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Clinical Hemorheology and Microcirculation

Giuseppe Di Stolfo
BACKGROUND: Carotid stenting stimulates intimal proliferation through platelet and stem cell activation. OBJECTIVE: The aim of this study is to evaluate whether the administration before or after carotid stenting of clopidogrel loading dose may play a role on circulating endothelial progenitor cells, stromal cell-derived factor-1α (SDF-1α) and neointimal hyperplasia. METHODS: We recruited 13 patients (aged 74.52±7.23) with indication of carotid revascularization and in therapy with salicylic acid and statin...
September 29, 2019: Clinical Hemorheology and Microcirculation
Katarzyna Filar-Mierzwa, Anna Marchewka, Zbigniew Dąbrowski, Aneta Bac, Jakub Marchewka
OBJECTIVE: The aim of this study was to analyse the effects of dance movement therapy exercises (DMT) on the rheological properties of blood in elderly women. METHODS: The study encompassed group of women (mean aged: 67 years), who were subjected to three-month dance movement therapy programme (n = 20). Blood samples from all the women were examined for their haematological, rheological, and biochemical parameters both prior to the study and three months thereafter...
January 31, 2019: Clinical Hemorheology and Microcirculation
Robert G Hahn, Emma Hasselgren, Håkan Björne, Markus Zdolsek, Joachim Zdolsek
BACKGROUND: Injury (shedding) of the endothelial glycocalyx layer, which alters local blood flow and microvascular permeability, is assessed by measuring components of this layer in circulating blood. The influence of renal function on their concentrations is unknown. METHODS: Plasma and urine concentrations of three shedding products (syndecan-1, hyaluronic acid, and heparan sulfate) and creatinine were measured over 5 hours in 15 healthy volunteers and 15 postoperative patients; this guaranteed a spread of kidney functions...
January 31, 2019: Clinical Hemorheology and Microcirculation
Laurence Beral, Marc Romana, Nathalie Lemonne, Thierry David, Philippe Connes
No abstract text is available yet for this article.
January 29, 2019: Clinical Hemorheology and Microcirculation
Annika Bach, Clarissa Hameister, Torsten Slowinski, Ernst Michael Jung, Anke Thomas, Thomas Fischer
BACKGROUND: Besides mammography, breast ultrasound is the most important imaging modality for women with suspected breast cancer. New software tools bear high potential for improved detectability and specification of malignant breast lesions. OBJECTIVE: To compare the halo depicted around malignant breast lesions by ultrasound using Acoustic Structure Quantification (ASQ) of raw image data with the echogenic rim seen in B-mode ultrasound. METHODS: This retrospective study included 37 women for whom conventional B-mode ultrasound of the breast and ASQ were available as well as histopathology findings for comparison...
January 29, 2019: Clinical Hemorheology and Microcirculation
Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Sunhye Shin, Sang Woo Kim, Seahyoung Lee, Soyeon Lim, Ki-Chul Hwang
BACKGROUND: Cardiac hypertrophy is an important risk factor for heart failure. The MEK-ERK axis has been reported as a major regulator in controlling cardiac hypertrophy. TAK733 is a potent and selective MEK inhibitor that suppresses cell growth in a broad range of cell lines. OBJECTIVE: Therefore, we aimed to investigate the anti-hypertrophic effect of TAK733 in cardiomyocytes. METHODS: Cardiomyocyte hypertrophy was induced with norepinephrine (NE) or phenylepinephrine (PE) using H9c2 cells...
January 29, 2019: Clinical Hemorheology and Microcirculation
Yi Zhang, Ruipeng Wu, Cheng Gu, Fulin Gao, Xiaojuan Hu, Tong Dong, Peixi Zang
OBJECTIVE: To investigate the role and potential mechanism of Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway in cognitive impairment induced by cerebral small vascular disease (CSVD), so as to provide a reference for the clinical treatment of CSVD-induced cognitive impairment. METHODS: Mice with TLR4 gene knockout (n = 20) and those with wild-type TLR4 gene (n = 40) aged 8-10 weeks old were divided into blank control group (Control group, n = 20), wild-type + CSVD group (WT + CSVD group, n = 20) and TLR4 gene knockout + CSVD group (TLR4 KO + CSVD group, n = 20)...
January 23, 2019: Clinical Hemorheology and Microcirculation
Le-Hang Guo, Dan-Dan Li, Dan Wang, Xiao-Long Li, Bo-Ji Liu, Shi-Gao Chen, Hui-Xiong Xu
OBJECTIVE: To investigate the stiffness distribution in the ablated zone after radiofrequency ablation (RFA), we used a device called tissue elastometer based on gross liver samples. MATERIALS: AND METHODS: Twelve freshly excised porcine livers were subject to RFA under a same setup to form elliptic ablated samples. Each sample was cut open for gross examination, and then the surface of the section plane was sliced into one piece for Young's modulus test using the tissue elastometer...
January 23, 2019: Clinical Hemorheology and Microcirculation
Isabell Renno, Anja M Boos, Raymund E Horch, Ingo Ludolph
BACKGROUND: Negative pressure wound therapy applied over closed incisions (ciNPT) has been shown to influence wound healing. Therefore, the aim of this study was to examine the short-term effects of ciNPT on skin perfusion patterns in postbariatric wounds. METHODS: 17 patients were included. Patients from the study group received a ciNPT dressing with a continuous negative pressure of - 125 mmHg for five days. Two intra- and two postoperative measurements were performed using both a combined laser Doppler spectrophotometry and an ICG angiography system to determine oxygen saturation (sO2), hemoglobin content (rHb) and perfusion patterns...
January 14, 2019: Clinical Hemorheology and Microcirculation
K Amit Saha, R Brendan Schmidt, Julie Wilhelmy, Vy Nguyen, Abed Abugherir, K Justin Do, Mohsen Nemat-Gorgani, W Ronald Davis, K Anand Ramasubramanian
BACKGROUND: Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disease. Amongst others symptoms, the disease is associated with profound fatigue, cognitive dysfunction, sleep abnormalities, and other symptoms that are made worse by physical or mental exertion. While the etiology of the disease is still debated, evidence suggests oxidative damage to immune and hematological systems as one of the pathophysiological mechanisms of the disease. Since red blood cells (RBCs) are well-known scavengers of oxidative stress, and are critical in microvascular perfusion and tissue oxygenation, we hypothesized that RBC deformability is adversely affected in ME/CFS...
December 28, 2018: Clinical Hemorheology and Microcirculation
Franz J Putz, Niklas Verloh, Anna Erlmeier, Roland C Schelker, Andreas G Schreyer, Matthias G Hautmann, Christian Stroszczynski, Bernhard Banas, Ernst M Jung
AIM: To assess the influence of difficult examination conditions onto the diagnostic performance of CEUS (contrast-enhanced ultrasound) in focal liver lesions (FLL). METHODS: 77 liver CEUS examinations of 75 patients were analysed retrospectively. CEUS was performed as the first diagnostic procedure by one experienced sonographer after bolus injection of 1.0 up to 2.4 ml sulphur hexafluoride microbubbles using a high-end ultrasound device with a high resolution multifrequency probe (1-6 MHz)...
December 18, 2018: Clinical Hemorheology and Microcirculation
Hoyoon Lee, Wonwhi Na, Byoung-Kwon Lee, Chae-Seung Lim, Sehyun Shin
The analysis of platelet aggregation and thrombosis kinetics has significantly advanced with progress in microfluidic technology. However, the results of platelet aggregation tests do not fully reflect the observed clinical outcomes. To address the present unmet clinical needs, the basic but essential biology of platelets should be reconsidered in relation to the characteristics of microfluidic systems employed for platelet tests. To this end, the present article provides an overview of commercially available point of care devices and focuses on recent microfluidic studies, describing their measurement principles...
December 18, 2018: Clinical Hemorheology and Microcirculation
M Georgieva, L Prantl, K Utpatel, I Wiesinger, C Stroszczynski, F Jung, E M Jung
OBJECTIVE: Objective of the study was to assess the performance of ultrasound strain elastography combined with conventional B-mode ultrasound to diagnose suspicious breast lesions (BI-RADS 4 and 5). METHODS: Between January 2015 and December 2017, a total of 86 patients (55±17.9 years) with solid or unclear, non-cystic breast lesions were enrolled in the study. The breast lesions were evaluated by B-mode ultrasound and subsequent ultrasound strain elastography...
December 18, 2018: Clinical Hemorheology and Microcirculation
Gabor Varga, Souleiman Ghanem, Balazs Szabo, Kitti Nagy, Noemi Pal, Bence Tanczos, Viktoria Somogyi, Barbara Barath, Adam Deak, Katalin Peto, Norbert Nemeth
BACKGROUND: Pathomechanism and optimal renoprotective protocol for remote ischemic preconditioning (RIPC) have not been completely revealed yet. OBJECTIVE: To investigate micro-rheological effects of early and delayed RIPC in renal ischemia-reperfusion (I/R) in the rat. METHODS: In Control group the left femoral artery was cannulated and the left kidney was gently exposed. In the I/R group 45-minute renal ischemia with 120-minute reperfusion period was monitored...
December 17, 2018: Clinical Hemorheology and Microcirculation
Sajad Ahmadizad, Ali Daraei, Minoo Bassami, Hiwa Rahmani
BACKGROUND: L-Arginine, the precursor of NO might be involved in improving the cardiovascular disorders via regulation of functional properties of erythrocytes. OBJECTIVE: This study investigated the effects of L-Arginine supplementation on responses of red blood cell (RBC) properties to high intensity interval exercise (HIIE). METHODS: Ten overweight healthy men participated voluntarily in the study and performed two HIIE trials with and without L-Arginine in two separate weeks...
December 17, 2018: Clinical Hemorheology and Microcirculation
Jarod T Horobin, Nobuo Watanabe, Masaya Hakozaki, Surendran Sabapathy, Michael J Simmonds
BACKGROUND: Red blood cells (RBC) are exposed to varying shear stress while traversing the circulatory system; this shear initiates RBC-derived nitric oxide (NO) production. OBJECTIVE: The current study investigated the effect of varying shear stress dose on RBC-derived NO production. METHODS: Separated RBC were prepared with the molecular probe, diamino-fluoreoscein diacetate, for fluorometric detection of NO. Prepared RBC were exposed to discrete magnitudes of shear stress (1-100 Pa), and intracellular and extracellular fluorescence was quantified via fluorescence microscopy at baseline (0 min) and discrete time-points (1-30 min)...
December 17, 2018: Clinical Hemorheology and Microcirculation
A Heine-Geldern, P N Broer, L Prantl, V Brebant, A M Anker, A Kehrer, A Thiha, D Lonic, D Ehrl, M Ninkovic, P I Heidekrueger
BACKGROUND: While complication rates in free tissue transfers have continuously decreased over time due to improved techniques, the intraoperative use of vasopressors and their negative effects on flap microcirculation and patency of the anastomoses remains controversial. To further elucidate this matter, this retrospective study examines the effect of intraoperative vasopressors on free gracilis muscle and free fasciocutaneous anterolateral thigh (ALT) flaps for lower extremity reconstruction...
December 17, 2018: Clinical Hemorheology and Microcirculation
Markus Reinthaler, Johan Bäckemo Johansson, Steffen Braune, Haitham Saleh Ali Al-Hindwan, Andreas Lendlein, Friedrich Jung
Circulating blood cells are prone to varying flow conditions when contacting cardiovascular devices. For a profound understanding of the complex interplay between the blood components/cells and cardiovascular implant surfaces, testing under varying shear conditions is required. Here, we study the influence of arterial and venous shear conditions on the in vitro evaluation of the thrombogenicity of polymer-based implant materials.Medical grade poly(dimethyl siloxane) (PDMS), polyethylene terephthalate (PET) and polytetrafluoroethylene (PTFE) films were included as reference materials...
December 17, 2018: Clinical Hemorheology and Microcirculation
G Negrão de Figueiredo, K Mueller-Peltzer, P Zengel, M Armbruster, J Rübenthaler, D A Clevert
BACKGROUND: Radiologic imaging, especially ultrasound has an important role in the assessment of gallbladder alteration. Contrast-enhanced ultrasound (CEUS) is an easy and fast imaging technique that overcomes the limitations of greyscale ultrasonography. It is a safe tool that can be used as an additional imaging modality in order to elucidate and differentiate gallbladder pathological findings. OBJECTIVE: The aim of this retrospective study analysis is to assess the diagnostic performance of CEUS in gallbladder alterations and compare the results to the histopathological findings...
December 17, 2018: Clinical Hemorheology and Microcirculation
G Negrão de Figueiredo, K Mueller-Peltzer, M Armbruster, J Rübenthaler, D A Clevert
BACKGROUND: The first method of choice for gallbladder alteration detection is the conventional ultrasound. Due to some imaging limitations, contrast-enhanced ultrasound (CEUS) has been widely used in the last years. CEUS is an additional modality that is able to depict microvessels flow and elucidate suspicious findings. OBJECTIVE: The aim of this retrospective mono-center analysis study is to evaluate the performance of CEUS in gallbladder diseases and compare it to cross-sectional imaging modalities and histopathological results as gold standard...
December 17, 2018: Clinical Hemorheology and Microcirculation
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