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Journals
Critical Care : the Official J...
Critical Care : the Official Journal of the Critical Care Forum
#21
JOURNAL ARTICLE
Dyssynchronous diaphragm contractions impair diaphragm function in mechanically ventilated patients.
Benjamin Coiffard, Jose Dianti, Irene Telias, Laurent J Brochard, Arthur S Slutsky, Jennifer Beck, Christer Sinderby, Niall D Ferguson, Ewan C Goligher
BACKGROUND: Pre-clinical studies suggest that dyssynchronous diaphragm contractions during mechanical ventilation may cause acute diaphragm dysfunction. We aimed to describe the variability in diaphragm contractile loading conditions during mechanical ventilation and to establish whether dyssynchronous diaphragm contractions are associated with the development of impaired diaphragm dysfunction. METHODS: In patients receiving invasive mechanical ventilation for pneumonia, septic shock, acute respiratory distress syndrome, or acute brain injury, airway flow and pressure and diaphragm electrical activity (Edi) were recorded hourly around the clock for up to 7 days...
April 2, 2024: Critical Care: the Official Journal of the Critical Care Forum
#22
REVIEW
Edith Elianna Rodriguez, Mario Zaccarelli, Elda Diletta Sterchele, Fabio Silvio Taccone
Severe acute brain injuries, stemming from trauma, ischemia or hemorrhage, remain a significant global healthcare concern due to their association with high morbidity and mortality rates. Accurate assessment of secondary brain injuries severity is pivotal for tailor adequate therapies in such patients. Together with neurological examination and brain imaging, monitoring of systemic secondary brain injuries is relatively straightforward and should be implemented in all patients, according to local resources...
April 1, 2024: Critical Care: the Official Journal of the Critical Care Forum
#23
LETTER
Hugues de Courson, Alexandre Loiseau, Grégoire Chadefaux, Matthieu Biais
No abstract text is available yet for this article.
March 29, 2024: Critical Care: the Official Journal of the Critical Care Forum
#24
JOURNAL ARTICLE
Johan Malmgren, Stefan Lundin, Ann-Charlotte Waldenström, Christian Rylander, Elias Johannesson
BACKGROUND: Quality of life (QoL) is a key outcome measure in healthcare. However, the heterogeneity in its definitions presents challenges in the objective evaluation of improvement. Universal questionnaires, tailored for a broad demographic group, inadequately represent the unique experiences of intensive care unit (ICU) survivors, including a lack of ability to discriminate issues related to QoL from issues that do not. METHODS: Using a 218-item, 13-domain provisional questionnaire, we assessed 395 adult ICU survivors, with a minimum 72-h stay at one of three Swedish university hospital ICUs, at 6 months to three years post-discharge...
March 29, 2024: Critical Care: the Official Journal of the Critical Care Forum
#25
LETTER
Antoine Guillon, Youenn Jouan, Arthur Kassa-Sombo, Christophe Paget, Pierre-François Dequin
No abstract text is available yet for this article.
March 28, 2024: Critical Care: the Official Journal of the Critical Care Forum
#26
REVIEW
Hang Ruan, Qin Zhang, You-Ping Zhang, Shu-Sheng Li, Xiao Ran
Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, assumes a pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive overview of HIF-1α's mechanism of action in sepsis, scrutinizing its involvement in inflammatory regulation, hypoxia adaptation, immune response, and organ dysfunction...
March 27, 2024: Critical Care: the Official Journal of the Critical Care Forum
#27
JOURNAL ARTICLE
Ki Hong Choi, Danbee Kang, Jin Lee, Hyejeong Park, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Juhee Cho, Jeong Hoon Yang
BACKGROUND: Despite the high workload of cardiac intensive care unit (ICU), there is a paucity of evidence on the association between nurse workforce and mortality in patients with cardiogenic shock (CS). This study aimed to evaluate the prognostic impact of the ICU nursing grade on mortality and cost-effectiveness in CS. METHODS: A nationwide analysis was performed using the K-NHIS database. Patients diagnosed with CS and admitted to the ICU at tertiary hospitals were enrolled...
March 25, 2024: Critical Care: the Official Journal of the Critical Care Forum
#28
JOURNAL ARTICLE
Karl Stattin, Mikael Eriksson, Robert Frithiof, Rafael Kawati, Michael Hultström, Miklos Lipcsey
BACKGROUND: Sepsis is a condition where the immune response to infection becomes dysregulated and life-threatening. It is not known whether lifestyle factors influence the risk of sepsis. The aim of the present study is to investigate the association between physical activity and the risk of acquiring and dying in infection or sepsis. METHODS: The population-based Swedish Mammography Cohort and Cohort of Swedish Men sent participants lifestyle questionnaires in 1997 and have subsequently followed participants in national Swedish registers, including the National Patient Register, the Swedish Intensive Care Registry and the Cause of Death Register...
March 24, 2024: Critical Care: the Official Journal of the Critical Care Forum
#29
REVIEW
Ross R McMullan, Daniel F McAuley, Cecilia M O'Kane, Jonathan A Silversides
Sepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function...
March 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
#30
JOURNAL ARTICLE
Shiqi Zhang, Laura A Hagens, Nanon F L Heijnen, Marry R Smit, Paul Brinkman, Dominic Fenn, Tom van der Poll, Marcus J Schultz, Dennis C J J Bergmans, Ronny M Schnabel, Lieuwe D J Bos
BACKGROUND: Acute respiratory distress syndrome (ARDS) poses challenges in early identification. Exhaled breath contains metabolites reflective of pulmonary inflammation. AIM: To evaluate the diagnostic accuracy of breath metabolites for ARDS in invasively ventilated intensive care unit (ICU) patients. METHODS: This two-center observational study included critically ill patients receiving invasive ventilation. Gas chromatography and mass spectrometry (GC-MS) was used to quantify the exhaled metabolites...
March 23, 2024: Critical Care: the Official Journal of the Critical Care Forum
#31
RANDOMIZED CONTROLLED TRIAL
Adriana C Panayi, Daren K Heyland, Christian Stoppe, Marc G Jeschke, Oliver Didzun, Dany Matar, Christian Tapking, Alen Palackic, Björn Bliesener, Leila Harhaus, Samuel Knoedler, Valentin Haug, Amir K Bigdeli, Ulrich Kneser, Dennis P Orgill, Gabriel Hundeshagen
BACKGROUND: Despite the growing prevalence of burn survivors, a gap persists in our understanding of the correlation between acute burn trauma and the long-term impact on psychosocial health. This study set out to investigate the prevalence of long-term pain and symptoms of anxiety and depression in survivors of extensive burns, comparing this to the general population, and identify injury and demographic-related factors predisposing individuals to psychosocial compromise. METHODS: RE-ENERGIZE was an international, double-blinded, randomized-controlled trial that enrolled 1200 patients with partial- or full-thickness burns that required surgical treatment...
March 22, 2024: Critical Care: the Official Journal of the Critical Care Forum
#32
Correction : Selected articles from the annual update in intensive care and emergency medicine 2020.
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
#33
MULTICENTER STUDY
Adrian Ceccato, Carles Forne, Lieuwe D Bos, Marta Camprubí-Rimblas, Aina Areny-Balagueró, Elena Campaña-Duel, Sara Quero, Emili Diaz, Oriol Roca, David De Gonzalo-Calvo, Laia Fernández-Barat, Anna Motos, Ricard Ferrer, Jordi Riera, Jose A Lorente, Oscar Peñuelas, Rosario Menendez, Rosario Amaya-Villar, José M Añón, Ana Balan-Mariño, Carme Barberà, José Barberán, Aaron Blandino-Ortiz, Maria Victoria Boado, Elena Bustamante-Munguira, Jesús Caballero, Cristina Carbajales, Nieves Carbonell, Mercedes Catalán-González, Nieves Franco, Cristóbal Galbán, Víctor D Gumucio-Sanguino, Maria Del Carmen de la Torre, Ángel Estella, Elena Gallego, José Luis García-Garmendia, José Garnacho-Montero, José M Gómez, Arturo Huerta, Ruth Noemí Jorge-García, Ana Loza-Vázquez, Judith Marin-Corral, Amalia Martínez de la Gándara, María Cruz Martin-Delgado, Ignacio Martínez-Varela, Juan Lopez Messa, Guillermo Muñiz-Albaiceta, María Teresa Nieto, Mariana Andrea Novo, Yhivian Peñasco, Juan Carlos Pozo-Laderas, Felipe Pérez-García, Pilar Ricart, Ferran Roche-Campo, Alejandro Rodríguez, Victor Sagredo, Angel Sánchez-Miralles, Susana Sancho-Chinesta, Lorenzo Socias, Jordi Solé-Violan, Fernando Suarez-Sipmann, Luis Tamayo-Lomas, José Trenado, Alejandro Úbeda, Luis Jorge Valdivia, Pablo Vidal, Jesus Bermejo, Jesica Gonzalez, Ferran Barbe, Carolyn S Calfee, Antonio Artigas, Antoni Torres
BACKGROUND: Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster...
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
#34
LETTER
Liangshan Wang, Xing Hao, Chenglong Li, Haixiu Xie, Feng Yang, Hong Wang, Zhongtao Du, Xiaotong Hou
No abstract text is available yet for this article.
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
#35
REVIEW
Matthieu Legrand, Sean M Bagshaw, Pavan K Bhatraju, Azra Bihorac, Ellen Caniglia, Ashish K Khanna, John A Kellum, Jay Koyner, Michael O Harhay, Fernando G Zampieri, Alexander Zarbock, Kevin Chung, Kathleen Liu, Ravindra Mehta, Peter Pickkers, Abigail Ryan, Juliane Bernholz, Laura Dember, Martin Gallagher, Patrick Rossignol, Marlies Ostermann
Acute kidney injury (AKI) often complicates sepsis and is associated with high morbidity and mortality. In recent years, several important clinical trials have improved our understanding of sepsis-associated AKI (SA-AKI) and impacted clinical care. Advances in sub-phenotyping of sepsis and AKI and clinical trial design offer unprecedented opportunities to fill gaps in knowledge and generate better evidence for improving the outcome of critically ill patients with SA-AKI. In this manuscript, we review the recent literature of clinical trials in sepsis with focus on studies that explore SA-AKI as a primary or secondary outcome...
March 21, 2024: Critical Care: the Official Journal of the Critical Care Forum
#36
LETTER
Yelin Gao, Ke Zhang, Maokun Li, Siyi Yuan, Qianlin Wang, Yi Chi, Yun Long, Zhanqi Zhao, Huaiwu He
No abstract text is available yet for this article.
March 20, 2024: Critical Care: the Official Journal of the Critical Care Forum
#37
JOURNAL ARTICLE
Giuseppe G F Leite, Justin de Brabander, Erik H A Michels, Joe M Butler, Olaf L Cremer, Brendon P Scicluna, Timothy E Sweeney, Miguel Reyes, Reinaldo Salomao, Hessel Peters-Sengers, Tom van der Poll
BACKGROUND: Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an immature bone-marrow-derived CD14+ monocyte phenotype with immune suppressive properties termed "monocyte state 1" (MS1) in patients with sepsis. Our objective was to determine the association of MS1 cell profiles with disease presentation, outcomes, and host response characteristics. METHODS: We used the transcriptome deconvolution method (CIBERSORTx) to estimate the percentage of MS1 cells from blood RNA profiles of patients with sepsis admitted to the intensive care unit (ICU)...
March 19, 2024: Critical Care: the Official Journal of the Critical Care Forum
#38
JOURNAL ARTICLE
Jotaro Tachino, Shigeto Seno, Hisatake Matsumoto, Tetsuhisa Kitamura, Atsushi Hirayama, Shunichiro Nakao, Yusuke Katayama, Hiroshi Ogura, Jun Oda
BACKGROUND: In trauma systems, criteria for individualised and optimised administration of tranexamic acid (TXA), an antifibrinolytic, are yet to be established. This study used nationwide cohort data from Japan to evaluate the association between TXA and in-hospital mortality among all patients with blunt trauma based on clinical phenotypes (trauma phenotypes). METHODS: A retrospective analysis was conducted using data from the Japan Trauma Data Bank (JTDB) spanning 2019 to 2021...
March 19, 2024: Critical Care: the Official Journal of the Critical Care Forum
#39
RANDOMIZED CONTROLLED TRIAL
Xiaodong Zhang, Qibing Zhang, Jiqin You, Rong Xu, Zhaojie Zhang, Yunlan Shi, Chunrong Han, Shiyan Zhao, Bangtao Yao, Yan Geng, Songqiao Liu
OBJECTIVE: To evaluate the effects of our self-developed endotracheal tube fixation device in mechanically ventilated patients. METHODS: In a dual-centre randomised controlled trial, patients who were expected to require mechanical ventilation for over 48 h were assigned to the observation group (using self-developed device) or the control group (using the traditional device). The primary endpoint was the incidence of endotracheal intubation-related pressure injury (EIRPI)...
March 19, 2024: Critical Care: the Official Journal of the Critical Care Forum
#40
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
March 19, 2024: Critical Care: the Official Journal of the Critical Care Forum
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