journal
https://read.qxmd.com/read/37738775/egress-of-resident-memory-t-cells-from-tissue-with-neoadjuvant-immunotherapy-implications-for-systemic-anti-tumor-immunity
#1
REVIEW
Magdalena A Rainey, Clint T Allen, Marco Craveiro
INTRODUCTION: Resident memory T (TRM ) cells are embedded in peripheral tissue and capable of acting as sentinels that can respond quickly to repeat pathogen exposure as part of an endogenous anti-microbial immune response. Recent evidence suggests that chronic antigen exposure and other microenvironment cues may promote the development of TRM cells within solid tumors as well, and that this TRM phenotype can sequester tumor-specific T cells into tumors and out of circulation resulting in limited systemic antitumor immunity...
September 20, 2023: Oral Oncology
https://read.qxmd.com/read/37734203/patterns-and-distribution-of-regional-nodal-involvement-and-recurrence-in-a-surgically-treated-oropharyngeal-squamous-cell-carcinoma-cohort-at-a-tertiary-center
#2
JOURNAL ARTICLE
Chadi N Abdel-Halim, Thomas J O'Byrne, Jeffrey P Graves, Christeebella O Akpala, Eric J Moore, Daniel L Price, Kendall T Tasche, Daniel J Ma, Michelle A Neben-Wittich, Scott C Lester, Mauricio Gamez, Katharine A Price, Harry E Fuentes Bayne, Jean Claude M Rwigema, Samir H Patel, Lisa A McGee, Jeffrey R Janus, Thomas H Nagel, Michael L Hinni, Panayiotis S Savvides, Kathryn M Van Abel, David M Routman
OBJECTIVES: To investigate and describe the patterns of regional metastases and recurrences after surgical treatment of oropharyngeal squamous cell cancer (OPSCC). MATERIALS AND METHODS: Retrospective study of patients diagnosed with OPSCC from 2006 to 2021 at a tertiary referral center. Only patients treated with surgery including a neck dissection were included. Patients with unknown human papillomavirus (HPV) status, prior head and neck cancer, distant metastases, or synchronous head and neck cancer were excluded...
September 19, 2023: Oral Oncology
https://read.qxmd.com/read/37717549/assessing-the-capacity-of-methylated-dna-markers-of-cervical-squamous-cell-carcinoma-to-discriminate-oropharyngeal-squamous-cell-carcinoma-in-human-papillomavirus-mediated-disease
#3
JOURNAL ARTICLE
Kathleen R Bartemes, Benjamin R Gochanour, David M Routman, Daniel J Ma, Karen A Doering, Kelli N Burger, Patrick H Foote, William R Taylor, Douglas W Mahoney, Calise K Berger, Xiaoming Cao, Sara S Then, Travis J Haller, Alyssa M Larish, Eric J Moore, Joaquin J Garcia, Rondell P Graham, Jamie N Bakkum-Gamez, John B Kisiel, Kathryn M Van Abel
OBJECTIVE: Early identification of human papillomavirus associated oropharyngeal squamous cell carcinoma (HPV(+)OPSCC) is challenging and novel biomarkers are needed. We hypothesized that a panel of methylated DNA markers (MDMs) found in HPV(+) cervical squamous cell carcinoma (CSCC) will have similar discrimination in HPV(+)OPSCC tissues. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissues were obtained from patients with primary HPV(+)OPSCC or HPV(+)CSCC; control tissues included normal oropharynx palatine tonsil (NOP) and cervix (NCS)...
September 15, 2023: Oral Oncology
https://read.qxmd.com/read/37713768/clinical-outcomes-following-observation-post-operative-radiation-therapy-or-post-operative-chemoradiation-for-hpv-associated-oropharyngeal-squamous-cell-carcinomas
#4
JOURNAL ARTICLE
Raj Singh, Shiyu Song
BACKGROUND: Intermediate and high-risk features (IRFs/HRFs) for locoregional recurrence following initial surgery for oropharyngeal SCCs (OP-SCCs) were defined prior to the known association of HPV with OP-SCC. There are limited reports on practice patterns and outcomes associated with post-operative radiation therapy (PORT) or chemoradiation (POCRT) for HPV-associated OP-SCCs. MATERIALS/METHODS: The National Cancer Database was queried for patients with HPV-associated OP-SCCs managed initially with surgery with IRFs or HRFs...
September 13, 2023: Oral Oncology
https://read.qxmd.com/read/37690364/lymph-node-ratio-independently-associated-with-postoperative-thyroglobulin-levels-in-papillary-thyroid-cancer
#5
JOURNAL ARTICLE
Hu Hei, Ziyu Luo, Chen Zheng, Wenbo Gong, Bin Zhou, Jugao Fang, Jianwu Qin
OBJECTIVES: To investigate the impact of the lymph node ratio (LNR) on postoperative thyroglobulin (Tg) levels in patients with papillary thyroid carcinoma (PTC). PATIENTS AND METHODS: This was a retrospective, cohort study. The association between clinicopathological variables and postoperative unstimulated Tg (uTg) levels, preablative-stimulated Tg (sTg) levels, and postablative unstimulated Tg levels was analysed. RESULTS: A total of 300 patients with PTC were identified...
September 8, 2023: Oral Oncology
https://read.qxmd.com/read/37683334/tongue-enlargement-associated-with-burning-sensation-an-atypical-case-of-breast-cancer-metastasis
#6
LETTER
Osias Vieira de Oliveira Filho, Dandara Menezes de Araújo Oliveira, Yuri de Lima Medeiros, Clóvis Antonio Lopes Pinto, Fabio Abreu Alves, Graziella Chagas Jaguar
No abstract text is available yet for this article.
September 6, 2023: Oral Oncology
https://read.qxmd.com/read/37672950/extra-imaging-beyond-nccn-surveillance-guidelines-is-cost-effective-for-hpv-but-not-hpv-oropharyngeal-cancer
#7
JOURNAL ARTICLE
Rema Shah, Sidharth Tyagi, Christina Liu, Benjamin Judson
No abstract text is available yet for this article.
September 4, 2023: Oral Oncology
https://read.qxmd.com/read/37666053/genome-wide-open-reading-frame-profiling-identifies-fibroblast-growth-factor-signaling-as-a-driver-of-pd-l1-expression-in-head-and-neck-squamous-cell-carcinoma
#8
JOURNAL ARTICLE
Jacqueline E Mann, Joshua D Smith, Aditi Kulkarni, Susan K Foltin, Erin B Scheftz, Isabel R Murray, Elizabeth Gensterblum-Miller, Collin V Brummel, Apurva Bhangale, Rebecca C Hoesli, J Chad Brenner
Head and neck squamous cell carcinomas (HNSCC) are associated with significant treatment-related morbidity and poor disease-free and disease-specific survival, especially in the recurrent and metastatic (R/M HNSCC) setting. Inhibition of the programmed death-1/ligand-1 (PD-1/PD-L1) immune checkpoint is accepted as a first-line treatment strategy for R/M HNSCC and has expanded into the neoadjuvant, definitive, and adjuvant settings. To understand cellular signals modulating the PD-L1 in HNSCC, we profiled a HNSCC cell-line with a genome-wide open reading frame (ORF) library of 17,000 individual constructs (14,000 unique genes)...
September 2, 2023: Oral Oncology
https://read.qxmd.com/read/37639766/radiation-therapy-for-ct1-2-carcinoma-of-the-palatine-tonsil-diagnosed-via-a-simple-tonsillectomy-dosimetry-and-patterns-of-care-in-the-imrt-era
#9
JOURNAL ARTICLE
Matthew C Ward, Michelle L Wallander, Jeffrey G Kuremsky, Reshika Dhakal, Lauren N Aldridge, Daniel S Brickman, Catherine H Frenkel, Zvonimir L Milas, James E McDermott, Jennifer L Atlas, Daniel R Carrizosa, Benjamin J Moeller
OBJECTIVE: Small carcinomas of the palatine tonsil are often diagnosed via simple tonsillectomy, a maneuver with non-therapeutic intent. Herein, practice patterns for this unique situation are evaluated. PATIENTS AND METHODS: A retrospective review was performed across 10 facilities to identify patients with cT1-2 squamous carcinomas of the tonsil diagnosed by simple tonsillectomy between 2010 and 2018. Patients who received curative-intent intensity modulated radiotherapy (IMRT) without additional surgery were included...
August 26, 2023: Oral Oncology
https://read.qxmd.com/read/37639765/induction-chemotherapy-response-of-hpv-related-multiphenotypic-sinonasal-carcinoma-first-ever-reported-therapeutic-outcome-and-a-brief-literature-review
#10
LETTER
Gustavo de Souza Vieira, Matheus Yung Perin, Tayná Figueiredo-Maciel, Amanda Jayne Guedes Risuenho, Vanessa Carvalho de Oliveira, Ligia Traldi Macedo, João Maurício Carrasco Altemani, Carlos Takahiro Chone, Erika Said Abu Egal, Carmen Silvia Passos Lima, Albina Altemani, Fernanda Viviane Mariano
A 54-year-old male patient complained of nasal obstruction and epistaxis for 2 years, with worsening of the symptoms in the preceding year. Physical examination revealed a friable, irregular mass, with yellowish secretion, in the left nasal fossa. Magnetic resonance imaging revealed an expansive lesion in the left nasal cavity, extending into the nasopharynx, ethmoid, right nasal cavity, and cortical bone of the hard palate. An incisional biopsy was then performed. Morphologically, a cellular malignant proliferation with a solid basaloid appearance admixed with adenoid cystic-like areas was observed...
August 26, 2023: Oral Oncology
https://read.qxmd.com/read/37633201/efficacy-of-induction-chemotherapy-in-lymph-node-positive-stage-iii-nasopharyngeal-carcinoma-and-identification-of-beneficiaries-based-on-clinical-features-a-propensity-score-matching-analysis
#11
JOURNAL ARTICLE
Yao-Can Xu, Kai-Hua Chen, Yong Liang, Ke-Quan Chen, Zhong-Guo Liang, Fan-Yan Zeng, Ling Li, Song Qu, Xiao-Dong Zhu
PURPOSE: To investigate the role of induction chemotherapy (IC) in lymph node-positive (LN-positive) stage III nasopharyngeal carcinoma (NPC) receiving concurrent chemoradiotherapy (CCRT). METHODS: In total, 627 patients with newly diagnosed LN-positive stage III NPC receiving CCRT or IC plus CCRT were included. The primary endpoint was progression-free survival (PFS). Propensity-score matching (PSM) was conducted to balance the intergroup covariates. Kaplan-Meier method with log-rank test was employed to compare survival curves...
August 24, 2023: Oral Oncology
https://read.qxmd.com/read/37633200/cost-benefit-analysis-of-immune-checkpoint-inhibitors-is-the-price-worth-their-value
#12
LETTER
Yash P Merchant, Vini Mehta, Muhammad Aaqib Shamim, Ankit Shah, Rathan Shetty
No abstract text is available yet for this article.
August 24, 2023: Oral Oncology
https://read.qxmd.com/read/37633199/letter-to-the-editor-regarding-gland-preserving-surgery-of-benign-parotid-tumors-via-postauricular-sulcus-incision-is-it-safe-and-effective-with-the-scarless-incision
#13
LETTER
Shihan Wu, Jia Qi, Maimaitituerxun Abudunaibi, Hui Xu
No abstract text is available yet for this article.
August 24, 2023: Oral Oncology
https://read.qxmd.com/read/37625360/time-to-treatment-patterns-of-head-and-neck-cancer-patients-before-and-during-the-covid-19-pandemic
#14
JOURNAL ARTICLE
Jason Tasoulas, Travis P Schrank, Blaine D Smith, Chris B Agala, Sulgi Kim, Siddharth Sheth, Colette Shen, Wendell G Yarbrough, Trevor Hackman, Christopher Blake Sullivan
OBJECTIVES: The delivery of healthcare has changed significantly over the past decades. This study analyzes the clinicodemographic factors and treatment patterns of head and neck squamous cell carcinoma (HNSCC) patients between 2004 and 2020. MATERIALS AND METHODS: Retrospective cohort analysis of HNSCC patients from the National Cancer Data Base from 2004 to 2020. RESULTS: A total of 164,290 patients were included. Increased times from diagnosis to definitive surgery (TTS) were seen across all facility types (academic centers, AC; non-academic centers, NAC) between 2004 and 2019, with NAC affected more...
August 23, 2023: Oral Oncology
https://read.qxmd.com/read/37619522/comment-on-role-of-ai-based-chatgpt-in-oral-and-maxillofacial-surgery-a-friend-or-foe
#15
LETTER
Amol S Dhane
No abstract text is available yet for this article.
August 22, 2023: Oral Oncology
https://read.qxmd.com/read/37619521/gene-expression-patterns-in-adenoid-cystic-carcinoma-with-and-without-diffuse-notch1-intracellular-domain-nicd1-immunohistochemistry-staining
#16
LETTER
Karan Patel, Massimiliano Manzo, Brindley Hapuarachi, Samuel Rack, Philip Jermann, Laura Feeney, Emily Heathcote, Guy Betts, Jon C Aster, Maximilien Murone, Maria Bobadilla, Rajwinder Lehal, Florian D Vogl, Kevin Harrington, Robert Metcalf
No abstract text is available yet for this article.
August 22, 2023: Oral Oncology
https://read.qxmd.com/read/37611434/feasibility-study-of-intensive-intervention-using-novel-trismus-device-during-adjuvant-radiation-for-head-and-neck-cancer-restorabite-tm
#17
LETTER
Emma Charters, Jamie Loy, Raymond Wu, Kai Cheng, Masako Dunn, Sarah Davies, Jonathan Clark
No abstract text is available yet for this article.
August 21, 2023: Oral Oncology
https://read.qxmd.com/read/37611433/mycobiota-profile-of-oral-fungal-infections-in-head-and-neck-cancer-patients-receiving-radiotherapy-a-6-year-retrospective-maldi-tof-mass-spectrometry-study
#18
JOURNAL ARTICLE
Khaled Al-Manei, Michał Jacek Sobkowiak, Rahul Harshad Nagadia, Robert Heymann, Margaret Sällberg Chen, Volkan Özenci
OBJECTIVES: Head and neck cancer (HNC) impairs patient immunity and increases susceptibility to oral fungal infections (OFIs). Effectively treating such infections requires accurate identification of the causative pathogens. This study aimed to characterize the mycobiota profile of OFIs in HNC patients undergoing radiation treatment (RT). MATERIALS AND METHODS: A 6-year retrospective analysis of oral mucosal samples from HNC patients with a history of RT and OFIs between 2014 and 2019 was conducted using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) profiling...
August 21, 2023: Oral Oncology
https://read.qxmd.com/read/37598609/relationship-between-glut-1-and-hif-1%C3%AE-is-it-a-friend-or-foe-for-studying-the-biological-behaviour-of-head-and-neck-tumorigenesis
#19
LETTER
Muthupandian Saravanan, Jesu Arockiaraj
No abstract text is available yet for this article.
August 18, 2023: Oral Oncology
https://read.qxmd.com/read/37595449/partial-response-to-rc-48-as-palliative-treatment-in-a-patient-with-locallocally-advanced-carcinoma-ex-pleomorphic-adenoma-harboring-a-her2-mutation-a-case-report
#20
JOURNAL ARTICLE
Wenyan Yu, Changli Ding, Kaichun Li
BACKGROUND: Carcinoma ex pleomorphic adenoma (CXPA) is a neoplasm of the salivary gland that causes 3.6% of salivary gland tumors and 12% of salivary gland malignancies. Its prognosis is determined by the histological progression beyond the adenoma capsule. CXPA is thought to be a malignant transformation of a primary or recurrent pleomorphic adenoma and is associated with both benign and malignant lesions. Salivary gland cancers represent a rare heterogeneous group of neoplasms with complex clinicopathological characteristics and distinct biological behavior...
August 16, 2023: Oral Oncology
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