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Clinical and Experimental Nephrology

Yusuke Sakuhara, Saori Nishio, Fumihiko Hattanda, Takeshi Soyama, Bunya Takahashi, Daisuke Abo, Hidefumi Mimura
PURPOSE: To assess the safety and effectiveness of transcatheter arterial embolization (TAE) with tris-acryl gelatin microspheres for patients with symptomatic enlarged polycystic liver disease (PCLD). MATERIALS AND METHODS: This prospective study was approved by our hospital's institutional review board and planned for patients with symptoms related to enlarged PCLD, such as distended abdomen, gastrointestinal obstruction and abdominal pain. Hemi-hepatic embolization with tris-acryl gelatin microspheres was performed in the hepatic artery supplying the hepatic lobe that showed the predominant presence of cysts...
February 15, 2019: Clinical and Experimental Nephrology
Hajime Kaga, Atsushi Komatsuda, Soh Yamamoto, Tadashi Kikuchi, Mika Kamata, Akiko Sato, Masafumi Odaka, Shin-Ichi Yokota, Naoto Takahashi, Hideki Wakui
BACKGROUND: The prevalence of antibodies against M-type anti-phospholipase A2 receptor (PLA2R) was reported to be ~ 70-80% in early studies on idiopathic membranous nephropathy (iMN) cohorts from Western countries, China, and Korea, and ~ 50% in recent studies on two Japanese iMN cohorts. METHODS: We developed an in-house enzyme-linked immunosorbent assay (ELISA) for the detection of anti-PLA2R antibodies, and examined sera from 217 patients with iMN, 22 patients with secondary MN (sMN), and 50 healthy individuals...
February 13, 2019: Clinical and Experimental Nephrology
Haresh Selvaskandan, Chee Kay Cheung, Masahiro Muto, Jonathan Barratt
IgA nephropathy is an inflammatory renal disease characterised by the deposition of IgA in the glomerular mesangium and is the most commonly reported primary glomerulonephritis worldwide. Thirty to forty percent of patients with the disease develop progressive renal function decline, requiring renal replacement therapy within two decades of diagnosis. Despite this, accurate individual risk stratification at diagnosis and predicting treatment response remains a challenge. Furthermore, there are currently no disease specific treatments currently licensed to treat the condition due to long standing challenges in the nature and prevalence of the disease...
February 13, 2019: Clinical and Experimental Nephrology
Olga Kukuy, Batia Kaplan, Sizilia Golderman, Alexander Volkov, Adrian Duek, Merav Leiba, Ilan Ben-Zvi, Avi Livneh
BACKGROUND: Plasma cell dyscrasias (PCD) comprise a wide spectrum of disorders, which may adversely affect the kidney. However, in some PCD cases associated with kidney disease, the routine laboratory tests may be incapable to determine precisely the form of PCD, i.e., benign or malignant. Moreover, the kidney biopsy needed for precise diagnosis may be risky or declined. To overcome these limitations, we have developed and reported a new non-invasive technique based on serum free light chains (FLC) monomer (M) and dimer (D) pattern analysis (FLC MDPA), which allowed differentiation between malignant and benign PCD forms...
February 8, 2019: Clinical and Experimental Nephrology
Yuhei Otobe, Koji Hiraki, Chiharu Hotta, Kazuhiro P Izawa, Tsutomu Sakurada, Yugo Shibagaki
BACKGROUND: No longitudinal study has investigated the impact of combination of kidney function (KF) and physical function (PF) on cognitive decline in these patients. METHODS: We conducted a 2-year prospective cohort study enrolling 131 patients ≥ 65 years with pre-dialysis chronic kidney disease (CKD). We assessed cognitive function with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). We calculated %MoCA-J based on the rate of change between baseline and follow-up MoCA-J scores, and defined cognitive decline over 2 years as a %MoCA-J of less than the first quartile value...
February 8, 2019: Clinical and Experimental Nephrology
Fangfang Zhou, Geping Yu, Guoyu Wang, Yunzi Liu, Liwen Zhang, Weiming Wang, Nan Chen
BACKGROUND: Epidemiological studies suggest that higher serum uric acid (SUA) level is significantly associated with kidney disease development. However, it remains debatable whether higher SUA is independently associated with new-onset kidney disease and rapid eGFR decline in individuals with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m2 and negative proteinuria. METHODS: This was a large, single-center, retrospective 6-year cohort study at People's Hospital of Tonglu County, Zhejiang, from 2001 to 2006...
February 8, 2019: Clinical and Experimental Nephrology
Qian Xu, Hangdi Wu, Lihan Zhou, Jingyuan Xie, Wen Zhang, Haijin Yu, Weiming Wang, Ying Qian, Qianying Zhang, Panpan Qiao, Yonghua Tang, Xiaonong Chen, Zhaohui Wang, Nan Chen
BACKGROUND: We aimed to investigate the clinical characteristics of Chinese patients with unilateral renal agenesis. METHODS: We enrolled patients with unilateral renal agenesis diagnosed radiologically at the Department of Nephrology from January 2008 to January 2016. Patients with a solitary kidney due to nephrectomy or renal atrophy due to secondary factors were excluded. Clinical data were recorded and analyzed. RESULTS: In this study, 118 Chinese patients with unilateral renal agenesis were recruited, and the gender ratio (male/female) was 1...
February 8, 2019: Clinical and Experimental Nephrology
Ioannis Bellos, Dimitrios C Iliopoulos, Despina N Perrea
BACKGROUND: Acute kidney injury constitutes a major complication of cardiac surgery in pediatric patients. The present meta-analysis aims to accumulate current literature and assess the efficacy of pharmacological interventions in preventing postoperative renal dysfunction after congenital heart surgery. METHODS: Literature search was conducted using Medline (1966-2018), Scopus (2004-2018), Cochrane Central Register of Controlled Trials CENTRAL (1999-2018), Clinicaltrials...
February 8, 2019: Clinical and Experimental Nephrology
Hideyo Oguchi, Ken Sakai, Yutaka Yamaguchi, Tetuo Mikami, Tetsuo Nemoto, Yasushi Ohashi, Takeshi Kawamura, Masaki Muramatsu, Yoshihiro Itabashi, Kazunobu Shinoda, Yoji Hyodo, Yusuke Takahashi, Yuki Kawaguchi, Hiroka Onishi, Yuko Hamasaki, Kazutoshi Shibuya, Seiichiro Shishido
AIM: We examined the clinicopathologic significance of hyalinosis in the vasa recta in the medulla of allograft kidney biopsies. METHOD: We analyzed biopsy specimens from January 2010 to December 2015, obtained from both the cortex and medulla (including the vasa recta) ≥ 1 year after living-donor kidney transplantation. We excluded biopsy specimens from recipients who had undergone transplantation due to diabetic nephropathy or who had diabetes mellitus after transplantation...
February 8, 2019: Clinical and Experimental Nephrology
Takashi Takaki, Nobuhiko Ohno, Sei Saitoh, Masaaki Nagai, Kensuke Joh
BACKGROUND: The interaction among the glomerular components plays an important role in the development of glomerular lesions; thus, investigation of the ultrastructural three-dimensional (3D) configuration of the human glomerular cells and extracellular matrix (ECM) is important for understanding the pathogenesis of glomerulosclerosis, especially glomerulonephritis. METHODS: We applied a new technique of serial block-face scanning electron microscopy (SBF-SEM), which helps to acquire serial electron microscopic images to reconstruct a 3D ultrastructure, to a human kidney biopsy specimen obtained from a 25-year-old woman with lupus nephritis...
February 8, 2019: Clinical and Experimental Nephrology
Abhilash Koratala
No abstract text is available yet for this article.
February 8, 2019: Clinical and Experimental Nephrology
Kazuko Kotoku, Tetsuhiko Yasuno, Shotaro Kawakami, Kanta Fujimi, Takuro Matsuda, Shihoko Nakashima, Yoshinari Uehara, Hiroaki Tanaka, Takao Saito, Yasuki Higaki
BACKGROUND: Acute exercise reduces renal blood flow (RBF). However, the effect of exercise intensity on RBF in patients with chronic kidney disease (CKD) stage 2 is not known. We investigated the association between RBF and exercise intensity in patients with CKD stage 2 using pulsed Doppler ultrasonography. METHODS: Eight men with CKD stage 2 (cystatin C-based estimate of glomerular filtration rate: 60-89 ml/min/1.73 m2 ) participated in this study. Using a bicycle ergometer, participants undertook a maximal graded exercise test (MGET) (experiment 1) and a multi-stage exercise test (experiment 2) to determine their lactate threshold (LT)...
February 7, 2019: Clinical and Experimental Nephrology
Malik Aydin, Ingo Franke, Lisa Kurylowicz, Rainer Ganschow, Michael Lentze, Mark Born, Rebekka Hagemann
BACKGROUND: Long-term outcomes of children with nephrotic syndrome have not been well described in the literature. METHODS: Cross-sectional study data analysis of n = 43 patients with steroid-sensitive (SSNS) and n = 7 patients with steroid-resistant (SRNS) nephrotic syndrome were retrospectively collected; patients were clinically examined at a follow-up visit (FUV), on average 30 years after onset, there was the longest follow-up period to date. RESULTS: The mean age at FUV was 33...
February 5, 2019: Clinical and Experimental Nephrology
Keita Hirano, Daiki Kobayashi, Naoto Kohtani, Yukari Uemura, Yasuo Ohashi, Yasuhiro Komatsu, Motoko Yanagita, Akira Hishida
BACKGROUND: Chronic kidney disease (CKD) is a public health challenge; however, evidence-based, optimal follow-up intervals for patients with CKD have not been identified. This study aimed to identify appropriate follow-up intervals for different stages of CKD. METHODS: We studied 2682 patients with CKD. The number of patients experiencing a 50% increase in creatinine and those reaching end-stage renal failure were examined on the basis of their CKD stage. The renal function testing interval was defined as the estimated time for 0...
January 28, 2019: Clinical and Experimental Nephrology
Akira Suzuki, Yoshitsugu Obi, Terumasa Hayashi, Naoto Kotani, Yukari Uemura, Enyu Imai, Hirofumi Makino, Akira Hishida
BACKGROUND: Greater variability in estimated glomerular filtration rate (eGFR) is associated with mortality in patients with chronic kidney disease (CKD). However, the association between eGFR variability and cardiovascular (CV) mortality and/or end-stage kidney disease (ESKD) in the CKD population is not very clear. This study aimed to clarify whether such an association exists. METHODS: We analyzed a final cohort of 2869 eligible Asian patients with CKD. Patients were stratified into three groups according to eGFR variability during the first year and were followed-up for a median of 3...
January 28, 2019: Clinical and Experimental Nephrology
Yusuke Kajimoto, Yoko Endo, Mika Terasaki, Shinobu Kunugi, Toru Igarashi, Akiko Mii, Yasuhiro Terasaki, Akira Shimizu
BACKGROUND: Thin basement membrane nephropathy (TBMN) is diagnosed by diffuse thinning of the glomerular basement membrane (GBM) without any clinical and pathologic findings of Alport syndrome and the other renal diseases. TBMN is characterized clinically by benign familial hematuria but rarely develops into end-stage renal disease. METHODS: In 27 cases of biopsy-proven TBMN, we evaluated the pathologic characteristics of TBMN, and examined the correlation between these pathologic characterizations and renal dysfunction...
January 28, 2019: Clinical and Experimental Nephrology
Tetsuhiro Tanaka, Masaomi Nangaku, Enyu Imai, Yoshiharu Tsubakihara, Masatoshi Kamai, Michihito Wada, Shinji Asada, Tadao Akizawa
In the original publication of the article, two sentences in the "Results" section were published incorrectly. The corrected texts are provided below.
January 23, 2019: Clinical and Experimental Nephrology
Takashin Nakayama, Yu Mimura, Keita Hirano
No abstract text is available yet for this article.
January 19, 2019: Clinical and Experimental Nephrology
Atsushi Okada, Ryosuke Ando, Kazumi Taguchi, Shuzo Hamamoto, Rei Unno, Teruaki Sugino, Yutaro Tanaka, Kentaro Mizuno, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui
BACKGROUND: Risk assessment for urinary stones has been mainly based on urinary biochemistry. We attempted to identify the risk factors for urinary stones by statistically analyzing urinary biochemical and inflammation-related factors. METHODS: Male participants (age, 20-79 years) who visited Nagoya City University Hospital were divided into three groups: a control group (n = 48) with no history of stones and two stone groups with calcium oxalate stone experience (first-time group, n = 22; recurring group, n = 40)...
January 18, 2019: Clinical and Experimental Nephrology
Konstantinos Koutroutsos, Rawya Charif, Linda Moran, Jill Moss, Terence Cook, Candice Roufosse, Charles Pusey, David Taube, Marina Loucaidou
BACKGROUND: Post-transplant focal segmental glomerulosclerosis (FSGS) is associated with renal allograft loss. Currently, optimal treatment remains controversial. METHODS: The aim of our study was to examine the efficacy and safety of therapeutic plasma exchange (TPE), and rituximab (RTX), in the management of post-transplant FSGS. The treatment protocol consisted of RTX and monthly cycles of 5 plasma exchanges for 6 months. We treated 10 transplant recipients with biopsy-proven post-transplant FSGS...
January 14, 2019: Clinical and Experimental Nephrology
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