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Journals Annals of Transplantation : Qu...

Annals of Transplantation : Quarterly of the Polish Transplantation Society

https://read.qxmd.com/read/38902916/long-term-graft-and-patient-survival-after-re-transplantation
#1
JOURNAL ARTICLE
Dana Bielopolski, Aviad Gravetz, Timna Agur, Renana Yemini, Benaya Rozen Zvi, Eviatar Nesher
BACKGROUND Kidney transplant recipients have higher life expectancy but may require subsequent transplantations, raising ethical concerns regarding organ allocation. We assessed the safety of multiple kidney transplants through long-term follow-up. MATERIAL AND METHODS A retrospective cohort study was conducted at a single center, categorizing patients based on the number of kidney transplantations received. The primary outcome was the composite of death-censored graft failure and overall mortality. The secondary outcome was death-censored graft failure...
June 21, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38887010/implementation-and-evaluation-of-discharge-planning-for-patients-undergoing-umbilical-cord-blood-transplantation
#2
JOURNAL ARTICLE
Lu Huang, Yan Zhu, Yun Wu, Ying-Ying Wang, Gui-Qi Song, Kai-di Song, Yao-Hua Wu, Yong-Liang Zhang
BACKGROUND Umbilical cord blood transplantation (UCBT) patients have high rates of unplanned readmissions and poor quality of life (QoL). The aim of this study was to evaluate the effects of discharge planning on unplanned readmissions, self-efficacy, QoL, and clinical outcomes. MATERIAL AND METHODS Patients who received their first UCBT from April 2022 to March 2023 were included. Participants (n=72) were assigned to a control group (CG: received usual care) or an intervention group (IG: received discharge planning from admission to 100 days after UCBT)...
June 18, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38859567/physical-activity-levels-in-transplant-recipients
#3
JOURNAL ARTICLE
Marta Hreńczuk, Ewelina Wasińska, Piotr Małkowski
BACKGROUND Physical activity is a key factor in improvement of quality of life. This study aimed to assess the extent of physical activity in solid-organ transplant recipients. MATERIAL AND METHODS The study involved 106 patients, mostly kidney (64.15%) and liver (28.30%) recipients, observed in a Warsaw transplant center. The study group was dominated by women (56.6%), mean age 49.25±14.09 years, the time since transplantation ranged from 1 month to 28 years, with a mean of 93.9±71.83 months. Recipients were educated about physical activity in the immediate post-transplant period and during follow-up visits...
June 11, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38831572/alternative-therapies-in-transplantology-as-a-promising-perspective-in-medicine
#4
REVIEW
Natasza Michalska, Ewa Totoń, Przemysław Kopczyński, Magdalena Jankowska-Wajda, Błażej Rubiś
Despite continuous and rapid progress in the transplantation of cells, tissues, and organs, many patients die before receiving them. This is because of an insufficient number of donors, which leads to a significant disproportion between the need for donors and their availability. This review aims to present the possibilities offered by alternative therapies. We use the term "functional transplantology" to describe such alternative methods of transplantation that could help change the current state of transplantation medicine...
June 4, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38803088/effect-of-dexmedetomidine-combined-with-remifentanil-on-emergence-agitation-during-awakening-from-sevoflurane-anesthesia-for-pediatric-liver-surgery
#5
RANDOMIZED CONTROLLED TRIAL
Yanting Wang, Cuicui Liu, Pei Wang, Linlin Li, Wei Feng
BACKGROUND We aimed to assess the effect of dexmedetomidine (Dex) combined with remifentanil on emergence agitation (EA) during awakening from sevoflurane anesthesia for pediatric liver surgery. MATERIAL AND METHODS Sixty children who underwent liver surgery in our hospital were prospectively selected and randomly allocated into group A (placebo+remifentanil+sevoflurane) or group B (Dex+remifentanil+sevoflurane). Mean arterial pressure (MAP) and heart rate (HR) at different time points, agitation score during awakening, behavioral status, pain level, and the incidence of postoperative adverse effects were compared in both groups...
May 28, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38769724/liver-transplantation-from-brain-dead-donors-with-hepatitis-b-or-c-in-south-korea-a-2014-2020-korean-organ-transplantation-registry-data-analysis
#6
JOURNAL ARTICLE
Hoonsung Park, Hanyoung Lee, Seungmin Baik, Myoung Soo Kim, Jaeseok Yang, Jong Cheol Jeong, Tai Yeon Koo, Deok-Gie Kim, Jae-Myeong Lee
BACKGROUND According to the current guidelines for liver transplantation (LT) of brain-dead donors with hepatitis B or C virus (HBV or HCV) in Korea, grafts from hepatitis B surface antigen (HBsAg)(+) or HCV antibody (anti-HCV)(+) donors must be transplanted only to HBsAg(+) or anti-HCV(+) recipients, respectively. We aimed to determine the current status and outcomes of brain-dead donor LT with HBV or HCV in Korea. MATERIAL AND METHODS This retrospective observational study included all LTs from brain-dead donors in the Korean Organ Transplantation Registry between April 2014 and December 2020...
May 21, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38741362/association-between-fev%C3%A2-decline-rate-and-mortality-in-long-term-follow-up-of-a-21-patient-pilot-clinical-trial-of-inhaled-liposomal-cyclosporine-plus-standard-of-care-versus-standard-of-care-alone-for-bronchiolitis-obliterans-syndrome-after-lung-transplantation
#7
RANDOMIZED CONTROLLED TRIAL
Aldo Iacono, Marniker Wijesinha, Andreas Völp, Maksim Korotun, Michael Terrin
BACKGROUND The association between forced expiratory volume in 1 second (FEV1) trajectory and mortality in bronchiolitis obliterans syndrome (BOS) is not well defined. Using long-term data from a prior clinical trial of inhaled liposomal cyclosporine A (L-CsA-I) for lung transplant patients with BOS, this study examined the association between longitudinal FEV₁ change and mortality. MATERIAL AND METHODS We analyzed long-term data from a clinical trial which randomized 21 patients with BOS (³20% decrease in FEV1 from personal maximum) to receive L-CsA-I plus standard-of-care (n=11) or standard-of-care (SOC) alone (n=10) for 24 weeks...
May 14, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38711249/transplant-nephrectomy-a-comparative-study-of-timing-and-techniques-in-a-single-institution
#8
COMPARATIVE STUDY
Ursula Pession, Ingrid Lammers, Ingeborg Hauser, Teresa Schreckenbach, Andreas Schnitzbauer, Jeannine Lang, Michael Heise, Wolf Otto Bechstein
BACKGROUND Transplant nephrectomy (TN) has historically been associated with high morbidity and mortality rates. Our objective is to share our own experience and compare indications and surgical outcomes between early and late TN and intracapsular (ICAN) and extracapsular allograft nephrectomy (ECAN) techniques. MATERIAL AND METHODS Our study included all 69 TN procedures performed between January 2010 and February 2021. Of these, 17 TN procedures were performed within the first 60 days after transplantation (referred to as 'early'), while the remaining 52 procedures were performed later ('late')...
May 7, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38685698/does-antibiotic-use-increase-the-risk-of-post-transplantation-diabetes-mellitus-a-retrospective-study-of-renal-transplant-patients
#9
JOURNAL ARTICLE
Zhenwei Jiang, Caomei Xu, Huan Hou, Xuping Yang, Minyan Qian, Lian Zuo, Peipei Wang, Qing Qian, Yan Jiang, Nan Hu
BACKGROUND This study aimed to investigate the incidence of post-transplant diabetes mellitus (PTDM) in renal transplant (RT) patients at our center and to explore new risk factors for PTDM. MATERIAL AND METHODS This retrospective study included RT patients from 2010 to 2022. Clinic data on RT patients were obtained from hospital electronic medical records. CYP3A5*3, POR*28, ABCB1 (3435 C>T), and ABCB1 (1236 C>T) were genotyped in RT patients. The associations between age, BMI, concentration of tacrolimus (TAC), polymorphism of genes, antibiotics (eg, penicillins, cephalosporins, oxazolidinones, quinolones), numbers and days of antibiotic use, and PTDM were analyzed...
April 30, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38650316/approaches-and-challenges-in-the-current-management-of-cytomegalovirus-in-transplant-recipients-highlighting-the-role-of-advanced-practice-providers-nurse-practitioners-and-physician-assistants
#10
JOURNAL ARTICLE
Willa V Cochran, M Veronica Dioverti, Julie Langlee, Lindsay N Barker, Audra Shedeck, Lindsay P Toman, Robin K Avery
Cytomegalovirus (CMV) infection is associated with increased morbidity and mortality in hematopoietic cell transplant (HCT) and solid organ transplant (SOT) recipients, with traditional anti-CMV therapies limited by their associated toxicities and the development of resistance. Clinical providers are often faced with challenging and complicated CMV infections that require multiple courses of antiviral therapies. Increasingly, advanced practice providers (APPs) are playing an important role in the day-to-day management of transplant recipients with CMV infection, including resistant/refractory CMV and other complex CMV syndromes...
April 23, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38622855/treatment-of-cavernous-transformation-of-portal-vein-caused-by-hepatic-cystic-echinococcosis-using-ex-vivo-liver-resection-and-autotransplantation
#11
JOURNAL ARTICLE
Ayidu Reyimu, Jiang Tiemin, Shao Yingmei, Zhu Xuepeng, Guo Wenjiang, Du Yuhao, Dilixiati Halimulati, Wusiman Ababokeli, Aji Tuerganaili, Wen Hao
BACKGROUND Hepatic cystic echinococcosis (HCE) is a frequently overlooked parasitic liver disease, for which the commonly recommended treatment is radical resection. However, this approach is often associated with severe comorbidities such as HBV/HCV, cirrhosis, and hepatic carcinoma, among others. CASE REPORT In this report, we present a case successfully managed by ex vivo liver resection and autologous liver transplantation (ELRA). In the described case, ex vivo resection was not feasible due to recurrent lesions and infections invading the portal vein, which resulted in portal vein cavernous transformation...
April 16, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38590090/impact-of-blood-products-transfusion-on-patients-in-the-immediate-post-lung-transplant-period-a-cohort-study
#12
JOURNAL ARTICLE
Atif S Siddiqui, Jawairia Shakil
BACKGROUND Anemia is common in post-transplant patients. Blood product transfusion is associated with mortality and rejection in solid organ transplants. In lung transplant recipients, transfusion predisposes to primary graft dysfunction (PGD). The adverse effects and associated mortality of perioperative transfusions in lung transplant recipients have not been evaluated. This study examined the effects of perioperative blood transfusions in lung transplant recipients. MATERIAL AND METHODS We conducted a retrospective study of the effects of blood product transfusions in patients who received single- or double-lung transplantation at Houston Methodist Hospital between August 2017 and September 2019...
April 9, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38561931/association-of-coronary-calcium-score-on-cardiac-pet-during-pre-kidney-transplant-assessment-with-persistent-hyperparathyroidism-a-retrospective-study
#13
JOURNAL ARTICLE
Ziad Arabi, Mazin Ibrahim Musab El Sarrag, Tarek Arabi, Muhannad Alqudsi, Areez Shafqat
BACKGROUND Secondary hyperparathyroidism and coronary calcifications are common complications in chronic kidney disease. However, the relation between coronary calcium score (CCS) and persistent hyperparathyroidism (pHPT) after kidney transplantation (KT) remains unknown. MATERIAL AND METHODS This was a single-center retrospective study of KT candidates from January 2017 to May 2020. We collected patients' demographics, cardiovascular (CV) risk factors, and the findings of pre-KT CV imaging. We also collected parathyroid hormone (PTH) values before KT, at 1-6 months, 6-12 months, and 12-24 months after KT...
April 2, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38528671/outcomes-of-renal-transplantation-in-anca-associated-vasculitis
#14
REVIEW
Xiaoqin Long, Xiaobing Yang, Shudong Yao, Jia Wu
BACKGROUND Antineutrophil cytoplasmic antibody-associated vasculitis is characterized by small-vessel inflammation and ANCA-positive serology that often lead to end-stage kidney disease. This study investigated the outcomes of renal transplantation in patients with antineutrophil cytoplasmic antibody-associated vasculitis. MATERIAL AND METHODS A comprehensive search of PubMed, Scopus, and Embase databases was done to retrieve studies that reported on the outcomes of renal transplantation in these patients. Data on mortality, survival, infection, and relapse rates were analyzed...
March 26, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38500255/long-term-outcomes-with-prolonged-release-tacrolimus-in-kidney-transplantation-a-retrospective-real-world-data-analysis
#15
JOURNAL ARTICLE
Wilfried Gwinner, Swapneel Anaokar, Martin Blogg, Birgit Hermann, Carola Del Pilar Repetur, Mario Schiffer
BACKGROUND Long-term real-world outcomes data for kidney transplant recipients (KTRs) converting from immediate-release tacrolimus (IRT) to prolonged-release tacrolimus (PRT) are limited. MATERIAL AND METHODS A retrospective, non-interventional review of adult KTRs treated with PRT for ≥1 month was conducted in Germany. Data were extracted from time of transplant (2008-2014) to 2018. Primary composite endpoints (graft loss, biopsy-confirmed acute rejection, graft dysfunction) and secondary endpoints (all-cause mortality, kidney function course, and tacrolimus dose/trough levels) were analyzed for sub-cohorts: de novo PRT, early conversion from IRT (within 6 months post-transplant), and late conversion (7 months to 3 years)...
March 19, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38526543/use-of-lcp-tacrolimus-lcpt-in-kidney-transplantation-a-delphi-consensus-survey-of-expert-clinicians
#16
JOURNAL ARTICLE
Alexander Wiseman, Tarek Alhamad, Rita R Alloway, Beatrice P Concepcion, Matthew Cooper, Richard Formica, Christina L Klein, Vineeta Kumar, Nicolae Leca, Fuad Shihab, David J Taber, Sarah Mulnick, Donald M Bushnell, Monica Hadi, Suphamai Bunnapradist
BACKGROUND LCPT (Envarsus XR®) is a common once-daily, extended-release oral tacrolimus formulation used in kidney transplantation. However, there are minimal evidence-based recommendations regarding optimal dosing and treatment in the de novo and conversion settings. MATERIAL AND METHODS Using Delphi methodology, 12 kidney transplantation experts with LCPT experience reviewed available data to determine potential consensus topics. Key statements regarding LCPT use were generated and disseminated to the panel in an online Delphi survey...
March 12, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38439530/no-prognostic-impact-of-graft-to-recipient-weight-ratio-on-hepatocellular-carcinoma-recurrence-following-living-donor-liver-transplantation
#17
JOURNAL ARTICLE
Geunhyeok Yang, Shin Hwang, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Dong-Hwan Jung, Gil-Chun Park, Young-In Yoon, Woo-Hyoung Kang, Sun-Hyung Joo, Sung-Gyu Lee
BACKGROUND The effects of a low graft-to-recipient weight ratio (GRWR) on the prognosis of patients with hepatocellular carcinoma (HCC) are unclear. The present study examined whether the GRWR had an impact on the rate of HCC recurrence following living donor liver transplantation (LDLT). MATERIAL AND METHODS This retrospective observational single-center study included 856 patients who underwent LDLT for HCC between January 2006 and December 2016 at Asan Medical Center and evaluated the association between GRWR and post-transplant tumor recurrence...
March 5, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38409779/successful-sequential-liver-and-isolated-intestine-transplantation-for-mitochondrial-neurogastrointestinal-encephalopathy-syndrome-a-case-report
#18
JOURNAL ARTICLE
Chandrashekhar A Kubal, Plamen Mihaylov, Riley Snook, Daiki Soma, Omer Saeed, Zachary Rokop, Marco Lacerda, Brett H Graham, Richard S Mangus
BACKGROUND Mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE) is an autosomal recessive disease caused by thymidine phosphorylase deficiency leading to progressive gastrointestinal dysmotility, cachexia, ptosis, ophthalmoparesis, peripheral neuropathy and leukoencephalopathy. Although liver transplantation corrects thymidine phosphorylase deficiency, intestinal deficiency of the enzyme persists. Retrospective chart review was carried out to obtain clinical, biochemical, and pathological details...
February 27, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38374615/lymphocele-outcomes-after-renal-transplantations-performed-by-an-experienced-surgeon-is-meticulously-performed-surgery-and%C3%A2-experience-adequate-to-prevent-lymphocele
#19
JOURNAL ARTICLE
Nurettin Ay, Vahhac Alp, Recai Duymuş, Sedat Çetin
BACKGROUND The purpose of the present study was to analyze the rate of lymphoceles in kidney transplant operations meticulously performed by the same senior surgeon. MATERIAL AND METHODS The present study included 315 patients who were operated on in our organ transplantation center and followed up in the polyclinic after July 2013. The patients were retrospectively divided into 2 groups: patients with and without lymphocele. Symptomatic lymphocele (SL) has been defined as symptomatic fluid collection around the graft that necessitates an intervention for the graft or patient...
February 20, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38347714/a-retrospective-study-of-long-term-outcomes-in%C3%A2-16-abo-incompatible-deceased-donor-pediatric-liver-transplants-from-a-national-transplant-center-at-helsinki-university-hospital-finland-1987-2022
#20
JOURNAL ARTICLE
Timo Jahnukainen, Inna Sareneva, Jouni Lauronen, Elisa Ylinen, Juuso Tainio, Arno Nordin, Maria Hukkinen, Mikko P Pakarinen, Hannu Jalanko
BACKGROUND The use of ABO-incompatible liver transplants (ABO-ILTs) from deceased donors has become more common due to the shortage of available donor livers and increased transplant waiting times. This retrospective study from a national transplant center at Helsinki University Hospital, Finland, aimed to assess the long-term outcomes of ABO-incompatible deceased donor pediatric liver transplants between 1987 and 2022. MATERIAL AND METHODS Sixteen (9.5%) of the 169 pediatric liver transplantations were ABO-ILTs...
February 13, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
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