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Journals Hepatology Research : the Offi...

Hepatology Research : the Official Journal of the Japan Society of Hepatology

https://read.qxmd.com/read/38770705/fulminant-hepatitis-in-a-hepatitis-b-surface-antigen-positive-patient-with-adult-t-cell-leukemia-lymphoma-after-mogamulizumab-monotherapy
#1
Takahiro Nakashima, Shigeru Kusumoto, Takashi Ishida, Chie Kato, Shinya Hagiwara, Tomoko Narita, Ayako Masaki, Asahi Ito, Masaki Ri, Hirokazu Komatsu, Hiroshi Inagaki, Yasuhito Tanaka, Shinsuke Iida
We report a case of fulminant hepatitis in a hepatitis B surface antigen (HBsAg)-positive patient with aggressive adult T-cell leukemia-lymphoma who received monotherapy with an anti-CCR4 monoclonal antibody, mogamulizumab, with decreased hepatitis B virus (HBV)- DNA levels by entecavir prophylaxis. Although HBV reactivation-related hepatitis was considered in the differential diagnosis, the patient did not meet the conventional criteria for HBV reactivation and was finally diagnosed with drug-induced hepatitis...
May 21, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38748484/a-nation-wide-medical-record-database-study-value-of-hepatitis%C3%A2-b-surface-antigen-loss-in-chronic-hepatitis%C3%A2-b-patients-in-japan
#2
JOURNAL ARTICLE
Kinya Okada, Yoshikazu Nakayama, Jennings Xu, Yang Cheng, Junko Tanaka
AIM: Hepatitis B surface antigen (HBsAg) seroclearance is considered to be one of the best surrogate endpoints of functional cure for hepatitis B virus (HBV) infection. However, evidence regarding the relationship between achieving HBsAg seroclearance or a low baseline HBsAg level, and long-term clinical outcomes in Japanese patients with chronic HBV infection remains to be confirmed in a real-world setting. METHODS: A retrospective observational cohort study was performed with an electronic medical record database, including data from 230 hospitals across Japan...
May 15, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38717068/early-drain-removal-after-hepatectomy-based-on-bile-leakage-prediction-using-drainage-fluid-volume-and-direct-bilirubin-level
#3
JOURNAL ARTICLE
Ryo Muranushi, Norifumi Harimoto, Takaomi Seki, Kei Hagiwara, Kouki Hoshino, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Kenichiro Araki, Ken Shirabe
AIMS: This study aimed to determine the value of the drainage fluid volume and direct bilirubin level for predicting significant bile leakage (BL) after hepatectomy and establish novel criteria for early drain removal. METHODS: Data from 351 patients who underwent hepatic resection at Gunma University in Japan between October 2018 and March 2022 were retrospectively analyzed. Clinical characteristics and surgical outcomes of patients with and without significant BL were compared...
May 8, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38703383/diagnostic-performances-of-fibrosis-4-index-and-nonalcoholic-fatty-liver-disease-fibrosis-score-in-metabolic-dysfunction-associated-steatotic-liver-disease-in-asian-primary-care-clinics
#4
JOURNAL ARTICLE
Huiyul Park, Mimi Kim, Hye-Lin Kim, Seon Cho, Eileen L Yoon, Dae Won Jun
AIMS: We aimed to explore the extent to which individuals previously diagnosed with nonalcoholic fatty liver disease (NAFLD) meet the criteria fulfilled with the new nomenclature, metabolic dysfunction-associated steatotic liver disease (MASLD), within an Asian primary clinic cohort. Additionally, we assessed the reliability of the diagnostic performance of FIB-4 and NAFLD fibrosis score (NFS) for MASLD within the primary clinic cohort. METHODS: This retrospective cross-sectional study included participants who underwent magnetic resonance elastography and abdominal ultrasonography during their health checkups at nationwide health promotion centers (n = 6740)...
May 4, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38685853/kinetics-of-the-hepatitis-b-core-related-antigen-and-treatment-responses-in-chronic-hepatitis-b-patients-treated-with-tenofovir-alafenamide
#5
JOURNAL ARTICLE
Norio Itokawa, Masanori Atsukawa, Akihito Tsubota, Toru Ishikawa, Hidenori Toyoda, Koichi Takaguchi, Tsunamasa Watanabe, Chikara Ogawa, Atsushi Hiraoka, Hironao Okubo, Haruki Uojima, Makoto Chuma, Akito Nozaki, Keizo Kato, Shigeru Mikami, Joji Tani, Asahiro Morishita, Toshifumi Tada, Toru Asano, Tomonori Senoh, Tsunekazu Oikawa, Tomomi Okubo, Takashi Kumada, Katsuhiko Iwakiri
AIM: An association between hepatitis B core-related antigen (HBcrAg) kinetics and hepatocarcinogenesis during nucleoside (t)id analog (NA) treatment has recently been reported. HBcrAg kinetics and factors associated with HBcrAg response during tenofovir alafenamide (TAF) administration remain unclear. In this multicenter retrospective study, we aimed to clarify the efficacy and safety of TAF in treatment-naïve patients with chronic hepatitis B, focusing on the reduction in HBcrAg levels...
April 29, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38683882/nutritional-counseling-improves-mortality-and-prevents-hepatic-encephalopathy-in-patients-with-alcohol-associated-liver-disease
#6
JOURNAL ARTICLE
Tatsunori Hanai, Kayoko Nishimura, Shinji Unome, Takao Miwa, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
AIM: Nutritional counseling improves malnutrition, which determines the prognosis of patients with chronic liver disease. In this study, we investigated the effects of nutritional counseling on mortality and the risk of overt hepatic encephalopathy (HE) in patients with alcohol-associated liver disease. METHODS: In this retrospective cohort study, we included 211 patients with alcohol-associated liver disease who visited Gifu University Hospital between August 2008 and June 2023...
April 29, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38666637/comparative-analysis-of-sorafenib-and-lenvatinib-on-hepg2-cells-and-human-umbilical-vein-endothelial-cells-involvement-of-transforming-growth-factor-%C3%AE-signaling-in-their-molecular-effects
#7
JOURNAL ARTICLE
Ting Wang, Yasuhiro Takikawa, Kazuyuki Suzuki, Hidekatsu Kuroda, Keisuke Kakisaka, Toshimi Chiba
AIM: This study aimed to compare the effects of the molecular targeted drugs, sorafenib and lenvatinib, on the survival, invasion, and angiogenesis of hepatocellular carcinoma cells. Additionally, we investigated the involvement of transforming growth factor beta (TGF-β) signaling in their molecular mechanisms. METHODS: To investigate the effects of sorafenib and lenvatinib, we conducted cell viability, invasion, and angiogenesis assays, as well as western blotting analyses...
April 26, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38662338/multiparametric-renal-function-assessment-in-cirrhotic-patients-shows-high-prevalence-of-medically-actionable-changes-in-multiple-modules
#8
JOURNAL ARTICLE
Richard Belmonte, Maël Silva-Rodriguez, Françoise Barbé, Mouni Bensenane, Vincent Haghenejad, Isabelle Vrillon, Asma Alla, Adrien Flahault, Raphael Kormann, Alice Corbel, Zakia Aitdjafer, Didier Quilliot, Laurence Derain-Dubourg, Farès Namour, Jean-Louis Guéant, Jean-Pierre Bronowicki, Abderrahim Oussalah
AIM: Renal dysfunction is a common complication of cirrhosis, occurring either as part of multiorgan involvement in acute illness or secondary to advanced liver disease. To date, no study has comprehensively assessed multiple renal function parameters in hospitalized patients with cirrhosis through a multiparametric analysis of renal biochemistry markers. METHODS: We conducted a retrospective, observational study including all consecutive patients hospitalized with cirrhosis who underwent a 43-multiparametric renal function assessment between January 1, 2021, and June 30, 2023...
April 25, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38661715/validation-study-of-age-independent-fibrosis-score-fibrosis-3-index-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease
#9
JOURNAL ARTICLE
Kazuhiro Nouso, Miwa Kawanaka, Hideki Fujii, Kazuya Kariyama, Hidenori Toyoda, Michihiro Iwaki, Hideki Hayashi, Satoshi Oeda, Hideyuki Hyogo, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Tsubasa Tsutsumi, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Naito, Asuka Araki, Shingo Arakaki, Takumi Kawaguchi, Hidenao Noritake, Masafumi Ono, Tsutomu Masaki, Satoshi Yasuda, Eiichi Tomita, Masato Yoneda, Akihiro Tokushige, Yoshihiro Kamada, Hirokazu Takahashi, Shinichiro Ueda, Shinichi Aishima, Yoshio Sumida, Atsushi Nakajima, Takashi Kumada, Takeshi Okanoue
BACKGROUND AND AIMS: Because the accuracy of the Fibrosis-4 (FIB-4) index for predicting liver fibrosis changes with age, the need for different cut-offs in various age groups has frequently been discussed. We developed the age-independent score, the Fibrosis-3 (FIB-3) index, and have shown its usefulness in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to validate the diagnostic ability of the FIB-3 index to predict fibrosis progression using a large new patient cohort...
April 25, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38656764/combined-effect-of-histological-findings-and-diabetes-mellitus-on-liver-related-events-in-patients-with-metabolic-dysfunction-associated-steatotic-liver-disease
#10
JOURNAL ARTICLE
Akihito Shiomi, Teruki Miyake, Shinya Furukawa, Bunzo Matsuura, Osamu Yoshida, Takao Watanabe, Ayumi Kanamoto, Masumi Miyazaki, Hironobu Nakaguchi, Yoshio Tokumoto, Masashi Hirooka, Masanori Abe, Yoichi Hiasa
AIM: Advanced fibrosis has a strong influence on the occurrence of liver-related events in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), while diabetes mellitus (DM), which is often complicated by MASLD, is associated with the progression of MASLD. We stratified patients with MASLD according to the severity of liver pathological findings and the presence of DM, aiming to examine whether these indices could be used to accurately assess the risk of developing liver-related events...
April 24, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38656751/circulating-myostatin-levels-as-a-prognostic-biomarker-in-patients-with-acute-liver-failure-and-late-onset-hepatic-failure
#11
JOURNAL ARTICLE
Manabu Hayashi, Kazumichi Abe, Tatsuro Sugaya, Yosuke Takahata, Masashi Fujita, Atsushi Takahashi, Hiromasa Ohira
AIM: Myostatin is a myokine involved in muscle mass regulation. The associations between circulating myostatin levels and clinical characteristics in patients with acute liver failure (ALF) and late-onset hepatic failure (LOHF) are unclear. METHODS: In this retrospective study, 51 patients with ALF or LOHF were included. Serum myostatin was measured using an enzyme-linked immunosorbent assay. RESULTS: Myostatin levels were significantly lower in patients with ALF and LOHF than in controls (ALF/LOHF: 2522 pg/mL, controls: 3853 pg/mL, p = 0...
April 24, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38651670/efficacy-of-antiviral-therapy-for-the-prevention-of-mother-to-child-transmission-of-hepatitis%C3%A2-b-virus-and-the-risk-of-postpartum-hepatitis-flare-after-discontinuation-of-antiviral-therapy
#12
Hayato Kawamura, Kentaro Matsuura, Koichi Ito, Tokio Sugiura, Takanori Suzuki, Kei Fujiwara, Hiromi Kataoka, Yasuhito Tanaka
The use of nucleos(t)ide analogs (NAs) is recommended for mothers with a high viral load of hepatitis B virus (HBV) during the second or third trimester of pregnancy. However, postpartum hepatitis flares can occur in some cases. We examined the efficacy of NA administration for the prevention of mother-to-child transmission of hepatitis B virus, and evaluated the risk of postpartum hepatitis flares in mothers after NA discontinuation. Nine pregnant women with a high viral load (HBV DNA ≥5.3 log IU/mL) received tenofovir disoproxil fumarate (TDF) at approximately 28 weeks of gestation, and TDF was discontinued at 4-10 weeks after delivery...
April 23, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38642343/recam-j-2023-validation-and-development-of-the-japanese-version-of-recam-for-the-diagnosis-of-drug-induced-liver-injury
#13
JOURNAL ARTICLE
Atsushi Tanaka, Keiji Tsuji, Yasuyuki Komiyama, Kota Tsuruya, Keisuke Kakisaka, Akemi Tsutsui, Keiko Ichimoto, Masayuki Ueno, Yuki Okazaki, Hiroteru Kamimura, Atsushi Takai, Noriyo Yamashiki, Takanori Ito, Masaaki Watanabe, Masanori Abe, Ken-Ichi Harada, Tatehiro Kagawa
AIM: The diagnosis of drug-induced liver injury (DILI) is challenging. We modified the revised electronic version of the Roussel Uclaf Causality Assessment Method (RUCAM) for the diagnosis of DILI (RECAM), the scoring system developed in US and Spanish cohorts in 2022, and developed RECAM-J 2023 to align with the clinical practice in Japan. In the current study, we introduce RECAM-J 2023 and verify its performance in the context of Japanese patients with DILI. METHODS: After translation of RECAM into Japanese, modifications were made to develop RECAM-J 2023 without any alteration to the scores...
April 20, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38638067/etiological-changes-of-liver-cirrhosis-and-hepatocellular-carcinoma-complicated-liver-cirrhosis-in-japan-updated-nationwide-survey-from-2018-to-2021
#14
JOURNAL ARTICLE
Hirayuki Enomoto, Norio Akuta, Hayato Hikita, Goki Suda, Jun Inoue, Nobuharu Tamaki, Kiyoaki Ito, Takemi Akahane, Tomokazu Kawaoka, Asahiro Morishita, Eiichi Ogawa, Ryosuke Tateishi, Hitoshi Yoshiji
AIM: A nationwide survey in 2018 showed decreasing involvement of viral hepatitis and increasing involvement of nonviral liver diseases in the etiology of liver cirrhosis (LC) in Japan. An updated nationwide survey was undertaken in 2023. METHODS: Cases of LC diagnosed between 2018 and 2021 were collected from 75 institutions, and the etiologies of LC were investigated. In addition, the data obtained were compared with the results of previous studies. RESULTS: Among the 15 517 cases, alcohol-related liver disease (ALD)-associated LC was the most frequent cause (n = 5,487, 35...
April 18, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38573773/epidemiological-assessment-of-hepatitis-e-virus-infection-among-1565-pregnant-women-in-siem-reap-cambodia-using-an-in-house-double-antigen-sandwich-elisa
#15
JOURNAL ARTICLE
Ulugbek Khudayberdievich Mirzaev, Ko Ko, Bunthen E, Zayar Phyo, Chanroth Chhoung, Akuffo Golda Ataa, Aya Sugiyama, Tomoyuki Akita, Kazuaki Takahashi, Junko Tanaka
AIM: This study investigated hepatitis E virus (HEV) prevalence among pregnant women in Siem Reap, Cambodia, by developing a cost-effective, user-friendly in-house enzyme-linked immunosorbent assay (ELISA) for detecting total anti-HEV immunoglobulins (Ig). METHODS: The in-house ELISA was designed for large-scale screening in resource-limited settings. Its performance was benchmarked against two commercial tests: the Anti-HEV IgG EIA (Institute of Immunology, Co...
April 4, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38573595/loss-of-seroprotective-antibody-after-a-full-series-of-hepatitis-a-virus-vaccination-in-people-with-hiv
#16
EDITORIAL
Chien-Ching Hung
No abstract text is available yet for this article.
April 4, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38571477/outcomes-of-immune-checkpoint-inhibitor-induced-liver-toxicity-managed-by-hepatologists-in-a-multidisciplinary-toxicity-team
#17
JOURNAL ARTICLE
Takanori Ito, Kazuyuki Mizuno, Takafumi Yamamoto, Tsukasa Yasuda, Shinya Yokoyama, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Masayo Hama, Tomomi Kataoka, Tomoya Shimokata, Yuichi Ando, Hiroki Kawashima
AIM: To detect immune-related adverse events (irAEs) early and treat them appropriately, our institute established an irAE-focused multidisciplinary toxicity team in cooperation with various departments. This study aimed to evaluate a consultation system involving a team of hepatologists in terms of its utility for the management of severe immune checkpoint inhibitor (ICI)-induced liver toxicity. METHODS: To analyze the diagnosis and treatment of severe ICI-induced liver toxicity (Grade 2 requiring corticosteroid therapy and Grade 3 or higher), we examined patients' clinical courses before and after the hepatologist consultation system was established (pre-period, September 2014 to February 2019; post-period, March 2019 to March 2023)...
April 4, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38539054/value-of-autotaxin-for-hepatocellular-carcinoma-risk-assessment-in-chronic-hepatitis%C3%A2-b-patients-treated-with-nucleos-t-ide-analogs
#18
JOURNAL ARTICLE
Yuichi Hiyama, Hatsue Fujino, Maiko Namba, Yasutoshi Fujii, Shinsuke Uchikawa, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Shiro Oka
AIM: Autotaxin (ATX) is a newly identified liver fibrosis biomarker; however, its clinical usefulness remains unclear. Therefore, we analyzed the changes in patients with chronic hepatitis B virus infection treated with nucleos(t)ide analogs (NAs) to evaluate its usefulness. We also investigated the predictors of hepatocellular carcinoma development, including ATX, in patients with chronic hepatitis B based on their clinical characteristics. METHODS: This retrospective study included 179 patients with hepatitis B virus infection treated with NAs for >2 years...
March 27, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38536662/natural-killer-group%C3%A2-2d-major-histocompatibility-complex-class%C3%A2-i-polypeptide-related-sequence%C3%A2-a-activation-enhances-natural-killer-cell-mediated-immunity-against-hepatocellular-carcinoma-a-review
#19
REVIEW
Jun Arai, Akinori Okumura, Naoya Kato, Kiyoaki Ito
The recent clinical introduction of immune checkpoint inhibitors has improved therapeutic outcomes in patients with advanced hepatocellular carcinoma. However, these therapies targeting CD8+ T lymphocytes have a response rate of approximately 30%. In addition to CD8+ T lymphocytes, natural killer (NK) cells represent promising therapeutic targets for hepatocellular carcinoma, because they comprise 30%-50% of all lymphocytes in the liver and contribute to antitumor immunity. A recent meta-analysis revealed that the percentage of infiltrating NK cells in hepatocellular carcinoma correlates with a better patient outcome...
March 27, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/38526972/epidemiology-of-fontan-associated-liver-disease-in-japan-results-from-a-nationwide-survey-in-2021
#20
JOURNAL ARTICLE
Satoko Ohfuji, Atsushi Tanaka, Tomomi Kogiso, Tatsuya Kanto
AIM: Although the Fontan procedure has improved the survival of patients with single-ventricle heart disease, the long-term consequences of the procedure have been a concern. This study aimed to explore the patients' postoperative clinical characteristics, including a diagnosis of Fontan-associated liver disease (FALD). METHODS: A nationwide Japanese epidemiological survey of post-Fontan patients was undertaken in 2021. The survey targets were selected from all departments of pediatrics, pediatric surgery, cardiology, cardiovascular surgery, and gastroenterology using stratified random sampling by the number of beds...
March 25, 2024: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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