journal
https://read.qxmd.com/read/38517783/expression-level-of-non-coding-mir-155-gene-as-biomarker-for-severity-of-coronaviruses-infection-among-vaccinated-and-non-vaccinated-iraqi-patients
#1
JOURNAL ARTICLE
Halah Kadhim, Abdulameer Ghareeb, Mohammed Alhilal
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 is influenced by genetic and epigenetic factors, including miR-155, which affects immune cell and virus functions and laboratory biomarkers. OBJECTIVE: T0 evaluates miR-155's role as a biomarker for SARS-CoV-2 detection and monitoring, examining its significance in identifying infection in both vaccinated and unvaccinated individuals using ROC curve analysis. METHODS: Blood samples were collected from 70 patients who attended Medical City Hospital in Baghdad from June 2022 to April 2023 and were determined to be associated with SARS-CoV-2 (35 patients were hospitalized at the Intensive Care Units due to the severity of their symptoms while the other 35 were left hospital upon treatment...
March 6, 2024: Human Antibodies
https://read.qxmd.com/read/38339926/effect-of-physical-exercise-on-inactivated-covid-19-vaccine-antibody-response-in-the-elderly
#2
JOURNAL ARTICLE
Ömer Şevgin, Songül Özer
BACKGROUND: Physical exercise has been proposed as a new alternative to chemical adjuvants. OBJECTIVE: To investigate the relationship between regular exercise and post-vaccination antibody response in the elderly. METHODS: The study was conducted with the elderly over the age of 65. 30 participants we randomized into 2 groups and divided into exercise and control groups. The experimental group received a 12-week exercise program...
January 25, 2024: Human Antibodies
https://read.qxmd.com/read/38339925/investigating-the-impact-of-the-genetic-variant-cxcr1-rs2234671-in-individuals-with-urinary-tract-infections
#3
JOURNAL ARTICLE
Hassan Hachim Naser, Mohanad Jawad Kadhim, Hazem Almhanna
BACKGROUND: Urinary tract infections (UTIs) are currently posing a worldwide health concern by affecting millions of people. The genetic variant rs2234671 in the CXCR1-interleukin-8 receptor is closely related to a raised UTI risk. OBJECTIVES: In this work, the impact of CXCR1 (rs2234671) on UTI individuals was examined. METHODS: The demographic features of 30 recurrent UTI patients and 20 controls were thoroughly investigated. Bacterial isolation and identification were performed by the implementation of cultural and biochemical methods...
January 23, 2024: Human Antibodies
https://read.qxmd.com/read/38339924/relationship-between-vitamin-d-receptor-genotypes-fok1rs2228570-and-il18-gene-expression-in-sample-of-multiple-sclerosis-iraqi-patients
#4
JOURNAL ARTICLE
Zahraa Kadhim Lafi And, Bushra Jasim Mohammed
BACKGROUND: Multiple Sclerosis Known as MS, this chronic inflammatory demyelinating condition affects the nervous system. It is a heterogenic and multifactorial disease. The goal of the current study was to investigate the relationship between MS patients' IL18 gene expression and the vitamin D receptor gene polymorphism (FOK1rs2228570). OBJECTIVE: The aim of the study to investigate the association of Vitamin D receptor (FOK1rs2228570) gene Polymorphism and pro inflammatory cytokine (IL18) gene expression among multiple sclerosis Iraqi Patients...
January 20, 2024: Human Antibodies
https://read.qxmd.com/read/38217591/does-tnf-%C3%AE-308%C3%A2-g-a-rs1800629-gene-polymorphism-associate-with-liver-and-pancreas-disorders-in-iraqi-adults-with-beta-thalassemia-major
#5
JOURNAL ARTICLE
Hawraa Allawi Luaibi, Bushra Jasim Mohammed
BACKGROUND: TNF-α has been considered as the key regulator of inflammatory responses and is known to be participated in the pathogenesis of several diseases. OBJECTIVE: The aim of this study was to explore the relationship of (rs1800629) gene polymorphism associated to liver and pancreas disorders in sample of β-thalassemia major adult Iraqi Patients. MATERIAL AND METHOD: Blood samples were obtained from 40 patients suffered from beta thalassemia with pancreas disorder, along with 40 patient suffered from thalassemia with liver disorder, and 40 patient suffered from thalassemia without pancreas or liver, from Ibn Al-Baladi Hospital, Baghdad, and 40 samples from age and gender-matched apparently healthy individuals as control group, all subjects with age more than 18 years...
December 25, 2023: Human Antibodies
https://read.qxmd.com/read/38217590/significance-of-antibody-numbering-systems-in-the-development-of-antibody-engineering
#6
JOURNAL ARTICLE
Riya Patel, Pratibha Verma, Anil Kumar Nagraj, Akshata Gavade, Om Prakash Sharma, Jaspal Patil
Immunotherapy has become increasingly popular in recent years for treating a variety of diseases including inflammatory, neurological, oncological, and auto-immune disorders. The significant interest in antibody development is due to the high binding affinity and specificity of an antibody against a specific antigen. Recent advances in antibody engineering have provided a different view on how to engineer antibodies in silico for therapeutic and diagnostic applications. In order to improve the clinical utility of therapeutic antibodies, it is of paramount importance to understand the various molecular properties which impact antigen targeting and its potency...
December 25, 2023: Human Antibodies
https://read.qxmd.com/read/38217589/demographic-and-clinico-pathological-characteristics-of-colorectal-cancer-in-kirkuk-governorate-iraq
#7
JOURNAL ARTICLE
Khalid Bahram Arif, Summer Said, Nawfal Khiro, Salih Ibrahem, Saleh Al-Ghamdi
BACKGROUND: World-wide Colorectal cancer (CRC) is the third most common cancer with one million new cases a year. Historically, a higher incidence of this disease has been recorded among the elderly in the western countries, but it is increasing in developing countries and in younger age groups. AIM: This study aims to find whether CRC cancer is progressively affecting the younger age groups known as early onset (< 50 years). In addition, it describes the pathological characteristics of CRC in early onset CRC cases...
December 25, 2023: Human Antibodies
https://read.qxmd.com/read/38143341/time-series-bioinformatics-analysis-of-sars-cov-infected-cells-to-identify-the-biological-processes-associated-with-severe-acute-respiratory-syndrome
#8
JOURNAL ARTICLE
Razieh Fatehi, Farinaz Khosravian, Mansoor Salehi, Mohammad Kazemi
BACKGROUND: The COVID-19 pandemic, caused by the new virus of the coronavirus family, SARS-CoV-2, could lead to acute respiratory syndrome. The molecular mechanisms related to this disorder are still debatable. METHODS: In this study to understand the pathogenicity mechanism of SARS-CoV-2, using the bioinformatics approaches, we investigated the expression of involved genes, their regulatory, and main signaling pathways during the time on days 1, 2, 3, and 4 of SARS-CoV infected cells...
November 30, 2023: Human Antibodies
https://read.qxmd.com/read/37574726/functional-characterization-of-small-and-large-alveolar-macrophages-in-sarcoidosis-and-idiopathic-pulmonary-fibrosis-compared-with-non-fibrosis-interstitial-lung-diseases
#9
JOURNAL ARTICLE
Sara El Fakihi, Aicha El Allam, Hicham Tahoune, Nouhaila Najimi, Chaimae Kadi, Azeddine Ibrahimi, Jamal-Eddine Bourkadi, Fouad Seghrouchni
BACKGROUND: Sarcoidosis is a granulomatous disease that mostly affects the lungs. Advanced tissue injury caused by this disease can progress to pulmonary fibrosis with similar characteristics shared with idiopathic pulmonary fibrosis (IPF). The initial presentations of both sarcoidosis and IPF may be shared with other interstitial lung diseases (ILDs). Two populations of macrophages have been described in the alveolar space: small alveolar macrophages (AMs) and large alveolar macrophages...
July 28, 2023: Human Antibodies
https://read.qxmd.com/read/37482988/expression-analysis-of-cytoskeleton-regulator-rna-and-cyclin-dependent-kinase-inhibitor-2b-genes-in-breast-cancer
#10
JOURNAL ARTICLE
Majid Mokhtari, Mahdi Gholipour, Solat Eslami, Atefe Abak, Bashdar Mahmud Hussen, Azadeh Rakhshan, Soudeh Ghafouri-Fard
BACKGROUND: Breast cancer has been found to be associated with deregulation of several non-coding genes and mRNA coding genes. OBJECTIVE: To assess expressions of CYTOR and CDKN2B in breast cancer and adjacent samples and find their relevance with clinical data. METHODS: We enumerated expression level of CDKN2B and CYTOR in 43 newly diagnosed breast cancer samples and their adjacent specimens using real-time PCR method Expression data was judged using Wilcoxon matched-pairs signed rank test...
July 14, 2023: Human Antibodies
https://read.qxmd.com/read/37482989/effect-of-il-6-and-crp-titer-with-antibody-level-on-severity-of-covid-19-infection
#11
JOURNAL ARTICLE
Adeq K Hachim, Aesha Saber Ali, Khalid B Arif
OBJECTIVE: SARS Coronavirus 2 (SARS-CoV-2) infection is combined with a high death rate and morbidity in different regions across the world. Interleukin-6 (IL-6) is a pleiotropic cytokine secreted in response to tissue injury, primarily produced by macrophages. C-reactive protein (CRP) is considered a part of innate immunity and is elevated in response to infection and cancer. METHODS: This study includes one hundred patients infected with the viral pathogen known as SARS-CoV-2 and fifty healthy individuals attending Al-Salam Hospital in Baghdad...
July 10, 2023: Human Antibodies
https://read.qxmd.com/read/37458030/sars-cov-2-strain-specific-anti-spike-igg-elisa-utilizing-spike-protein-produced-by-silkworms
#12
JOURNAL ARTICLE
Takeyuki Goto, Tomoki Sasaki, Yong Chong, Masahiro Taniguchi, Jae Man Lee, Akitsu Masuda, Takeru Ebihara, Kenichiro Shiraishi, Naoki Tani, Akiko Yonekawa, Kei Gondo, Hiroyuki Kuwano, Nobuyuki Shimono, Hideyuki Ikematsu, Koichi Akashi, Takahiro Kusakabe
BACKGROUND: A cost-effective and eco-friendly method is needed for the assessment of humoral immunity against SARS-CoV-2 in large populations. OBJECTIVE: We investigated the performance of an ELISA that uses silkworm-produced proteins to quantify the strain-specific anti-Spike IgG (anti-S IgG) titer. METHODS: The OD values for the anti-His-tag antibody, a standard material of ELISA quantification, were measured. Correlations between the ELISA for each strain and the Abbott SARS-CoV-2 IgG II Quant assay for the wild type were evaluated with serum samples from nine participants with various infection and vaccination statuses...
July 1, 2023: Human Antibodies
https://read.qxmd.com/read/37458031/evaluation-of-il-6-and-il-17a-gene-polymorphisms-in-iraqi-patients-infected-with-covid-19-and-type-2-diabetes-mellitus
#13
JOURNAL ARTICLE
Qusay Abdulwahab Khalaf, Khetam Habeeb Rasool, Eman Natiq Naji
BACKGROUND: In patients with COVID-19, diabetes mellitus type 2 (T2DM) increases the risk of hospitalization and death. Patients who have IL-6 and IL-17A single nucleotide polymorphisms (SNPs) are more likely to have severe COVID-19. This study aims to determine whether SNPs of the IL-6 gene at rs1800795 (G > C) and the IL-17A gene at rs2275913 (G > A) are associated with COVID-19 and T2DM in the Iraqi population. PATIENTS AND METHODS: Twenty-four people were divided into 4 groups as follows: six patients with severe COVID-19 and T2DM were placed in Group 1 as "G1", six patients with COVID-19 but no T2DM were placed in Group 2 as "G2", and six patients with T2DM were placed in Group 3 as "G3"...
June 30, 2023: Human Antibodies
https://read.qxmd.com/read/37334588/immunoglobulin-g-follow-up-and-immune-response-longevity-analysis-in-sars-cov-2-convalescent-patients-and-vaccinated-individuals-a-longitudinal-analysis
#14
JOURNAL ARTICLE
Fadia Mothafar Maki, Anima Namma Al-Thwani, Kareem Shahal Jiad, Karar Nadhum Jawad Musafer
BACKGROUND: Although the detection of immunoglobulin G (IgG) molecules has long been considered to be crucial for successful humoral immune defence against infections and harmful metabolites, it has become increasingly important in relation to SARS-CoV-2 research. OBJECTIVE: To compare longitudinal changes in IgG titres in post-infection and post-vaccination Iraqi participants, and to estimate the protective benefits of the two principal vaccines used in Iraq. METHODS: This quantitative study used samples from SARS-CoV-2 recovered patients (n= 75), those vaccinated with two doses of Pfizer or Sinopharm vaccine (n= 75), and healthy unvaccinated individuals (n= 50) who formed a control group...
May 29, 2023: Human Antibodies
https://read.qxmd.com/read/37248893/postural-orthostatic-tachycardia-syndrome-like-symptoms-following-covid-19-vaccination-an-overview-of-clinical-literature
#15
JOURNAL ARTICLE
Phu Tv, Thu Thao Tran, Huynh Trung Hao, Nguyen Thi Hien Hau, Nityanand Jain, Aigars Reinis
BACKGROUND: Postural Orthostatic Tachycardia Syndrome (POTS) is a common condition affecting more than 170 people per 100,000 population. However, POTS following COVID-19 vaccination remains a rare reporting in the medical literature. OBJECTIVE: We, herein, summarize and highlight the evidence that has been reported regarding POTS-like symptoms following COVID-19 vaccination. METHODS: We conducted a literature search and summarized the findings in the form of a narrative commentary...
May 22, 2023: Human Antibodies
https://read.qxmd.com/read/37005883/non-invasive-monitoring-associated-with-b-lymphoma-cells-in-post-transplant-lymphoproliferative-disorder-ptld-patients-systematic-review
#16
REVIEW
Naser Honar, Iraj Shahramian, Mohammad Hadi Imanieh, Maryam Ataollahi, Masoud Tahani, Shiva Rakhshaninasab, Amin Javadifar
BACKGROUND: One of the most severe side effects of solid-organ transplantation is posttransplant lymphoproliferative disease (PTLD). People with human immunodeficiency virus infection (HIV), an immunosuppressive disease comparable to HIV, have a higher chance of developing lymphoma when their peripheral blood contains elevated levels of the immunoglobulins kappa and lambda free light chains (FLCs). METHODS: This systematic review's objective was to monitor associated B lymphoma cells in PTLD patients...
March 24, 2023: Human Antibodies
https://read.qxmd.com/read/36776045/immunological-analysis-of-interleukin-10-il-10-tumor-necrosis-factor-a-tnf-a-and-prostate-specific-antigen-psa-in-benign-and-malignant-prostate-cancer
#17
JOURNAL ARTICLE
Azhar S H Al-Nasralla, Suzan Saadi Hussian, Nihad Khalawe Tektook
INTRODUCTION: Among the cancers that impacts men, prostate cancer considerably raises deaths for males around the world. Persons with tumours can have a localized or advanced form of the illness. OBJECTIVE: The present study aimed to determining the relationship between the level of cytokines (IL-10 and TNF-a) and PSA in the sera of patients and compared it with healthy. MATERIALS AND METHODS: A case control study consist of three group included was in this study...
January 18, 2023: Human Antibodies
https://read.qxmd.com/read/36641663/interferon-gamma-interleukin-6-and-tissue-necrosis-factor-alpha-levels-among-asymptomatic-hiv-patients-in-benin-city-nigeria
#18
JOURNAL ARTICLE
Godwin Aigbedo Aikpitanyi-Iduitua, Isaiah Nnana Ibeh, Nosakhare Lawrence Idemudia, Rosemary Osamede Aikpitanyi-Iduitua, Richard Omoregie
BACKGROUND: Morbidity and mortality associated with HIV infection is immune-mediated, and an understanding of HIV immunology will be beneficial in the management of HIV infectionOBJECTIVE: The objective of this research was to measure the levels of TNF-α, IL-6 and IFN-γ in asymptomatic HIV patients and non-HIV subjects, as well as their relationship with CD4 count. METHOD: Blood samples were collected from 173 subjects, consisting of 125 asymptomatic HIV patients (44 HAART-naïve and 81 on HAART) and 48 non-HIV subjects...
January 4, 2023: Human Antibodies
https://read.qxmd.com/read/37248894/association-of-lupus-anticoagulants-with-risk-factors-for-obstetric-complications-and-adverse-gestational-outcome
#19
JOURNAL ARTICLE
Murat Cagan, Hanife Guler Donmez, Zeliha Gunnur Dikmen, Mehmet Sinan Beksac
BACKGROUND: Lupus anticoagulant (LA) may be a cause of poor obstetric outcome. OBJECTIVE: To search the association of LA with risk factors for obstetric complications and adverse gestational outcome. METHODS: This retrospective cohort was consisted of 2 groups of pregnancies with poor obstetric history; 1) LA (+) gestations (Study Group, n= 20) and 2) LA (-) gestations (Control Group, 78). All patients were admitted to a special antenatal care program and were examined in terms of risk factors for thrombotic events, placenta-related obstetric complications, and poor gestational outcomes...
2023: Human Antibodies
https://read.qxmd.com/read/36617778/the-impact-of-hiv-on-the-risk-of-covid-19-death-among-hospitalized-patients
#20
JOURNAL ARTICLE
Mehdi Azizmohammad Looha, Nazanin Taraghikhah, Maedeh Amini, Pegah Salimi Pormehr, Negin Talaei, Mahmood Khodadoost, Saeid Gholamzadeh, Reza Vafaee, Gohar Mohammadi
BACKGROUND: Little is known about the association between Human Immunodeficiency Virus (HIV) infection and risk of death among hospitalized COVID-19 patients. We aimed to investigate this association using a multicenter study. MATERIAL AND METHODS: This multicenter study was conducted using the registry database of Coronavirus Control Operations Headquarter from March 21, 2021 to January 18, 2020 in the province of Tehran, Iran. The interest outcome was COVID-19 death among hospitalized patients living with and without HIV...
December 26, 2022: Human Antibodies
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