Jialyu Huang, Zheng Fang, Xingwu Wu, Leizhen Xia, Yuxin Liu, Jiawei Wang, Yufang Su, Dingfei Xu, Ke Zhang, Qiqi Xie, Jia Chen, Peipei Liu, Qiongfang Wu, Jun Tan, Haibin Kuang, Lifeng Tian
Cumulus granulosa cells (CGCs) play a crucial role in follicular development, but so far, no research has explored the impact of SARS-CoV-2 infection on ovarian function from the perspective of CGCs. In the present study, we compared the cycle outcomes between infected and uninfected female patients undergoing controlled ovarian stimulation, performed bulk RNA-sequencing of collected CGCs, and used bioinformatic methods to explore transcriptomic changes. The results showed that women with SARS-CoV-2 infection during stimulation had significantly lower number of oocytes retrieved and follicle-oocyte index, while subsequent fertilization and embryo development were similar...
February 26, 2024: Apoptosis: An International Journal on Programmed Cell Death