journal
Journals Experimental and Clinical Card...

Experimental and Clinical Cardiology

https://read.qxmd.com/read/24294037/validation-of-the-vitronectin-knockout-mouse-as-a-model-for-studying-myocardial-infarction-vitronectin-appears-to-influence-left-ventricular-remodelling-following-myocardial-infarction
#21
Gordon E Pate, Hubert P Walinski, Lubos Bohunek, Thomas J Podor
BACKGROUND: Vitronectin (VN) is an abundant acute-phase plasma protein that regulates cell adhesion and migration as well as interactions with components of the plasminogen activator/plasmin system, specifically plasminogen activator inhibitor type 1. This system plays a major role in tissue remodelling regulating wound healing after myocardial infarction. OBJECTIVES: To investigate the feasibility of using VN knockout mice (VN(-/-)) to study the role of VN on ventricular remodelling following myocardial infarction...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294036/effect-of-the-stellate-ganglion-on-atrial-fibrillation-and-atrial-electrophysiological-properties-and-its-left-right-asymmetry-in-a-canine-model
#22
Qina Zhou, Jialu Hu, Yujun Guo, Feng Zhang, Xi Yang, Ling Zhang, Xiaoxia Xu, Lingpeng Wang, Hongli Wang, Yuemei Hou
OBJECTIVE: To investigate the effect of the stellate ganglion (SG) and its left-right asymmetry on atrial fibrillation (AF) inducibility, AF duration and atrial electrophysiological properties. METHODS: Sixteen adult mongrel dogs were randomly assigned to three groups. The control group (n=4) underwent 6 h rapid atrial pacing (RAP) only; the right SG (RSG) group (n=6) underwent 6 h RSG stimulation plus RAP; and the left SG (LSG) group (n=6) underwent 6 h LSG stimulation plus RAP...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294035/pacemaker-mediated-angina
#23
Morhaf Ibrahim, Reham Hasan
Angina is a clinical syndrome characterized by discomfort in the chest, jaw, shoulder, back or arm. It is typically aggravated by exertion or emotional stress and relieved by nitroglycerin. Atherosclerotic coronary artery disease is the most common cause of angina. Dual-chamber pacemakers track the atrial electrical activity by pacing the ventricle. The present article reports the first case in the literature involving pacemaker-mediated angina. A 78-year-old man complained of chest pain shortly after the placement of a permanent dual-chamber pacemaker and experienced immediate relief of his pain after the pacemaker mode was switched from tracking the atrium and pacing the ventricle to sensing and pacing the ventricle...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294034/cardioverter-defibrillator-implantation-in-myeloma-associated-cardiac-amyloidosis
#24
JOURNAL ARTICLE
Alfonso Campanile, Fabiola B Sozzi, Ciro Canetta, Gian Battista Danzi
A 62-year-old woman with multiple myeloma and light-chain amyloidosis with significant heart involvement developed an in-hospital cardiac arrest. After cardiopulmonary resuscitation, a stable sinus rhythm without any cerebral damage was restored, and the patient was admitted to the coronary care unit. A cardioverter-defibrillator was implanted, and it successfully intervened in two sustained ventricular tachycardia episodes and one ventricular fibrillation episode, which were recorded during hospitalization...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294033/right-ventricular-myocardial-infarction-from-pathophysiology-to-prognosis
#25
REVIEW
Tomas Ondrus, Jan Kanovsky, Tomas Novotny, Irena Andrsova, Jindrich Spinar, Petr Kala
Right ventricle myocardial infarctions (RVMIs) accompany inferior wall ischemia in up to one-half of cases. The clinical sequelae of RVMIs vary from no hemodynamic compromise to severe hypotension and cardiogenic shock. Diagnosis is based on physical examination, electrocardiography, echocardiography and coronary angiography. Because the standard 12-lead electrocardiogram is insufficient for the assessment of RV involvement, right-sided precordial leads should always be included. Adequate fluid administration in combination with positive inotropic agents and early coronary reperfusion are crucial components of treatment, while diuretics and nitrates should be avoided...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294032/mitral-valve-repair-versus-replacement-in-simultaneous-aortic-and-mitral-valve-surgery
#26
JOURNAL ARTICLE
Marian Urban, Jan Pirk, Ondrej Szarszoi, Ivo Skalsky, Jiri Maly, Ivan Netuka
BACKGROUND: Double valve replacement for concomitant aortic and mitral valve disease is associated with substantial morbidity and mortality. Excellent results with valve repair in isolated mitral valve lesions have been reported; therefore, whether its potential benefits would translate into better outcomes in patients with combined mitral-aortic disease was investigated. METHODS: A retrospective observational study was performed involving 341 patients who underwent aortic valve replacement with either mitral valve repair (n=42) or double valve replacement (n=299)...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294031/percutaneous-coronary-intervention-delays-pacemaker-implantation-in-coronary-artery-disease-patients-with-established-bradyarrhythmias
#27
JOURNAL ARTICLE
Lihua Zhong, Yanhui Gao, Hongyuan Xia, Xueqi Li, Shipeng Wei
BACKGROUND: Pacemakers have long been used to assist the heart under pathological conditions, and they are the first choice in the treatment of systematic bradyarrhythmias. However, the effect of percutaneous coronary intervention (PCI) in patients with coronary artery disease as well as bradyarrhythmias remains unknown. METHODS: In the present study, 42 patients with chest pain and/or abnormal stress test results were surveyed. Before coronary angiography, patients underwent complete examination, including a 24 h dynamic electrocardiogram, which was used to diagnose bradyarrhythmias that were not suitable for pacemaker implantation due to a lack of arrhythmia-related symptoms...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294030/effect-of-prostaglandin-e1-inhalation-on-pulmonary-hypertension-following-corrective-surgery-for-congenital-heart-disease
#28
JOURNAL ARTICLE
Chun-Yan Zhang, Zeng-Shan Ma, Long-Le Ma, Le-Xin Wang
BACKGROUND: Intravenous infusion of prostaglandin E1 (PGE1) has been used to treat pulmonary arterial hypertension (PAH); however, the efficacy and safety of inhaled PGE1 is unclear. OBJECTIVES: To investigate the effect of inhaled PGE1 on PAH following corrective surgery for congenital heart disease. METHODS: Sixty patients with postoperative residual PAH following corrective surgery for congenital heart disease were randomly assigned to a control group, a PGE1 infusion group (intravenous PGE1 infusion; 30 ng/kg/min daily for 10 days) or a PGE1 inhalation group (100 μg nebulized PGE1 every 8 h for 10 days)...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/24294029/depression-increases-the-risk-for-uncontrolled-hypertension
#29
JOURNAL ARTICLE
Alberto Francisco Rubio-Guerra, Leticia Rodriguez-Lopez, German Vargas-Ayala, Saul Huerta-Ramirez, David Castro Serna, Jose Juan Lozano-Nuevo
BACKGROUND: Because hypertension and depression share common pathways, it is possible that each disease has an impact on the natural history of the other. OBJECTIVE: To determinate whether depression influences blood pressure control in hypertensive patients. METHODS: Forty hypertensive patients undergoing antihypertensive treatment, excluding beta-blockers and central-acting agents, self-measured their blood pressure several times a day for three days using a validated, commercially available device...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940456/ischemic-postconditioning-decreases-matrix-metalloproteinase-2-expression-during-ischemia-reperfusion-of-myocardium-in-a-rabbit-model-a-preliminary-report
#30
JOURNAL ARTICLE
Zhong-Zhi Liu, Jing-Bo Kong, Feng-Zhi Li, Long-Le Ma, Shu-Qin Liu, Le-Xin Wang
OBJECTIVE: To investigate the effect of ischemic postconditioning on the expression of matrix metalloproteinase (MMP)-2 during ischemia-reperfusion of myocardium in a rabbit model. METHODS: Thirty-six male New Zealand white rabbits were randomly divided into sham, ischemia-reperfusion and ischemic postconditioning groups. Myocardial ischemia-reperfusion was created by ligating the left anterior descending coronary artery for 30 min followed by 3 h of reperfusion...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940455/effects-of-low-dose-hydroxychloroquine-on-expression-of-phosphorylated-akt-and-p53-proteins-and-cardiomyocyte-apoptosis-in-peri-infarct-myocardium-in-rats
#31
JOURNAL ARTICLE
Jing Zhou, Gang Li, Zhi-Hua Wang, Li-Ping Wang, Pu-Jiang Dong
BACKGROUND: Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear. OBJECTIVE: To explore the effects of low-dose HCQ on the expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium in a rat model...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940454/exercise-induced-st-segment-elevation-during-the-recovery-phase-of-an-exercise-stress-test
#32
JOURNAL ARTICLE
Morhaf Ibrahim, Reham Hasan, Peter Pitonak
To the authors' knowledge, the present report represents the first case in the medical literature in which an ST-segment elevation during the recovery phase of an exercise stress test indicated significant left main coronary artery stenosis. Although the patient did not complain of chest pain during the test, the ST-segment elevation persisted 20 min into recovery.
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940453/oxidative-stress-predictive-marker-for-coronary-artery-disease
#33
JOURNAL ARTICLE
Teodora Vichova, Zuzana Motovska
The role of oxidative stress in cardiovascular disease processes, such as atherogenesis, ischemic-reperfusion injury and cardiac remodelling, has been increasingly recognized in the past few decades. Currently, an increasing number of studies suggest that levels of oxidative stress markers in body fluids correlate with atherosclerotic disease activity. This finding may lead to novel clinical approaches in patients with coronary artery disease. Assessment of oxidative stress markers could modify risk stratification and treatment of patients with suspected coronary artery disease or myocardial infarction...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940452/nitrate-induced-paradoxical-ischemia-predicts-adverse-outcomes-in-elderly-patients-with-healed-myocardial-infarcts
#34
JOURNAL ARTICLE
Gian Piero Carboni
BACKGROUND: It is well known that nitrates can induce paradoxical myocardial ischemia. METHODS AND RESULTS: Fifty patients (median age 73 years; range 67 to 78 years; 80% male) with healed myocardial infarcts were selected. All patients underwent resting single-photon emission computed tomography (SPECT) and resting baseline gated-SPECT using sestamibi or thallium-201 after the sublingual administration of 5 mg isosorbide dinitrate (ISD). Forty-eight per cent (24 of 50) of the patients demonstrated ISD-induced peri-infarct ischemia as observed by SPECT...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940451/predictors-of-preinterventional-patency-of-infarct-related-artery-in-patients-with-st-segment-elevation-myocardial-infarction-importance-of-neutrophil-to-lymphocyte-ratio-and-uric-acid-level
#35
JOURNAL ARTICLE
Durmuş Yıldıray Sahin, Mustafa Gür, Zafer Elbasan, Ali Yıldız, Zekeriya Kaya, Yahya Kemal Içen, Ali Kıvrak, Caner Türkoğlu, Remzi Yılmaz, Murat Caylı
BACKGROUND: Patients with ST-segment elevation myocardial infarction (STEMI) and a patent infarct-related artery (IRA) experience lower mortality and better clinical outcome, but little is known about the predictors of IRA patency before primary percutaneous coronary intervention (PCI) in the setting of STEMI. OBJECTIVE: To assess possible predictors of patency of IRA before primary PCI in patients with STEMI. METHODS: A total of 880 patients with STEMI undergoing primary PCI were prospectively included (646 male, 234 female; mean [± SD] age 58...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940450/correlation-between-major-adverse-cardiac-events-and-coronary-plaque-characteristics
#36
JOURNAL ARTICLE
Bin He, Luyue Gai, Jingjing Gai, Huaiyu Qiao, Shuoyang Zhang, Zhiwei Guan, Li Yang, Yundai Chen
BACKGROUND: Unstable plaque is believed to be responsible for major adverse cardiac events (MACE). OBJECTIVE: To determine whether coronary computed tomography angiography (CCTA) could be used to predict future MACE. METHODS: Patients undergoing CCTA between January 2008 and February 2010 were consecutively enrolled in the study. The hospital database was screened for patients who later developed acute ST segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) or cardiac death...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940449/functions-of-cyclophilin-a-in-atherosclerosis
#37
JOURNAL ARTICLE
Zhang Tian-Tian, Zhang Jun-Feng, Ge Heng
Cyclophilin A (CypA) is a ubiquitously distributed protein present both in intracellular and extracellular spaces. In atherosclerosis, various cells, including endothelial cells, monocytes, vascular smooth muscle cells and platelets, secrete CypA in response to excessive levels of reactive oxygen species. Atherosclerosis, a complicated disease, is the result of the interplay of different risk factors. Researchers have found that CypA links many risk factors, including hyperlipidemia, hypertension and diabetes, to atherosclerosis that develop into a vicious cycle...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940448/a-modified-murine-model-for-the-study-of-reverse-cardiac-remodelling
#38
JOURNAL ARTICLE
Xiu Zhang, Hadi Javan, Ling Li, Amanda Szucsik, Ren Zhang, Yubin Deng, Craig H Selzman
BACKGROUND: The authors previously reported a murine model of left ventricular hypertrophy (LVH) and regression using a suture technique of transverse aortic arch constriction and subsequent removal. A number of issues have limited the widespread adoption of this method. The present study assessed a modification of this model using a titanium clip. METHODS: Male C57BL/6 mice (n=95) underwent minimally invasive aortic banding for three, four or six weeks with or without subsequent band removal for one week...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940447/the-effect-of-trans-resveratrol-on-platelet-neutrophil-complex-formation-and-neutrophil-burst-in-hypercholesterolemic-rats
#39
JOURNAL ARTICLE
Ayşe Yeşim Göçmen, Durmuş Burgucu, Ihsan Karadoğan, Ayşen Timurağaoğlu, Saadet Gümüşlü
Transresveratrol (t-resveratrol; 3,5,4'-trihydroxy-trans-stilbene) is a polyphenolic compound found in fresh grapes, grape juice and wine, and has been found to reduce the total cholesterol level in hypercholesterolemic rats. The objective of the present study was to assess the effects of t-resveratrol on platelet-neutrophil complex formation and neutrophil reactive oxygen species (ROS) status in control and hypercholesterolemic rats using a modified flow cytometric method. Rats (n=80) were divided into five groups (control, ethanol, resveratrol, hypercholesterolemic and resveratrol-administered hypercholesterolemic groups), comprising 16 animals per group...
2013: Experimental and Clinical Cardiology
https://read.qxmd.com/read/23940446/the-effects-of-cyclooxygenase-and-nitric-oxide-synthase-inhibition-on-cardiodynamic-parameters-and-coronary-flow-in-isolated-rat-hearts
#40
JOURNAL ARTICLE
Vladimir Zivkovic, Dragan Djuric, Drenka Turjacanin-Pantelic, Zeljko Marinkovic, Djordje Stefanovic, Ivan Srejovic, Vladimir Jakovljevic
BACKGROUND: Despite the widespread clinical use of cyclooxygenase (COX) inhibitors, dilemmas regarding the potential impact of these drugs on the cardiovascular system persist. OBJECTIVE: To estimate the effects of different COX inhibitors (meloxicam, acetylsalicylic acid [ASA] and SC-560) on cardiac function and coronary flow in isolated rat hearts, with special focus on the L-arginine/nitric oxide system. METHODS: The hearts of eight-week-old male Wistar albino rats (n=72; 12 rats per group; body mass 180 g to 200 g) were retrogradely perfused according to the Langendorff technique at gradually increased perfusion pressure (40 cmH2O to 120 cmH2O)...
2013: Experimental and Clinical Cardiology
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