Scott A Wilke, Crystal L Johnson, Juliana Corlier, Katharine G Marder, Andrew C Wilson, Christopher M Pleman, Andrew F Leuchter
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD). Psychostimulant medication use may be associated with improved rTMS outcomes, but a detailed understanding of these relationships is lacking. METHODS: We compared MDD subjects taking psychostimulants (n = 37) with those not taking one of these medications (n = 53) during a course of 30 rTMS treatments. Changes in the 30-item Inventory of Depressive Symptomatology Self Report (IDS-SR30) subscale scores were examined at treatment 30...
May 2022: Depression and Anxiety
Sofia Cussotto, Inês Delgado, Giovanni Oriolo, Jonas Kemper, Diane Begarie, Sandra Dexpert, Julie Sauvant, Marion Leboyer, Bruno Aouizerate, Rocío Martin-Santos, Martin Schaefer, Lucile Capuron
BACKGROUND: Major depressive disorder (MDD) is characterized by a high rate of treatment resistance. Omega (ω)-3 polyunsaturated fatty acids (PUFAs) were shown to correlate with depressive phenotype both in rodents and in humans. However, few studies to date have investigated the role of PUFAs in antidepressant response. The primary aim of this study was to assess the link between baseline PUFA composition and changes in depressive symptoms as well as antidepressant response in a multicenter study of depressed patients...
May 2022: Depression and Anxiety
Holger C Bringmann, Andreas Michalsen, Michael Jeitler, Christian S Kessler, Benno Brinkhaus, Stefan Brunnhuber, Peter Sedlmeier
OBJECTIVE: Depression is a global key challenge in mental health care. The implementation of effective, low-risk and cost-effective interventions to reduce its disease burden is a necessity. The aim of this study was to investigate the efficacy of the new Meditation-Based Lifestyle Modification (MBLM) program, a "second-generation" mindfulness-based intervention, in depressive outpatients. METHODS: Eighty-one patients with mild to moderate depression were randomized into three groups: intervention group (MBLM), control group (CONTROL), and treatment as usual group (TAU)...
May 2022: Depression and Anxiety
Zhishun Wang, Martine Fontaine, Marilyn Cyr, Moira A Rynn, Helen Blair Simpson, Rachel Marsh, David Pagliaccio
BACKGROUND: Obsessive-compulsive disorder (OCD) implicates alterations in cortico-striato-thalamo-cortical and fronto-limbic circuits. Building on prior structural findings, this is the largest study to date examining subcortical surface morphometry in OCD. METHODS: Structural magnetic resonance imaging data were collected from 200 participants across development (5-55 years): 28 youth and 75 adults with OCD and 27 psychiatrically healthy youth and 70 adults. General linear models were used to assess group differences and group-by-age interactions on subcortical shape (FSL FIRST)...
April 29, 2022: Depression and Anxiety
Thomas S Blank, Bernhard M Meyer, Marie-Kathrin Wieser, Ulrich Rabl, Paul Schögl, Lukas Pezawas
BACKGROUND: Early-onset (EO) major depressive disorder (MDD) patients experience more depressive episodes and an increased risk of relapse. Thus, on a neurobiological level, adult EO patients might display brain structure and function different from adult-onset (AO) patients. METHODS: A total of 103 patients (66 females) underwent magnetic resonance imaging. Structural measures of gray matter volume (GMV) and functional connectivity networks during resting state were compared between EO (≤19 years) and AO groups...
April 14, 2022: Depression and Anxiety
Kaori Saitoh, Takuya Yoshiike, Yoshiyuki Kaneko, Tomohiro Utsumi, Kentaro Matsui, Kentaro Nagao, Rei Otsuki, Sayaka Aritake-Okada, Hiroshi Kadotani, Kenichi Kuriyama, Masahiro Suzuki
BACKGROUND: Nonrestorative sleep (NRS), defined as insufficiently rested or refreshed sleep, is considered to play an important role in the development of depression. The aim of this study is to investigate the predictive ability of insomnia-related symptoms, including NRS, for incident depressive symptoms (DEPs) in a longitudinal manner. METHODS: We used data of 1196 samples aged 18-64 years who participated in both the Hispanic Community Health Study/Study of Latinos conducted in 2008-2010 and the follow-up study (Sueño Ancillary Study) conducted in 2010-2013...
April 4, 2022: Depression and Anxiety
Zhewu Wang, Zachary D Zuschlag, Ursula S Myers, Mark Hamner
BACKGROUND: PTSD and ADHD often occur comorbidly. Research indicates that the cognitive deficits in PTSD may be related to the same disturbance of fronto-temporal systems as observed in ADHD, and ADHD has been shown to impact PTSD treatment outcomes. The presented study evaluated the safety and efficacy of atomoxetine in Veterans with comorbid ADHD/PTSD. METHODS: A double blind, randomized, placebo controlled, cross-over pilot and feasibility study was conducted...
April 2022: Depression and Anxiety
Daifeng Dong, Emily L Belleau, Maria Ironside, Xue Zhong, Xiaoqiang Sun, Ge Xiong, Chang Cheng, Chuting Li, Xiang Wang, Shuqiao Yao, Diego A Pizzagalli
BACKGROUND: Emerging evidence has highlighted the moderating effect of childhood maltreatment (CM) in shaping neurobiological abnormalities in major depressive disorder (MDD). However, whether neural mechanisms underlying stress sensitivity in MDD are affected by the history of CM is unclear. METHODS: Two hundred and thirteen medication-free female participants were recruited for a functional magnetic resonance imaging study assessing the effects of psychosocial stress on neural responses...
April 2022: Depression and Anxiety
Richard A Bryant, Jenny Tran, Thomas Williamson, Mayuresh S Korgaonkar
BACKGROUND: A common feature of complex posttraumatic stress disorder (CPTSD) is impulsivity. Despite the importance of this characteristic in functional difficulties in CPTSD, little is known about its mechanisms. The aim of this study was to identify the distinctive neural profile of CPTSD during attempted inhibition. METHODS: The present study examined functional alterations in neural networks involved in inhibitory control across functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) paradigms in CPTSD (n = 30), PTSD (n = 40), and healthy control (n = 40) participants who completed a Go/NoGo response inhibition task during separate fMRI and EEG sessions...
April 2022: Depression and Anxiety
Ben Porter, Felicia R Carey, Kimberly A Roenfeldt, Rudolph P Rull, Carl A Castro
BACKGROUND: The transition from military to civilian life is a dramatic change that is often stressful for veterans. However, little is known regarding how mental health symptoms fluctuate in the period leading up to and following separation from the military. METHODS: The current study examined posttraumatic stress disorder and depression symptoms reported on surveys completed within 1 year of military separation from 23,887 active duty Millennium Cohort Study participants...
March 28, 2022: Depression and Anxiety
Nadia Al-Dajani, Adam G Horwitz, Ewa K Czyz
BACKGROUND: Youth suicide has been increasing at an alarming rate. Identifying how youth at risk for suicide cope with daily distress and suicidal thoughts could inform prevention and intervention efforts. We investigated the relationship between previous-day coping and next-day suicidal urge intensity in a high-risk adolescent sample for a 4-week period. We also investigated the influence of adolescents' average coping levels, over 4 weeks, on daily severity of suicidal urges. METHODS: A total of 78 adolescents completed daily diaries after psychiatric hospitalization (n = 1621 observations)...
March 24, 2022: Depression and Anxiety
Sage E Hawn, Zoe Neale, Erika J Wolf, Xiang Zhao, Meghan Pierce, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark Logue, Mark W Miller
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with inflammation and various forms of chronic disease. The Absent in Melanoma 2 (AIM2) gene has been implicated in mechanisms of inflammation and anxiety, and methylation at a particular locus in this gene (cg10636246) has previously been shown to influence the association between PTSD and elevated C-reactive protein levels in blood. METHOD: We tested if this association might extend to other indicators of inflammation and to plasma-based measures of neuropathology in a cohort of post-9/11 US military veterans...
March 21, 2022: Depression and Anxiety
Johannah Bashford-Largo, Ru Zhang, Avantika Mathur, Jaimie Elowsky, Amanda Schwartz, Matthew Dobbertin, Robert James R Blair, Karina S Blair, Sahil Bajaj
BACKGROUND: Widespread structural alterations have been shown to be implicated in individuals with generalized anxiety disorder (GAD). However, there have been inconsistent findings in cortical volume (CV) differences. Most structural neuroimaging studies looking at GAD used region-based approach with relatively small sample sizes, let alone be specific to adolescents with GAD. We believe this is the first study to look at CV measures using a network-based approach in a larger sample of adolescents with GAD...
March 21, 2022: Depression and Anxiety
Lee Smith, Jae Il Shin, Laurie Butler, Yvonne Barnett, Hans Oh, Louis Jacob, Karel Kostev, Nicola Veronese, Pinar Soysal, Mark Tully, Guillermo F López Sánchez, Ai Koyanagi
BACKGROUND: There is a scarcity of literature on the association between physical multimorbidity (i.e., ≥2 chronic physical conditions) and depression among older adults, especially from low- and middle-income countries (LMICs). In addition, the mediators in this association are largely unknown. Therefore, we aimed to examine this association among adults aged ≥50 years from six LMICs (China, Ghana, India, Mexico, Russia, and South Africa), and to identify potential mediators. METHODS: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health were analyzed...
March 21, 2022: Depression and Anxiety
Emily Olfson, Eli R Lebowitz, Grace Hommel, Neha Pashankar, Wendy K Silverman, Thomas V Fernandez
BACKGROUND: Genetic factors contribute to the development of anxiety disorders, yet few risk genes have been previously identified. One genomic approach that has achieved success in identifying risk genes in related childhood neuropsychiatric conditions is investigations of de novo variants, which has yet to be leveraged in childhood anxiety disorders. METHODS: We performed whole-exome DNA sequencing in 76 parent-child trios (68 trios after quality control) recruited from a childhood anxiety disorder clinic and compared rates of rare and ultra-rare de novo variants with 790 previously sequenced control trios (783 trios after quality control)...
March 21, 2022: Depression and Anxiety
Kewei Wang, Jun Qiu, Liping Meng, Xin Lai, Zhenzhen Yao, Songxu Peng
BACKGROUND: Many psychological and obstetrical factors contribute to the development of postpartum depression. However, little is known about how postpartum hemorrhage (PPH) influences postpartum depressive symptoms. This study explored the relationship between PPH and postpartum depressive symptoms in the Chinese population. METHODS: A retrospective cohort study was conducted at the Baoan Maternal and Child Health Hospital in Shenzhen, China, from January 2016 to June 2020...
March 2022: Depression and Anxiety
Hannah L Grassie, Sarah M Kennedy, Elizabeth R Halliday, Sierra A Bainter, Jill Ehrenreich-May
UNLABELLED: Depression and anxiety disorders confer a significant public health concern for youth and their co-occurrence places youth at a higher risk for poorer psychosocial outcomes. In the present study, we use network analysis to investigate the role of and interactions among individual depression and anxiety symptoms in a treatment-seeking clinical sample. METHODS: We estimate regularized partial correlation networks for youth- and parent reported symptoms in a transdiagnostic sample of youth (N = 417, ages 8-18)...
March 2022: Depression and Anxiety
Cindy-Lee Dennis, Flavia Marini, Justine Dol, Simone N Vigod, Sophie Grigoriadis, Hilary K Brown
OBJECTIVE: To determine the prevalence of comorbid depression and anxiety symptoms in fathers and investigate the predictors for comorbidity during the first- and second-year following birth. METHODS: In a longitudinal Canadian study, couples were recruited within 3 weeks of childbirth. Fathers completed a survey after the birth of their child followed by questionnaires at 3, 6, 9, 12, 18, and 24 months postpartum on paternal depression and anxiety symptoms and potential risk factors...
March 2022: Depression and Anxiety
Suzannah K Creech, Aimee Kroll-Desrosiers, Justin K Benzer, Carey S Pulverman, Kristin Mattocks
BACKGROUND: The experience of sexual assault and harassment during military service (military sexual trauma [MST]) is associated with increased risk for perinatal and reproductive health problems among women veterans. The objective of this study was to examine the associations between mothers' MST exposure and mother-infant bonding, as well as to examine whether there are any salient sociodemographic or military service characteristics among women veterans with greater impairment to mother-infant bonding, including stress during pregnancy and posttraumatic stress disorder (PTSD) diagnosis...
March 2022: Depression and Anxiety
Alex M Mirman, Juliana Corlier, Andrew C Wilson, Reza Tadayonnejad, Katharine G Marder, Christopher M Pleman, David E Krantz, Scott A Wilke, Jennifer G Levitt, Nathaniel D Ginder, Rashi Ojha, Zafiris J Daskalakis, Andrew F Leuchter, Jonathan C Lee
BACKGROUND: Symptoms of major depressive disorder (MDD) are reported to change early in treatment with repetitive transcranial magnetic stimulation (rTMS). We evaluated early changes in sleep, anxiety, and mood as predictors of nonresponse to rTMS treatment. METHODS: Three hundred twenty-nine subjects with nonpsychotic MDD completed a 6-week course of rTMS treatment. Subjects were stratified by the severity of their baseline depression, and had their overall depressive symptoms recorded every week of treatment...
February 2022: Depression and Anxiety
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