IEEE Transactions on Information Technology in Biomedicine

This work presents the first method of digital blind forensics within the medical imaging field with the objective to detect whether an image has been modified by some processing (e.g. filtering, lossy compression and so on). It compares two image features: the Histogram statistics of Reorganized Block-based Discrete cosine transform coefficients (HRBD), originally proposed for steganalysis purposes, and the Histogram statistics of Reorganized Block-based Tchebichef moments (HRBT). Both features serve as input of a set of SVM classifiers built in order to discriminate tampered images from original ones as well as to identify the nature of the global modification one image may have undergone...

Congenital pulmonary hypoplasia is a devastating condition affecting fetal and newborn pulmonary physiology, resulting in great morbidity and mortality. The fetal lung develops in a fluid-filled environment. In this work, we describe a novel, implantable pressure sensing and recording device which we use to study the pressures present in the fetal pulmonary tree throughout gestation. The system achieves 0.18 cm H2O resolution and can record for twenty one days continuously at 256 Hz. Sample tracings of in vivo fetal lamb recordings are shown...

There are many examples of problems in pattern analysis for which it is often possible to obtain systematic characterizations, if in addition a small number of useful features or parameters of the image are known a priori or can be estimated reasonably well. Often the relevant features of a particular pattern analysis problem are easy to enumerate, as when statistical structures of the patterns are well understood from the knowledge of the domain. We study a problem from molecular image analysis, where such a domain-dependent understanding may be lacking to some degree and the features must be inferred via machine-learning techniques...

Childhood obesity is nowadays considered as one of the major health problems that many societies suffer from. The obesity epidemic leads to several life threatening conditions such as diabetes, heart disease, high blood pressure, and mental health problems like depression, anxiety and loneliness just to mention a few. Several approaches, including physical exercises, strict dietary, and exergames among others, have been adopted to address the obesity epidemic. Exergames are considered the innovative approach for fighting several health problem such as the obesity, where a combination of exercise and 3D gaming are proposed to incite kids to exercise as a team...

Wireless body area networks (BANs) have drawn much attention from research community and industry in recent years. Multimedia healthcare services provided by BANs can be available to anyone, anywhere, and anytime seamlessly. A critical issue in BANs is how to preserve the integrity and privacy of a person's medical data over wireless environments in a resource efficient manner. This paper presents a novel key agreement scheme that allows neighboring nodes in BANs to share a common key generated by electrocardiogram (ECG) signals...

The Radio Frequency Identification (RFID) technology promises to improve several processes in the healthcare scenario, especially those related to traceability of people and things. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies in the healthcare field. Among these, the evaluation of potential thermal and non-thermal effects due to the exposure of biopharmaceutical products to electromagnetic fields is very challenging, but still slightly investigated...

Most alignment algorithms find an initial equivalent residue pair followed by an iterative optimization process to explore better near-optimal alignments in the surrounding solution space of the initial alignment. It plays a decisive role in determining the alignment quality since a poor initial alignment may make the final alignment trapped in an undesirable local optimum even with an iterative optimization. We proposed a vector-based alignment algorithm with a new initial alignment approach accounting for local structure features called MIRAGE-align...

This paper presents the prototype implementation of a Bio-Patch using fully integrated low-power System-on-Chip (SoC) sensor and paper-based inkjet printing technology. The SoC sensor is featured with programmable gain and bandwidth to accommodate a variety of bio-signals. It is fabricated in a 0.18-ìm standard CMOS technology, with a total power consumption of 20 ìW from a 1.2 V supply. Both the electrodes and interconnections are implemented by printing conductive nano-particle inks on a flexible photo paper substrate using inkjet printing technology...

Ultrasound-guided needle placement is a key step in a lot of radiological intervention procedures such as biopsy, local anesthesia and fluid drainage. To help training future intervention radiologists, we develop a serious game to teach the skills involved. We introduce novel techniques for realistic simulation and integrate game elements for active and effective learning. This game is designed in the context of needle placement training based on the some essential characteristics of serious games. Training scenarios are interactively generated via a block-based construction scheme...

This paper presents a systematic approach to system identification and closed-loop control of end-tidal carbon dioxide partial pressure (PETCO2) in mechanically ventilated patients. An empirical model consisting of a linear dynamic system followed by an affine transform is proposed to derive a low-order and high-fidelity representation that can reproduce the positive and inversely proportional dynamic input-output relationship between PETCO2 and minute ventilation (MV) in mechanically ventilated patients. The predictive capability of the empirical model was evaluated using experimental respiratory data collected from eighteen mechanically ventilated human subjects...

The growing number of elderly population at home and abroad necessitates improved approaches to elderly care provision. Elders, often with cognitive and physical impairment, need assistance in their activities of daily living (ADLs), which is usually provided by human caregivers. As the demand for caregivers assistance increases, the shortage of traditional care resources becomes obvious. In this paper, we present the Virtual Caregiver (ViCare) framework that supports a human caregiver to monitor continuously the elderly by being aware of their surroundings...

E-Health systems provide a collaborative platform for sharing patients medical data typically stored in distributed autonomous healthcare data sources. Each autonomous source stores its medical and multimedia data without following any global structure. This causes heterogeneity in the underlying sources with respect to the data and storage structure. Therefore, a data interoperability mechanism is required for sharing the data among the heterogeneous sources. A proper metadata structure is also necessary to represent multimedia content in the sources to enable efficient query processing...

In this paper, we propose a novel and efficient semisupervised technique for automated prostate cancer localization using multiparametric magnetic resonance imaging (MRI). This method can be used in guiding biopsy, surgery, and therapy. We systematically present a new segmentation technique by developing a multiparametric graph based random walker (RW) algorithm with automated seed initialization to perform prostate cancer segmentation using multiparametric MRI. RW algorithm has proved to be accurate and fast in segmentation applications; however it requires a set of (user provided) seed points in order to perform segmentation...

The application of advanced error concealment techniques applied as a post-process to conceal lost video information in error-prone channels, such as the wireless channel, demand additional processing at the receiver. This increases the delivery delay and needs more computational power. However, in general, only a small region within medical video is of interest to the physician and thus if only this area is considered, the number of computations can be curtailed. In this paper we present a technique whereby the Region of Interest (ROI) specified by the physician is used to delimit the area where the more complex concealment techniques are applied...

The development of medical sensor networks (MSNs) is imperative for e-healthcare, but security remains a formidable challenge yet to be resolved. Traditional cryptographic mechanisms do not suffice given the unique characteristics of MSNs, and the fact that MSNs are susceptible to a variety of node misbehaviors. In such situations, the security and performance of MSNs depend on the cooperative and trust nature of the distributed nodes, and it is important for each node to evaluate the trustworthiness of other nodes...

An autonomous task-prompting system is presented to increase workplace and life independence for people with cognitive impairments such as traumatic brain injury, intellectual disability, schizophrenia, and Down syndrome. This paper describes an approach to providing distributed cognition support of work engagement for persons with cognitive disabilities. In the pilot study, a prototype was built and tested in a community-based rehabilitation program involving pre-service food preparation training of 8 participants with cognitive impairments...

A new method is introduced to increase the signal-to-noise ratio (SNR) in low-field magnetic resonance imaging (MRI) systems by using a vertically stacked phased coil array. It is shown theoretically that the SNR is increased with the square root of the number of coils in the array if the array signals are properly combined to remove the mutual coupling effect. Based on this, a number of vertically stacked phased coil arrays have been designed and characterized by a numerical simulation method. The performance of these arrays confirms the significant increase of SNR by increasing the number of coils in the arrays...

The objective of this study was to assess whether there is evidence of motor unit loss in muscles paralyzed by spinal cord injury (SCI), using a measurement called motor unit number index (MUNIX). The MUNIX technique was applied in SCI (n=12) and neurologically intact (n=12) subjects. The maximum M waves and voluntary surface electromyography (EMG) signals at different muscle contraction levels were recorded from the first dorsal interosseous (FDI) muscle in each subject. The MUNIX values were estimated using a mathematical model describing the relation between the surface EMG signal and the ideal motor unit number count derived from the M wave and surface EMG measurements...

In this paper, we present a new method for classification of electroencephalogram (EEG) signals using empirical mode decomposition (EMD) method. The intrinsic mode functions (IMFs) generated by EMD method can be considered as a set of amplitude and frequency modulated (AM-FM) signals. The Hilbert transformation of IMFs provides an analytic signal representation of the IMFs. The two bandwidths, namely amplitude modulation bandwidth (B(AM)) and frequency modulation bandwidth (B(FM)), computed from the analytic IMFs, have been used as an input to least squares support vector machine (LS-SVM) for classifying seizure and non-seizure EEG signals...

Oral squamous cell carcinoma (OSCC) constitutes the predominant neoplasm of the head and neck region, featuring particularly aggressive nature, associated with quite unfavorable prognosis. In this work we formulate a Decision Support System (DSS) which integrates a multitude of heterogeneous data (clinical, imaging and genomic), thus, framing all manifestations of the disease. Our primary aim is to identify the factors that dictate OSCC progression and subsequently predict potential relapses (local or metastatic) of the disease...