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JOURNAL ARTICLE
I Ulu, A Jafarzade
OBJECTIVE: Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder that leads to follicular dysfunction and even infertility. Prokineticin 1 (PROK1) has been shown to be released from the theca interna and stroma of ovaries. PROK1 is also known to be a major prokineticin involved in reproduction and to play a crucial role in ovarian physiology. The present study investigated whether PROK1 might be a reliable biomarker for PCOS. PATIENTS AND METHODS: The present study was conducted in Koru Ankara Hospital, Department of Obstetrics and Gynecology...
March 2023: European Review for Medical and Pharmacological Sciences
#2
JOURNAL ARTICLE
G-C Ma, L-L Zou, W Dai, Z-Z Wang, Y-H Cao
OBJECTIVE: Growing evidence shows that sarcopenia is more prevalent in patients with type 2 diabetes mellitus (T2DM) than in the normal population. However, currently, data on the relationship between blood glucose fluctuation and sarcopenia in elderly patients with T2DM are still limited. PATIENTS AND METHODS: In this study, 280 patients ≥ 60 years with T2DM were divided into sarcopenic group and non-sarcopenic group, according to the diagnostic criteria of the 2019 Asian Working Group for Sarcopenia...
March 2023: European Review for Medical and Pharmacological Sciences
#3
JOURNAL ARTICLE
N Maggialetti, A Torrente, P Lazzari, I Villanova, P Marvulli, R Maresca, C Paparella, N M Lucarelli, A Sardaro, V Granata, A Scardapane, A A Stabile Ianora
OBJECTIVE: COVID-19 pneumonia, caused by the virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the WHO on 11th March 2020. While Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) represents the diagnostic gold standard of infection, computed tomography (CT) has been shown to have an important role in supporting the diagnosis, quantifying the severity, and assessing the efficacy of treatment and its response. Coronary artery calcification (CAC) is a CT finding that estimates atherosclerosis and can be quantified using the coronary artery calcium score (CACS)...
March 2023: European Review for Medical and Pharmacological Sciences
#4
JOURNAL ARTICLE
P Oboza, N Ogarek, M Olszanecka-Glinianowic, P Kocelak
By March 21, 2022, 6.1 million deaths from COVID-19 were reported, most of them in the United States, Brazil, and India. Between January 1, 2020, and December 31, 2021, the global estimated mortality due to the COVID-19 pandemic was 120.3 deaths (113.1-129.3) per 100,000 of the population for all ages. So far, many of the potentially fatal mechanisms of COVID-19 have been reported. In this manuscript, we analyzed the available data on the causes of deaths from COVID-19. This analysis suggests that the primary attributable cause of death from COVID-19 is multiple organ failure resulting from numerous pathological mechanisms, including genetic predisposition to the severe inflammatory response...
March 2023: European Review for Medical and Pharmacological Sciences
#5
JOURNAL ARTICLE
H Mahmoud, A Alhathla, A El-Fiky, M S Alghamdi, R Alwafi, M S El-Sayed, A A Thabet, A M Alkhateeb, S R Elgendy, R Hegazy, A Darweesh
OBJECTIVE: The purpose of this systematic review was to study the incidence, risk factors and patients subjected to Guillain-Barré syndrome (GBS) after COVID-19. MATERIALS AND METHODS: For qualitative assessment and assessing the methodological quality, the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) checklist were utilized. Data from PubMed, Cochrane, Embase, CINAHIL, Medline, ResearchGate, and Scopus were searched...
March 2023: European Review for Medical and Pharmacological Sciences
#6
JOURNAL ARTICLE
G Akkuzu, C Bes, D S Özgür, B Karaalioğlu, M Y Mutlu, F Yıldırım, P Atagündüz, A Gündüz, M Soy
OBJECTIVE: An increasing number of new on-set autoimmune-inflammatory rheumatic diseases (AIRD) after COVID-19 vaccination has begun to be reported in the literature. In this article, we present our patients with new-onset AIRD after vaccination for COVID-19 and review the literature on the subject. PATIENTS AND METHODS: We investigated the clinical characteristics and laboratory parameters of previously described "newly developed AIRD in individuals recently vaccinated for COVID-19", in 22 cases vaccinated with one of the COVID-19 vaccines (BNT162b2 or CoronaVac) approved in our country...
March 2023: European Review for Medical and Pharmacological Sciences
#7
JOURNAL ARTICLE
O Baydar Toprak, T Akpolat, O Uzun, P Pınar Deniz, N Kokturk, A Varol, E Guzel, M Ercelik, O Gultekin, R Guner, S Turan, Ş Gökbulut Bektaş, N Coskun, N Bakan, M Nuri Yakar, O Eren Kutsoylu, B Ergan, S Argun Barış, I Başyiğit, H Boyacı, F Çetinkaya, H Çolak, N Aykac, B Baran Ketencioğlu, Z Türe Yüce, S Akkaya Isık, E Serap Yılmaz, S Karaoğlanoğlu, S Berik Safci, G Ozkan, N Kose, D Kizilirmak, Y Havlucu, S Nural, F Kerget, Ö Sunal, A Yuksel, Z Bestepe Dursun, F Deveci, M Kuluozturk, O Ataoglu, M Dursun, S Keskin, M Emin Sezgin, E N Aktepe Sezgin, F Eser, L Akyildiz, M Selim Almaz, B Kayaaslan, I Hasanoğlu, M Bayrak, A Gümüş, G Sağcan, C Cuhadaroglu, H Kucuk, T Onyilmaz, B Mete, O Kilinc, B Oya Itil
OBJECTIVE: As the pandemic continues, different vaccine protocols have been implemented to maintain the protection of vaccines and to provide protection against new variants. The aim of this study was to assess hospitalized patients' vaccination status and document the efficacy of boosters. PATIENTS AND METHODS: The patients that were hospitalized due to COVID-19 were enrolled from 28 hospitals in Turkey for five months from September 2021. 5,331 confirmed COVID-19 patients from collaborating centers were randomly enrolled to understand/estimate the distribution of vaccination status in hospitalized patients and to compare the efficacy of vaccination/booster protocols...
March 2023: European Review for Medical and Pharmacological Sciences
#8
JOURNAL ARTICLE
M Okşul, Ö Bilge, E Taştan, F Işık, Ü İnci, H Akın, S Söner, A D Cömert, R Tüzün, M Çap, Y Z Şener, E Baysal
OBJECTIVE: The impact of COVID-19 infection still continues all over the world and is an important cause of mortality. The mortality rate due to infection varies between 1-5%. The mortality rate is higher in those with cardiovascular risk factors, especially in cases with hypertension. Some studies have shown that blood urea nitrogen (BUN) and albumin levels are associated with worse prognosis in patients with COVID-19. In our study, we aimed to investigate whether the BUN/albumin (BAR) ratio has an effect on in-hospital mortality in hypertensive COVID-19 patients...
March 2023: European Review for Medical and Pharmacological Sciences
#9
JOURNAL ARTICLE
A O Hantal, S Kayhan, S B Sagmen, M Soy
OBJECTIVE: The most important cause of mortality and morbidity of COVID-19 is lung involvement. In this study, the effects of pulmonary rehabilitation (PR) in the post-acute COVID-19 period on lung functions, functional capacity, dyspnea, quality of life, and psychiatric state were investigated. PATIENTS AND METHODS: Patients were admitted to a PR program after discharge when their general condition had stabilized. The patients' scores of forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio, maximum vital capacity (VCmax), peripheral arterial oxygen saturation (PaO2), 6-minute walking distance (6MWD), Medical Research Council Dyspnea Scale (MRC), St...
March 2023: European Review for Medical and Pharmacological Sciences
#10
JOURNAL ARTICLE
H Topcu, T Alıç, M Yalvaç, A Akdağli Ekici
OBJECTIVE: We aimed to find out how the pandemic process changed the anesthesia methods applied in Çorum Single Tertiary Region Hospital. In our hospital, we investigated the anesthesia methods used for surgical procedures before and during the pandemic, the number of cases, and the impact of the pandemic on emergency and elective surgeries. MATERIALS AND METHODS: This is a retrospective cohort study comparing COVID-19 pandemic's effect on the number of surgical operations and anesthesia techniques...
March 2023: European Review for Medical and Pharmacological Sciences
#11
JOURNAL ARTICLE
D E Afşin, A Aksakal, A F Kılıç, N K Baygutalp, B Kerget
OBJECTIVE: Mannose-binding lectin (MBL) is one of the important parts of the complement system. In our study, we aimed to determine serum MBL levels and their relationship with intensive care hospitalization. PATIENTS AND METHODS: Ninety COVID-19-positive patients from outpatient clinics and clinics were included in this study. The patients were evaluated in three groups as mild, moderate, and severe groups. Each group consisted of 30 patients. A venous blood sample was taken once from each patient...
March 2023: European Review for Medical and Pharmacological Sciences
#12
JOURNAL ARTICLE
H Aladag, M Aladag
OBJECTIVE: In our country, transmission from mother to baby is the most common form of transmission of viral hepatitis B. A high viral load in the mother and HBeAg positivity pose the greatest risk of transmission from mother to baby. The best way to prevent this is to try to eliminate the viral load in the mother by using a strong antiviral such as prenatal TDF in mothers with a high viral load during pregnancy. This study aimed to evaluate the efficacy and safety of TDF in pregnant women with high viral load...
March 2023: European Review for Medical and Pharmacological Sciences
#13
JOURNAL ARTICLE
Y Nomier, G Khuwaja, S R Penakalapati, S Alshahrani, Z Rehman, R Khawaji, W Alhazmi, A Mubarak, M F Alam, T Anwer, H Rashid, E Shaheen, K Alkashef
OBJECTIVE: The present study was taken up to evaluate the combination of two drugs in the management of behavioral disorders such as locomotor activity, muscle relaxation, analgesic, and anxiolytic activity. MATERIALS AND METHODS: In the methodology, Wistar rats weighing (150-180 g) were divided into six groups of 6 each (n=6). All the animals (groups II to VI) were subjected to stress and analyzed for anxiolytic activity using an elevated plus maze. The animals were treated for 28 days with poppy seed oil in lower and higher doses (1,000 and 2,000 mg/kg), tramadol in lower and higher doses (1...
March 2023: European Review for Medical and Pharmacological Sciences
#14
JOURNAL ARTICLE
A M Alkhayal, A S Alothman, A H Alathel, A AlMaslamani, O N Alfehaid, I A Alhassan, K A Alrabeeah, Y G Ghazwani
OBJECTIVE: World Health Organization (WHO) reports that medical applications used in different fields account for the majority of the artificial source of radiation. Due to the high exposure to ionizing radiation, healthcare workers (HCWs) and patients are considered at high risk of suffering its harmful effects. SUBJECTS AND METHODS: A questionnaire survey was used to conduct a cross-sectional study that aimed to estimate the radiation safety, knowledge, attitude and the use of protective measures among HCWs in a tertiary hospital...
March 2023: European Review for Medical and Pharmacological Sciences
#15
JOURNAL ARTICLE
S W Lee, E H Jung, H J Kim, C Min, S H Yoo, Y J Kim, S Y Rha, D K Yon, B Kang
OBJECTIVE: Previous studies have comprehensively investigated the prevalence and various potential risk factors for delirium among patients with advanced cancer admitted to the acute palliative care unit (APCU). Our objective was to evaluate the comprehensive association between delirium and various risk factors among patients with advanced cancer in an acute palliative care setting using a patient-based multicenter registry cohort. PATIENTS AND METHODS: We performed a multicenter, patient-based registry cohort study collected in South Korea between January 1, 2019, and December 31, 2020...
March 2023: European Review for Medical and Pharmacological Sciences
#16
JOURNAL ARTICLE
A İlhan, F Gurler, F Yilmaz, E Eraslan, M Dogan
OBJECTIVE: The prognostic significance of hemoglobin (HGB) -red cell distribution width (RDW) ratio (HRR) has been indicated in various cancer types. However, its clinical significance in patients with metastatic pancreas cancer (MPC) is unknown. In this study, we aimed to investigate the prognostic importance of pre-treatment HRR in patients with metastatic pancreas cancer. PATIENTS AND METHODS: MPC patients (≥18 years of age) who received at least one course of chemotherapy between January 2001 and January 2021, were evaluated retrospectively in terms of pre-treatment HRR values...
March 2023: European Review for Medical and Pharmacological Sciences
#17
JOURNAL ARTICLE
W-D Lin, L-N Ye, Z-S Song, K-P Wang, Y-F Feng, C-Y Pan
OBJECTIVE: Hepatocellular carcinoma (HCC) is the sixth leading cause of malignant tumors worldwide. Liver resection is a pivotal treatment modality for HCC. Surgical margin plays an important role in decreasing recurrence and improving prognosis for HCC patients. MATERIALS AND METHODS: This paper aimed to perform a systematic review of the literature in regard to surgical margin in HCC patients with microvascular invasion (MVI). RESULTS: Residual MVI due to insufficient surgical margins is the main origin of postoperative recurrence and metastasis in HCC patients...
March 2023: European Review for Medical and Pharmacological Sciences
#18
JOURNAL ARTICLE
H Li, Q He, G-M Zhou, W-J Wang, P-P Shi, Z-H Wang
OBJECTIVE: The liver is a unique organ containing large populations of immune cells. Immunotherapy for liver cancer is a promising yet particularly challenging method. Therefore, it harbors great significance for the identification of immune-related subtypes and the potential therapeutic targets for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Firstly, we classified the HCC samples downloaded from the dataset of Cancer Genome Atlas (TCGA) into two clusters based on the immune cell infiltration...
March 2023: European Review for Medical and Pharmacological Sciences
#19
JOURNAL ARTICLE
G M Baldini, A Mastrorocco, S Hatirnaz, A Malvasi, G Cazzato, E Cascardi, M Dellino, D Baldini
OBJECTIVE: Frozen-thawed embryo transfer (FET) cycles require the use of luteal phase support (LPS) for supporting implantation, endometrial and embryo maturity. Individualized LPS should be chosen according to the used endometrial preparation protocol. The aim of the study was to analyze the effectiveness of two different vaginal Progesterone doses for women who underwent FET cycle and the same endometrial preparation without using the GnRh analogue. PATIENTS AND METHODS: 607 women who underwent FET cycle were included in the study...
March 2023: European Review for Medical and Pharmacological Sciences
#20
JOURNAL ARTICLE
M Barbero, A Villasco, M Villa, E Badellino, E Marello, G Botta
OBJECTIVE: Vulvovaginal atrophy is a condition closely related to low circulating estrogen levels, with post-menopause being the main cause. However, patients of childbearing age may also present with these symptoms due to treatments that reduce estrogen production. Local estrogen therapy is the causal treatment of local symptoms, but it is not always accepted and is often abandoned by patients. In recent years, alternative therapies have been proposed: fractional CO2 laser or the conjugate treatment with normobaric oxygen and hyaluronic acid, the latter being the subject of this study...
March 2023: European Review for Medical and Pharmacological Sciences
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