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Annals of Diagnostic Pathology

Nezeen Z Abualhaj, Zain Dardas, Belal Azab, Dema Ali, Maher A Sughayer, Tariq N Aladily, Mamoun Ahram
The transmembrane receptor NOTCH1 is thought to be associated with the development and progression of T-acute lymphoblastic leukemia (T-ALL)/T-lymphoblastic lymphoma (T-LBL) and chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The current study aimed to characterize NOTCH1 expression and elucidate the variants in the functional PEST domain of the receptor in T-ALL/LBL and CLL/SLL. The nuclear expression of NOTCH1 protein was detected in 25% and 5% of cases of T-ALL/LBL and CLL/SLL, respectively, whereas cytoplasmic expression was detected in 33...
January 24, 2019: Annals of Diagnostic Pathology
Aziza E Abdelrahman, Hayam E Rashed, Ehab Elkady, Eman A Elsebai, Ahmed El-Azony, Ihab Matar
Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease which has an unpredictable risk of progression to muscle-invasive bladder cancer (MIBC). The selection of patients who may benefit from early radical intervention is a challenge. To define the useful prognostic markers for progression, we analyzed the immunohistochemical expression of fatty acid synthase (FASN), Her2/neu, and E2F1 in 60 cases of NMIBC who underwent TURBT and adjuvant intravesical bacillus-Calmette-Guérin (BCG). Their predicting role for tumor recurrence, progression, recurrence-free survival (RFS) and progression-free survival (PFS) was analyzed...
January 17, 2019: Annals of Diagnostic Pathology
Xiaofei Zhang, Minghua Yu
No abstract text is available yet for this article.
January 10, 2019: Annals of Diagnostic Pathology
Lucas Delmonico, Maurício Augusto Silva Magalhães Costa, Marcia Vasconcellos Fournier, Sérgio de Oliveira Romano, Cristina Moreira do Nascimento, Andréia Soares Barbosa, Aline Dos Santos Moreira, Luciano Rios Scherrer, Maria Helena Faria Ornellas, Gilda Alves
Breast impalpable lesions have become a clinical dilemma because they are small, presenting a heterogeneous cellular phenotype. The aim of this study was to evaluate the mutational profile of the PIK3CA, TP53, and CDKN2A genes, comparing the mammary tissue with the respective circulating free DNA (cfDNA). The PIK3CA, TP53, and CDKN2A genes were sequenced (PCR-Sanger) in 58 women with impalpable lesions (49 malignant and 9 benign) with the respective cfDNA. The chi-square or Fisher's exact test was used to evaluate statistical significance between the clinical variables and mutational profile...
January 3, 2019: Annals of Diagnostic Pathology
Amrou Abdelkader, Tamara Giorgadze
No abstract text is available yet for this article.
December 28, 2018: Annals of Diagnostic Pathology
Ameer Hamza, Sidrah Khawar, Ahmed Alrajjal, Sajad Salehi
BACKGROUND: There is contradictory evidence in literature with respect to diagnosis and management of follicular lesions of the thyroid gland. From surgical pathology stand point, pathologists require submission and processing of entire capsule for microscopic evaluation. This can be extremely challenging especially in larger lesions. METHOD: We studied the impact of submitting entire capsule on final pathologic diagnosis in cases on which only representative sections were submitted initially and entire capsule was submitted subsequently...
December 23, 2018: Annals of Diagnostic Pathology
Dale C Snover
Premalignant polyps of the large intestine are common specimens in surgical pathology. They consist of several different subtypes identifiable by histological criteria that are associated with different molecular characteristics and with the development of different types of colorectal carcinoma. The most common of these is the conventional adenoma, which most commonly leads to carcinomas with a low degree of methylation (CIMP-L) that are microsatellite stable. In Lynch syndrome patients these polyps lead to CIMP-L carcinomas that are microsatellite instable...
December 22, 2018: Annals of Diagnostic Pathology
Cansu Karakas, Paul Christensen, Donghwa Baek, Minjung Jung, Jae Y Ro
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal lesions of the gastrointestinal tract. A small minority of GISTs exhibit morphologic and phenotypic changes and differentiate into an unusual phenotype through the process of dedifferentiation. Dedifferentiation can occur either de novo or after prolonged treatment with imatinib, a selective tyrosine kinase inhibitor. GISTs can present with various morphologies including rhabdomyosarcoma, angiosarcoma, or undifferentiated pleomorphic sarcoma...
December 18, 2018: Annals of Diagnostic Pathology
Büşra Yaprak Bayrak, Sevgiye Kaçar Özkara
No abstract text is available yet for this article.
December 18, 2018: Annals of Diagnostic Pathology
Natàlia Castrejón, Carlos Nicolau, Ana González-Cordón, Iván Archilla, Manel Solé
No abstract text is available yet for this article.
December 14, 2018: Annals of Diagnostic Pathology
Alcina F Nicol, Cecilia Vianna de Andrade, Saint Clair Gomes, Marion G Brusadelli, Hannah M Lodin, Susanne I Wells, Gerard J Nuovo
Importin-β, exportin-5, p16, Ki-67, Mcl1, PDL1, and cFLIP are each over-expressed in the majority of CIN 1 lesions. These biomarkers, plus HPV E6/E7 RNA, were analyzed in carcinoma-in-situ (CIS), microinvasive, and squamous cell carcinoma (SCC) of the uterine cervix and cervical carcinoma cell lines. Only p16 and Ki-67 continued to be over-expressed in CIS, with a concomitant marked increase in E6/E7 RNA. There was a highly significant increase in PDL1 expression and decrease in Ki-67 (each p < 0.001) in microinvasive cancer compared to CIS whereas p16 and E6/E7 remained stable...
December 14, 2018: Annals of Diagnostic Pathology
Fengming Chen, Yongjun Liu, Annie Tsay, Brian P McAllister, Dipti M Karamchandani
BACKGROUND: Current literature shows a variable degree of concordance between endoscopic and histopathologic findings in gastric mucosal biopsies. Most prior studies have focused on specific gastric entities such as gastritis in patients with high prevalence of Helicobacter pylori (H. pylori). In this study, we assess concordance between histologic and endoscopic findings in a wide spectrum of targeted as well as non-targeted gastric endoscopic biopsies. METHODS: We retrospectively reviewed pathology database and slides at Hershey Medical Center to identify 630 gastric mucosal biopsies obtained from 525 consecutive patients...
December 14, 2018: Annals of Diagnostic Pathology
Mohsin Aijaz, Kiran Alam, Veena Maheshwari, Seema Hakim, Maria Kamal
CD34 is a transmembrane glycoprotein that is thought to be involved in the modulation of cell adhesion and signal transduction. The connective tissue stroma of virtually all human organs contain large amounts of resident CD34+ fibrocytes, which are involved in multiple functions such as wound healing, secretion of cytokines and also participate in stromal remodeling. It has been seen in various studies that absence of CD34+ fibrocytes within the stroma is associated with invasive carcinomas. In our study, we also investigated the presence and distribution of CD34+ fibrocytes in cervical intraepithelial neoplasia, invasive cervical carcinoma and adjacent normal cervical stroma...
November 29, 2018: Annals of Diagnostic Pathology
Juliana E Hidalgo-Lopez, Maria Gisela Higa, Selena Ferrian, Pei Lin, Jorge Blando, L Jeffrey Medeiros, Carlos E Bueso-Ramos
No abstract text is available yet for this article.
November 28, 2018: Annals of Diagnostic Pathology
Heba E M El-Deek, Asmaa M Ahmed, Rabab Ahmed A Mohammed
Nrf2 and Bach1 are important transcriptional factors that protect against reactive oxygen species (ROS). Although aberration of these molecules was associated with malignant transformation and progression, their aberration pattern in colorectal carcinoma (CRC) is not yet fully studied. In this study, Nrf2 and Bach1 were immunohistochemically examined in 93 formalin-fixed paraffin-embedded blocks of colonic tumors (65 carcinoma with their corresponding surgical margins and 28 adenomas). Nrf2 expression was gradually increased in the apparently normal mucosa (57 ± 41)-adenoma (90 ± 36)-carcinoma (198 ± 78) direction and only showed significant higher mean of expression in CRC with brisk inflammatory peritumoral response...
November 22, 2018: Annals of Diagnostic Pathology
Reza Alaghehbandan, Monika Ulamec, Petr Martinek, Kristyna Pivovarcikova, Kvetoslava Michalova, Faruk Skenderi, Milan Hora, Michal Michal, Ondrej Hes
Clear cell renal cell carcinoma (ccRCC), the most common histologic subtype of RCCs, demonstrates a wide spectrum of morphologic features (i.e., low-grade spindle cell, syncytial giant cells, and mucin-producing cells). However, papillary growth pattern in ccRCCs is rather a rare finding, which can present challenges in differential diagnostic work up. The aim of this study was to investigate ccRCCs with predominant papillary features from morphologic, immunohistochemical and molecular genetic perspectives...
November 22, 2018: Annals of Diagnostic Pathology
Ann E Walts, Joseph Frye, David M Engman, Alberto M Marchevsky
It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH...
November 22, 2018: Annals of Diagnostic Pathology
Xinmin Liu, Xiaohong Wang, Jianmin Ding, Yan Gao, Yiming Zhao, Ruihua Zhao, Qigang Sun, Songlin Zhang
Regulatory T cells (Tregs) are CD4+ T cells that express CD25 and transcription factor Forkhead box P3 (FOXP3), and Tregs play a central role in regulation of tumor immunity. FOXP3 immunohistochemistry has been widely used to study Tregs in paraffin embedded tissue, and flow cytometry using fresh tissue has been used to identify FOXP3+/CD25+ double positive Tregs. In our study, we validated the FOXP3/CD25 double staining antibody cocktails for detecting Tregs in paraffin-embedded tissue. Tissue microarrays (TMA) included 115 malignant tumors, 3 ovarian mucinous borderline tumors and 15 benign tissues...
November 22, 2018: Annals of Diagnostic Pathology
Robert Terlević, Melita Perić Balja, Davor Tomas, Faruk Skenderi, Božo Krušlin, Semir Vranic, Alma Demirović
Neuroendocrine breast cancer (NEBC) is a group of rare tumors, which could benefit from therapy targeting the somatostatin receptors (SSTRs). In particular, SSTR2A and SSTR5 are potential targets given their consistent expression in gastrointestinal and pancreatic primary and metastatic neuroendocrine cancers. Currently, there are no studies describing the expression of SSTRs in NEBC. The purpose of our study was to characterize the immunohistochemical expression of SSTR2A and SSTR5 in a cohort of NEBC. Thirty-one primary NEBC cases were analyzed, and SSTR2A and SSTR5 immunohistochemistry performed and scored using the modified immunoreactive score proposed by Remmele and Stanger...
November 20, 2018: Annals of Diagnostic Pathology
Jason L Hornick
Pleomorphic sarcomas are a heterogeneous group of mesenchymal neoplasms with widely varied clinical behavior but overlapping histologic appearances. The following guidelines are helpful when approaching the diagnosis of a pleomorphic sarcoma. (1) Be aware of the relative incidence of the various sarcoma types: several pleomorphic sarcomas are relatively common (e.g., dedifferentiated liposarcoma and undifferentiated pleomorphic sarcoma), whereas others are exceptionally rare. (2) Pay attention to anatomic location: some pleomorphic sarcomas have a predilection for somatic soft tissues, especially the thigh (e...
December 2018: Annals of Diagnostic Pathology
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