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Journals
Hepatology Research : the Offi...
Hepatology Research : the Official Journal of the Japan Society of Hepatology
#1
JOURNAL ARTICLE
Yoko Yoshimaru, Katsuya Nagaoka, Kentaro Tanaka, Satoshi Narahara, Hiroki Inada, Sotaro Kurano, Takayuki Tokunaga, Estuko Iio, Takehisa Watanabe, Hiroko Setoyama, Masakuni Tateyama, Koji Yoshida, Takuya Tsunoda, Yusuke Nakamura, Motohiko Tanaka, Yutaka Sasaki, Yasuhito Tanaka
AIM: We evaluated the safety and efficacy of vascular endothelial growth factor receptor (VEGFR) -targeted peptide vaccines for the immunization of patients with unresectable hepatocellular carcinoma who had responded to transarterial chemoembolization. METHODS: Twenty-two patients were randomized 1:1 to receive VEGFR-targeted peptides or placebo. The primary endpoint was the safety assessment of the immunization. The secondary endpoints were evaluation of immunological responses and clinical outcomes...
November 29, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#2
JOURNAL ARTICLE
Natsuko Kobayashi, Toshifumi Tada, Takashi Nishimura, Tomomitsu Matono, Yukihisa Yuri, Tomoyuki Takashima, Nobuhiro Aizawa, Naoto Ikeda, Shinya Fukunishi, Mariko Hashimoto, Mitsumasa Ohyanagi, Hirayuki Enomoto, Hiroko Iijima
AIM: It remains unclear whether the newly defined concept of metabolic dysfunction-associated steatotic liver disease (MASLD) appropriately includes patients with nonalcoholic fatty liver disease (NAFLD) with significant liver fibrosis. METHODS: A total of 4,112 patients in whom NAFLD was diagnosed by ultrasonography during medical check-ups were enrolled. We defined a fibrosis-4 (FIB-4) index ≥1.3 aged <65 years and ≥2.0 aged ≥65 years as significant liver fibrosis...
November 28, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#3
JOURNAL ARTICLE
Tetsuya Tajima, Jung-Ho Shin, Susumu Kunisawa, Noriko Sasaki, Koichiro Hata, Kiyohide Fushimi, Etsuro Hatano, Yuichi Imanaka
AIM: Living-donor liver transplantation (LDLT) is a highly effective life-saving procedure; however, it requires substantial medical resources, and the cost-effectiveness of LDLT vs. conservative management (CM) for adult patients with end-stage liver disease (ESLD) remains unclear in Japan. METHODS: We conducted a cost-effectiveness analysis using the Diagnostic Procedure Combination (DPC) data from the nationwide database of the DPC research group. We selected adult patients (18 years or older) who were admitted or discharged between 2010 and 2021 with a diagnosis of ESLD with Child-Pugh classes C or B...
November 20, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#4
JOURNAL ARTICLE
Takeshi Hatanaka, Satoru Kakizaki, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Keisuke Yokohama, Hiroki Nishikawa, Takashi Nishimura, Noritomo Shimada, Kazuhito Kawata, Hisashi Kosaka, Atsushi Naganuma, Yutaka Yata, Hideko Ohama, Hidekatsu Kuroda, Tomoko Aoki, Kazunari Tanaka, Takaaki Tanaka, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Masaki Kaibori, Hiroko Iijima, Yoichi Hiasa, Masatoshi Kudo, Takashi Kumada
AIM: Elderly patients are believed to have a reduced immune capacity, which may make immunotherapy less effective. The aim of this study was to compare the therapeutic outcome of atezolizumab plus bevacizumab (Atez/Bev) and lenvatinib (LEN) for advanced hepatocellular carcinoma (HCC) in patients aged 80 years and older. METHODS: From March 2018 to July 2022, 170 and 92 elderly patients who received LEN and Atez/Bev as first-line treatment, respectively, were retrospectively analyzed...
November 20, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#5
JOURNAL ARTICLE
Kazuhiro Murai, Hayato Hikita, Takahiro Kodama, Masaki Kaibori, Yuki Nishimura, Tomohide Tatsumi, Tomomi Yamada, Tatsuya Kanto, Satoshi Mochida, Tetsuo Takehara
BACKGROUND AND AIM: Coronavirus disease 2019 (COVID-19) emerged in December 2019 and spread worldwide. This study aimed to clarify the impact of the COVID-19 pandemic on the diagnosis and treatment of hepatocellular carcinoma (HCC) in Japan. METHODS: First, we collected the monthly numbers of HCC-related general medical practices from January 2019 to December 2021 at liver disease-specific medical institutions in Japan. Next, we collected individual clinical information from patients with newly diagnosed HCC during this period...
November 20, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#6
JOURNAL ARTICLE
Tomoya Sano, Keisuke Amano, Tatsuya Ide, Hiroshi Isoda, Yuichi Honma, Yasuyo Morita, Yoichi Yano, Hiroki Nakamura, Satoshi Itano, Ichiro Miyajima, Miki Shirachi, Reiichiro Kuwahara, Miki Ohno, Toshihiro Kawaguchi, Tsubasa Tsutsumi, Dan Nakano, Teruko Arinaga-Hino, Machiko Kawaguchi, Yuichiro Eguchi, Takuji Torimura, Hirokazu Takahashi, Masaru Harada, Takumi Kawaguchi, Saks Study Group
AIMS: Hepatocellular carcinoma (HCC) develops even in patients with hepatitis C virus (HCV) eradication by direct-acting antiviral agents. Fatty liver and metabolic dysfunction are becoming major etiologies of HCC. We aimed to evaluate the impact of metabolic dysfunction-associated steatotic liver disease (MASLD), a new definition of steatotic liver disease, on the development of HCC after HCV eradication. METHODS: We enrolled 1,280 elderly patients with HCV eradication and no history of HCC...
November 17, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#7
(no author information available yet)
No abstract text is available yet for this article.
November 13, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#8
JOURNAL ARTICLE
Dor Yoeli, Cara L Mack, Yuhuan Luo, Alexander Chaidez, Nathaly Limon De La Rosa, Zhaohui Wang, Eduardo Cervantes-Alvarez, Christene A Huang, Nalu Navarro-Alvarez
BACKGROUND & AIMS: Biliary atresia (BA) is characterized by intrahepatic inflammation and rapid progression of liver fibrosis. Galectin-3, a beta-galactoside binding protein, is a key regulator of inflammation and fibrosis. The aim of this study was to characterize circulating and hepatic Galectin-3 levels in children with BA. METHODS: Plasma and liver samples were obtained from children with early BA at time of Kasai hepatoportoenterostomy, late BA at time of transplant, early and late other cholestatic liver diseases (CLD), and controls...
November 11, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#9
JOURNAL ARTICLE
Yasuyuki Shigematsu, Kazuhito Tanaka, Gulanbar Amori, Hiroaki Kanda, Yu Takahashi, Yutaka Takazawa, Kengo Takeuchi, Kentaro Inamura
AIM: Vessels encapsulating tumor clusters (VETC) represents an adverse prognostic morphological feature of hepatocellular carcinoma (HCC), which is associated with an immunosuppressive tumor-immune microenvironment (TIM). However, the underlying factors characterizing the tumor cells and TIM in HCC with a VETC pattern (VETC-positive HCC) remain uncertain. Oncostatin M (OSM), a pleiotropic cytokine of the interleukin-6 family, regulates various biological processes, including inflammation, proliferation, and invasiveness of tumor cells...
November 10, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#10
JOURNAL ARTICLE
Yuka Hasegawa, Hiroshi Okada, Hanako Nakajima, Nobuko Kitagawa, Takuro Okamura, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Yuki Nakahata, Akihiro Obora, Takao Kojima, Masahide Hamaguchi, Michiaki Fukui
AIM: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major health concern. This cohort study aimed to evaluate the association between weight loss and remission of MAFLD in the Japanese population to aid the development of efficient treatment strategies. METHODS: This retrospective cohort study was conducted at a Japanese health screening center. Participants included 3,309 individuals diagnosed with baseline MAFLD between 2004 and 2016. Logistic regression analysis was used to assess the association between MAFLD remission from baseline to 5 years and weight change...
November 8, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#11
JOURNAL ARTICLE
Kazuto Tajiri, Nozomu Muraishi, Aiko Murayama, Yuka Hayashi, Ichiro Yasuda
AIM: Sequential therapies are essential to extend overall survival (OS) in patients with unresectable hepatocellular carcinoma (HCC). Several second-line treatments with molecular target agents (MTAs) have shown survival benefits. However, the significance of post-progression survival (PPS) in extending OS in HCC patients given such treatments remains uncertain. METHODS: Through a systematic review of the literature in the PubMed database, this study investigated the correlation between PPS and OS and that between progression free survival (PFS) and OS in HCC patients given second-line treatments...
November 4, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#12
JOURNAL ARTICLE
Li-Jun Wang, Liang Yin, Kai-Cai Liu, Wei-Fu Lv, Dong Lu
AIM: The study aimed to investigate the clinical features, incidence, pathogenesis, and management of liver abscess after drug-eluting bead transarterial chemoembolization (DEB-TACE) for primary and metastatic hepatic malignant tumors. METHODS: From June 2019 to June 2021, patients with liver abscess after DEB-TACE for primary and metastatic hepatic malignant tumors were reviewed and evaluated at our hospital. Demographic and clinical data, radiological findings, management approaches, and prognosis were retrospectively analyzed...
November 4, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#13
JOURNAL ARTICLE
Akira Uchiyama, Kazuyoshi Kon, Satoshi Sakuma, Toshifumi Sato, Maki Morinaga, Hiroo Fukada, Hisafumi Yamagata, Reiko Yaginuma, Kyoko Fukuhara, Shunhei Yamashina, Shuko Nojiri, Kenichi Ikejima
AIM: Following the coronavirus outbreak, a state of public emergency was declared worldwide, which enforced lifestyle changes. This study therefore aimed to investigate the changes in lifestyle, body composition, hepatic steatosis and fibrosis in patients with chronic liver disease (CLD) under lockdown. METHODS: During the lockdown period, 1344 patients with CLD answered a lifestyle questionnaire. In 298 patients, body composition and liver stiffness measure (LSM) / controlled attenuation parameter (CAP) were analyzed by InBody® and FibroScan®, respectively, and serial data were obtained in 137 patients...
November 3, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#14
JOURNAL ARTICLE
Tatsuo Kanda, Reina Sasaki-Tanaka, Koji Ishii, Ryosuke Suzuki, Jun Inoue, Atsunori Tsuchiya, Shingo Nakamoto, Ryuzo Abe, Keiichi Fujiwara, Osamu Yokosuka, Tian-Cheng Li, Satoshi Kunita, Hiroshi Yotsuyanagi, Hiroaki Okamoto
In 2018, there was a hepatitis A outbreak in Japan, and HAV infection is considered a sexually transmitted disease. In general, patients with hepatitis A should be given attention, and this disease should be prevented more than ever. The Japan Agency for Medical Research and Development (AMED) Hepatitis A and E viruses (HAV and HEV) Study Group has worked on the project to create "Recent Advances in Hepatitis A Virus (HAV) Research and Clinical Practice Guidelines for HAV Infection in Japan". The group consists of expert hepatologists and virologists who gathered at virtual meeting on 5 August 2023...
October 31, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#15
JOURNAL ARTICLE
Satomi Makiuchi, Ying Tian, Mao Fujimoto, Junko Kuramoto, Noboru Tsuda, Hidenori Ojima, Masahiro Gotoh, Nobuyoshi Hiraoka, Teruhiko Yoshida, Yae Kanai, Eri Arai
AIM: The aim of this study was to clarify the significance of DNA methylation alterations of cryptogenic hepatocellular carcinomas (HCCs). METHODS: Using the Infinium assay, we performed genome-wide DNA methylation analysis of 250 liver tissue samples, including noncancerous liver tissue (U-N) and corresponding cancerous tissue (U-T) from patients with cryptogenic HCC without a history of excessive alcohol use and hepatitis virus infection, and whose U-N samples showed no remarkable histological features (no microscopic evidence of simple steatosis, any form of hepatitis including nonalcoholic steatohepatitis, or liver cirrhosis)...
October 31, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#16
JOURNAL ARTICLE
Misako Tanaka, Takemi Akahane, Hideto Kawaratani, Nobuyuki Yorioka, Aritoshi Koizumi, Shohei Asada, Takuya Matsuda, Satoshi Iwai, Yuki Tsuji, Yukihisa Fujinaga, Norihisa Nishimura, Koh Kitagawa, Kosuke Kaji, Tadashi Namisaki, Hitoshi Yoshiji
AIM: Entecavir (ETV) and tenofovir alafenamide fumarate (TAF) are considered safe nucleos(t)ide analogs (NA) for the kidney. This study aimed to investigate the long-term effects of ETV or TAF on renal function in elderly patients with chronic hepatitis B (CHB) in Japan. METHODS: The study included 246 CHB patients treated with ETV (184 patients) or TAF (62 patients) for at least 2 years. These patients were divided into two groups: those <65 years of age (130 patients) and those ≥65 years of age (116 patients)...
October 28, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#17
JOURNAL ARTICLE
Jiarong Xie, Hui Gao, Cenqin Liu, Yue Pan, Chengfu Xu, Lei Xu
BACKGROUND: It is unclear whether NAFLD acts as a direct contributing factor of multiple extrahepatic cancers. We aimed to systematically investigate the causal relationships of nonalcoholic fatty liver disease (NAFLD) with extrahepatic cancers. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis to assess the causal effects of NAFLD on 22 extrahepatic cancers. We examined the association of NAFLD with extrahepatic cancers using multiple methods in the largest genome-wide association study (GWAS) meta-analysis to date...
October 25, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#18
JOURNAL ARTICLE
Chi-Ling Chen, Tai-Chung Tseng, Chun-Jen Liu, Jia-Horng Kao, Pei-Jer Chen, Wei-Shiung Yang
BACKGROUND: /Aims: Chronic hepatitis B virus (HBV) infection still poses major threat to global health. Oligoadenylate synthetase-Ribonuclease L (OAS-RNase-L) antiviral pathway is one of interferon-induced antiviral effectors. The relationship between RNase-L and HBV has never been investigated and we aim to examine the serum RNase-L levels in patients with different stage of chronic HBV infection. METHODS: The patients were enrolled from 1985 to 2000, who had been HBsAg-positive for longer than 6 months, at the National Taiwan University Hospital...
October 20, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#19
JOURNAL ARTICLE
Hiroki Kanamori, Yohei Yamada, Yoko Ito, Koji Shirosaki, Satoko Yamagishi, Maeda Yutaro, Yumi Kudo, Tomoshige Umeyama, Nobuhiro Takahashi, Mototoshi Kato, Yasushi Hasegawa, Kentaro Matsubara, Masahiro Shinoda, Hideaki Obara, Rie Irie, Hanako Tsujikawa, Hajime Okita, Phuong Thanh Nguyen, Kenichi Saigo, Shigeki Mitsunaga, Ituro Inoue, Yuko Kitagawa, Tatsuo Kuroda
AIM: To evaluate the use of donor-derived cell-free DNA (dd-cfDNA) in diagnosing graft injuries in Japanese liver transplantation (LTx), including family-related living donors. METHODS: A total of 321 samples from ten newly operated LTx recipients were collected to monitor the early dynamics of dd-cfDNA levels after LTx. Fifty-five samples from 55 recipients were collected during protocol biopsies (PB), whereas 36 samples from 27 recipients were collected during event biopsies, consisting of 11 biopsy-proven acute rejections (AR), 20 acute dysfunctions without rejection (ADWR), and 5 chronic rejections (CR)...
October 18, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
#20
JOURNAL ARTICLE
Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Hisanori Muto, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Shunya Takada, Yoichi Nakagawa, Takuya Maeda, Masanao Nakamura, Masatoshi Ishigami, Hiroo Uchida, Hiroki Kawashima
AIMS: Biliary atresia (BA) is a congestive biliary disease that develops in the neonatal period or early infancy. It may present with portal hypertension and varices needing treatment (VNT) even after successful Kasai portoenterostomy. This study aimed to stratify the risk of VNT in children and adolescents with BA. METHODS: In this prospective cross-sectional study, we measured liver stiffness (LS) and spleen stiffness (SS) by two-dimensional shear wave elastography and checked for VNT endoscopically in 53 patients with BA who attended for follow-up between July 2018 and September 2022...
October 16, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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