journal
Journals Clinical Hemorheology and Micr...

Clinical Hemorheology and Microcirculation

https://read.qxmd.com/read/38995770/the-value-of-contrast-enhanced-ultrasound-combined-with-microflow-imaging-in-predicting-microvascular-invasion-of-hepatocellular-carcinoma-before-operation
#1
JOURNAL ARTICLE
Yingtan Zhang, Xiao Chen, Peipei Li, Jiesi Zhang, Qiujie Yu, Li Li
OBJECTIVE: To evaluate the preoperative predictive value of contrast-enhanced ultrasound (CEUS) combined with microflow imaging (MFI) in microvascular invasion (MVI) of hepatocellular carcinoma (HCC). METHODS: In our study, 80 patients with HCC were analyzed retrospectively. According to the gold standard of postoperative pathology, the patients were divided into MVI positive group (n = 39) and MVI negative group (n = 41). we were to analyze the correlation between CEUS and MVI in combination with MFI, to identify independent risk factors for the occurrence of MVI positive, and to analyze the predictive efficacy of every independent risk factor and their combination in preoperative prediction of MVI...
July 9, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38995769/ultrasound-findings-and-clinical-characteristics-in-differentiating-renal-urothelial-carcinoma-from-endophytic-clear-cell-renal-cell-carcinoma
#2
JOURNAL ARTICLE
Dong-Dong Jin, Jin-Hua Lin, Shi-Hui Li, Bo-Wen Zhuang, Xiao-Yan Xie, Xiao-Hua Xie, Yan Wang
OBJECTIVE: This study aimed to evaluate the clinical characteristics and features of conventional ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) in differentiating between renal urothelial carcinomas (RUC) and endophytic clear cell renal cell carcinomas (EccRCC). METHODS: A total of 72 RUCs and 120 EccRCCs confirmed by pathology were assessed retrospectively. Both CUS and CEUS were performed within 4 weeks before the surgery. Logistic regression analyses were used to select statistically significant variables of clinical, CUS, and CEUS features for the differentiation of RUC and EccRCC...
July 9, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38995771/increased-platelet-leucocyte-complexes-do-not-result-in-coagulation-activation-in-plateletpheresis-donors
#3
JOURNAL ARTICLE
Fatih Tastekin, Olga Meltem Akay, Ertugrul Colak, Eren Gunduz
BACKGROUND: Although plateletpheresis donation is commonly accepted as a safe procedure, its influence on platelet function, coagulation system and fibrinolysis is not completely elucidated. OBJECTIVES: In this study, we tried to assess the effects of plateletpheresis on donor's hemostasis system by measuring platelet activation, development of platelet-leukocyte aggregates, and coagulation activation. STUDY DESIGN: Prospective observational study...
July 8, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38995768/protective-effects-of-ruscus-extract-in-combination-with-ascorbic-acid-and-hesperidine-methylchalcone-on-increased-leukocyte-endothelial-interaction-and-macromolecular-permeability-induced-by-ischemia-reperfusion-injury
#4
JOURNAL ARTICLE
Maria das Gra├žas C de Souza, Fatima Z G A Cyrino, Eliete Bouskela
BACKGROUND: Despite the well-recognized effectiveness of Ruscus aculetus extract combined or not with ascorbic acid (AA) and hesperidine methyl chalcone (HMC) on ischemia reperfusion (I/R) injury protection, little is known about the contribution of each constituent for this effect. OBJECTIVE: To investigate the effects of AA and HMC combined or not with Ruscus extract on increased macromolecular permeability and leukocyte-endothelium interaction induced by I/R injury...
July 6, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38968045/h19-lncrna-triggers-ferroptosis-exacerbating-ox-ldl-induced-artery-endothelial-cell-damage-in-vitro
#5
JOURNAL ARTICLE
Feng Tang, Long-Hai Tian, Xiao-Han Zhu, Sen Yang, Huan Zeng, Yong-Yao Yang
BACKGROUND: The precise association between lncRNA H19 and ferroptosis in the context of atherosclerosis remains uncertain. OBJECTIVE: This study is to clarify the underlying process and propose novel approaches for the advancement of therapeutic interventions targeting atherosclerosis. METHODS: Assessment of ferroptosis, which entails the evaluation of cell viability using CCK-8 and the quantification of intracellular MDA, GSH, and ferrous ions...
July 1, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38943385/lnc-216-regulates-the-mir-143-5p-mmp2-signaling-axis-aggravates-retinal-endothelial-cell-dysfunction
#6
JOURNAL ARTICLE
Fang Wang, Zhangmei Guo, Guiqi Yang, Fan Yang, Qi Zhou, Hongbin Lv
PURPOSE: Diabetic retinopathy (DR) is a serious retinal vascular disease that affects many individuals in their prime working years. The present research aimed at whether and how LOC681216 (LNC-216) is involved in retinal vascular dysfunction under diabetic conditions. METHODS: Rat retinal microvascular endothelial cells (RRMECs) treated with high glucose (HG) were used for functional analysis. Gene expression analysis was conducted using the Clariom D Affymetrix platform...
June 27, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38943384/temporary-decrease-in-microvascular-tissue-saturation-after-transcatheter-aortic-valve-implantation
#7
JOURNAL ARTICLE
Manuel Stern, Sven Baasen, Patricia Wischmann, Theresa Herbrand, Johanna Schremmer, Oliver Maier, Marc Stern, Christian Jung, Christian Heiss, Malte Kelm, Roberto Sansone, Lucas Busch
BACKGROUND: Data on the effect of transcatheter aortic valve implantation (TAVI) on peripheral microcirculation are limited. OBJECTIVE: The aim of this study is to evaluate peripheral microvascular tissue saturation (StO2) before and after TAVI in relation to central and peripheral hemodynamics, cardiac and renal function. METHODS: In this single-center prospective study, patients with severe aortic stenosis (sAS) scheduled for TAVI or cardiac catheterization (control) were assessed before and up to five days after the procedure...
June 25, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/37066904/inhibition-of-circ_0000231-suppresses-oxidized-low-density-lipoprotein-induced-apoptosis-autophagy-and-inflammation-in-human-umbilical-vein-endothelial-cells-by-regulating-mir-590-5p-pdcd4-axis
#8
JOURNAL ARTICLE
Haiyan Lin, Da Gao, Shengjie Wang, Zicheng Wang, Haiwang Guan, Yanwei Wang, Ying Zhou
BACKGROUND: Circular RNAs (circRNAs) are the emerging informative RNAs, involved in cardiovascular diseases including atherosclerosis (AS). Endothelial injury is the initial qualitative change of AS. Thus, the objective of this study was to confirm the dysregulation and mechanism of circ_0000231 in cell model of AS at early stage in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (ox-LDL). METHODS: The expression of circ_0000231, miR-590-5p and programmed cell death 4 (PDCD4) was detected using real-time quantitative PCR and western blot...
June 21, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38905035/calculated-whole-blood-viscosity-in-non-diabetic-subjects-with-asymptomatic-carotid-atherosclerosis-how-insulin-resistance-may-affect-blood-viscosity
#9
JOURNAL ARTICLE
G Caimi, C Urso, S Brucculeri, R Lo Presti, M Carlisi
BACKGROUND AND OBJECTIVE: Asymptomatic atherosclerosis is an important early marker of vascular damage and, among its risk factors, hemorheological alterations play an important role. PATIENTS AND METHODS: In a cohort of 85 non-diabetic subjects with asymptomatic carotid atherosclerosis (ACA), we have measured whole blood viscosity (cWBV) according to the haematocrit and plasma fibrinogen level. The cWBV distinguish the subgroup of ACA subjects with 3-5 cardiovascular risk factors (CRFs) from that with 1-2 CRFs and the same behavior is present for haematocrit and plasma fibrinogen level...
June 20, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38905038/impact-and-mechanisms-of-drag-reducing-polymers-on-shear-stress-regulation-in-pulmonary-hypertension
#10
JOURNAL ARTICLE
Yali Wang, Qing Ye, Yongqi Cui, Yunjiang Wu, Sipei Cao, Feng Hu
BACKGROUND: Pulmonary hypertension (PH) is a refractory disease characterized by elevated pulmonary artery pressure and resistance. Drag-reducing polymers (DRPs) are blood-soluble macromolecules that reduce vascular resistance by altering the blood dynamics and rheology. Our previous work indicated that polyethylene oxide (PEO) can significantly reduce the medial wall thickness and vascular resistance of the pulmonary arteries, but the specific mechanism is still unclear. METHODS: This study was designed to investigate the role and mechanism of PEO on intracellular calcium [Ca2 +] i and cytoskeletal proteins of endothelial cells (ECs) induced by low shear stress (LSS) in PH...
June 19, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38905037/a-comparative-study-of-blood-viscometers-of-3-different-types
#11
JOURNAL ARTICLE
Ju Seok Oh, Prem Prabhakaran, Dong Kil Seo, Do Yeon Kim, Woonhyoung Lee, Kyung Hyun Ahn
 The greater the viscosity of the blood, the more difficult its flow becomes, leading to an increased incidence of diseases caused by blood circulation disorders. These diseases are commonly associated with the cardiovascular and cerebrovascular systems. High blood viscosity is a primary cause of circulatory system diseases. Studies have shown that accurately measuring blood viscosity and applying this data in clinical trials can help prevent circulatory system diseases. Viscosity data can vary depending on the measurement methods used, even when these methods are based on hydrodynamic principles...
June 19, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38905036/baicalein-alleviates-palmitic-acid-induced-endothelial-cell-dysfunction-via-inhibiting-endoplasmic-reticulum-stress
#12
JOURNAL ARTICLE
Jian Chen, Fei-Yu Chen, Chan-Jun Lu, Sheng-Wu Yi
OBJECTIVE: Endothelial cells play a critical role in maintaining vascular function and kinetic homeostasis, but excessive accumulation of palmitic acid (PA) may lead to endoplasmic reticulum stress and trigger endothelial cell dysfunction. Baicalin (BCL), a natural plant extract, has received widespread attention for its biological activities in anti-inflammation and anti-oxidative stress. However, the mechanism of BCL on PA-induced endothelial cell dysfunction is unclear. Therefore, the aim of this study was to investigate whether BCL could inhibit PA-induced endoplasmic reticulum stress and thus attenuate endothelial cell dysfunction...
June 19, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38848169/effect-of-alprostadil-plus-cilostazol-on-the-treatment-outcomes-and-inflammatory-factors-in-patients-with-lower-extremity-arteriosclerosis-obliterans-receiving-evidence-based-care
#13
JOURNAL ARTICLE
Hai Liang, Panwang Liu, Miao Yang, Panpan Di, Wei Wu, Huafeng Li, Yuchen Liu
This study aims to elucidate the effect of alprostadil (ALP) plus cilostazol (CIL) on the treatment outcomes and inflammatory factors in patients with lower extremity arteriosclerosis obliterans (LEASO) receiving evidence-based care. Firstly, 130 patients with LEASO were selected from February 2020 to February 2023 and then randomly divided into two groups with 65 patients each. Excluding the dropouts, 59 patients in the control group (6 cases of dropout) received ALP and 62 patients in the research group (3 cases of dropout) received ALP plus CIL...
June 6, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38848171/clinical-application-of-dual-layer-spectral-ct-multi-parameter-feature-to-predict-microvascular-invasion-in-hepatocellular-carcinoma
#14
JOURNAL ARTICLE
Yi-Xiang Li, Wen-Jing Li, Yong-Sheng Xu, Lu-Lu Jia, Miao-Miao Wang, Meng-Meng Qu, Li-Li Wang, Xian-de Lu, Jun-Qiang Lei
OBJECTIVE: This study aimed to investigate the feasibility of using dual-layer spectral CT multi-parameter feature to predict microvascular invasion of hepatocellular carcinoma. METHODS: This retrospective study enrolled 50 HCC patients who underwent multiphase contrast-enhanced spectral CT studies preoperatively. Combined clinical data, radiological features with spectral CT quantitative parameter were constructed to predict MVI. ROC was applied to identify potential predictors of MVI...
May 31, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38848170/contrast-enhanced-ultrasound-ceus-characteristics-of-atypical-enhanced-papillary-thyroid-carcinoma-ptc
#15
JOURNAL ARTICLE
Guojuan Wang, Ci Yin, Yanfang Wang, Qi Li, Dan Yang, Peihua Wang, Fang Nie
OBJECTIVE: To investigate the diagnostic value of CEUS in atypical-enhanced PTC. METHODS: The clinical data, qualitative and quantitative parameters of CEUS in 177 Iso/hyper-enhanced thyroid nodules with definite pathological results were retrospectively analyzed in the Lanzhou University Second Hospital from June 2019 to January 2021. And the clinical value of CEUS in the diagnosis of atypical-enhanced PTC was assessed using univariate and multivariate analysis...
May 31, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38820014/furin-knockdown-inhibited-endmt-and-abnormal-proliferation-and-migration-of-endothelial-cells
#16
JOURNAL ARTICLE
Rui Zeng, Yimin Wang, Jun Chen, Qiang Liu
BACKGROUND: In the pathogenesis of atherosclerotic cardiovascular disorders, vascular endothelium is crucial. A critical step in the development of atherosclerosis is endothelial dysfunction. Furin may play a factor in vascular remodeling, inflammatory cell infiltration, regulation of plaque stability, and atherosclerosis by affecting the adhesion and migration of endothelial cells. It is yet unknown, though, how furin contributes to endothelial dysfunction. METHODS: We stimulated endothelial cells with oxidized modified lipoprotein (ox-LDL)...
May 29, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38788062/quantitative-analysis-of-contrast-enhanced-ultrasound-and-superb-microvascular-imaging-for-the-evaluation-of-disease-activity-in-inflammatory-bowel-disease
#17
JOURNAL ARTICLE
Chi Zhang, Chunyao Zheng, Zhiqi Zhang, Xueliang Yan, Jianhua Xu, Changyan Gu, Fang Nie
OBJECTIVE: To evaluate the effectiveness of conventional US (ultrasound), SMI (superb microvascular imaging), and CEUS (contrast-enhanced ultrasound) features for the assessment of the activity of inflammatory bowel disease. METHODS: Conventional US, CEUS and SMI features of 76 patients were retrospectively analyzed. Patients were categorized into two groups: active group (n = 57) and inactive group (n = 19), with endoscopic results as reference standard...
May 24, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38788061/activation-of-pink1-parkin-mediated-mitochondrial-autophagy-alleviates-exertional-heat-stroke-induced-acute-lung-injury-in-rats
#18
JOURNAL ARTICLE
Jiaxing Wang, Zhengzhong Sun, Liya Jiang, Lyv Xuan, Yunya Ma, Jiao Wang, Yan Gu, Yuxiang Zhang
OBJECTIVE: To investigate the role of Pink1/Parkin-mediated mitochondrial autophagy in exertional heat stroke-induced acute lung injury in rats. METHODS: Sixty SD rats were divided into four groups: normal group (CON group), normal Parkin overexpression group (CON + Parkin group), exertional heat stroke group (EHS group), and exertional heat stroke Parkin overexpression group (EHS + Parkin group). Adeno-associated virus carrying the Parkin gene was intravenously injected into the rats to overexpress Parkin in the lung tissue...
May 18, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38788060/comparison-of-dexmedetomidine-versus-propofol-sedation-on-microcirculation-and-organ-injuries-in-critically-ill-surgical-patients-a-randomized-controlled-pilot-study
#19
JOURNAL ARTICLE
Po-Yu Chen, Hsing-Hao Huang, Wing-Sum Chan, Chih-Min Liu, Tsung-Ta Wu, Jyun-Han Chen, Anne Chao, Yu-Wen Tien, Ching-Tang Chiu, Yu-Chang Yeh
BACKGROUND: Recent studies have shown that dexmedetomidine may improve microcirculation and prevent organ failure. However, most evidence was obtained from experimental animals and patients receiving cardiac surgery with cardiopulmonary bypass. This study aimed to investigate the effect of dexmedetomidine on microcirculation and organ injuries in critically ill general surgical patients. METHODS: In this prospective randomized trial, patients admitted to the surgical intensive care unit after general surgery were enrolled and randomly allocated to the dexmedetomidine or propofol groups...
May 18, 2024: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/38758993/neutrophil-hdl-c-lymphocyte-hdl-c-and-monocyte-hdl-c-in-subjects-with-asymptomatic-carotid-atherosclerosis
#20
JOURNAL ARTICLE
Gregorio Caimi, Rosalia Lo Presti, Caterina Urso, Salvatore Brucculeri, Melania Carlisi
BACKGROUND: Leukocyte count is a prognostic marker for cardiovascular diseases, with key role in atherosclerosis development. Specific number of neutrophils, lymphocytes and monocytes can predict cardiovascular risk, also in asymptomatic subjects. Among the lipoprotein fractions, HDL-C is a protective factor in the cardiovascular disorders. For the above reason, we have examined the peripheral count of leukocytes, neutrophils, lymphocytes and monocytes, and the ratios between neutrophils/HDL-cholesterol, lymphocytes/HDL-cholesterol, and monocytes/HDL-cholesterol, to evaluate the possible utility of the obtained values in progression of asymptomatic carotid atherosclerosis...
May 16, 2024: Clinical Hemorheology and Microcirculation
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