journal
Journals Hematology (Amsterdam, Netherl...

Hematology (Amsterdam, Netherlands)

https://read.qxmd.com/read/39017035/role-of-metabolites-in-mediating-the-effect-of-triacylglycerol-on-aplastic-anemia
#1
JOURNAL ARTICLE
Jingkui Zhu, Wen Li
BACKGROUND: Observational studies have found a link between lipid metabolism disorders and aplastic anemia (AA). However, due to confounding variables and reverse causation, it is difficult to conclude such a causal link. The precise mechanism and potential implications of lipid metabolism disorder in AA remain unclear, necessitating further studies in this area. METHOD: This study aimed to examine the causal relationship between 38 different subtypes of triacylglycerols and AA using two-sample Mendelian randomization (MR)...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/39012217/identification-and-prognostic-analysis-of-metabolic-genes-associated-with-tp53-mutation-in-multiple-myeloma
#2
JOURNAL ARTICLE
Xiaoyan Tang, Yongping Chen
BACKGROUND: TP53 gene mutation is crucial in determining the prognosis of Multiple Myeloma (MM) patients. Understanding metabolic genes linked to TP53 mutation is vital for developing targeted therapies for these patients. METHOD: We analyzed The Cancer Genome Atlas (TCGA) dataset to identify genes related to TP53 mutation and metabolism. Using univariate Cox regression and protein-protein interaction (PPI) analysis, we identified key genes. We categorized patients into high and low metabolism groups via non-negative matrix factorization (NMF) clustering, which led to the discovery of relevant differential genes...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/39012197/regulation-of-stat5-phosphorylation-and-interaction-with-shp1-by-lnc-ac004893-a-long-non-coding-rna-overexpressed-in-myeloproliferative-neoplasms
#3
JOURNAL ARTICLE
Junjun Yang, Jichen Ruan, Bin Zhou, Sisi Ye, Shenmeng Gao, Xiaoqun Zheng
OBJECTIVES: Constitutive activation of Janus kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway is central to the pathogenesis of myeloproliferative neoplasms (MPNs). Long noncoding RNAs (lncRNAs) regulate diverse biological processes. However, the role of lncRNAs in MPN pathogenesis is not well studied. METHODS: The expression of lnc-AC004893 in MPN patients was measured by quantitative real-time PCR (qRT-PCR). Gene-specific short hairpin RNAs (shRNAs) were designed to inhibit the expression of lnc-AC004893, and western blot was performed to explore the role of lnc-AC004893 via regulating the JAK2/STAT5 signaling pathway...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/39007736/a-network-meta-analysis-of-the-effectiveness-of-different-basic-preconditioning-regiments-in-allogeneic-hematopoietic-stem-cell-transplantation
#4
REVIEW
Si-Ting Wu, Chun-Li Wang, Li Wang, Cai-Yun Zhang
OBJECTIVE: To investigate and compare the effects of basic preconditioning regimens Bu/Cy, Cy/TBI and Flu/Bu for the treatment of patients in allogeneic hematopoietic stem cell transplantation. METHODS: It comprised exploring the published literature in the databases of PubMed, EMBASE, Cochrane Library, and Web of Science, using suitable keywords pertaining to various basic pretreatments Bu/Cy, Cy/TBI, and Flu/Bu, prior to allogeneic hematopoietic stem cell transplantation, and then extracting the searched outcome indicators of Overall Survival (OS) and survival (herein represented as OS and survival)...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/39007733/case-report-tp53-c-848g-a-germline-mutation-as-a-possible-screening-target-at-initial-diagnosis-for-acute-lymphoblastic-leukemia
#5
JOURNAL ARTICLE
Fang Hua, Yue Hu, Guang-Cui He, Si-Han Lai, Ying He, Shan Zhang, Yan Deng, Ying Han, Xiao-Dong Liu, Kun Yang, Hui-Xiu Zhong, Jian Xiao, Zhong-Zheng Zheng, Hai Yi
BACKGROUD: Li-Fraumeni syndrome is a hereditary tumor syndrome characterized by an elevated risk of malignancy, particularly acute lymphoblastic leukemia (ALL), which can be caused by the heterozygous germline mutation. TP53 gene germline mutation is considered a potential risk factor and crucial prognostic parameter for acute leukemia development and diagnosis, but rarely occurs in adults, and its specific pathogenic significance in acute leukemia is unclear. CASE PRESENTATION: We describes a case of a 45-year-old woman diagnosed with ALL...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38994877/analysis-of-coagulation-alteration-and-its-correlation-with-%C3%AE-2-microglobulin-in-371-patients-with-newly-diagnosed-multiple-myeloma
#6
JOURNAL ARTICLE
Miao Hu, Yanfen Ma, Keli Jia, SaSa Liu, Huarong Jing, Ruicheng Li
OBJECTIVES: To explore the changes in the coagulation function of patients newly diagnosed with multiple myeloma (MM) at different stages and with different M protein types, and to analyze the correlation between coagulation indexes and β2-microglobulin (β2-MG). METHODS: A total of 371 Patients with newly diagnosed MM ( n  = 371) and healthy controls ( n  = 48) were selected from January 2016 to December 2022. Baseline data, β2-MG and coagulation index values were collected...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38994874/the-role-of-cd83-in-the-pathogenesis-of-immune-thrombocytopenia
#7
JOURNAL ARTICLE
Xiuli Wang, Qiyuan Zhou, Wen Yang, Hui Bi, Honghui Wang, Yacan Wang, Yadong Du, Lin Liu, Yuebo Liu, Liefen Yin, Jin Yao, Jingxing Yu, Wei Tao, Yongchun Zhou, Zeping Zhou
BACKGROUND: CD83 are closely related to the pathogenesis of immune thrombocytopenia (ITP), but the exact mechanism remains unclear. AIM: To explore the relationship between CD83 and CD4+ T cell subsets and clarify the role of CD83 in the pathogenesis of ITP. METHODS: RT-qPCR and Flow cytometry were used to illustrate CD83 expression. The downregulation and overexpression of DC-CD83 were co-cultured with CD4+ T cells to detect cell proliferation, co-cultured supernatant cytokines and Tregs expression...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38975808/a-retrospective-study-of-prognostic-factors-and-treatment-outcome-in-advanced-stage-mycosis-fungoides-and-sezary-syndrome
#8
JOURNAL ARTICLE
Zhuo-Fan Xu, Hongyun Chen, Yuehua Liu, Wei Zhang, Hongzhong Jin, Jie Liu
Background : Mycosis fungoides (MF) and Sezary Syndrome (SS) comprise over half of all Cutaneous T-cell lymphoma diagnoses. Current risk stratification is largely based on TNMB staging, few research investigated the prognostic value of clinical exams. Current systemic therapy for advanced disease includes immunomodulatory drugs, chemotherapy, and HADC inhibitors. Few clinical trials or retrospective research compared the efficacy of different drugs. Method : Here, we performed a retrospective analysis of prognostic factors and treatment outcomes of 92 patients diagnosed with MF/SS at the Peking Union Medical College Hospital from 2013-2023...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38975804/patient-centric-care-in-primary-immune-thrombocytopenia-itp-shared-decision-making-and-assessment-of-health-related-quality-of-life
#9
REVIEW
Hillary Maitland, Catherine Lambert, Waleed Ghanima
ABSTRACT Immune thrombocytopenia (ITP), an autoimmune disease characterized by low platelet counts and increased bleeding risk, can impair health-related quality of life (HRQoL), impacting patients' daily lives and mental health. A number of patient-reported outcome (PRO) measures (both generic and specific to ITP) can be used to understand the impact of ITP on HRQoL and generate evidence to guide disease management. As well - developed PRO tools could help in HRQoL assessment, their optimization could help to solidify a patient-centric approach to ITP management...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38958506/treatment-pattern-among-patients-with-relapsed-refractory-multiple-myeloma-rrmm-who-had-received-pomalidomide-based-regimens-in-taiwan
#10
JOURNAL ARTICLE
Chieh-Lin Jerry Teng, Su-Peng Yeh, Tsai-Yun Chen, Yu-Chin Hung, Yun-Chu Lin, Sin Syue Li, Ming-Chung Wang, Shang-Yi Huang
BACKGROUND/PURPOSE: The treatment landscape of relapsed/refractory multiple myeloma (RRMM) is rapidly evolving in Taiwan. The present study aimed to assess the treatment patterns among RRMM patients in Taiwan. METHODS: This retrospective, chart review-based, non-interventional study collected data on RRMM patients (≥20 years old) receiving pomalidomide-based treatment between January 2017 and December 2020 across five sites in Taiwan. RESULTS: Median age of the study population was 65...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38934722/association-between-bcl2-interacting-protein-3-like-bnip3l-genetic-polymorphisms-and-the-risk-of-multiple-myeloma-in-china
#11
JOURNAL ARTICLE
Qicai Wang, Yu Wang, Jing Wu, Xing Xie, Hongping Qin, Chunni Huang, Zhongqing Li, Zhian Ling, Ruolin Li
BACKGROUND: The BCL2 interacting protein 3-like (BNIP3L) protein is involved in multiple myeloma (MM) development and progression. This study aims to explore the connection between BNIP3L single-nucleotide polymorphisms (SNPs) and MM. METHODS: SNaPshot was used to examine six SNP loci of the BNIP3L gene in enrolled subjects. The relationship between these loci and MM susceptibility and prognosis was explored. Survival analysis was used to evaluate the impact of different factors on patient survival...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38934707/a-need-for-greater-awareness-a-mixed-methods-study-of-patient-and-healthcare-professional-perspectives-on-the-diagnosis-journey-for-haemophagocytic-lymphohistiocytosis-hlh
#12
JOURNAL ARTICLE
Tracy Machado, Judith Lawrence, Daniel Eriksson, Jason Donohue
OBJECTIVES: Our aim was to better understand and raise awareness of the diagnosis journey and quantify any barriers for timely diagnosis of haemophagocytic lymphohistiocytosis (HLH), to support patients' struggle with diagnosis and reduce time to diagnosis. METHODS: Patients diagnosed with, or caregivers for those diagnosed with primary or secondary HLH and physicians involved in the treatment of HLH were recruited. Quantitative interviews were undertaken with patients/caregivers to quantify key elements of the diagnosis journey, followed by qualitative interviews with participants...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38889342/future-directions-in-haploidentical-hematopoietic-stem-cell-transplantation
#13
REVIEW
Pongthep Vittayawacharin, Piyanuch Kongtim, Stefan O Ciurea
Outcomes of haploidentical hematopoietic stem cell transplantation (haplo-SCT) have improved over time. Graft failure and graft-versus-host disease (GVHD), which were important complications in major human leukocyte antigen (HLA)-disparity stem cell transplantation, have significantly decreased. These improvements have led to an exponential increase in the use of haploidentical donors for transplantation, as well as in the number of publications evaluating haplo-SCT outcomes. Many studies focused on factors important in donor selection, novel conditioning regimens or GVHD prophylaxis, the impact of donor-specific anti-HLA antibodies (DSA), as well as strategies to prevent disease relapse post-transplant...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38864494/detection-of-%C3%AE-thalassemia-south-east-asian-deletion-based-on-a-fully-integrated-digital-polymerase-chain-reaction-system-dropxpert-s6
#14
JOURNAL ARTICLE
Youqiong Li, Junwei Ye, Liang Liang, Xiao Tan, Lihong Zheng, Ting Qin, Linfen Yu
OBJECTIVES: This study aimed to establish a droplet digital polymerase chain reaction (ddPCR) assay for South-East Asian (SEA) deletion based on a fully integrated digital PCR system DropXpert S6. METHODS: A total of 151 whole blood samples, 10 chorionic villus samples, and 17 amniotic fluid samples were collected, including 106 SEA heterozygotes, 43 normal individuals, 10 Hb Bart's hydrops details, and 19 SEA deletions combined with other genotypes.Genotypes of these samples were determined by the Gap-PCR method...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38864489/non-invasive-hemoglobin-screening-device-a-promising-digital-method-for-reducing-anemia-prevalence-through-routine-screening-and-timely-intervention
#15
JOURNAL ARTICLE
Partha Pratim Das Mahapatra, Chaitali Roy, Komal Agarwal, Sonal Deep Sharma, Sudip Roy Chowdhury, Sandeep Sharma, Harshavardhan Rajagopal, Dayanidhi Meher
BACKGROUND: Several non-invasive technologies are nowadays available in the market which claim to determine the hemoglobin levels instantly without the requirement of the blood sample. But no study has shown the significance of such non-invasive devices on a routine basis for determining their impact on anemia reduction programs. This study is conducted to determine the impact of regular hemoglobin screening on the women population to determine its potential in reducing anemia, using a digitalized non-invasive device...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38828928/successful-treatment-of-two-cases-with-philadelphia-chromosome-positive-acute-lymphoblastic-leukemia-who-relapsed-after-allogeneic-stem-cell-transplantation-and-the-treatments-with-novel-immunotherapies-and-ponatinib
#16
JOURNAL ARTICLE
Takayoshi Tachibana, Masatsugu Tanaka, Yuma Noguchi, Yuho Najima, Daichi Sadato, Yuka Harada, Yotaro Tamai, Noriko Doki, Hideaki Nakajima
The outcomes of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) resistant to new drugs such as tyrosine kinase inhibitors, inotuzumab ozogamicin (InO) and blinatumomab are dismal. We treated two cases of Ph+ALL resistant to these drugs that achieved long-term survival after treatment with chimeric antigen receptor (CAR)-T cell therapy or a second allogeneic hematopoietic stem cell transplantation (HCT) with a sequential conditioning regimen. Case 1: A 15-year-old boy was diagnosed with Ph+ALL...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38828919/metabolomics-based-study-on-the-significance-of-differential-metabolite-binding-igg-isoforms-in-hemolytic-disease-of-newborn
#17
JOURNAL ARTICLE
Shipeng Zhang, Sijin Li, Xuan Meng, Jia Chen, Yan Tang, Xiaobin Li
BACKGROUND: Hemolytic disease of the newborn (HDN) is a common condition that can have a severe impact on the health of newborns due to the hemolytic reactions it triggers. Although numerous studies have focused on understanding the pathogenesis of HDN, there are still many unanswered questions. METHODS: In this retrospective study, serum samples were collected from 15 healthy newborns and 8 infants diagnosed with hemolytic disease. The relationship between different metabolites and various IgG subtypes in Healthy, HDN and BLI groups was studied by biochemical technique and enzyme-linked immunosorbent assay (ELISA)...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38819332/prevalence-of-monoclonal-gammopathy-of-undetermined-significance-in-shenzhen-china
#18
JOURNAL ARTICLE
Anping Xu, Tong Guo, Shuping Zhang, Houlong Luo, Mengxue Shen, Yinghui Ye, Ling Ji
BACKGROUND: Data on the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in China are very limited. Our aim was to determine the prevalence and clinical characteristics of MGUS in a large Chinese population. METHODS: This study included 49,220 healthy people who received serum immunofixation electrophoresis (sIFE) and serum protein electrophoresis (SPE) tests. Serum free light chain ratio, immunoglobulin quantification, and other clinically correlates of MGUS were performed for all patients with M-protein...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38804886/the-characteristics-of-calr-mutations-in-myeloproliferative-neoplasms-a-clinical-experience-from-a-tertiary-care-center-in-qatar-and-a-literature-review
#19
REVIEW
Mostafa Najim, Mohammad Abu-Tineh, Awni Alshurafa, Mohamed Izham Mohamed Ibrahim, Soubiya Ansari, Hazem Faraj, Saif Alateeg, Susanna Jane Akiki, Mohamed A Yassin
BACKGROUND: Myeloproliferative neoplasms (MPNs) are hematological disorders characterized by abnormal production of myeloid cells due to genetic mutations. Since 2013, researchers have identified somatic mutations in the Calreticulin (CALR) gene, primarily insertions or deletions, in two Philadelphia chromosome-negative MPNs; essential thrombocytosis (ET) and primary myelofibrosis (PMF), and occasionally in chronic myelomonocytic leukemia (CMML). This study aims to identify the various types of CALR mutations and their impact on CALR-positive MPN patients' clinical manifestations and outcomes...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38785187/overexpression-of-ptpn21-promotes-proliferation-of-egf-stimulated-acute-lymphoblastic-leukemia-cells-via-the-mapk-signaling-pathways
#20
JOURNAL ARTICLE
Ni Zhu, Jieping Wei, Li-Mengmeng Wang, He Huang, Haowen Xiao
OBJECTIVES: This study aims to investigate the role of excessive Protein Tyrosine Phosphatase Non-Receptor Type 21 (PTPN21) in the proliferation of Acute Lymphoblastic Leukemia (ALL) cells with EGF stimulation. METHODS: PTPN21 was overexpressed in ALL cell lines by lentiviral transfection. Apoptosis was assayed by Annexin V/7-AAD staining. The proliferation and cell cycle of EGF-treated ALL cells were assessed by MTT and Ki-67/7-AAD staining respectively. The phosphorylation of Src tyrosine kinase and mediators of distinct MAPK pathways were assessed by Western blot...
December 2024: Hematology (Amsterdam, Netherlands)
journal
journal
32756
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.