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Journal of Medical and Dental Sciences

Koki Hobo, Kanako Noritake, Masayo Sunaga, Tomoe Miyoshi, Ridan Cao, Hiroshi Nitta, Yuji Kabasawa, Atsuhiro Kinoshita
With the development of technology, the knowledge and skills needed to become a dentist are increasing. Computer-assisted simulation learning materials have been utilized for dental education because of their high efficiency and efficacy. However, it is not well understood which material design is strongly associated with an education effect. We therefore investigated the effects of interactivity with learning materials on learners' knowledge acquisition, memory retention, and anxiety reduction. Learning effects and degree of anxiety were compared between dental residents who learned using an interactive-type material, which required decision making and provided feedback (Group I, n=26), and those who learned using a display-type material, which merely displayed the appropriate action on a computer screen (Group D, n=23)...
2017: Journal of Medical and Dental Sciences
Tomoe Miyoshi, Koki Hobo, Masayo Sunaga, Atsuhiro Kinoshita
The aim of this study was to examine the effectiveness of interactive simulation materials with decision making in knowledge acquisition and anxiety reduction. Dental students in their fourth year at Tokyo Medical and Dental University were randomly divided into Groups I and D. Participants read a scenario, learned with interactive-type (Group I) or display-type (Group D) learning materials about pulpectomy, and took the State-Trait Anxiety Inventory-JYZ, a quiz for measuring learning effects, and a questionnaire for evaluation of the material...
2017: Journal of Medical and Dental Sciences
Momoe Endo, Yoko Soroida, Masaya Sato, Tamaki Kobayashi, Hiromi Hikita, Mamiko Sato, Hiroaki Gotoh, Tomomi Iwai, Shinji Sone, Tetsuo Sasano, Yuki Sumi, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda
BACKGROUND AND AIMS: Because of the low penetration rate of transient elastography (TE) or its limitations in patients with obesity, narrow intercostal spaces, or ascites, the physical appearance of the liver as visualized using ultrasonography (US) is still thought to provide important information for the prediction of liver fibrosis. We examined the accuracy of various US signs when assessing the presence of liver cirrhosis, compared with TE. METHODS: We enrolled 189 patients who had undergone both conventional US and TE examinations...
2017: Journal of Medical and Dental Sciences
Keisuke Abe, Takuya Ohkubo, Takanori Yokota
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. A common characteristic of ALS pathology is cytoplasmic inclusions primarily composed of transactive response DNA-binding protein of 43 kDa (TDP-43). Production of TDP-43 in the central nervous system is strictly regulated, but it is not known whether this is also true in the skin of ALS patients. We found a gradual but significant reduction in epidermal TDP-43 mRNA expression with illness progression in ALS patients with upper-limb onset...
2017: Journal of Medical and Dental Sciences
Katsura Yamamoto, Kenichi Tabei, Narumi Katsuyama, Masato Taira, Ken Kitamura
Patients with unilateral sensorineural hearing loss (UHL) often complain of hearing difficulties in noisy environments. To clarify this, we compared brain activation in patients with UHL with that of healthy participants during speech perception in a noisy environment, using functional magnetic resonance imaging (fMRI). A pure tone of 1 kHz, or 14 monosyllabic speech sounds at 65‒70 dB accompanied by MRI scan noise at 75 dB, were presented to both ears for 1 second each and participants were instructed to press a button when they could hear the pure tone or speech sound...
2017: Journal of Medical and Dental Sciences
Tetsuya Yano, Yurie Soejima, Yutaka Nakajima, Takumi Akashi, Motoji Sawabe
BACKGROUND: Anticancer drugs for targeted molecular therapies have been applied to the treatment of lung cancer. Since the effects of medicine for adenocarcinoma (ADC) or squamous cell carcinoma (SQCC) differ, the ability to discriminate these lesions is important. In the present study, we examined whether ADC and SQCC could be distinguished using low-vacuum scanning electron microscopy (LVSEM) to examine cytopathological specimens. METHODS: Thirty-seven cases of bronchoscopic samples were retrospectively examined using LVSEM on the surface structures of the cancer cells...
2017: Journal of Medical and Dental Sciences
Takutoshi Inoue, Tomoaki Sugiyama, Toshiyuki Ikoma, Hideaki Shimazu, Ryo Wakita, Haruhisa Fukayama
The present study investigates how effectively lidocaine ions are transported across a cellophane membrane through the application of either a direct current (DC) or alternating current (AC). The cellophane membrane was set on a parallelplate- type acrylic cell with platinum electrodes at both ends, filled with a donor cell of a 1 % aqueous solution of lidocaine and a receptor cell with distilled water. Lidocaine concentrations were measured for 60 min while the following voltages were applied, with changes every 10 min: 3 V DC and 7...
2016: Journal of Medical and Dental Sciences
Toshiyuki Ohara, Takeshi Muneta, Yusuke Nakagawa, Yu Matsukura, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya
Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus regeneration. Use of primary MSCs is the preferable because these cells are safer than cells passaged several times in terms of probability of chromosome abnormalities. The effect of hypoxia on the proliferation of MSCs is controversial and remains unknown in primary synovial MSCs. Primary synovial MSCs were cultured at normoxia or hypoxia, and colony number, cell number, surface epitopes, mitochondria activity, TEM finding, and chondrogenic potential were analyzed...
2016: Journal of Medical and Dental Sciences
Masatoshi Nakagawa, Kazuyuki Kojima, Mikito Inokuchi, Keiji Kato, Hirofumi Sugita, Sho Otsuki, Kenichi Sugihara
Introduction The purpose of this study was to identify the frequency, severity, and risk factors of complications after open gastrectomy using the Clavien- Dindo classification because institution-specific criteria were mostly used in the previous articles. Materials and Methods All complication data were obtained from our prospectively collected database of open gastrectomy from January 1999 to December 2012 (n=539). Complications were classified into either major surgical complications such as pancreatic fistula, abdominal abscess, and anastomotic leakage, or others...
2016: Journal of Medical and Dental Sciences
Daisuke Ikeda, Makiko Sugawa, Kazuo Kawahara
Nucleic acid amplification test (NAT), which was introduced by the Japanese Red Cross Society in October 1999, began to be performed for screening of blood transfusion formulations in Japan in August 2014. In this study, the precision of immunological screenings of hepatitis B (HBsAg, HBcAb, and HBsAb), hepatitis C (HCVAb), and human immunodeficiency (HIVAb) virus antigens in donated blood were evaluated. In addition, the sensitivity of the alanine aminotransferase (ALT) test for detection of the hepatitis B and C viruses was re-evaluated...
2016: Journal of Medical and Dental Sciences
Mana Doi-Kanno, Hiroki Fukahori
AIM: This study identified the factors associated with depression in patients diagnosed with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI). METHODS: We searched the literature using PubMed and CINAHL from their inception in 1946 to December 2014. The search terms were "myocardial infarction," "depression," and "percutaneous coronary intervention." Studies which investigated factors associated with depression in patients diagnosed with MI who underwent typical medical procedures were searched...
2016: Journal of Medical and Dental Sciences
Abulimiti Zainuer, Yoshinori Inoue, Toshifumi Kudo, Takahiro Toyofuku, Kimihiro Igari, Tatsuyuki Kawano
UNLABELLED: The aim of this study was to investigate which parameters among the ankle brachial index (ABI), toe brachial pressure index (TBI) and transfer function index (TFI) are useful to accurately diagnose PAD in patients with / without arterial calcification, who have undergone some type of diagnostic imaging. PATIENTS AND METHODS: A total of 102 patients with 192 limbs (mean age: 72.0 ± 8.4 years) underwent plain radiography, ABI, TBI and TFI. A receiver operating characteristics (ROC) analysis was performed to assess possible threshold values that predict PAD in these patients...
2016: Journal of Medical and Dental Sciences
Naoya Abe, Kozue Matsuo, Toshio Kumasaka, Koichi Naka, Syoichi Hashimoto, Tamiko Takemura, Mutsunori Fujiwara, Yukiko Ito, Ryo Nakata, Takuya Hashimoto, Masatoshi Makuuchi, Yurie Soejima, Motoji Sawabe
Endoscopic retrograde cholangiopancreatography (ERCP) brushing cytology often cannot distinguish adenocarcinoma from reactive epithelial changes. We attempted to improve the diagnostic sensitivity of ERCP using the following methods: systematic cytological evaluation, immunocytochemical examination of minichromosome maintenance proteins (MCM) 2 and p53, and a combination of these methods. ERCP specimens from 53 patients (13 benign and 40 malignant cases) were studied. First, we reclassified the cases into three categories according to the systematic cytological evaluation: negative, suspicious, and positive...
2016: Journal of Medical and Dental Sciences
Takeo Niga, Maiko Mori, Kazuo Kawahara
In order to address regional inequality in healthcare delivery in Japan, healthcare districts were established in 1985. However, regional healthcare delivery has now become a national issue because of population migration and the aging population. In this study, the state of healthcare delivery at the district level is examined by analyzing population, the number of physicians, and the number of hospital beds. The results indicate a continuing disparity in healthcare delivery among districts. We find that the rate of change in population has a strong positive correlation with that in the number of physicians and a weak positive correlation with that in the number of hospital beds...
2016: Journal of Medical and Dental Sciences
Naoko Seki, Janelle Moross, Masayo Sunaga, Koki Hobo, Tomoe Miyoshi, Hiroshi Nitta, Atsuhiro Kinoshita, Ikuko Morio
Even though English is most frequently the common language when the patient's native language differs from that of a dentist, the opportunities for Japanese undergraduate dental students to learn dental English are now quite limited. The purposes of our study were to investigate: the effectiveness and feasibility of the computer-assisted simulation materials as one solution strategy for dental English education in Japan, and the needs and demands for dental English from the learners' side. Interactive simulation materials for medical interviews in English and clinical cases which were translated to English, were delivered via Learning Management System (LMS) to nineteen trainee residents of dentistry (residents)...
2016: Journal of Medical and Dental Sciences
Michie Nagayoshi, Taiko Hirose, Takahide Omori, Kyoko Toju, Shigenobu Suzuki, Motoko Okamitsu, Aki Kawamura, Naoko Takeo
This study aimed to clarify the relationships among developmental characteristics of retinoblastoma (RB) infants, mother-infant interaction, and mental health of mothers. Prospective studies were conducted twice with 13 dyads of mothers and infants who were between one (Time 1) and two years old (Time 2). Cross-sectional and longitudinal analyses were performed. The mean Developmental Quotients (DQ) significantly decreased between Time 1 and Time 2 (p < .05). Four (30.8%) infants showed DQ p < 85 at Time 1...
2015: Journal of Medical and Dental Sciences
Satoshi Yago, Taiko Hirose, Aki Kawamura, Takahide Omori, Motoko Okamitsu
This study aimed to clarify the characteristics of the Japanese version of the Infant-Toddler Social and Emotional Assessment (J-ITSEA), a parentreport questionnaire concerning social-emotional/behavioral problems and delays in competence in 1- to 3-year-old children. The differences in score between genders, ages, and between the J-ITSEA and the original Infant-Toddler Social and Emotional Assessment were examined. The data of 617 participants recruited from Saitama prefecture through stratified two-stage sampling were analyzed...
2015: Journal of Medical and Dental Sciences
Keiko Komoto, Taiko Hirose, Takahide Omori, Naoko Takeo, Motoko Okamitsu, Noriko Okubo, Hiroji Okawa
This study investigated the effects of the Japanese Early Promotion Program (JEPP), which is based on the Infant Mental Health (IMH) program. The JEPP aims to promote mother-infant interactions by enhancing the mother's ability to respond appropriately her child. Mothers in the JEPP group (n = 15) received support from IMH nurses in a pediatric clinic until their infants reached 12 months of age. The nurses provided positive feedback that emphasized strength of parenting, and assisted the mothers in understanding the construct of their infants...
2015: Journal of Medical and Dental Sciences
Yuko Ojiro, Toshiro Kubota, Kozo Takase
The "Guidelines for Obstetrical Practice in Japan" are the first consensus-based guidelines in the field of obstetrics and were published in 2008 owing to an obstetric medical care crisis in Japan. The Guidelines describe appropriate methods for obstetric care and were based on consensus among obstetricians in Japan. Originally, the Guidelines were not intended to be a rulebook to limit physician discretion; however, from a medical care litigation standpoint, medical practices that conform to the Guidelines are following the "medical standard"...
2015: Journal of Medical and Dental Sciences
Kyoko Obama, Mitsue Maru, Rumi Maeda, Toshiro Kubota
PURPOSE: To examine the relationship between cancer-related fatigue (CRF) and physical activity in daily living in premenopausal disease-free cervical and endometrial cancer survivors. METHODS: A physical activity monitor was used to collect objective data on daily physical activity. CRF and related variables were measured using self-report scales in a cross-sectional manner. RESULTS: The average age was 44.9 years among 64 women. The higher CRF group comprised 22 women (34%), 10% of whom had severe fatigue...
2015: Journal of Medical and Dental Sciences
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