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European Journal of Paediatric Neurology : EJPN

https://read.qxmd.com/read/36931152/predicting-respiratory-failure-and-outcome-in-pediatric-guillain-barr%C3%A3-syndrome
#1
JOURNAL ARTICLE
Joyce Roodbol, Rudolf Korinthenberg, Esmee Venema, Marie-Claire Y de Wit, Hester F Lingsma, Coriene E Catsman-Berrevoets, Bart C Jacobs
BACKGROUND: Guillain-Barré syndrome (GBS) has a highly variable clinical course and outcome as indicated by the risk of developing respiratory failure and residual inability to walk. Prognostic models as Erasmus GBS Respiratory Insufficiency Score (EGRIS) developed in adult patients are inaccurate in children. Our aim was to determine the prognostic factors of respiratory failure and inability to walk in children with GBS and to develop a new clinical prognostic model for individual patients (EGRIS-Kids)...
March 10, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36905830/comprehensive-neurological-evaluation-of-a-cohort-of-patients-with-neurofibromatosis-type-1-from-a-single-institution
#2
JOURNAL ARTICLE
Daniela Angelova-Toshkina, Josua A Decker, Thomas Traunwieser, Johannes Holzapfel, Stefanie Bette, Simon Huber, Mareike Schimmel, Kurt Vollert, Brigitte Bison, Thomas Kröncke, Nuria C Bramswig, Dagmar Wieczorek, Astrid K Gnekow, Michael C Frühwald, Michaela Kuhlen
Neurofibromatosis type 1 (NF1) is a phenotypically heterogenous multisystem cancer predisposition syndrome manifesting in childhood and adolescents. Central nervous system (CNS) manifestations include structural, neurodevelopmental, and neoplastic disease. We aimed to (1) characterize the spectrum of CNS manifestations of NF1 in a paediatric population, (2) explore radiological features in the CNS by image analyses, and (3) correlate genotype with phenotypic expression for those with a genetic diagnosis. We performed a database search in the hospital information system covering the period between January 2017 and December 2020...
March 5, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36893678/neurocognitive-profile-of-a-cohort-of-sma-type-1-pediatric-patients-and-emotional-aspects-resilience-and-coping-strategies-of-their-caregivers
#3
JOURNAL ARTICLE
Michele Tosi, Francesca Cumbo, Michela Catteruccia, Adelina Carlesi, Irene Mizzoni, Giacomo De Luca, Claudio Cherchi, Renato Cutrera, Enrico Bertini, Adele D'Amico
Spinal muscular atrophy (SMA) type 1 represents the most severe condition of the spectrum of SMA 5q. In the absence of therapeutic interventions, patients do not achieve any motor milestone and their life expectancy does not exceed two years of age. To date, three disease-modifying drugs have been approved for SMA type I. These treatments have radically changed the natural history of the disease, improving motor, respiratory and bulbar functions. In recent years huge amount of data have been collected worldwide related to motor, respiratory and swallowing function outcome in treated patients, whereas the neurocognitive profile of treated patients has been poorly explored...
March 3, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36905829/the-pathogenetic-basis-for-a-disease-continuum-in-early-and-late-onset-ataxia-dystonia-supports-a-unified-genetic-diagnostic-approach
#4
JOURNAL ARTICLE
M Garofalo, F Vansenne, D S Verbeek, D A Sival
INTRODUCTION: Genetically inherited ataxic disorders are classified by their age of disease presentation into early- and late-onset ataxia (EOA and LOA, presenting before or after the 25th year-of-life). In both disease groups, comorbid dystonia co-occurs frequently. Despite overlapping genes and pathogenetic features, EOA, LOA and dystonia are considered as different genetic entities with a separate diagnostic approach. This often leads to diagnostic delay. So far, the possibility of a disease continuum between EOA, LOA and mixed ataxia-dystonia has not been explored in silico...
February 28, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36878110/safety-and-feasibility-of-transcranial-direct-current-stimulation-stratified-by-corticospinal-organization-in-children-with-hemiparesis
#5
JOURNAL ARTICLE
Samuel T Nemanich, Daniel H Lench, Ellen N Sutter, Jesse L Kowalski, Sunday M Francis, Gregg D Meekins, Linda E Krach, Tim Feyma, Bernadette T Gillick
Children with hemiparesis (CWH) due to stroke early in life face lifelong impairments in motor function. Transcranial direct current stimulation (tDCS) may be a safe and feasible adjuvant therapy to augment rehabilitation. Given the variability in outcomes following tDCS, tailored protocols of tDCS are required. We evaluated the safety, feasibility, and preliminary effects of a single session of targeted anodal tDCS based on individual corticospinal tract organization on corticospinal excitability. Fourteen CWH (age = 13...
February 28, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36871341/clinical-and-radiological-findings-of-posterior-reversible-encephalopathy-syndrome-in-children-about-16-children-hospitalized-in-the-pediatric-department-of-a-tunisian-tertiary-care-hospital
#6
JOURNAL ARTICLE
Houda Ajmi, Jawher Brahim, Sameh Mabrouk, Amel Ben Abdallah, Noura Zouari, Fadoua Majdoub, Salsabil Nouir, Ibtissem Hasni, Yasser Ben Cheikh, Jalel Chemli, Hela Jemni, Saoussan Abroug
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity most frequently described in young- or middle-aged adults with a rare occurrence among children. AIM: To determine the clinical, radiological features and outcome of PRES in children admitted to a Tunisian tertiary care pediatric department. METHODS: we retrospectively reviewed records of all children under 18 years old diagnosed with PRES and admitted to the PICU of the Pediatric department of Sahloul University Hospital from January 2000 to August 2021...
February 19, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36857971/intense-work-up-is-required-for-pediatric-covid-related-acute-necrotizing-encephalopathy-with-ranbp2-variants
#7
LETTER
Josef Finsterer, Fulvio A Scorza
No abstract text is available yet for this article.
February 18, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36739787/pediatric-neurotuberculosis-a-cases-series-and-review-of-the-literature
#8
JOURNAL ARTICLE
Maha Jamoussi, Hanene Benrhouma, Zouhour Miladi, Thouraya Ben Younes, Hedia Klaa, Aïda Rouissi, Ichraf Kraoua, Ilhem Ben Youssef
Neurotuberculosis or central nervous system tuberculosis is a form of tuberculous infection that affects any part of the nervous system. Although it is more frequent in adults, pediatric cases have been reported in endemic countries and it is potentially a deadly affection. Therefore, any unusual neurological manifestation in a formerly healthy child, independently of their vaccination status, must bring suspicion of CNS tuberculosis among other diagnoses. We report four cases of pediatric neurotuberculosis with various clinical presentations and outcome and a brief review of the litterature...
February 1, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36724688/ocrelizumab-in-pediatric-multiple-sclerosis
#9
JOURNAL ARTICLE
Ceren Bibinoğlu Amirov, Sema Saltık, Cengiz Yalçınkaya, Melih Tütüncü, Sabahattin Saip, Aksel Siva, Uğur Uygunoğlu
BACKGROUND: Ocrelizumab is a recombinant humanized anti-CD20 monoclonal IgG1, approved by FDA and EMA for adult patients with multiple sclerosis (MS). The data on the efficacy and safety of Ocrelizumab for pediatric MS cases are limited. OBJECTIVE: Here, we describe pediatric relapsing-remitting MS (P-RRMS) cases who were treated with Ocrelizumab as a disease-modifying drug. METHOD: P-RRMS cases who were started Ocrelizumab below 18 years-of-age and followed-up >12 months with Ocrelizumab treatment were included...
January 27, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36746017/post-traumatic-cerebral-sinovenous-thrombosis-in-children-a-retrospective-and-multicenter-study
#10
JOURNAL ARTICLE
Helena Roth, Roman Ränsch, Manoelle Kossorotoff, Adela Chahine, Olivier Tirel, David Brossier, Isabelle Wroblewski, Gilles Orliaguet, Stéphane Chabrier, Guillaume Mortamet
CONTEXT: Cerebral sinovenous thrombosis (CSVT) is a rare but life-threatening condition in the pediatric population and there is no pediatric guidelines regarding anticoagulation for post traumatic CSVT. OBJECTIVE: This study aims to describe a cohort of children with post traumatic CSVT and the use of anticoagulant therapy in this population. METHODS: A multicenter retrospective study. Patients admitted with post traumatic CSVT in the six participating Pediatric Intensive Care Unit were included...
January 25, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36738658/long-term-monitoring-of-children-with-pseudo-tumor-cerebri-syndrome-by-transbulbar-sonography
#11
JOURNAL ARTICLE
V Kraus, F Krampe-Heni, M Steinborn
Determination of optic nerve sheath diameter (ONSD) with transbulbar sonography has become an easily accessible and time-effective tool in the assessment of increased intracranial pressure. The aim of our study was to evaluate the usefulness of transbulbar sonography in the initial diagnosis and in follow-up examinations of children and adolescents with the diagnosis of pseudotumor cerebri syndrome (PTCS). We retrospectively reviewed imaging results of 24 patients aged 0.75-17 years with PTCS. Serial transbulbar sonography examinations were performed between 2011 and 2021...
January 19, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36706682/associations-between-muscle-morphology-and-spasticity-in-children-with-spastic-cerebral-palsy
#12
JOURNAL ARTICLE
Nicky Peeters, Britta Hanssen, Lynn Bar-On, Friedl De Groote, Nathalie De Beukelaer, Marjan Coremans, Christine Van den Broeck, Bernard Dan, Anja Van Campenhout, Kaat Desloovere
INTRODUCTION: Due to the heterogeneous clinical presentation of spastic cerebral palsy (SCP), which makes spasticity treatment challenging, more insight into the complex interaction between spasticity and altered muscle morphology is warranted. AIMS: We studied associations between spasticity and muscle morphology and compared muscle morphology between commonly observed spasticity patterns (i.e. different muscle activation patterns during passive stretches). METHODS: Spasticity and muscle morphology of the medial gastrocnemius (MG) and semitendinosus (ST) were defined in 74 children with SCP (median age 8 years 2 months, GMFCS I/II/III: 31/25/18, bilateral/unilateral: 46/27)...
January 10, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36645949/visuospatial-processing-skills-following-unilateral-arterial-ischemic-stroke-in-childhood
#13
JOURNAL ARTICLE
Sophie Mandl, Astrid Novak, Kathrin Kollndorfer, Rainer Seidl, Lisa Bartha-Doering
Due to the rare occurrence of childhood stroke, its impact on later cognitive functioning remains unclear. While it is often assumed that children recover better than adults, recent studies suggest that childhood stroke can negatively affect a wide range of cognitive domains, such as attention, language, and processing speed, among others. We examined the effect of unilateral stroke on children's visuoconstructive ability and visual memory. Seventeen children with left- or right-sided arterial ischemic stroke were tested using subtests of the Hamburg-Wechsler Intelligenztest für Kinder and the Rey-Osterrieth Complex Figure (ROCF)...
January 10, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36641854/lesion-size-and-long-term-cognitive-outcome-after-pediatric-stroke-a-comparison-between-two-techniques-to-assess-lesion-size
#14
JOURNAL ARTICLE
Regula Everts, Shana Bertato, Maja Steinlin, Nedelina Slavova, Sebastian Grunt, Leonie Steiner
BACKGROUND: There is little consensus on how lesion size impacts long-term cognitive outcome after pediatric arterial ischemic stroke (AIS). This study, therefore, compared two techniques to assessed lesion size in the chronic phase after AIS and determined their measurement agreement in relation to cognitive functions in patients after pediatric stroke. METHODS: Twenty-five patients after pediatric AIS were examined in the chronic phase (>2 years after stroke) in respect to intelligence, memory, executive functions, visuo-motor functions, motor abilities, and disease-specific outcome...
January 7, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36641348/anxiety-in-children-with-sma-an-underestimated-problem
#15
EDITORIAL
Heike Kölbel
No abstract text is available yet for this article.
January 7, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36720654/guardians-of-the-epilepsy-genome
#16
EDITORIAL
Julie Xian, Ingo Helbig
No abstract text is available yet for this article.
January 6, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36639305/editorial-commentary-on-sonographic-evaluations-of-the-skeletal-muscles-in-patients-with-pompe-disease-by-y-h-chiu-et%C3%A2-al
#17
EDITORIAL
Georgios K Papadimas
No abstract text is available yet for this article.
January 6, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36634526/migraine-in-childhood-gender-differences
#18
REVIEW
Fabiana Ursitti, Massimiliano Valeriani
Migraine is a common neurological disorder in developmental age, involving up to 20% of children and adolescents. Although gender differences in migraine epidemiology and clinical characteristics have been largely investigated in adulthood, this issue is considerably less known in pediatric patients. We aim at providing an overview of gender differences in pediatric migraine. The most recent literature was reviewed taking into account the epidemiological, pathophysiological, and clinical differences between boys and girls with migraine...
January 6, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36631364/good-news-never-hurts
#19
EDITORIAL
Sithara Ramdas, Laurent Servais
No abstract text is available yet for this article.
January 6, 2023: European Journal of Paediatric Neurology: EJPN
https://read.qxmd.com/read/36621064/pediatric-recurrent-acute-necrotizing-encephalomyelitis-ranbp2-genotype-and-sars-cov-2-infection-diagnosis-pathogenesis-and-targeted-treatments-from-a-case-study
#20
JOURNAL ARTICLE
Cristina Forest, Michele Laudisi, Cristina Malaventura, Valeria Tugnoli, Giuditta Pellino, Elisabetta Marangoni, Eleonora Baldi, Luca Borgatti, Maura Pugliatti, Agnese Suppiej
Acute necrotizing encephalopathy (ANE) is a rare disease not yet described in children with Covid-19. RANBP2 gene variations are implicated in recurrences in the genetic form of ANE, the so called ANE1. We report the first case of pediatric ANE1 following Sars-CoV-2 infection. She had a first episode at 2 years of age following influenza type A with full recovery, many other respiratory and non-respiratory febrile viral infections without recurrences and a severe recurrence following Sars-CoV-2 infection, suggesting a potentiation effect on cytokine cascade...
January 4, 2023: European Journal of Paediatric Neurology: EJPN
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