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Apoptosis: An International Journal on Programmed Cell Death

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https://read.qxmd.com/read/30997620/proteasome-inhibitors-trigger-mutations-via-activation-of-caspases-and-cad-but-mutagenesis-provoked-by-the-hdac-inhibitors-vorinostat-and-romidepsin-is-caspase-cad-independent
#1
Mark A Miles, Michael A Harris, Christine J Hawkins
Genotoxic anti-cancer therapies such as chemotherapy and radiotherapy can contribute to an increase in second malignancies in cancer survivors due to their oncogenic effects on non-cancerous cells. Inhibition of histone deacetylase (HDAC) proteins or the proteasome differ from chemotherapy in that they eliminate cancer cells by regulating gene expression or cellular protein equilibrium, respectively. As members of these drug classes have been approved for clinical use in recent times, we investigated whether these two drug classes exhibit similar mutagenic capabilities as chemotherapy...
April 17, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30989459/17-aminogeldanamycin-selectively-diminishes-ire1%C3%AE-xbp1s-pathway-activity-and-cooperatively-induces-apoptosis-with-mek1-2-and-braf-v600e-inhibitors-in-melanoma-cells-of-different-genetic-subtypes
#2
Aleksandra Mielczarek-Lewandowska, Malgorzata Sztiller-Sikorska, Marta Osrodek, Malgorzata Czyz, Mariusz L Hartman
Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17-aminogeldanamycin more potently activated caspase-3/7 in BRAFV600E melanoma cells than geldanamycin, another inhibitor of heat shock protein 90 (HSP90). 17-aminogeldanamycin alleviated self-triggered compensatory increase in HSP70 mRNA level and induced endoplasmic reticulum (ER) stress, which was followed by selective diminution of cytoprotective IRE1α-XBP1s pathway activity of unfolded protein response (UPR), inhibition of ERK1/2 activity and induction of apoptosis...
April 15, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30949883/matrix-metalloproteinase-9-induces-keratinocyte-apoptosis-through-fasl-fas-pathway-in-diabetic-wound
#3
Ying Liang, Chuan Yang, Yongqing Lin, Yasir Parviz, Kan Sun, Wei Wang, Meng Ren, Li Yan
Apoptosis is a mechanism to remove unwanted cells in the tissue. In diabetic wound, which is characterized by delayed healing process, excessive apoptosis is documented and plays a crucial role. Matrix metalloproteinase 9 (MMP9), which is elevated in non-healed diabetic wound, is necessary for healing process but its abnormality resulted in a delayed healing. The classical function of MMP9 is the degradation of extracellular matrix (ECM). However, there is some literature evidence that MMP9 triggers cell apoptosis...
April 4, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30941553/recombinant-human-lactoferrin-induces-apoptosis-disruption-of-f-actin-structure-and-cell-cycle-arrest-with-selective-cytotoxicity-on-human-triple-negative-breast-cancer-cells
#4
Blanca F Iglesias-Figueroa, Tania S Siqueiros-Cendón, Denisse A Gutierrez, Renato J Aguilera, Edward A Espinoza-Sánchez, Sigifredo Arévalo-Gallegos, Armando Varela-Ramirez, Quintín Rascón-Cruz
Breast cancer is the most frequently diagnosed cancer among women worldwide. Here, recombinant human lactoferrin (rhLf) expressed in Pichia pastoris was tested for its potential cytotoxic activity on a panel of six human breast cancer cell lines. The rhLf cytotoxic effect was determined via a live-cell HTS imaging assay. Also, confocal microscopy and flow cytometry protocols were employed to investigate the rhLf mode of action. The rhLf revealed an effective CC50 of 91.4 and 109.46 µg/ml on non-metastatic and metastatic MDA-MB-231 cells, with favorable selective cytotoxicity index values, 11...
April 2, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30937671/potential-role-of-anastasis-in-cancer-initiation-and-progression
#5
LETTER
A Thirumal Raj, Supriya Kheur, Ramesh Bhonde, Archana A Gupta, Vikrant R Patil, Avinash Kharat
No abstract text is available yet for this article.
April 1, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30929105/calreticulin-in-phagocytosis-and-cancer-opposite-roles-in-immune-response-outcomes
#6
REVIEW
Alejandro Schcolnik-Cabrera, Bernardo Oldak, Mandy Juárez, Mayra Cruz-Rivera, Ana Flisser, Fela Mendlovic
Calreticulin (CRT) is a pleiotropic and highly conserved molecule that is mainly localized in the endoplasmic reticulum. Recently, CRT has gained special interest for its functions outside the endoplasmic reticulum where it has immunomodulatory properties. CRT translocation to the cell membrane serves as an "eat me" signal and promotes efferocytosis of apoptotic cells and cancer cell removal with completely opposite outcomes. Efferocytosis results in a silenced immune response and homeostasis, while removal of dying cancer cells brought about by anthracycline treatment, ionizing-irradiation or photodynamic therapy results in immunogenic cell death with activation of the innate and adaptive immune responses...
March 30, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30923989/correction-to-autophagy-inhibition-with-chloroquine-reverts-paclitaxel-resistance-and-attenuates-metastatic-potential-in-human-nonsmall-lung-adenocarcinoma-a549-cells-via-ros-mediated-modulation-of-%C3%AE-catenin-pathway
#7
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
The original version of this article unfortunately contained an error in acknowledgment text. The authors would like to include a statement: "Moumita Dasgupta is supported by Junior Research Fellowship from University Grant Commission, India." in acknowledgment section.
March 28, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30911960/effects-of-annexin-a7-inhibitor-abo-on-the-expression-and-distribution-of-long-noncoding-rna-cerna1-in-vascular-endothelial-cells-apoptosis
#8
Wei Lu, Xiaoying He, Le Su, BaoXiang Zhao, JunYing Miao
More and more studies reported that diverse biological roles of long noncoding RNAs were usually dependent on their subcellular location. In our previous study, long noncoding RNA CERNA1 was identified both located in cytoplasm and nucleus of vascular endothelial cells (VECs). And CERNA1 in cytoplasm, which functioned as competitive endogenous RNA (ceRNA), alleviated the apoptosis of VECs. However, the function of CERNA1 in nucleus was still unclear. In this study, we found that nuclear CERNA1 positively regulated BCL2L10, which accelerated the serum and FGF-2 starvation-induced apoptosis of VECs, by enhancing the histone modification level of H3K9ac and H3K4me3 in BCL2L10 promoter region...
March 25, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30895494/cell-death-rocks
#9
EDITORIAL
Arjan W Griffioen, Patrycja Nowak-Sliwinska
No abstract text is available yet for this article.
March 20, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30879166/activator-protein-1-and-caspase-8-mediate-p38%C3%AE-mapk-dependent-cardiomyocyte-apoptosis-induced-by-palmitic-acid
#10
Charles C Oh, John Lee, Karen D'Souza, Weiyang Zhang, Raymond Q Migrino, Kent Thornburg, Peter Reaven
Lipoapoptosis of cardiomyocytes may underlie diabetic cardiomyopathy. Numerous forms of cardiomyopathies share a common end-pathway in which apoptotic loss of cardiomyocytes is mediated by p38α mitogen activated protein kinase (MAPK). Although we have previously shown that palmitic acid (PA), a saturated fatty acid (SFA) elevated in plasma of type 2 diabetes mellitus and morbid obesity, induces apoptosis in cardiomyocytes via p38α MAPK-dependent signaling, the downstream cascade events that cause cell death remain unknown...
March 16, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30879165/improved-in-vivo-targeting-of-bcl-2-phenotypic-conversion-through-hollow-gold-nanoshell-delivery
#11
Erin Morgan, John T Gamble, Martin C Pearce, Daniel J Elson, Robert L Tanguay, Siva Kumar Kolluri, Norbert O Reich
Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56...
March 16, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30877409/bdnf-mediated-mitophagy-alleviates-high-glucose-induced-brain-microvascular-endothelial-cell-injury
#12
Hong Jin, Yi Zhu, Yiping Li, Xiuyu Ding, Wenqi Ma, Xiqiong Han, Bilei Wang
Endothelial cell dysfunction and diabetic vascular complications are intrinsically linked. Although BDNF plays a protective role in cerebral microvascular complications caused by diabetes, the mechanisms of this activity are not fully clear. In this study, we investigated the role of BDNF in the hyperglycemic injury of BMECs and its associated intracellular signal transduction pathways. BMECs were treated with 33 mM glucose to imitate the endothelium under hyperglycemic conditions. The high-glucose treatment caused cell dysfunction, as evaluated by oxidative stress and cell apoptosis, which could be alleviated by BDNF...
March 15, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30850922/fibroblasts-from-patients-with-idiopathic-pulmonary-fibrosis-are-resistant-to-cisplatin-induced-cell-death-via-enhanced-ck2-dependent-xrcc1-activity
#13
Jintaek Im, Richard Seonghun Nho
Idiopathic pulmonary fibrosis (IPF) is a deadly and progressive fibrotic lung disease, but the precise etiology remains elusive. IPF is characterized by the presence of apoptosis-resistant (myo)fibroblasts that relentlessly produce a collagen-rich extracellular matrix (ECM). Recent studies showed that an anti-cancer chemotherapy drug cisplatin is implicated in the development of pulmonary fibrosis, suggesting that the treatment of cancer patients with cisplatin may alter fibroblast viability. To address this possibility, we investigated the cisplatin-induced cell death mechanism in lung fibroblasts derived from IPF and non-IPF patients in response to a collagen matrix...
March 8, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30840161/inhibition-of-tnf-%C3%AE-induced-neuronal-apoptosis-by-antidepressants-acting-through-the-lysophosphatidic-acid-receptor-lpa-1
#14
Maria C Olianas, Simona Dedoni, Pierluigi Onali
Tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine considered to be implicated in the pathogenesis of major depressive disorder, is a critical regulator of neuronal cell fate. In the present study we found that TNF-α-induced apoptosis of HT22 hippocampal cells, a neuroblast-like cell line, was markedly attenuated by the antidepressants mianserin, mirtazapine and amitriptyline. The anti-apoptotic effect of the antidepressants was blocked by either pharmacological inhibition or gene silencing of the lysophosphatidic acid receptor LPA1 ...
March 6, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30796611/drosophila-jumu-modulates-apoptosis-via-a-jnk-dependent-pathway-and-is-required-for-other-processes-in-wing-development
#15
Xiao Chun Wang, Ziguang Liu, Li Hua Jin
Previous studies in several model organisms have revealed that members of the Forkhead (Fkh) transcription factor family have multiple functions. Drosophila Jumeau (Jumu), a member of this family, participates in cardiogenesis, hematopoiesis and immune system homeostasis. Here, we show that loss of jumu function positively regulates or triggers apoptosis via a JNK-dependent pathway in wing development. jumu mutants showed reduced wing size and increased apoptosis. Moreover, we observed a loss of the anterior cross vein (ACV) phenotype that was similar to that observed in wings in which JNK signaling has been ectopically activated...
February 22, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30788651/simultaneous-polychromatic-flow-cytometric-detection-of-multiple-forms-of-regulated-cell-death
#16
D Bergamaschi, A Vossenkamper, W Y J Lee, P Wang, E Bochukova, G Warnes
Currently the study of Regulated Cell Death (RCD) processes is limited to the use of lysed cell populations for Western blot analysis of each separate RCD process. We have previously shown that intracellular antigen flow cytometric analysis of RIP3, Caspase-3 and cell viability dye allowed the determination of levels of apoptosis (Caspase-3+ ve /RIP3- ve ), necroptosis (RIP3Hi + ve /Caspase-3- ve ) and RIP1-dependent apoptosis (Caspase-3+ ve /RIP3+ ve ) in a single Jurkat cell population. The addition of more intracellular markers allows the determination of the incidence of parthanatos (PARP), DNA Damage Response (DDR, H2AX), H2AX hyper-activation of PARP (H2AX/PARP) autophagy (LC3B) and ER stress (PERK), thus allowing the identification of 124 sub-populations both within live and dead cell populations...
February 20, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30778709/the-neuroprotective-action-of-3-3-diindolylmethane-against-ischemia-involves-an-inhibition-of-apoptosis-and-autophagy-that-depends-on-hdac-and-ahr-cyp1a1-but-not-er%C3%AE-cyp19a1-signaling
#17
J Rzemieniec, A Wnuk, W Lasoń, W Bilecki, M Kajta
There are no studies examining the effects of 3,3'-diindolylmethane (DIM) in neuronal cells subjected to ischemia. Little is also known about the roles of apoptosis and autophagy as well as AhR and ERα signaling and HDACs in DIM action. We demonstrated for the first time the strong neuroprotective capacity of DIM in mouse primary hippocampal cell cultures exposed to ischemia at early and later stages of neuronal development. The protective effects of DIM were mediated via inhibition of ischemia-induced apoptosis and autophagy that was accompanied by a decrease in AhR/CYP1A1 signaling and an increase in HDAC activity...
February 18, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30767087/autophagy-inhibition-with-chloroquine-reverts-paclitaxel-resistance-and-attenuates-metastatic-potential-in-human-nonsmall-lung-adenocarcinoma-a549-cells-via-ros-mediated-modulation-of-%C3%AE-catenin-pathway
#18
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
Paclitaxel is one of the most commonly used drugs for the treatment of nonsmall cell lung cancer (NSCLC). However acquired resistance to paclitaxel, epithelial to mesenchymal transition and cancer stem cell formation are the major obstacles for successful chemotherapy with this drug. Some of the major reasons behind chemoresistance development include increased ability of the cancer cells to survive under stress conditions by autophagy, increased expression of drug efflux pumps, tubulin mutations etc. In this study we found that inhibition of autophagy with chloroquine prevented development of paclitaxel resistance in A549 cells with time and potentiated the effect of paclitaxel by increased accumulation of superoxide-producing damaged mitochondria, with elevated ROS generation, it also increased the apoptotic rate and sub G0/ G1 phase arrest with time in A549 cells treated with paclitaxel and attenuated the metastatic potential and cancer stem cell population of the paclitaxel-resistant cells by ROS mediated modulation of the Wnt/β-catenin signaling pathway, thereby increasing paclitaxel sensitivity...
February 14, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30756206/minocycline-promotes-cardiomyocyte-mitochondrial-autophagy-and-cardiomyocyte-autophagy-to-prevent-sepsis-induced-cardiac-dysfunction-by-akt-mtor-signaling
#19
Erfei Zhang, Xiaoying Zhao, Li Zhang, Nan Li, Jinqi Yan, Ke Tu, Ruhu Yan, Jianqiang Hu, Mingming Zhang, Dongdong Sun, Lichao Hou
Myocardial damage is responsible for the high mortality of sepsis. However, the underlying mechanism is not well understood. Cardiomyocyte autophagy alleviates the cardiac injury caused by myocardial infarction. Enhanced cardiomyocyte autophagy also has protective effects against cardiomyocyte mitochondrial injury. Minocycline enhances autophagy in many types of cells under different types of pathological stress and can be easily taken up by cardiomyocytes. The present study investigated whether minocycline prevented myocardial injury caused by sepsis and whether cardiomyocyte autophagy participated in this process...
February 12, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/30737648/eukaryotic-elongation-factor-2-eef2-kinase-eef2-plays-protective-roles-against-glucose-deprivation-induced-cell-death-in-h9c2-cardiomyoblasts
#20
Satoshi Kameshima, Muneyoshi Okada, Hideyuki Yamawaki
During the development of cardiac hypertrophy, glucose deprivation (GD) associated with coronary microvascular rarefaction is caused, leading to cardiomyocyte death. Phosphorylation (inactivation) of eukaryotic elongation factor 2 (eEF2) by eEF2 kinase (eEF2K) inhibits protein translation, a highly energy consuming process, which plays protective roles against nutrient deprivation-induced cell death. We previously showed that eEF2 phosphorylation was increased in isolated heart from several cardiac hypertrophy models...
February 8, 2019: Apoptosis: An International Journal on Programmed Cell Death
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