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Journals Hepatology Research : the Offi...

Hepatology Research : the Official Journal of the Japan Society of Hepatology

https://read.qxmd.com/read/33242365/impact-of-antiviral-therapy-on-risk-prediction-model-for-hepatocellular-carcinoma-development-in-patients-with-chronic-hepatitis-b
#1
Hye Yeon Chon, Jae Seung Lee, Hye Won Lee, Ho Soo Chun, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
AIM: Risk prediction models for hepatocellular carcinoma (HCC) development are available. However, the influence of antiviral therapy (AVT) on these models in patients with chronic hepatitis B (CHB) is unknown. METHODS: The dynamic changes in risk prediction models during AVT and the association between risk prediction model and the risk of CHB-related HCC development were investigated. Between 2005 and 2017, 4,917 patients with CHB (3,361 non-cirrhotic, 1,556 cirrhotic) were recruited...
November 26, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33242359/zinc-deficiency-predicts-overt-hepatic-encephalopathy-and-mortality-in-liver-cirrhosis-patients-with-minimal-hepatic-encephalopathy
#2
Takao Miwa, Tatsunori Hanai, Toshihide Maeda, Yui Ogiso, Kenji Imai, Atsushi Suetsugu, Koji Takai, Makoto Shiraki, Naoki Katsumura, Masahito Shimizu
AIM: Minimal hepatic encephalopathy (MHE) is associated with poor outcomes and the development of overt hepatic encephalopathy (OHE) in patients with liver cirrhosis (LC). Zinc plays a key role in the detoxification of ammonia, a risk factor of hepatic encephalopathy. This study aimed to investigate whether zinc deficiency predicts OHE occurrence and mortality in LC patients with MHE. METHOD: This retrospective study included 100 LC patients with MHE. MHE was diagnosed using a computer-aided neuropsychiatric test...
November 26, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33238074/comparison-of-therapeutic-outcomes-of-sorafenib-and-lenvatinib-as-primary-treatments-for-hepatocellular-carcinoma-with-a-focus-on-molecular-targeted-agent-sequential-therapy-a-propensity-score-matched-analysis
#3
Tetsu Tomonari, Yasushi Sato, Joji Tani, Akira Hirose, Chikara Ogawa, Akihiro Morishita, Hironori Tanaka, Takahiro Tanaka, Tatsuya Taniguchi, Koichi Okamoto, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Kazushige Uchida, Tsutomu Masaki, Tetsuji Takayama
AIM: The optimal choice between sorafenib (SOR) or lenvatinib (LEN) as the first-line treatment for unresectable hepatocellular carcinoma (u-HCC) remains debatable. Using propensity score matching, this study compares the outcomes of SOR and LEN in the molecular-targeted agent (MTA) sequential treatment of u-HCC patients. METHODS: This retrospective, multicenter, observational study recruited 137 u-HCC patients who underwent primary treatment with LEN (n = 52) or SOR (n = 85) between June 2017 and June 2020 after regorafenib was approved as the secondary treatment for u-HCC...
November 25, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33227168/metabolomic-profiles-of-breath-odor-compounds-for-prognostic-prediction-in-patients-with-acute-on-chronic-liver-failure-a-pilot-study
#4
Jing Jing, Xiu-Xiu Sang, Shao-Li You, Bin Zhu, Yan-Fei Cui, Chun-Yu Li, Zhong-Xia Wang, Xu Zhao, Xiao-Yi Liu, Miao Tian, Yue-Bo Ren, Si-Miao Yu, Xiao-He Xiao, Jia-Bo Wang, Ming Niu, Rui-Lin Wang
AIM: The aim of this study was to use a metabonomics approach to identify potential biomarkers of exhaled breath condensate (EBC) for predicting the prognosis of acute-on-chronic liver failure (ACLF). METHODS: Using liquid chromatography mass spectrometry, EBC metabolites of ACLF patients surviving without liver transplantation (n=57) and those with worse outcomes (n=45), and controls (n=16) were profiled from a specialized liver disease center in Beijing. The metabolites were used to identify candidate biomarkers, and the predicted performance of potential biomarkers was tested...
November 23, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33217113/multicenter-prospective-study-of-stereotactic-body-radiotherapy-for-previously-untreated-solitary-primary-hepatocellular-carcinoma-the-strsph-study
#5
Tomoki Kimura, Atsuya Takeda, Naoko Sanuki, Keisuke Ariyoshi, Takuhiro Yamaguchi, Toshiyuki Imagumbai, Norio Katoh, Takahisa Eriguchi, Yohei Oku, Shuichi Ozawa, Yuichiro Tsurugai, Masaki Kokubo, Shinichi Shimizu, Satoshi Ishikura
AIM: To prospectively evaluate the efficacy and safety of stereotactic body radiotherapy (SBRT) for patients with previously untreated solitary primary hepatocellular carcinoma (HCC). METHODS: The main eligibility criteria included the following: (1) primary solitary HCC; (2) no prior treatment for HCC; (3) Child-Turcotte-Pugh score of seven or less; and (4) unsuitability for or refusal of surgery and RFA. The prescribed dose of SBRT was 40 Gy in five fractions...
November 20, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33217105/characteristics-of-patients-aged-over-75-years-with-hepatitis-c-virus-infection-treated-with-direct-acting-antivirals-in-japan-evidence-based-on-the-nationwide-real-world-database-in-japan
#6
Naohiko Masaki, Youhei Kawasaki, Yuichi Nozaki, Mikio Yanase
AIM: Direct-acting antivirals (DAAs) have dramatically changed the treatment of chronic hepatitis C. Their high efficacy helps in eradicating hepatitis C virus with few adverse events. Information on real-world use of DAAs therapy in patients aged 75 years and older is inadequate. METHODS: The Japanese DAAs database was constructed in 2014 as a cooperative system between 18 prefectures. The medical reports filled in by doctors and anonymized at the local government office were collected...
November 20, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33207029/assessment-of-treatment-options-for-patients-with-hepatitis-c-virus-recombinant-form-2k-1b
#7
Mamuka Zakalashvili, Jaba Zarkua, Robert G Gish, Maia Zhamutashvili, Vakhtang Sartania, Michael Weizenegger, Jan Bartel, Monika Raabe, Lia Gvinjilia, Sophia Metreveli, Maka Barnova, Nikoloz Abramishvili, Irakli Rtskhiladze, David Metreveli
AIM: Hepatitis C virus (HCV) intergenotype recombinant form (RF) 2k/1b has been actively circulating in HCV-infected patients, and the Republic of Georgia has one of the highest prevalence of this RF virus so far reported worldwide. The aim of this study was to define the optimal treatment regimen for patients with RF_2k/1b. METHODS: We analyzed the data of 2735 patients who initiated treatment in the Medical Center Mrcheveli within Georgia's hepatitis C elimination program from May 2015 through December 2019...
November 18, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33210415/the-association-of-histological-progression-with-biochemical-response-to-ursodeoxycholic-acid-in-primary-biliary-cholangitis
#8
REVIEW
Tadashi Namisaki, Yukihisa Fujinaga, Kei Moriya, Hitoshi Yoshiji
Primary biliary cholangitis (PBC) is currently diagnosed at an early stage; therefore, the number of patients with PBC without symptoms at the time of diagnosis is increasing. However, up to 30% of patients with PBC exhibit the suboptimal response to ursodeoxycholic acid (UDCA) and are at high risk of end-stage liver disease. Obeticholic acid is an approved second-line therapy for patients with PBC that are refractory to UDCA. Novel surrogate endpoints are required to identify individuals eligible for second-line therapies...
November 17, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33201542/hypofractionated-radiotherapy-for-hepatocellular-carcinomas-adjacent-to-the-gastrointestinal-tract
#9
Yuichiro Tsurugai, Atsuya Takeda, Takahisa Eriguchi, Naosko Sanuki, Yousuke Aoki
AIM: Decisions regarding therapeutic plans for inoperable patients with hepatocellular carcinoma (HCC) adjacent to the gastrointestinal (GI) tract are challenging because radiofrequency ablation has the potential risk of thermal injury. Moreover, the response rate of transcatheter arterial chemoembolization is relatively low and stereotactic body radiotherapy (SBRT) is believed to be too toxic. We have applied hypofractionated radiotherapy (HFRT) for such lesions. This study investigated the outcomes and toxicities of this treatment...
November 17, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33197087/safety-and-efficacy-of-sorafenib-followed-by-regorafenib-or-lenvatinib-in-patients-with-hepatocellular-carcinoma
#10
Takeshi Terashima, Tatsuya Yamashita, Noboru Takata, Yasuhito Takeda, Hidenori Kido, Noriho Iida, Masaaki Kitahara, Tetsuro Shimakami, Hajime Takatori, Kuniaki Arai, Kazunori Kawaguchi, Kazuya Kitamura, Taro Yamashita, Yoshio Sakai, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
AIM: Sequential administration of sorafenib followed by regorafenib or lenvatinib is effective against advanced hepatocellular carcinoma (HCC). In this study, we compared the safety profiles and anti-tumor effects of sequential sorafenib and regorafenib or lenvatinib therapy in patients with HCC. METHODS: We investigated adverse events, treatment responses, and dose intensities in patients with HCC who were consecutively treated with sorafenib followed by regorafenib or lenvatinib at the individual level...
November 16, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33141991/the-calf-and-arm-circumference-as-simple-markers-for-screening-sarcopenia-in-patients-with-chronic-liver-disease
#11
Kei Endo, Takuro Sato, Keisuke Kakisaka, Yasuhiro Takikawa
AIM: To prevent the progression of sarcopenia, early identification is important. We investigated the usefulness of sarcopenia screening tests using the arm and calf circumferences in patients with chronic liver disease. METHODS: This was a single-center cross-sectional study based on data collected from a university hospital. We analyzed simple anthropometric data and sarcopenia-related chemical data or imaging data between April and December 2019. Sarcopenia was defined according to the Japan Society of Hepatology guidelines...
November 3, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33126288/changes-in-disease-characteristics-of-primary-biliary-cholangitis-an-observational-retrospective-study-from-1982-to-2016
#12
Masaaki Takamura, Yasunobu Matsuda, Naruhiro Kimura, Masafumi Takatsuna, Toru Setsu, Atsunori Tsuchiya, Akihiko Osaki, Nobuo Waguri, Masahiko Yanagi, Toru Takahashi, Soichi Sugitani, Yuka Kobayashi, Akira Yoshikawa, Toru Ishikawa, Toshiaki Yoshida, Toshiaki Watanabe, Hitoshi Bannai, Tomoyuki Kubota, Kazuhiro Funakoshi, Hiroto Wakabayashi, So Kurita, Norio Ogata, Masashi Watanabe, Yuhsaku Mita, Shigeki Mori, Motoya Sugiyama, Toru Miyajima, Sumio Takahashi, Shuichi Sato, Kisei Ishizuka, Hironobu Ohta, Yutaka Aoyagi, Shuji Terai
BACKGROUND & AIMS: Disease characteristics of primary biliary cholangitis have changed recently. However, detailed studies on the subject have been limited. We therefore aimed to clarify disease characteristics of recent primary biliary cholangitis patients using the cohort from Niigata University and 21 affiliated hospitals. METHODS: Overall, 508 patients were enrolled in this study from 1982 to 2016, divided into three cohorts according to their year of diagnosis: ≤1999, 2000-2009, and ≥2010...
October 30, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33119937/single-nucleus-transcriptomics-data-integration-recapitulates-the-major-cell-types-in-human-liver
#13
Klev Diamanti, Juan Salvador Inda Díaz, Amanda Raine, Gang Pan, Claes Wadelius, Marco Cavalli
AIM: The aim of this study was to explore the benefits of data integration from different platforms for single nucleus transcriptomics profiling to characterize cell populations in human liver. METHODS: We generated single nucleus RNA-seq (snRNA-seq) data from Chromium 10X Genomics and Drop-seq for a human liver sample. We utilized state of the art bioinformatics tools to perform a rigorous quality control and to integrate the data into a common space summarizing the gene expression variation from the respective platforms, while accounting for known and unknown confounding factors...
October 29, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33091191/hepatocellular-carcinoma-and-other-complications-of-nonalcoholic-fatty-liver-disease-and-nonalcoholic-steatohepatitis-in-japan-a-structured-literature-review-article
#14
REVIEW
Yuichiro Eguchi, Gabriel Wong, I-Heng Lee, Omar Akhtar, Ricardo Lopes, Yoshio Sumida
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a significant cause of morbidity and mortality in Japan. As the treatment of viral hepatitis improves, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are rapidly becoming leading causes of HCC in Japan. This structured literature review aims to characterize the morbidity and mortality of HCC and other malignant and non-malignant complications among Japanese NAFLD and NASH patients. METHODS: An English and Japanese structured literature search was conducted in Pubmed, Embase and ICHUSHI, identifying 6,553 studies, 34 of which met pre-defined inclusion criteria...
October 22, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33080094/the-ursodeoxycholic-acid-response-score-predicts-pathological-features-in-primary-biliary-cholangitis
#15
Kazuhito Kawata, Satoru Joshita, Shinji Shimoda, Yuki Yamashita, Maho Yamashita, Kensuke Kitsugi, Shingo Takatori, Kazuyoshi Ohta, Jun Ito, Shin Shimoyama, Hidenao Noritake, Takafumi Suda, Kenichi Harada
AIM: The ursodeoxycholic acid response score (URS) can predict the biochemical response to 12 months of ursodeoxycholic acid (UDCA) treatment in patients with primary biliary cholangitis (PBC). We investigated the relationship between the URS and the histopathological features before and after UDCA treatment. METHODS: Patients with PBC (n=126) were examined for the association between the probability of response (POR) to UDCA based on the URS formulas and the clinicopathological features...
October 20, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33047431/the-association-of-coagulopathy-with-liver-dysfunction-in-patients-with-covid-19
#16
Takeya Tsutsumi, Makoto Saito, Hiroyuki Nagai, Shinya Yamamoto, Kazuhiko Ikeuchi, Lay Ahyoung Lim, Eisuke Adachi, Michiko Koga, Kazuya Okushin, Hiroyuki Akai, Akira Kunimatsu, Hiroshi Yotsuyanagi
AIM: Liver dysfunction is sometimes observed in patients with coronavirus disease 2019 (COVID-19), but most of studies are from China and the frequency in other countries is unclear. In addition, previous studies suggested several mechanisms of liver damage but precise or additional mechanisms are not clearly elucidated. Therefore, we examined COVID-19 patients to explore the proportion of patients with liver dysfunction and also the factors associated with liver dysfunction. METHODS: We retrospectively examined sixty COVID-19 patients hospitalized in our hospital...
October 12, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33037858/hepatocellular-carcinoma-after-fontan-surgery-a-systematic-review
#17
Enrique Rodríguez de Santiago, Luis Téllez, Antonio Guerrero, Agustín Albillos
AIM: Fontan surgery is often the procedure of choice for patients with congenital single effective ventricle. In the long term, elevated systemic venous pressure and chronic ischaemia following this procedure may lead to advanced chronic liver disease and there is also a risk of hepatocellular carcinoma (HCC). This review systematically summarizes the characteristics and outcomes of this rare condition. METHODS: Pubmed and Embase were searched from inception to January 2020 for studies reporting on HCC after Fontan surgery...
October 10, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33037855/characterization-of-hepatitis-b-virus-dna-integration-patterns-in-intrahepatic-cholangiocarcinoma
#18
Mengge Li, Min Du, Hui Cong, Yuanyuan Gu, Yuan Fang, Jin Li, Yu Gan, Hong Tu, Jinyang Gu, Qiang Xia
AIM: Hepatitis B virus (HBV) integration is one of the mechanisms contributing to the hepatocellular carcinoma (HCC) development. However, the status of HBV integration in intrahepatic cholangiocarcinoma (ICC) is poorly understood. This study aims to characterize the viral integration in HBV-related ICC. METHODS: The presence of HBV S and C gene in ICCs and the para-tumor tissue was determined by PCR direct sequencing. HBV integration was detected by a high-throughput capture sequencing method (HIVID)...
October 10, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33037853/prevalence-of-anti-hepatitis-e-antibodies-and-impact-on-disease-severity-in-non-alcoholic-fatty-liver-disease
#19
Rafael Paternostro, Stefan Traussnigg, Katharina Staufer, Mattias Mandorfer, Emina Halilbasic, Heimo Lagler, Judith Stift, Fritz Wrba, Petra Munda, Michael Trauner
BACKGROUND&AIMS: In most immune-competent individuals hepatitis E (HEV) infections appear silent. It is unclear whether past HEV infections deteriorate disease severity in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: Patients with biopsy proven NAFLD and data on Anti-HEV-IgM- (HEV-IgM) and Anti-HEV-IgG-Antibodies (HEV-IgG) were included. The NAFLD-activity score (NAS) was used to grade and stage all liver biopsy samples. HEV-IgG prevalence was compared to a healthy cohort of 997 subjects...
October 10, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://read.qxmd.com/read/33034106/donor-dominant-one-way-matching-of-hla-a-b-dr-alleles-predicts-graft-versus-host-disease-following-living-donor-liver-transplantation
#20
Masaaki Hirata, Shintaro Yagi, Takero Shindo, Atsushi Yoshizawa, Gozo Kiguchi, Masakatsu Kaneshiro, Kimiko Yurugi, Yosuke Miyachi, Sena Iwamura, Siyuan Yao, Shinji Uemoto
AIMS: Graft-versus-host disease (GVHD) following liver transplantation is rare but fatal. Therefore, it is important to identify possible risk factors before transplantation. Although it has been suggested that donor-dominant one-way human leukocyte antigen (HLA) matching of three loci (HLA-A/B/DR) is associated with the occurrence of GVHD, the precise significance of HLA matching including HLA-C/DQ/DP remains unclear. METHODS: We retrospectively analyzed the impact of donor-dominant one-way HLA matching at six HLA loci at the allele level on GVHD using clinical registry data from 1,759 cases who underwent living-donor liver transplantation from June 1990 through June 2019...
October 8, 2020: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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