency. Ultraviolet light is one such unavoidable factor for airborne microplastic particulates and a known modifier of polystyrene surface chemistry. As an experimental model, we aged commercially-available polystyrene microspheres for five weeks with ultraviolet radiation, then compared the cellular responses in A549 lung cells to both pristine and irradiated particulates...
March 7, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36882182/investigations-into-hydrogen-sulfide-induced-suppression-of-neuronal-activity-in-vivo-and-calcium-dysregulation-in-vitro
#10
JOURNAL ARTICLE
Dong-Suk Kim, Isaac N Pessah, Cristina M Santana, Benton Purnell, Rui Li, Gordon F Buchanan, Wilson K Rumbeiha
Acute exposure to high concentrations of hydrogen sulfide (H2S) leads to sudden death and, if survived, lingering neurological disorders. Clinical signs include seizures, loss of consciousness, and dyspnea. The proximate mechanisms underlying H2S-induced acute toxicity and death have not been clearly elucidated. We investigated electrocerebral, cardiac and respiratory activity during H2S exposure using electroencephalogram (EEG), electrocardiogram (EKG) and plethysmography. H2S suppressed electrocerebral activity and disrupted breathing...
March 6, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36869685/a-model-template-approach-for-rapid-evaluation-and-application-of-physiologically-based-pharmacokinetic-models-extension-to-volatile-organic-compounds
#11
JOURNAL ARTICLE
Amanda S Bernstein, Bidya Prasad, Paul M Schlosser, Dustin F Kapraun
Chemical risk assessors use physiologically based pharmacokinetic (PBPK) models to perform dosimetric calculations, including extrapolations between exposure scenarios, species, and populations of interest. Assessors should complete a thorough quality assurance (QA) review to ensure biological accuracy and correct implementation prior to using these models. This process can be time-consuming, and we developed a PBPK model template that allows for faster, more efficient QA review. The model template consists of a single model "superstructure" with equations and logic commonly found in PBPK models, allowing users to implement a wide variety of chemical-specific PBPK models...
March 3, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36857595/fine-particulate-matter-pm2-5-induced-pulmonary-oxidative-stress-contributes-to-changes-in-the-plasma-lipidome-and-liver-transcriptome-in-mice
#12
JOURNAL ARTICLE
Zimple Kurlawala, Parul Singh, Bradford G Hill, Petra Haberzettl
Fine particulate matter (PM2.5) air pollution exposure increases the cardiovascular disease risk. Although the specific mechanisms remain elusive, it is thought that PM2.5-induced oxidative stress and endothelial dysfunction contribute to this pathogenesis. Our previous findings indicate that PM2.5 impairs vascular health via a circulating factor and that plasma lipid changes contribute to the observed vascular effects. In the current study, we extend on these findings by further characterizing PM2.5-induced changes in circulating lipids and examining whether the observed changes were accompanied by related alterations in the liver transcriptome...
March 1, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36857578/glyphosate-toxicity-in-vivo-in-vitro-and-epidemiological-evidence
#13
JOURNAL ARTICLE
Rachel Lacroix, Deborah M Kurrasch
Glyphosate is the most applied agricultural chemical worldwide and has become nearly ubiquitous throughout the environment. Glyphosate is an effective herbicide because it disrupts the shikimate pathway, which is responsible for the synthesis of essential amino acids in plants and microorganisms. Given that there is no known target for glyphosate in higher animals, its toxicity to humans and other animals is heavily debated, especially after the 2015 IARC ruling that glyphosate is carcinogenic. Today, a growing body of literature shows in vitro, in vivo, and epidemiological evidence for the toxicity of glyphosate across animal species...
March 1, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36856729/excretion-of-polybrominated-diphenyl-ethers-and-ahr-activation-in-breastmilk-among-firefighters
#14
JOURNAL ARTICLE
Alesia M Jung, Shawn C Beitel, Shannon L Gutenkunst, Dean Billheimer, Sara A Jahnke, Sally R Littau, Mandie White, Christiane Hoppe-Jones, Nathan Cherrington, Jefferey L Burgess
Excretion of toxicants accumulated from firefighter exposures through breastmilk represents a potential hazard. We investigated if firefighting exposures could increase the concentration of polybrominated diphenyl ethers (PBDEs) and aryl hydrocarbon receptor (AhR) activation in excreted breastmilk. Firefighters and non-firefighters collected breastmilk samples prior to any firefighting responses (baseline) and at 2, 8, 24, 48, and 72 hours after a structural fire (firefighters only). Five PBDE analytes (BDEs 15, 28, 47, 99, and 153) detected in at least 90% of samples were summed for analyses...
February 28, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36847456/postnatal-administration-of-s-adenosylmethionine-restores-developmental-ahr-activation-induced-deficits-in-cd8-t-cell-function-during-influenza-a-virus-infection
#15
JOURNAL ARTICLE
Christina M Post, Jason R Myers, Bethany Winans, B Paige Lawrence
Developmental exposures can influence life-long health; yet, counteracting negative consequences is challenging due to poor understanding of cellular mechanisms. The aryl hydrocarbon receptor (AHR) binds many small molecules, including numerous pollutants. Developmental exposure to the signature environmental AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly dampens adaptive immune responses to influenza A virus (IAV) in adult offspring. CD8+ cytotoxic T lymphocytes (CTL) are crucial for successful infection resolution, which depends on the number generated and the complexity of their functionality...
February 27, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36847453/cigarette-smoke-and-tumor-micro-environment-co-promote-aggressiveness-of-human-breast-cancer-cells
#16
JOURNAL ARTICLE
Louise Benoit, Celine Tomkiewicz, Maxime Delit, Hanna Khider, Karine Audouze, Flavie Kowandy, Sylvie Bortoli, Robert Barouki, Xavier Coumoul, Meriem Koual
Breast cancer is a major public health issue and the role of pollutants in promoting breast cancer progression has recently been suggested. We aimed to assess if a mixture of pollutants, cigarette smoke, could favor the aggressivity of breast cancer cells. We also evaluated the impact of the tumor micro-environment, largely represented by adipocytes, in mediating this modification of cell phenotype. Breast cancer cells lines MCF-7 were cultured using a transwell coculture model with preadipocytes hMADS cells or were cultured alone...
February 27, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36790081/epigenetic-programming-of-tbx2-cx43-mediates-lower-sperm-quality-in-male-offspring-induced-by-prenatal-dexamethasone-exposure
#17
JOURNAL ARTICLE
Yi Liu, Yi Liu, Guanghui Chen, Hui Wang
Decreased sperm quality is the main cause of male infertility. Studies have found that prenatal dexamethasone exposure (PDE) decreases sperm quality in male offspring after birth, but the mechanism is unclear. Wistar pregnant rats were subcutaneously injected with 0.1, 0.2 and 0.4 mg/kg.d dexamethasone at gestational day 9-20. The testes and sperm of first-generation (F1) offspring were collected, and F1 offspring were mated with wild-type female rats to obtain F2. Compared with the control group, F1 offspring in PDE group had lower sperm count and motility after birth, and the deformity rate increased...
February 15, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36782369/ahr-activation-affects-nitrergic-neuronal-survival-and-delays-intestinal-motility-in-mice
#18
JOURNAL ARTICLE
Anitha Vijay, Nina R Boyle, Supriya M Kumar, Gary H Perdew, Shanthi Srinivasan, Andrew D Patterson
Despite progress describing the effects of persistent organic pollutants (POPs) on the central nervous system, the effect of POPs on enteric nervous system (ENS) function remains underexplored. We studied the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a POP and a potent aryl hydrocarbon receptor (AHR) ligand, on the ENS and intestinal motility in mice. C57Bl/6J mice treated with TCDD (2.4 µg/kg body weight) for eight weeks (once per week) exhibited significant delay in intestinal motility as shown by reduced stool frequency, prolonged intestinal transit time, and a persistence of the dye in the jejunum compared to control mice with maximal dye retention in the ileum...
February 14, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36782357/identification-of-flucloxacillin-modified-hepatocellular-proteins-implications-in-flucloxacillin-induced-liver-injury
#19
JOURNAL ARTICLE
Serat-E Ali, James C Waddington, Adam Lister, Rowena Sison-Young, Robert P Jones, Adeeb H Rehman, Chris E P Goldring, Dean J Naisbitt, Xiaoli Meng
Flucloxacillin is a β-lactam antibiotic associated with a high incidence of drug-induced liver injury. Although expression of HLA-B*57:01 is associated with increased susceptibility, little is known of the pathological mechanisms involved in the induction of the clinical phenotype. Irreversible protein modification is suspected to drive the reaction through the provision of flucloxacillin-modified peptides that are presented to T-cells by the protein encoded by the risk allele. In this study, we have shown that flucloxacillin binds to multiple proteins within human primary hepatocytes, including major hepatocellular proteins (haemoglobin and albumin) and mitochondrial proteins...
February 14, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://read.qxmd.com/read/36782355/a-pragmatic-framework-for-the-application-of-new-approach-methodologies-in-one-health-toxicological-risk-assessment
#20
JOURNAL ARTICLE
Kelly A Magurany, Xiaoqing Chang, Rebecca Clewell, Sandra Coecke, Esther Haugabrooks, Sue Marty
Globally, industries and regulatory authorities are faced with an urgent need to assess the potential adverse effects of chemicals more efficiently by embracing new approach methodologies (NAMs). NAMs include cell and tissue methods (in vitro), structure-based/toxicokinetic models (in silico), methods that assess toxicant interactions with biological macromolecules (in chemico), and alternative models. Increasing knowledge on chemical toxicokinetics (what the body does with chemicals) and toxicodynamics (what the chemicals do with the body) obtained from in silico and in vitro systems continues to provide opportunities for modernizing chemical risk assessments...
February 14, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
journal
journal
32959
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.