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Journals Neuromodulation : Journal of t...

Neuromodulation : Journal of the International Neuromodulation Society

https://read.qxmd.com/read/38752947/implanted-pulse-generators-in-lower-extremity-neuroprostheses-a-25-year-review
#1
JOURNAL ARTICLE
Lizbeth A Leapo, Michael E Miller, Harry A Hoyen, Gilles C Pinault, Ronald J Triolo
OBJECTIVES: Neuroprosthetic devices can improve quality of life by providing an alternative option for motor function lost after spinal cord injury, stroke, and other central nervous system disorders. The objective of this study is to analyze the outcomes of implanted pulse generators that our research group installed in volunteers with paralysis to assist with lower extremity function over a 25-year period, specifically, to determine survival rates and common modes of malfunction, reasons for removal or revision, and precipitating factors or external events that may have adversely influenced device performance...
May 15, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38752945/effects-of-pulsed-radiofrequency-duration-in-patients-with-chronic-lumbosacral-radicular-pain-a-randomized-double-blind-study
#2
JOURNAL ARTICLE
Chan-Sik Kim, Yujin Kim, Doo-Hwan Kim, Hyun-Jung Kwon, Jin-Woo Shin, Seong-Soo Choi
OBJECTIVES: We hypothesized that the duration of pulsed radiofrequency (PRF) application may affect the effectiveness of PRF in patients with chronic lumbosacral radicular pain (LRP). MATERIALS AND METHODS: In this prospective, double-blind, randomized study, 68 patients were randomly allocated to two groups: a 6-minute group, in which PRF was applied at 42 °C for 2 minutes followed by a 2-minute pause, repeated three times; and a 12-minute group, with a continuous application at 42 °C for 12 minutes...
May 15, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38752946/the-polyanalgesic-consensus-conference-pacc-%C3%A2-intrathecal-drug-delivery-guidance-on-safety-and-therapy-optimization-when-treating-chronic-noncancer-pain
#3
REVIEW
Timothy R Deer, Salim M Hayek, Jay S Grider, Jonathan M Hagedorn, Gladstone C McDowell, Philip Kim, Denis Dupoiron, Vasudha Goel, Rui Duarte, Julie G Pilitsis, Michael S Leong, Jose De Andrés, Christophe Perruchoud, Harry Sukumaran, Alaa Abd-Elsayed, Michael Saulino, Dennis Patin, Lawrence R Poree, Natalie Strand, Karina Gritsenko, Jill A Osborn, Ivano Dones, Anjum Bux, Jay M Shah, Brad L Lindsey, Erik Shaw, Tony L Yaksh, Robert M Levy
INTRODUCTION: The International Neuromodulation Society convened a multispecialty group of physicians and scientists based on expertise with international representation to establish evidence-based guidance on intrathecal drug delivery in treating chronic pain. This Polyanalgesic Consensus Conference (PACC)® project, created more than two decades ago, intends to provide evidence-based guidance for important safety and efficacy issues surrounding intrathecal drug delivery and its impact on the practice of neuromodulation...
May 13, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38752944/the-effect-of-various-spinal-neurostimulation-paradigms-on-the-supraspinal-somatosensory-evoked-response-a-systematic-review
#4
REVIEW
Laurien J Reinders, Janne A M Luijten, Sander P G Frankema, Frank J P M Huygen, Cecile C de Vos
INTRODUCTION: Spinal neurostimulation is a therapy for otherwise intractable chronic pain. Spinal neurostimulation includes stimulation of the spinal cord (SCS), dorsal root ganglion (DRGS), and dorsal root entry zone (DREZS). New paresthesia-free neurostimulation paradigms may rely on different mechanisms of action from those of conventional tonic neurostimulation. The aim of this systematic review is to assess the existing knowledge on the effect of spinal neurostimulation on somatosensory processing in patients with chronic pain...
May 13, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38739062/randomized-placebo-controlled-trial-of-60-day-percutaneous-peripheral-nerve-stimulation-treatment-indicates-relief-of-persistent-postoperative-pain-and-improved-function-after-knee-replacement
#5
JOURNAL ARTICLE
Johnathan H Goree, Stuart A Grant, David M Dickerson, Brian M Ilfeld, Yashar Eshraghi, Sandeep Vaid, Ali K Valimahomed, Jarna R Shah, G Lawson Smith, John J Finneran, Nirav N Shah, Maged N Guirguis, Maxim S Eckmann, Ajay B Antony, Brian J Ohlendorf, Mayank Gupta, John E Gilbert, Amorn Wongsarnpigoon, Joseph W Boggs
OBJECTIVES: Total knee arthroplasty (TKA) is an effective surgery for end-stage knee osteoarthritis, but chronic postoperative pain and reduced function affect up to 20% of patients who undergo such surgery. There are limited treatment options, but percutaneous peripheral nerve stimulation (PNS) is a promising nonopioid treatment option for chronic, persistent postoperative pain. The objective of the present study was to evaluate the effect of a 60-day percutaneous PNS treatment in a multicenter, randomized, double-blind, placebo-controlled trial for treating persistent postoperative pain after TKA...
May 10, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38691076/a-low-intensity-transcranial-focused-ultrasound-parameter-exploration-study-of-the-ventral-capsule-ventral-striatum
#6
JOURNAL ARTICLE
Tina Chou, Brian J Kochanowski, Ashley Hayden, Benjamin M Borron, Miguel C Barbeiro, Junqian Xu, Joo-Won Kim, Xuefeng Zhang, Richard R Bouchard, Kinh Luan Phan, Wayne K Goodman, Darin D Dougherty
OBJECTIVES: Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is effective for treatment-resistant obsessive-compulsive disorder (OCD); however, DBS is associated with neurosurgical risks. Transcranial focused ultrasound (tFUS) is a newer form of noninvasive (ie, nonsurgical) stimulation that can modulate deeper regions, such as the VC/VS. tFUS parameters have just begun to be studied and have often not been compared in the same participants. We explored the effects of three VC/VS tFUS protocols and an entorhinal cortex (ErC) tFUS session on the VC/VS and cortico-striato-thalamo-cortical circuit (CSTC) in healthy individuals for later application to patients with OCD...
April 29, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38691075/numerical-investigation-of-layered-homogeneous-skull-model-for-simulations-of-transcranial-focused-ultrasound
#7
JOURNAL ARTICLE
Hyeon Seo, Mun Han, Jong-Ryul Choi, Seungmin Kim, Juyoung Park, Eun-Hee Lee
BACKGROUND AND OBJECTIVES: The influence of the intracranial pressure field must be discussed with the development of a single-element transducer for low-intensity transcranial focused ultrasound because the skull plays a significant role in blocking and dispersing ultrasound wave propagation. Ultrasound propagation is mainly affected by the structure and acoustic properties of the skull; thus, we aimed to investigate the impact of simplifying the acoustic properties of the skull on the simulation of the transcranial pressure field to present guidance for efficient skull modeling in full-wave simulations...
April 29, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38639705/quantitative-sensory-testing-in-spinal-cord-stimulation-a-narrative-review
#8
REVIEW
Turo Nurmikko, Dave Mugan, Angela Leitner, Frank J P M Huygen
OBJECTIVES: Quantitative sensory testing (QST) has been used for decades to study sensory abnormalities in multiple conditions in which the somatosensory system is compromised, including pain. It is commonly used in pharmacologic studies on chronic pain but less so in conjunction with neuromodulation. This review aims to assess the utility of QST in spinal cord stimulation (SCS) protocols. MATERIALS AND METHODS: For this narrative review, we searched PubMed for records of studies in which sensory testing has been performed as part of a clinical study on SCS from 1975 onward until October 2023...
April 18, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38639704/neurodots-from-single-target-to-brain-network-modulation-why-and-what-is-needed
#9
REVIEW
Dirk De Ridder, Muhammad Ali Siddiqi, Justin Dauwels, Wouter A Serdijn, Christos Strydis
OBJECTIVES: Current techniques in brain stimulation are still largely based on a phrenologic approach that a single brain target can treat a brain disorder. Nevertheless, meta-analyses of brain implants indicate an overall success rate of 50% improvement in 50% of patients, irrespective of the brain-related disorder. Thus, there is still a large margin for improvement. The goal of this manuscript is to 1) develop a general theoretical framework of brain functioning that is amenable to surgical neuromodulation, and 2) describe the engineering requirements of the next generation of implantable brain stimulators that follow from this theoretic model...
April 16, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38597859/long-term-efficacy-of-bilateral-globus-pallidus-stimulation-in-the-treatment-of-meige-syndrome
#10
JOURNAL ARTICLE
Shiyu Fu, Zhiquan Yang, Xinghui He, Dingyang Liu, Zhuanyi Yang, Junmei Zhang, Liangchao Du
OBJECTIVE: This study aimed to investigate the long-term efficacy and prognosis of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with benign essential blepharospasm (BEB) and complete Meige syndrome, and to search for the best therapeutic subregion within the GPi. MATERIALS AND METHODS: Data were collected for 36 patients with Meige syndrome who underwent bilateral GPi-DBS surgery at our hospital between March 2014 and February 2022...
April 9, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38583173/case-series-of-multicontact-peripheral-nerve-stimulation-in-the-transversus-abdominis-plane-for-chronic-abdominal-wall-pain
#11
JOURNAL ARTICLE
Caroline Eden, Ramanjot S Kang, Ankur A Patel, Amitabh Gulati
OBJECTIVES: Managing abdominal pain can be difficult. This is due to the nonspecific nature of the pain, the multiple etiologies, and the different mechanisms underlying this type of pain. Abdominal wall pain in particular poses its own challenges. Traditionally, chronic abdominal wall pain has been managed with nonopioid analgesics, and in severe cases, opioid therapy has been considered. For patients with chronic abdominal wall pain refractory to medication management, peripheral nerve blocks and spinal cord stimulation also have been trialed with some success...
April 5, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38573280/short-term-dorsal-genital-nerve-stimulation-increases-subjective-arousal-in-women-with-and-without-spinal-cord-injury-a-preliminary-investigation
#12
JOURNAL ARTICLE
Elizabeth C Bottorff, Priyanka Gupta, Giulia M Ippolito, Mackenzie B Moore, Gianna M Rodriguez, Tim M Bruns
OBJECTIVES: Female sexual dysfunction (FSD) affects an estimated 40% of women. Unfortunately, FSD is understudied, leading to limited treatment options for FSD. Neuromodulation has shown some success in alleviating FSD symptoms. We developed a pilot study to investigate the short-term effect of electrical stimulation of the dorsal genital nerve and tibial nerve on sexual arousal in healthy women, women with FSD, and women with spinal cord injury (SCI) and FSD. MATERIALS AND METHODS: This study comprises a randomized crossover design in three groups: women with SCI, women with non-neurogenic FSD, and women without FSD or SCI...
April 2, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38551547/evaluation-of-washout-periods-after-dorsal-root-ganglion-stimulation-trial
#13
JOURNAL ARTICLE
Kenneth B Chapman, Ahmad Amireh, Noud van Helmond, Tariq A Yousef
OBJECTIVE: Dorsal root ganglion stimulation (DRG-S) is a novel therapy to treat chronic pain. It has shown efficacy when delivered intermittently, suggesting a delayed washout effect exists. To measure the washout period, and to determine whether there are differences in washout times among different types of treated pain, we measured the time for pain to return at the end of the patients' one-week DRG stimulation trials. MATERIALS AND METHODS: Patients who completed a successful DRG-S trial were included...
March 28, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38551546/dorsal-root-ganglion-stimulation-relieves-chronic-neuropathic-pain-along-with-a-decrease-in-cortical-%C3%AE-power
#14
JOURNAL ARTICLE
Matthias Hubert Morgalla, Yi Zhang, Bankim Subhash Chander
BACKGROUND: Stimulation of dorsal root ganglion (DRG) is an ideal neuromodulative intervention, providing pain relief in localized chronic pain conditions because γ-band oscillations reflect the intensity of ongoing chronic pain in patients affected. OBJECTIVE: We aimed to observe the role of cortical γ-band power associated with the relief of chronic neuropathic pain through DRG stimulation (DRGS). MATERIALS AND METHODS: We examined nine patients (two women, mean age 56...
March 27, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38520459/prospective-six-month-analysis-of-multiarea-burst-spinal-cord-stimulation-correlating-intraoperative-neuromonitoring-with-postoperative-programming-and-clinical-outcomes
#15
JOURNAL ARTICLE
Steven M Falowski, Ameya C Nanivadekar
INTRODUCTION: DeRidder burst spinal cord stimulation (SCS) has shown superior relief from overall pain to traditional tonic neurostimulation therapies and a reduction in back and leg pain. However, nearly 80% of patients have two or more noncontiguous pain areas. This affects the ability to effectively program stimulation and deliver long-term efficacy of the therapy. Multiple DeRidder burst region programming is an option to treat multisite pain by interleaving stimulation at multiple areas along the spinal cord...
March 22, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38506767/effects-of-transcranial-direct-current-stimulation-on-clinical-outcomes-calcitonin-gene-related-peptide-and-pituitary-adenylate-cyclase-activating-polypeptide-38-levels-in-menstrual-migraine
#16
JOURNAL ARTICLE
Buse Rahime Hasırcı Bayır, Serkan Aksu, Haşim Gezegen, Zerrin Karaaslan, Hande Yüceer, Tuba Cerrahoğlu Şirin, Cem İsmail Küçükali, Adnan Kurt, Sacit Karamürsel, Vuslat Yılmaz, Betül Baykan
OBJECTIVES: Transcranial direct current stimulation (tDCS) has been suggested as an alternative treatment option for migraine. The present study aimed to evaluate the efficacy of tDCS on clinical outcomes in addition to calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide 38 (PACAP-38) levels in individuals with menstrual-related migraine (MRM) for the first time. MATERIALS AND METHODS: In this parallel study, 58 female patients between the ages of 18 and 45 years, including 36 with MRM and 22 with nonmenstrual migraines (nMM), were recruited...
March 19, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38506766/effects-of-transcranial-ultrasound-stimulation-on-blood-oxygen-metabolism-and-brain-rhythms-in-nitroglycerin-induced-migraine-mice
#17
JOURNAL ARTICLE
Nannan Bian, Yi Yuan, Xiaoli Li
OBJECTIVES: In this study, we aimed to investigate the regulatory mechanism of transcranial ultrasound stimulation (TUS) on nitroglycerin-induced migraine in mice. MATERIALS AND METHODS: The experiment was divided into four groups, namely, the normal saline control group (n = 9), ultrasound stimulation control group (n = 6), nitroglycerin-induced migraine group (n = 9), and ultrasound stimulation group (n = 9). The behavior, blood oxygen metabolism, and brain rhythm distribution of the four groups were analyzed...
March 18, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38483366/five-year-longitudinal-follow-up-of-restorative-neurostimulation-shows-durability-of-effectiveness-in-patients-with-refractory-chronic-low-back-pain-associated-with-multifidus-muscle-dysfunction
#18
JOURNAL ARTICLE
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Dawood Sayed, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
BACKGROUND: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology. MATERIALS AND METHODS: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38466259/frequency-specific-effects-of-noninvasive-median-nerve-stimulation-on-gastric-slow-wave-activity-in-humans
#19
JOURNAL ARTICLE
Elliot Thomas Hendry, Joseph Gonzales Balfe, Peng Du, Yusuf Ozgur Cakmak
OBJECTIVES: The present study explored the effects of different frequencies of noninvasive median nerve stimulation (nMNS) on two autonomic responses: gastric slow waves under water-loading condition and heart rate variability (HRV). To the best of our knowledge, this is the first study to document the effects of different frequencies of nMNS on gastric slow waves (GSW) in humans under 5-minute water-loading condition. MATERIALS AND METHODS: Twenty healthy adult participants were fitted with a noninvasive body-surface gastric mapping, electrocardiogram (ECG), and a transcutaneous electrical nerve stimulation device and administered with four different nMNS frequencies (placebo-0 Hz, 40 Hz, 120 Hz, and 200 Hz) on four separate counterbalanced days...
March 11, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38456889/spinal-cord-stimulation-trial-electrodes-rapidly-produce-epidural-scarring-impeding-surgical-paddle-lead-placement
#20
JOURNAL ARTICLE
Randall W Treffy, Justin Morris, Rahul Koshy, Dylan J Coss, Peter A Pahapill
OBJECTIVES: After a successful percutaneous cylindrical electrode five-to-seven-day trial of spinal cord stimulation, subsequent permanent surgical paddle lead (SPL) placement can be impeded by epidural scar induced by the trial leads (TLs). Our goal was to determine whether a delay between TL and subsequent SPL placement provokes enhanced epidural scarring with an increased need for laminotomy extension required for scar removal for optimal SPL placement. MATERIALS AND METHODS: Using a prospectively maintained data base, a single-facility/surgeon retrospective study identified 261 patients with newly placed thoracolumbar SPLs from June 2013 to November 2023...
March 8, 2024: Neuromodulation: Journal of the International Neuromodulation Society
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