Shimin Zhang, Qiong Wang, Xiyuan Wang, Kaili Qi, Yanxin Zhou, Chengchao Zhou
BACKGROUND: The underlying mechanism between sensory impairments (SIs) and depressive symptoms among Chinese older adults is not well understood. This study aims to explore the mediating role of functional limitation on the longitudinal relationship between SIs and depressive symptoms among older adults in China. METHODS: A total of 4130 older adults who participated in the 3-year follow-up China Health and Retirement Longitudinal Study (CHARLS) were included in the analysis...
August 2022: Depression and Anxiety
Tatsui Otsuka, Yumi Sugawara, Sanae Matsuyama, Ichiro Tsuji
BACKGROUND: Social support (SS) has been reported as a factor preventing suicide death, but whether this association is independent of mental status is unclear. The present study examined the effect modification of SS on the association between psychological distress status and risk of suicide death. METHODS: Follow-up data for 43,015 subjects participating in a prospective cohort study were analyzed. At baseline, the subjects were asked about SS and mental status with the Kessler six-item Distress (K6) Scale...
August 2022: Depression and Anxiety
Mercedes J Szpunar, Marlene P Freeman, Lauren A Kobylski, Phoebe S Caplin, Peter Gaccione, Adele C Viguera, David Chitayat, Sonia Hernández-Díaz, Lee S Cohen
BACKGROUND: Perinatal anxiety affects 20% of women, and untreated maternal mental illness can cause deleterious effects for women and their children. Benzodiazepines are commonly used to treat anxiety disorders. The reported risk of congenital malformations after in utero benzodiazepine exposure has been inconsistent. METHODS: The Massachusetts General Hospital National Pregnancy Registry for Psychiatric Medications prospectively enrolls pregnant women with psychiatric illness who take one or more psychiatric medications...
July 31, 2022: Depression and Anxiety
Andrea D Spadoni, Meghan Vinograd, Bruna Cuccurazzu, Katy Torres, Laura M Glynn, Elysia P Davis, Tallie Z Baram, Dewleen G Baker, Caroline M Nievergelt, Victoria B Risbrough
BACKGROUND: Recent studies in both human and experimental animals have identified fragmented and unpredictable parental and environmental signals as a novel source of early-life adversity. Early-life unpredictability may be a fundamental developmental factor that impacts brain development, including reward and emotional memory circuits, affecting the risk for psychopathology later in life. Here, we tested the hypothesis that self-reported early-life unpredictability is associated with psychiatric symptoms in adult clinical populations...
July 14, 2022: Depression and Anxiety
Catrin Lewis, Katie Lewis, Alice Roberts, Claudia Evison, Bethan Edwards, Ann John, Keith Lloyd, Holly Pearce, Rob Poole, Natalie Richards, Catherine Robinson, Ian Jones, Jonathan I Bisson
BACKGROUND: Prevalence estimates of COVID-19-related posttraumatic stress disorder (PTSD) have ranged from 1% to over 60% in the general population. Individuals with lived experience of a psychiatric disorder may be particularly vulnerable to COVID-19-related PTSD but this has received inadequate attention. METHODS: Participants were 1571 adults with lived experience of psychiatric disorder who took part in a longitudinal study of mental health during the COVID-19 pandemic...
July 2022: Depression and Anxiety
Antonella Sociali, Marta Borgi, Mauro Pettorruso, Francesco Di Carlo, Chiara Di Natale, Antonio Tambelli, Maria C Alessi, Laura Ciavoni, Alessio Mosca, Andrea Miuli, Stefano L Sensi, Giovanni Martinotti, Francesca Zoratto, Massimo Di Giannantonio
BACKGROUND: Cognitive remediation (CR) is a promising technique in the treatment of the cognitive dimension of depression. The present study evaluated the potential of CR in treating depressive symptoms and provides practical information about its usefulness in clinical settings. METHODS: We performed two meta-analyses of published randomized (and nonrandomized) clinical trials, comparing CR to control conditions in subjects with current depressive symptomatology...
July 2022: Depression and Anxiety
Shin Tae Kim, Jun Ho Seo, Sangmin Lee, Sumoa Jeon, Chun Il Park, Se Joo Kim, Jee In Kang
BACKGROUND: The 2019 coronavirus disease (COVID-19) pandemic has had a profound impact on the mental health of people worldwide. This study examined dysfunctional coronavirus anxiety in nonpsychotic psychiatric outpatients during the pandemic using the coronavirus anxiety scale (CAS) and examined the relationship between coronavirus anxiety and clinical symptoms using network analysis. METHODS: In this cross-sectional study, 192 patients who first visited the psychiatric outpatient clinic of Severance Hospital during the COVID-19 pandemic with chief complaints of depressed mood, anxiety, somatic symptoms, or insomnia were included...
July 2022: Depression and Anxiety
Chang Liu, Zeyuan Wang, Qin Hui, Jack Goldberg, Nicholas L Smith, Amit J Shah, Nancy Murrah, Lucy Shallenberger, Emily Diggers, James Douglas Bremner, Yan V Sun, Viola Vaccarino
INTRODUCTION: Prior studies have shown inconsistent findings of an association between depression and epigenetic aging. DNA methylation (DNAm) age acceleration can measure biological aging. We adopted a robust co-twin control study design to examine whether depression is associated with DNAm age acceleration after accounting for the potential confounding influences of genetics and family environment. METHODS: We analyzed data on a sub-cohort of the Vietnam Era Twin Registry...
June 27, 2022: Depression and Anxiety
Hans S Schroder, Ka I Ip, Jessica L Hruschak, Faith Horbatch, Melissa Hall, Yanni Liu, Kristin Mannella, Maria Muzik, Kate L Rosenblum, Jason S Moser, Kate D Fitzgerald
OBJECTIVE: Underdeveloped cognitive control (CC)-the capacity to flexibly adjust to changing environments-may predispose some children to early onset anxiety disorders and represents a promising intervention target. The current study established and pilot-tested "Camp Kidpower"-a novel group-based, interactive CC training intervention-and assessed its impacts on behavioral and neurophysiological indices of CC among preschool children with elevated anxiety symptoms. METHODS: Forty-four anxious children (4-6 years) were enrolled in Camp Kidpower, delivered in four sessions over 10 days...
June 16, 2022: Depression and Anxiety
Stephen J Cozza, Christin M Ogle, Joscelyn E Fisher, Jing Zhou, Rafael F Zuleta, Carol S Fullerton, Robert J Ursano
BACKGROUND: Although much has been learned about the physical and psychological impacts of deployment and combat injury on military service members, less is known about the effects of these experiences on military spouses. METHODS: The present study examined self-reported mental health symptoms (using the Brief Symptom Inventory [BSI]-18 and the posttraumatic stress disorder [PTSD] Checklist [PCL-C]) in wives of service members who were combat-injured (CI; n = 60); noninjured with cumulative deployment longer than 11 months (NI-High; n = 51); and noninjured with cumulativel deployment less than 11 months (NI-Low; n = 53)...
June 16, 2022: Depression and Anxiety
Rong Bi, Wanxin Dong, Zixin Zheng, Sijin Li, Dandan Zhang
BACKGROUND: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards. However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear. METHODS: We conducted a functional magnetic resonance imaging study and employed an adapted Effort-Expenditure for Rewards Task in subthreshold depressive (SD) participants (n = 33) and healthy controls (HC) (n = 32)...
June 3, 2022: Depression and Anxiety
Murray B Stein Md Mph Frcpc
No abstract text is available yet for this article.
June 2022: Depression and Anxiety
Resh S Gupta, Lindsay Dickey, Autumn Kujawa
BACKGROUND: Stressful events, such as those imposed by the COVID-19 pandemic, are associated with depression risk, raising questions about processes that make some people more susceptible to the effects of stress on mental health than others. Emotion regulation may be a key process, but methods for objectively measuring emotion regulation abilities in youth are limited. We leveraged event-related potential (ERP) measures and a longitudinal study of adolescents oversampled for depression and depression risk to examine emotion regulation difficulties as prospective predictors of depressive symptoms in response to pandemic-related stress...
June 2022: Depression and Anxiety
Cheryl R Stein, Margaret A Sheridan, William E Copeland, Laura S Machlin, Kimberly L H Carpenter, Helen L Egger
BACKGROUND: The association between adversity and psychopathology in adolescents and adults is characterized by equifinality. These associations, however, have not been assessed during early childhood when psychopathology first emerges. Defining adversity using both dimensional and cumulative risk approaches, we examined whether specific types of adversity are differentially associated with psychopathology in preschool-aged children. METHODS: Measures of threat, deprivation, and total adversities (i...
June 2022: Depression and Anxiety
Lara J Farrell, Allison M Waters, Evelin Tiralongo, Sharna Mathieu, Matthew McKenzie, Vinay Garbharran, Robert S Ware, Melanie J Zimmer-Gembeck, Harry McConnell, Cassie Lavell, Jacinda Cadman, Thomas H Ollendick, Jennifer L Hudson, Ronald M Rapee, Brett McDermott, Daniel Geller, Eric A Storch
OBJECTIVE: To examine the efficacy of weight-adjusted D-cycloserine (DCS) (35 or 70 mg) relative to placebo augmentation of intensive exposure therapy for youth with obsessive-compulsive disorder (OCD) in a double-blind, randomised controlled trial, and examine whether antidepressant medication or patient age moderated outcomes. METHODS: Youth (n = 100, 7-17 years) with OCD were randomised in a 1:1 ratio to either DCS + exposure (n = 49) or placebo + exposure (n = 51)...
June 2022: Depression and Anxiety
Andy P Siddaway, Richard Meiser-Stedman, Verity Chester, Jack Finn, Cliodhna O Leary, David Peck, Camilla Loveridge
Trauma-focused guided self-help (TF-GSH) is an important alternative to psychological therapy delivered by a therapist. This meta-analysis evaluates the efficacy of TF-GSH in reducing posttraumatic stress disorder  (PTSD) symptoms and comorbid depressive and anxiety symptoms. A total of 17 trials were included that compared a TF-GSH intervention (N = 610) to various control comparators (N = 570). Control conditions included treatment as usual (k = 2), waiting list (k = 11), phone monitoring (k = 1), nontrauma writing (k = 1), general support (k = 1), and supportive counseling (k = 1)...
May 27, 2022: Depression and Anxiety
Noah T Kreski, Katherine M Keyes, Michael J Parks, Megan E Patrick
PURPOSE: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is associated with worsening mental health among young adults, but further research is necessary to quantify the associations with depression and anxiety. METHODS: Using Monitoring the Future data (N = 1244 young adults, modal age: 19, Fall 2020 supplement), we examined internalizing symptoms (Patient Health Questionnaire-8 and Generalized Anxiety Disorder Scale-7 separately), dividing the sample into those without clinically significant scores, significant scores but minimal pandemic-attributed symptoms, and significant scores with substantial pandemic-attributed symptoms...
May 27, 2022: Depression and Anxiety
Laura Nawijn, Richard Dinga, Moji Aghajani, Marie-José van Tol, Nic J A van der Wee, Andreas Wunder, Dick J Veltman, Brenda W H J Penninx
BACKGROUND: Comorbid anxiety disorders and anxious distress are highly prevalent in major depressive disorder (MDD). The presence of the DSM-5 anxious distress specifier (ADS) has been associated with worse treatment outcomes and chronic disease course. However, little is known about the neurobiological correlates of anxious distress in MDD. METHODS: We probed the relation between the DSM-5 ADS and task-related reactivity to emotional faces, as well as resting-state functional connectivity patterns of intrinsic salience and basal ganglia networks in unmedicated MDD patients with (MDD/ADS+, N = 24) and without ADS (MDD/ADS-, N = 48) and healthy controls (HC, N = 59)...
May 10, 2022: Depression and Anxiety
Paul M Cinciripini, George Kypriotakis, Charles Green, David Lawrence, Robert M Anthenelli, Jennifer Minnix, Janice A Blalock, Diane Beneventi, Chad Morris, Maher Karam-Hage
IMPORTANCE: Improving treatment outcomes for smokers with major depressive disorder (MDD) can have significant public health implications. OBJECTIVE: To evaluate the safety and efficacy of smoking cessation pharmacotherapy among smokers with MDD. DESIGN: Secondary analysis of a randomized, double-blind, active- (nicotine patch) and placebo-controlled trial of 12 weeks of either varenicline or bupropion with a 12-week follow-up. PARTICIPANTS: Community volunteers 18-75 years of age; smoke 10+ cigarettes/day; with clinically stable MDD (N = 2635) or no psychiatric disorder (N = 4028), from 140 sites in 16 countries...
May 2022: Depression and Anxiety
Hannah Lemke, Lina Romankiewicz, Katharina Förster, Susanne Meinert, Lena Waltemate, Stella M Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinsträter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski
INTRODUCTION: The investigation of disease course-associated brain structural alterations in Major Depressive Disorder (MDD) have resulted in heterogeneous findings, possibly due to low reliability of single clinical variables used for defining disease course. The present study employed a principal component analysis (PCA) on multiple clinical variables to investigate effects of cumulative lifetime illness burden on brain structure in a large and heterogeneous sample of MDD patients. METHODS: Gray matter volumes (GMV) was estimated in n = 681 MDD patients (mean age: 35...
May 2022: Depression and Anxiety
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.