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Congestive Heart Failure | Page 2

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https://read.qxmd.com/read/23332030/aldosterone-antagonists-evidence-based-yet-underutilized-effective-heart-failure-therapy
#21
EDITORIAL
Carl J Lavie, James J DiNicolantonio, James H O'Keefe, Hector O Ventura
No abstract text is available yet for this article.
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23279210/what-is-causing-extremely-elevated-amino-terminal-brain-natriuretic-peptide-in-cancer-patients
#22
COMPARATIVE STUDY
Jesal Popat, Abel Rivero, Pravin Pratap, Maya Guglin
High levels of B-type natriuretic peptide in cancer patients are poorly studied. Previously published data suggest that they are not related to fluid overload and are encountered mostly in solid cancers. The authors investigated the distribution of amino terminal pro-brain natriuretic peptide (NT-proBNP) between hematologic and solid organ malignancies and the relationship of NT-proBNP with volume status in oncologic patients. A total of 145 consecutive patients with at least one occurrence of NT-proBNP exceeding the upper normal range 10-fold were identified...
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23279139/characterization-and-prediction-of-natriuretic-peptide-nonresponse-during-heart-failure-management-results-from-the-probnp-outpatient-tailored-chronic-heart-failure-protect-and-the-nt-probnp-assisted-treatment-to-lessen-serial-cardiac-readmissions-and-death
#23
RANDOMIZED CONTROLLED TRIAL
Hanna K Gaggin, Quynh A Truong, Shafiq U Rehman, Asim A Mohammed, Anju Bhardwaj, Kimberly A Parks, Dorothy A Sullivan, Annabel Chen-Tournoux, Stephanie A Moore, A Mark Richards, Richard W Troughton, John G Lainchbury, Rory B Weiner, Aaron L Baggish, Marc J Semigran, James L Januzzi
Many proven heart failure (HF) therapies decrease N-terminal pro B-type natriuretic peptide (NT-proBNP) values over time, yet some patients have an NT-proBNP >1000 pg/mL following treatment, which is associated with poor outcomes. A total of 151 patients with left ventricular systolic dysfunction were treated with aggressive HF therapy in the ProBNP Outpatient Tailored Chronic Heart Failure (PROTECT) study. Clinical characteristics and NT-proBNP were measured at each visit during 10 months. In this post hoc analysis, biomarker nonresponse was defined as an NT-proBNP >1000 pg/mL and its relationship with echocardiographic and clinical characteristics and outcomes were explored...
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23241105/left-ventricular-ejection-fraction-and-left-ventricular-end-diastolic-volume-in-patients-with-diastolic-dysfunction
#24
COMPARATIVE STUDY
Ion S Jovin, Keita Ebisu, Yi-Hwa Liu, Laurie A Finta, Adriana D Oprea, Cynthia A Brandt, James Dziura, Frans J Wackers
Diastolic dysfunction can be diagnosed on equilibrium radionuclide angiocardiography (ERNA) by a low peak filling rate (PFR) in the setting of a normal left ventricular ejection fraction (LVEF). The authors evaluated the relationship between diastolic dysfunction, LVEF, and end-diastolic volume (EDV). A total of 408 predominantly asymptomatic patients with an LVEF ≥50% by ERNA were studied. LVEF of patients with a low PFR was compared with the LVEF of patients with a normal PFR. Correlation analyses to evaluate the association between PFR and EDV were also performed...
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23241077/potentials-of-cystatin-c-and-uric-acid-for-predicting-prognosis-of-heart-failure
#25
COMPARATIVE STUDY
Hyungseop Kim, Hyuck-Jun Yoon, Hyoung-Seob Park, Yun-Kyeong Cho, Chang-Wook Nam, Seung-Ho Hur, Yoon-Nyun Kim, Kwon-Bae Kim
Few studies have explored the clinical potentials of combined Cystatin C (Cys) and uric acid (UA) in heart failure (HF). The authors evaluated Cys and UA as predictors of clinical outcomes compared with conventional renal biomarkers. This prospective cohort study included 587 HF patients presenting with dyspnea. At admission, Cys, UA, and other renal measures including serum urea nitrogen (BUN), creatinine (Cr), and glomerular filtration rate (GFR) were obtained. The primary endpoint was the composite of cardiac death and rehospitalization for worsening HF...
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23241032/when-conventional-heart-failure-therapy-is-not-enough-angiotensin-receptor-blocker-direct-renin-inhibitor-or-aldosterone-antagonist
#26
REVIEW
Sripal Bangalore, Sunil Kumar, Franz H Messerli
In patients on conventional heart failure therapy including angiotensin-converting enzyme (ACE) inhibitors, the addition of angiotensin receptor blockers (ARBs), direct renin inhibitors (DRIs), or aldosterone antagonists are therapeutic options to further reduce the risk of cardiovascular events. However, whether one is preferable over the other is not known. PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched for randomized clinical trials (RCTs), until March 2011, of trials testing either an ARB, DRI, or an aldosterone antagonist in patients with heart failure who were on conventional heart failure therapy with follow-up of at least 3 months...
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23121695/utility-of-right-ventricular-strain-imaging-in-predicting-pulmonary-vascular-resistance-in-patients-with-pulmonary-hypertension
#27
COMPARATIVE STUDY
Nasim Naderi, Zahra Ojaghi Haghighi, Ahmad Amin, Farah Naghashzadeh, Hooman Bakhshandeh, Sepide Taghavi, Majid Maleki
Pulmonary vascular resistance (PVR) has important prognostic implications in the assessment of patients with pulmonary hypertension. Using echocardiography to measure PVR would have the advantage of being able to follow patients serially and to assess their response to treatment noninvasively. The authors sought to assess whether right ventricular strain rate imaging (SRI) can predict PVR in patients with pulmonary hypertension. The study population consisted of 46 patients referred for right heart catheterization...
May 2013: Congestive Heart Failure
https://read.qxmd.com/read/23336425/a-diuretic-protocol-increases-volume-removal-and-reduces-readmissions-among-hospitalized-patients-with-acute-decompensated-heart-failure
#28
COMPARATIVE STUDY
Jeffrey H Barsuk, Robert A Gordon, Elaine R Cohen, William G Cotts, David Malkenson, Clyde W Yancy, Mark V Williams
Despite the widespread use of loop diuretics to treat acute decompensated heart failure (ADHF), robust data supporting their role and optimal dosing strategies are scarce. This analysis aimed to compare clinical outcomes of patients admitted with ADHF who received a diuretic dosing protocol with those who received the usual diuretic therapy. We performed an observational medical records review to compare the use of a nurse-driven diuretic dosing protocol with usual diuretic dosing for patients admitted with ADHF during a 1-year period...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/23279262/biomarkers-in-acute-heart-failure-from-risk-markers-to-therapeutic-targets
#29
EDITORIAL
Andreas P Kalogeropoulos, Vasiliki V Georgiopoulou, Javed Butler
No abstract text is available yet for this article.
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/23241003/is-chronic-sildenafil-therapy-safe-and-clinically-beneficial-in-patients-with-systolic-heart-failure
#30
RANDOMIZED CONTROLLED TRIAL
Ahmad Amin, Ebrahim Mahmoudi, Hossein Navid, Mitra Chitsazan
Sildenafil is a selective phosphodiesterase-5 inhibitor and causes vasodilatation, particularly in pulmonary circulation. Since left heart failure may be associated with pulmonary hypertension "out of proportion to left heart disease," sildenafil may have beneficial effect in such patients. The present investigation was designed as a 12-week, single-center, randomized, double-blind, placebo-controlled study evaluating the effects of sildenafil on mean blood pressure (primary endpoint) in patients with left systolic heart failure...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/23066917/low-density-lipoprotein-levels-in-patients-with-acute-heart-failure
#31
COMPARATIVE STUDY
Mark R Kahn, Constantine E Kosmas, Gabriel Wagman, Gregory W Serrao, Arzhang Fallahi, Kathleen M Grady, Timothy J Vittorio
Statins do not appear to have a significant benefit in heart failure (HF) as they do in coronary artery disease (CAD). Significant evidence exists that low serum cholesterol levels may be harmful in HF. This study sought to determine the optimal low-density lipoprotein (LDL) level in patients hospitalized with acute HF. Patients were included if they presented to the hospital with acute HF and had a lipid panel drawn during admission. The primary outcome was all-cause mortality, and secondary outcomes were rates of major cardiovascular (CV) events, left ventricular assist device (LVAD) implantation, and orthotopic heart transplantation (OHT)...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/23057677/elevated-levels-of-interleukin-6-and-c-reactive-protein-associated-with-cognitive-impairment-in-heart-failure
#32
Ponrathi Athilingam, Jan Moynihan, Leway Chen, Rita D'Aoust, Maureen Groer, Kevin Kip
There is abundant evidence on inflammatory mechanisms in heart failure (HF) that are used for prognostication of the disease; however, data are lacking regarding the association between elevated cytokines, C-reactive protein (CRP), and cognition in HF. A cross-sectional pilot study of 38 patients with HF, aged 62 years (standard deviation± 9 years), predominantly men (68%) and Caucasian (79%) were screened for cognitive function using the Montreal Cognitive Assessment (MoCA). The study aimed to examine cognitive scores on MoCA with cytokines, interleukin 6 [IL-6] and tumor necrosis factor α [TNF-α], and CRP as indicators of early cognitive changes in HF...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/23057654/tai-chi-in-patients-with-heart-failure-with-preserved-ejection-fraction
#33
RANDOMIZED CONTROLLED TRIAL
Gloria Y Yeh, Malissa J Wood, Peter M Wayne, Mary T Quilty, Lynne W Stevenson, Roger B Davis, Russell S Phillips, Daniel E Forman
Although exercise is an important component of heart failure management, optimal regimens, particularly in heart failure with preserved ejection fraction (HFPEF), are uncertain. Tai chi (TC) is a mind-body exercise that may have potential benefits but has not been studied in this population. The authors randomized 16 patients with HFPEF to either 12 weeks TC or aerobic exercise. Assessments included peak oxygen uptake, 6-minute walk, quality of life, echocardiography, mood, and self-efficacy at baseline and at 12 weeks...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/23020287/clinical-outcomes-after-tricuspid-valve-annuloplasty-in-addition-to-mitral-valve-surgery
#34
COMPARATIVE STUDY
Gille Koppers, David Verhaert, Frederik H Verbrugge, Rozette Reyskens, Herbert Gutermann, Chris Van Kerrebroeck, Pieter Vandervoort, W H Wilson Tang, Robert Dion, Wilfried Mullens
Current guidelines recommend tricuspid valve annuloplasty (TVP) together with mitral valve surgery in cases of tricuspid annulus dilation (≥40 mm) or functional tricuspid valve regurgitation >2/4. Baseline clinical and echocardiographic data of patients undergoing mitral valve surgery in a single tertiary care hospital between 2007 and 2010 were analyzed. Mortality and heart failure hospitalization data were collected and groups with or without TVP were compared. Patients with TVP (n=89) had similar baseline characteristics compared with patients without (n=86), except for lower right ventricular fractional area change and more concomitant aortic valve surgery...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/22958534/is-exercise-training-beneficial-for-heart-failure-patients-taking-%C3%AE-adrenergic-blockers-a-systematic-review-and-meta-analysis
#35
Hashbullah Ismail, James McFarlane, Neil A Smart
The authors sought to conduct a systematic review comparing the effects of exercise training in heart failure patients taking β-blockers vs those not. A systematic search of exercise training trials in chronic heart failure patients that compared groups who took β-blocker medication or compared selective and nonselective β-blockers during exercise training was conducted. Eight prospective studies met the criteria for the quantitative synthesis, which included data from 236 participants. The increment in peak oxygen consumption (VO(2)) was greater in exercising vs control participants, with a mean difference (MD) of 1...
March 2013: Congestive Heart Failure
https://read.qxmd.com/read/22963032/relationship-of-cardiac-magnetic-resonance-imaging-and-myocardial-biopsy-in-the-evaluation-of-nonischemic-cardiomyopathy
#36
Jennifer A Dickerson, Subha V Raman, Peter M Baker, Carl V Leier
This study was performed to determine the relative role of cardiac magnetic resonance (CMR) imaging and endomyocardial biopsy (EMB) in the evaluation of cardiomyopathy. Sixty-six patients with a clinical diagnosis of nonischemic dilated cardiomyopathy or restrictive cardiomyopathy underwent both EMB and CMR imaging as part of their diagnostic evaluation. The authors retrospectively reviewed the results of these two methods to determine their diagnostic impact and congruency. CMR imaging provided data on cardiac anatomy, left ventricular volumes, mass, and function in 85% of the patients, uncovered fibrosis in 31%, myocardial ischemia in 7%, and fibrofatty infiltration in two patients...
January 2013: Congestive Heart Failure
https://read.qxmd.com/read/22963002/rate-of-change-in-physical-fitness-and-quality-of-life-and-depression-following-exercise-training-in-patients-with-congestive-heart-failure
#37
Neil A Smart, Robert Murison
Exercise training appears to improve peak oxygen consumption (VO(2) ) and quality of life (QOL) in heart failure patients, although disease etiology, patient demographics and medication may alter the rate of adaptation. The authors sought to identify rate of change from baseline in fitness, QOL, and depression following exercise training in a cohort of patients with congestive heart failure. Thirty male systolic heart failure patients (aged 63.8±8.3 years, baseline peak VO(2) 12.2±4.8 mL/kg/min, left ventricular ejection fraction 28...
January 2013: Congestive Heart Failure
https://read.qxmd.com/read/22958623/heart-rate-control-in-patients-with-chronic-atrial-fibrillation-and-heart-failure
#38
RANDOMIZED CONTROLLED TRIAL
Helme Silvet, Lee Ann Hawkins, Alan K Jacobson
The goal of this study was to determine whether aggressive heart rate (HR) control in patients with both chronic atrial fibrillation (AF) and heart failure (HF) is associated with improved outcomes. HR control is one of the mainstays in management of patients with AF. However, rate control can be challenging in patients with HF. This study was designed as an interventional clinical trial, using patients with chronic AF and left ventricular systolic dysfunction with left ventricular ejection fraction ≤40% (n=20) as their own controls...
January 2013: Congestive Heart Failure
https://read.qxmd.com/read/22958604/patient-reported-selective-adherence-to-heart-failure-self-care-recommendations-a-prospective-cohort-study-the-atlanta-cardiomyopathy-consortium
#39
MULTICENTER STUDY
Catherine N Marti, Vasiliki V Georgiopoulou, Grigorios Giamouzis, Robert T Cole, Anjan Deka, W H W Tang, Sandra B Dunbar, Andrew L Smith, Andreas P Kalogeropoulos, Javed Butler
Simultaneous adherence with multiple self-care instructions among heart failure (HF) patients is not well described. Patient-reported adherence to 8 recommendations related to exercise, alcohol, medications, smoking, diet, weight, and symptoms was assessed among 308 HF patients using the Medical Outcomes Study Specific Adherence Scale questionnaire (0="never" to 5="always," maximum score=40). A baseline cumulative score of ≥32/40 (average ≥80%) defined good adherence. Clinical events (death/transplantation/ventricular assist device), resource utilization, functional capacity (6-minute walk distance), and health status (Kansas City Cardiomyopathy Questionnaire [KCCQ]) were compared among patients with and without good adherence...
January 2013: Congestive Heart Failure
https://read.qxmd.com/read/22958577/cognitive-profile-in-persons-with-systolic-and-diastolic-heart-failure
#40
Ponrathi Athilingam, Rita F D'Aoust, Leslie Miller, Leway Chen
Persons with heart failure (HF) have four times the risk of having cognitive impairment compared with the general population and display different patterns of cognitive impairment. This secondary analysis of a published cross-sectional study of 90 community-dwelling adults examined the Montreal Cognitive Assessment (MoCA) scores and HF differentiated as systolic and diastolic HF. Mean MoCA score was 22.9 (standard deviation±2.31) in persons with systolic HF (n=69) and 24.8 (standard deviation±2.76) in persons with diastolic HF (n=21) with statistically significant mean difference between groups (t=-2...
January 2013: Congestive Heart Failure
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