journal
https://read.qxmd.com/read/35938242/prognostic-significance-of-programmed-death-1-and-programmed-death-ligand-1-proteins-in-breast-cancer
#21
JOURNAL ARTICLE
Imtiaz Mahmood Tahir, Abdur Rauf, Huma Mehboob, Samia Sadaf, Muhammad Shaiful Alam, Fadia Kalsoom, Abdelhakim Bouyahya, Aicha El Allam, Nasreddine El Omari, Saad Bakrim, Muhammad Akram, Syed Kashif Raza, Talha Bin Emran, Yahia N Mabkhot, Gokhan Zengin, Marina Derkho, Suray Natalya, Mohammad Ali Shariati
In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed to determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such as PubMed, Google scholar, home pages of publishing groups, medical, clinical, and pharmaceutical sciences journals, as well as other relevant sources to discover the importance of PD-1 and PD-L1 expression in breast cancer therapies and also recurrence. The keywords used in this search were autoimmunity, programmed cell death, PD-L1 or PD-1, and breast cancer...
July 21, 2022: Human Antibodies
https://read.qxmd.com/read/35912736/impact-of-anti-thyroid-peroxidase-and-anti-thyroglobulin-antibodies-on-the-gestational-outcome-of-euthyroid-pregnancies-a-retrospective-study
#22
JOURNAL ARTICLE
Kemal Beksac, Hanife Guler Donmez, Murat Cagan, Mehmet Sinan Beksac
BACKGROUND: Thyroglobulin (anti-TG) and/or thyroid peroxidase (anti-TPO) autoantibodies are associated with higher rates of poor gestational outcomes. OBJECTIVE: To demonstrate the impact of anti-TPO and anti-TG autoantibodies on the gestational outcomes of euthyroid pregnant women with a history of poor gestational outcome and thyroid gland disorders. METHODS: This retrospective study included totally 75 euthyroid pregnant, 30 of women with high thyroid autoantibodies (Anti-TPO/Thyroglobulin-positive group) and 45 of them without autoantibodies (control group)...
July 19, 2022: Human Antibodies
https://read.qxmd.com/read/35786649/comparison-of-some-hematological-parameters-between-male-and-female-patients-infected-with-covid-19
#23
JOURNAL ARTICLE
Hayder H Abed, Ahmed Ghdhban Al-Ziaydi, Ihab Abbas Taher, Ahmed K Al Dulaimi
BACKGROUND: COVID-19 is a highly contagious virus that is rapidly spreading across the world. As the number of COVID-19 patients is quickly rising, and certain nations and areas, such as the third world countries, lack the medical resources, it is critical to track and monitor a patient's status using blood parameters on regular testing. The aim of this study is to compare the serum D-dimer levels, Ferritin, CRP, WBCs, Lymphocytes, and Neutrophils in male and female patients infected with COVID-19...
June 24, 2022: Human Antibodies
https://read.qxmd.com/read/35431235/assessment-of-specific-human-antibodies-against-recombinant-sars-cov-2-receptor-binding-domain-by-rapid-in-house-elisa
#24
JOURNAL ARTICLE
Nahla A Hussein, Esraa A A Ali, Amr E El-Hakim, Ashraf A Tabll, Asmaa El-Shershaby, Azza Salamony, Mohamed N F Shaheen, Ibrahim Ali, Mahmoud Elshall, Yasser E Shahein
BACKGROUND: The recently emerged SARS-CoV-2 caused a global pandemic since the last two years. The urgent need to control the spread of the virus and rapid application of the suitable health measures raised the importance of available, rapid, and accurate diagnostic approaches. OBJECTIVE: The purpose of this study is to describe a rapid in-house optimized ELISA based on the expression of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein in a prokaryotic system...
March 31, 2022: Human Antibodies
https://read.qxmd.com/read/35342084/hla-alleles-and-haplotype-frequencies-in-iranian-population
#25
JOURNAL ARTICLE
Soudeh Ghafouri-Fard, Bahdar Mahmud Hussen, Sara Pashmforoush, Mohammad Taghi Akbari, Shahram Arsang-Jang, Naghme Nazer, Amir Ali Hamidieh, Abbas Hajifathali, Marcel E Dinger, Arezou Sayad, Mohammadreza Ostadali Dehaghi
BACKGROUND: HLA genotyping is a prerequisite for selection of suitable donors in the process of bone marrow transplantation. METHODS: In the current study, the frequencies of HLA-A, -B, -C and -DRB1 alleles and A-B-C-DRB1 haplotypes were assessed in 855 healthy Iranian persons using a low-resolution sequence specific primer (SSP) kit. RESULTS: Frequencies were compared between 11 subpopulations including Armani, Balouch, Bandari, Turk, Turkaman, Arab, Fars, Kurd, Gilaki, Lor and Mazani...
March 18, 2022: Human Antibodies
https://read.qxmd.com/read/35342083/the-seroprevalence-of-celiac-disease-in-patients-with-symptoms-of-irritable-bowel-syndrome-a-cross-sectional-study-in-north-of-iran
#26
JOURNAL ARTICLE
Farahnaz Joukar, Sara Yeganeh, Afshin Shafaghi, Alireza Mahjoob, Soheil Hassanipour, Luigi Santacroce, Sara Mavaddati, Fariborz Mansour-Ghanaei
BACKGROUND: Celiac disease (CD) is a common cause of malabsorption that is definitively diagnosed by abnormal bowel biopsy, symptoms and histologic changes to gluten free diet. The symptoms of irritable bowel syndrome (IBS) are common in our community as the majority of people in Guilan, north of Iran, consume rice daily. Also, a number of celiac patients are unknown, and IBS are mistakenly diagnosed. OBJECTIVE: This study aimed to evaluate the prevalence of CD among IBS patients...
March 16, 2022: Human Antibodies
https://read.qxmd.com/read/35124636/erratum
#27
(no author information available yet)
No abstract text is available yet for this article.
January 28, 2022: Human Antibodies
https://read.qxmd.com/read/35001885/singleton-pregnancy-losses-before-gestational-week-22-among-patients-with-autoimmune-disorders-and-methylenetetrahydrofolate-reductase-polymorphisms
#28
JOURNAL ARTICLE
Murat Cagan, Ummuhan Okuducu, Hanife Guler Donmez, Mehmet Sinan Beksac
BACKGROUND: The rates of pregnancy losses (PLs) are increased by maternal risk factors such as autoimmune disorders (AD) and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. OBJECTIVE: To evaluate singleton PLs before gestational week (gw) 22 among patients with AD and MTHFR polymorphisms. METHODS: Totally, 1108 singleton pregnancies in 243 women were categorized as: 1) 148 pregnancies in 33 patients with AD, 2) 316 pregnancies in 66 patients with MTHFR polymorphisms, 3) 644 pregnancies in 144 patients with AD +MTHFR polymorphisms...
January 4, 2022: Human Antibodies
https://read.qxmd.com/read/35662114/monoclonal-antibodies-for-the-treatment-of-acute-lymphocytic-leukemia-a-literature-review
#29
REVIEW
Hossein Pourmontaseri, Niloofar Habibzadeh, Sarina Entezari, Fatemeh Samadian, Shamim Kiyani, Mina Taheri, Ali Ahmadi, Mohammad Sadegh Fallahi, Farzad Sheikhzadeh, Arina Ansari, Amirhossein Tamimi, Niloofar Deravi
BACKGROUND: Acute lymphocytic leukemia (ALL) is a type of blood cancer that is more prevalent in children. Several treatment methods are available for ALL, including chemotherapy, upfront treatment regimens, and pediatric-inspired regimens for adults. Monoclonal antibodies (Mabs) are the novel Food and Drug Administration (FDA) approved remedies for the relapsed/refractory (R/R) adult ALL. In this article, we aimed to review studies that investigated the efficacy and safety of Mabs on ALL...
2022: Human Antibodies
https://read.qxmd.com/read/35094990/cytometric-analysis-and-clinical-features-in-a-moroccan-cohort-with-severe-combined-immunodeficiency
#30
JOURNAL ARTICLE
Aicha El Allam, Sara El Fakihi, Hicham Tahoune, Karima Sahmoudi, Houria Bousserhane, Youssef Bakri, Naima El Hafidi, Fouad Seghrouchni
Severe combined immunodeficiency (SCID) is a form of primary immunodeficiency disease (PID). It is characterized by a serious abnormality of the cellular and sometimes humoral system due to a deficiency in development of T cells, B cells and/or NK cells. The early diagnosis of SCID improves the prognosis. Typically, the initial consideration of SCID is made based on low lymphocyte counts. Notwithstanding, the heterogeneity of lymphocyte count presentation makes the diagnosis of SCID a significant challenge...
2022: Human Antibodies
https://read.qxmd.com/read/34864653/evaluation-of-molecular-apoptosis-signaling-pathways-and-its-correlation-with-ebv-viral-load-in-sle-patients-using-systems-biology-approach
#31
JOURNAL ARTICLE
Soad Ghabeshi, Ali Najafi, Batol Zamani, Mozhdeh Soltani, Amanuel Godana Arero, Shim Izadi, Ahmad Piroozmand
BACKGROUND: Considerable evidence supports that SLE could be related to apoptotic cells and EBV infection. OBJECTIVE: The aim of this study was to identify the transcriptional signature of EBV infection in SLE patients for survey of the molecular apoptosis signaling pathways. METHODS: The PBMCs gene expression profiles of healthy control and SLE patients were obtained from GEO. Functional annotation and signaling pathway enrichment were carried out using DAVID, KEGG...
2022: Human Antibodies
https://read.qxmd.com/read/34958012/mini-review-the-market-growth-of-diagnostic-and-therapeutic-monoclonal-antibodies-sars-cov-2-an-example
#32
REVIEW
Yasmine El Abd, Ashraf Tabll, Robert Smolic, Martina Smolic
BACKGROUND: The emergence of novel viruses poses severe challenges to global public health highlighting the crucial necessity for new antivirals. MAIN BODY: Monoclonal antibodies (mAbs) are immunoglobulins that bind with a single epitope. Mouse mAbs are generated by classic hybridoma technology and are mainly used for immunodiagnostics. For immunotherapy, it is critical to use monoclonal antibodies in the human form to minimize adverse reactions. They have been successfully used to treat numerous illnesses, accordingly, an increasing number of mAbs, with high potency against emerging viruses is the target of every biopharmaceutical company...
December 24, 2021: Human Antibodies
https://read.qxmd.com/read/34864655/transcript-levels-of-cytokine-coding-genes-in-peripheral-blood-and-tissues-of-patients-with-periodontitis
#33
JOURNAL ARTICLE
Mohammad Taheri, Leila Gholami, Fwad Nicknafs, Bashdar Mahmud Hussen, Shahram Arsang-Jang, Arezou Sayad, Soudeh Ghafouri-Fard
Periodontal diseases are common conditions in almost all age groups and a public health problem. Numerous risk factors have been demonstrated for this condition. The main mechanism of tissue destruction in the periodontitis is the functional interactions between microbial pathogens and host immune responses, thus cytokines have crucial roles in the pathogenesis periodontitis. Our previous study has demonstrated the susceptibility role of HLA-DRB1*04 allele in development of this disease. So, the individuals who were positive for HLA-DRB1*04 allele were excluded...
November 26, 2021: Human Antibodies
https://read.qxmd.com/read/34864654/covid-19-pandemic-insights-into-genetic-susceptibility-to-sars-cov-2-and-host-genes-implications-on-virus-spread-disease-severity-and-outcomes
#34
JOURNAL ARTICLE
Saba Dastar, Jalal Gharesouran, Deniz Mortazavi, Hassan Hosseinzadeh, Seyed Jalal Kian, Mohammad Taheri, Soudeh Ghafouri-Fard, Elena Jamali, Maryam Rezazadeh
The outbreak of the newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) all over the world has caused global public health emergencies, international concern and economic crises. The systemic SARS-CoV-2 disease (COVID-19) can lead to death through causing unrestrained cytokines-storm and subsequent pulmonary shutdown among the elderly and patients with pre-existing comorbidities. Additionally, in comparison with poor nations without primary health care services, in developed countries with advanced healthcare system we can witness higher number of infections per one million people...
November 26, 2021: Human Antibodies
https://read.qxmd.com/read/34511496/circulating-macrophage-inflammatory-protein-1%C3%AE-il-12p40-ratio-predicts-sofosbuvir-based-treatment-outcome-in-hcv-genotype-4-patients
#35
JOURNAL ARTICLE
Heba Shawky, Reem El-Shenawy, Naiera M Helmy
This study aimed to evaluate the prognostic value of baseline macrophage inflammatory protein (MIP)-1β/IL12p40 ratio for antiviral treatment outcome in HCV genotype 4 patients. METHODS: Sera of 450 treatment-naïve chronic HCV patients and 50 healthy individuals were collected. Liver transaminases, total bilirubin and albumin were biochemically tested, viral RNA was quantified, and circulating MIP-1β and IL-12p40 were estimated using human anti-MIP-1β and IL-12p40 antibodies in Sandwich ELISA...
September 3, 2021: Human Antibodies
https://read.qxmd.com/read/34459390/assessment-of-cancer-prevention-effect-of-exercise
#36
JOURNAL ARTICLE
Reza Vafaee, Mostafa Rezaei Tavirani, Sina Rezaei Tavirani, Mohammadreza Razzaghi
There are many documents about benefits of exercise on human health. However, evidences indicate to positive effect of exercise on disease prevention, understanding of many aspects of this mechanism need more investigations. Determination of critical genes which effect human health.GSE156249 including 12 gene expression profiles of healthy individual biopsy from vastus lateralis muscle before and after 12-week combined exercise training intervention were extracted from gene expression omnibus (GEO) database...
August 13, 2021: Human Antibodies
https://read.qxmd.com/read/34397407/anti-drug-antibodies-to-antibody-based-therapeutics-in-multiple-sclerosis
#37
JOURNAL ARTICLE
David Baker, A Nazli Asardag, Olivia A Quinn, Alex Efimov, Angray S Kang
Multiple sclerosis is the major demyelinating autoimmune disease of the central nervous system. Relapsing MS can be treated by a number of approved monoclonal antibodies that currently target: CD20, CD25 (withdrawn), CD49d and CD52. These all target potentially pathogenic memory B cell subsets and perhaps functionally inhibit pathogenic T cell function. These consist of chimeric, humanized and fully human antibodies. However, despite humanization it is evident that all of these monoclonal antibodies can induce binding and neutralizing antibodies ranging from < 1% to over 80% within a year of treatment...
August 6, 2021: Human Antibodies
https://read.qxmd.com/read/34334388/effect-of-kras-and-braf-mutations-in-metastatic-colorectal-cancer-patients-a-systematic-review-and-meta-analysis-based-on-tumor-sidedness-and-kras-subtypes
#38
Khadijeh Saravani, Morteza Salarzaei, Fateme Parooie
INTRODUCTION: Metastatic or recurrent colorectal cancer (MRCRC) has a poor prognosis. The aim of the present meta-analysis was to assess the prevalence of different subtypes of KRAS mutation and BRAF mutation in metastatic CRC patients, and evaluate the relationship between the tumor sidedness and prevalence of KRAS and BRAF mutation. METHODS: We searched MEDLINE/PubMed, the Cochrane Library, and ClinicalTrials.gov from January 2010 to July 2020. The data were extracted independently according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
July 23, 2021: Human Antibodies
https://read.qxmd.com/read/34275896/association-of-increased-c-reactive-protein-and-hypocomplementemia-with-risk-factors-for-thrombosis-in-women-who-have-susceptibility-for-poor-gestational-outcome-importance-of-preconceptional-counseling
#39
JOURNAL ARTICLE
Mehmet Sinan Beksac, Hanife Guler Donmez
This study aimed to investigate the association of increased C-Reactive Protein (CRP) and hypocomplementemia with risk factors for thrombosis such as Factor V Leiden (FVLP) and Prothrombin G20210A polymorphisms (PP), increased Activated Protein C Resistance (APCR) and decreased anti-thrombin III (ATIII) activity in women who have metabolic (MTHFR polymorphisms) and immunological risk factors (autoimmune antibody positivity, autoimmune disorders, and chronic inflammatory diseases). All patients (n= 197) were evaluated in terms of risk factors for thrombosis including FVLP, PP, increased APCR, and decreased ATIII activity as well as CRP and complement (C) 3 and C4 levels within a framework of preconceptional care program...
July 5, 2021: Human Antibodies
https://read.qxmd.com/read/34151785/blood-microbiota-composition-in-iranian-pre-diabetic-and-type-2-diabetic-patients
#40
JOURNAL ARTICLE
Farahnaz Ghaemi, Abolfazl Fateh, Abbas Akhavan Sepahy, Mehrangiz Zangeneh, Mostafa Ghanei, Seyed Davar Siadat
BACKGROUND: Type 2 diabetes as the most prevalent metabolic disorder, is one of the major causes of morbidity and mortality worldwide. Recent studies suggest that body microbiota may play a role in developing metabolic disorders including type 2 diabetes. The objective of the present study was to investigate the blood microbiota composition in Iranian pre-diabetic and type 2 diabetic patients compared to healthy individuals. METHODS: Blood samples were taken after 12-h fasting from 90 participants, 30 healthy individuals, 30 type 2 diabetes patients and 30 pre-diabetic participants...
June 19, 2021: Human Antibodies
journal
journal
32816
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.