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Journals Hematology (Amsterdam, Netherl...

Hematology (Amsterdam, Netherlands)

https://read.qxmd.com/read/38407192/cytomegalovirus-immunoglobulin-serology-prevalence-in-patients-with-newly-diagnosed-multiple-myeloma-treated-within-the-gmmg-mm5-phase-iii-trial
#1
JOURNAL ARTICLE
Hans Salwender, Niels Weinhold, Axel Benner, Kaya Miah, Maximilian Merz, Mathias Haenel, Christian Jehn, Elias Mai, Ekaterina Menis, Igor Blau, Christof Scheid, Dirk Hose, Anja Seckinger, Steffen Luntz, Britta Besemer, Markus Munder, Peter Brossart, Bertram Glass, Hans-Walter Lindemann, Katja Weisel, Christine Hanoun, Paul Schnitzler, Sarah Klemm, Hartmut Goldschmidt, Marc Raab, Ahmet Elmaagacli
OBJECTIVES: The seroprevalence of antibodies against Cytomegalovirus (CMV) is an established poor prognostic factor for patients receiving an allogeneic stem cell transplantation. However, the impact of CMV serology on outcome after autologous stem cell transplantation remains unknown. METHODS: Here, we analyzed the CMV immunoglobulin (Ig) serology of 446 newly-diagnosed multiple myeloma (MM) patients of the GMMG-MM5 phase III trial with a median follow-up of 58 months...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38376107/real-world-long-term-safety-and-effectiveness-of-turoctocog-alfa-in-the-treatment-of-haemophilia-a-in-japan-results-from-a-multicentre-non-interventional-post-marketing-study
#2
JOURNAL ARTICLE
Azusa Nagao, Ayumi Deguchi, Keiji Nogami
OBJECTIVES: To assess the safety and effectiveness of turoctocog alfa in previously treated patients (PTPs) and previously untreated patients (PUPs) with haemophilia A in a real-world setting in Japan. METHODS: This multicentre, non-interventional, post-marketing study recruited patients with haemophilia A who initiated treatment with turoctocog alfa from 18 sites (08/2014-12/2018). The primary endpoint was adverse events (AEs) during the 2-year study period. RESULTS: The safety and effectiveness analysis set included 39 patients...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38346146/the-influence-of-dead-space-in-blood-sampling-needle-on-fviii-level-and-pharmacokinetic-profiles-in-children-with-hemophilia
#3
JOURNAL ARTICLE
Yingzi Zhen, Di Ai, Kun Huang, Gang Li, Zhenping Chen, Runhui Wu
OBJECTIVE: To investigate the influence of the dead space in disposable blood sampling needle on activated partial thromboplastin time (APTT), FVIII level and pharmacokinetic (PK) profiles in children with hemophilia. METHODS: Children (<18 years) with severe hemophilia A were enrolled. After three days' washout-period, blood samples were collected at pre-dose, 1 h, 3 h, 9 h, 24 h and 48 h post-infusion. At each timepoint, two 2 mL vacuum tubes with 3...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38332700/more-about-post-transplant-cyclophosphamide-in-haploidentical-grafts-full-or-reduced-doses
#4
JOURNAL ARTICLE
Moisés Manuel Gallardo-Pérez, César Homero Gutiérrez-Aguirre, Juan Carlos Olivares-Gazca, Guillermo José Ruiz-Argüelles
Haploidentical hematopoietic can be conducted on an outpatient basis but the two main reasons to accept into the hospital a patient in this setting are complications of the hematological toxicity and/or the cytokine-release syndrome. With the aim of reducing the post-transplant cyclophosphamide-dependent toxicity without compromising its effectivity, attempts to reduce the dose of post-transplant cyclophosphamide have been made: Decreases from the conventional total dose of post-transplant cyclophosphamide (100 mg/Kg) have been explored worldwide, showing that decreasing the total dose to even 50 mg/Kg significantly decreases the toxicity of the procedure without compromising its efficacy, safety and results...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38329272/renal-outcome-in-multiple-myeloma-patients-with-cast-nephropathy-a-retrospective-analysis-of-potential-predictive-values-on-clinical-and-renal-outcome
#5
JOURNAL ARTICLE
Lina Z Rüsing, Nicolas Kozakowski, Georg Jeryczynski, Lea Vospernik, Julia Riedl, Thomas Reiter, Heinz Gisslinger, Hermine Agis, Maria-Theresa Krauth
OBJECTIVE: Cast nephropathy (CN) is the leading cause of acute kidney injury (AKI) in multiple myeloma (MM). Since it is sparsely documented why some patients with CN do achieve a renal response while others do not, we describe a single-center cohort of patients with multiple myeloma and biopsy-confirmed CN to evaluate potential markers of renal response. METHODS: The data was collected as a retrospective, single-center analysis of CN-patients treated at the Medical University Vienna between 01/01/2004 and 01/01/2022...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38326994/correction
#6
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38323781/clinical-features-and-outcomes-of-patients-with-acute-myeloid-leukemia-the-single-center-experience-of-668-patients-in-china
#7
JOURNAL ARTICLE
Jie Ding, Yang Su, Yinglu Ruan, Nan Li, Qianchao Meng, Jiabang Yang, Li Chen, Chi Liu
OBJECTIVE: To investigate efficacy and prognostic factors in the treatment of adult newly-diagnosed acute myeloid leukemia (AML) with or without allogeneic hematopoietic stem cell transplantation (Allo-HSCT). METHODS: We retrospectively analyzed 668 patients with newly-diagnosed AML (non-M3 type) in the Department of Hematology at Shanghai Changhai Hospital from January 2012 to December 2021. Based on different induction chemotherapy regimens, patients were categorized into an IA (idarubicin, IDA + cytarabine, Ara-C) (3 + 7, regimen) group (n = 303) and a DA (daunorubicin, DNR + cytarabine, Ara-C) (3 + 7, regimen) group (n = 365) with or without allo-HSCT...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38319083/clinical-features-and-prognosis-of-chronic-natural-killer-cell-lymphoproliferative-disorders
#8
JOURNAL ARTICLE
Dong-Lin Liu, Yan-Jie Wang, Si-Yu Qian, Shan-Shan Ma, Meng-Jie Ding, Meng Dong, Jie-Ming Zhang, Ming-Zhi Zhang, Qing-Jiang Chen, Xu-Dong Zhang
OBJECTIVE: To analyze the current treatment status and prognostic regression of the chronic NK cell lymphoproliferative disorder (CLPD-NK). METHODS: We retrospectively analyzed the clinical features, treatment and prognosis of 18 patients with CLPD-NK who were treated at our Hospital between September 2016 and September 2022. RESULTS: Eighteen patients were included: three patients were treated with chemotherapy, five patients underwent immune-related therapy, one patient was treated with glucocorticoids alone, five patients were administered granulocyte colony-stimulating factor, blood transfusion therapy, or anti-infection therapy, followed by observation and follow-up, and four patients were observed without treatment...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38305411/indicators-of-stress-hematopoiesis-in-the-blood-predict-covid-19-progression-in-patients-over-65-years-old
#9
JOURNAL ARTICLE
Miodrag Vučić, Jelena Milenkovic, Boris Djindjic, Vladana Stojiljkovic, Dijana Stojanovic, Branka Djordjevic, Maja Milojkovic, Sanja Velickovic
OBJECTIVES: Advanced age is a well-established risk factor for severe coronavirus disease 2019 (COVID-19). Exacerbated inflammation affects multiple organs, among which hematopoiesis responds by increased output of various cells. We aimed to determine the association between COVID-19 progression and large immature cell (LIC) counts, changes in erythrocyte and platelet distribution widths (RDW, PDW) with reference to patients' age. METHODS: A total of 755 patients with complete blood cell (CBC) analysis in the first 24 h of hospitalization were enrolled...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38305210/effect-of-lncrna-xist-on-acute-myeloid-leukemia-cells-via-mir-142-5p-pfkp-axis
#10
JOURNAL ARTICLE
Zhaozhi Jiang, Tingting Liu, Youhong Wang, Jiao Li, Lusheng Guo
Acute myeloid leukemia (AML) is the common blood cancer in hematopoietic system-related diseases and has a poor prognosis. Studies have shown that long non-coding RNAs (lncRNAs) are closely related to the pathogenesis of a variety of diseases, including AML. However, the specific molecular mechanism remains unclear. Hence, the objective of this study was to investigate the effect and mechanism of lncRNA X inactive specific transcript (lncRNA XIST) on AML. To achieve our objective, some tests were performed...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38299685/correlation-analysis-of-bone-marrow-microvessel-density-and-mirna-expression-on-drug-resistance-in-patients-with-chronic-myelogenous-leukemia-after-tyrosine-kinase-inhibitor-treatment
#11
JOURNAL ARTICLE
Yi-Gang Guo, Lu-Lu Zhang, Ping Hu, Zhang-Zhi Li, Rui-Bo Zhang, Xi Lv, Qiong Yi, Ling-Bo Zhan, Xue-Lian Feng
OBJECTIVE: This study analyzed the relationship between bone marrow microvessel density (MVD) and the expression of four miRNAs with chronic myelogenous leukemia (CML) resistance after tyrosine kinase inhibitor (TKI) treatment. METHODS: 234 CML patients were divided into resistance and non-resistance groups in terms of the results of the 5-year follow-up. Patients were divided into the Optimum response group and the Warning/Failure group based on TKI response. MVD was determined by immunohistochemistry, and the expression levels of four miRNAs (miR-106a, miR-155, miR-146a, and miR-340) in bone marrow biopsy specimens were examined by qPCR...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38251872/the-prognostic-significance-of-pod24-in-peripheral-t-cell-lymphoma
#12
JOURNAL ARTICLE
Huimin Chen, Ruixue Ma, Qianqian Zhang, Fengyi Lu, Yuhan Ma, Jingxin Zhou, Jiang Cao, Kunming Qi, Zhiling Yan, Wei Sang, Feng Zhu, Haiying Sun, Depeng Li, Zhenyu Li, Hai Cheng, Kailin Xu, Wei Chen
BACKGROUND: Peripheral T-cell lymphomas (PTCL) are an aggressive group of mature T-cell neoplasms, often associated with poor outcomes, in part, due to frequent relapsed/refractory disease. The objective of this study was to assess the prognostic impact of disease progression within 24 months (POD24) on overall survival (OS) for patients diagnosed with PTCL. METHODS: A retrospective analysis was conducted on a cohort of patients with newly diagnosed PTCL who underwent chemotherapy at the Affiliated Hospital of Xuzhou Medical University between January 2010 and September 2021...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38251842/lymphocyte-subpopulations-a-potential-predictor-of-a-response-in-patients-with-immune-thrombocytopenia
#13
JOURNAL ARTICLE
Kateřina Žibřidová, Ondřej Souček, Lenka Kujovská Krčmová, Karolína Jankovičová, Markéta Gančarčíková, Mária Anna Pejková, Jan Drugda, Denisa Nováková, Milan Košťál
OBJECTIVES: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder caused by increased platelet destruction and altered production. Despite the well-described pathophysiological background of immune dysregulation, current treatment guidelines consist of monotherapy with different drugs, with no tool to predict which patient is more suitable for each therapeutic modality. METHODS: In our study, we attempted to determine differences in the immune setting, comparing the patients' responses to administered therapy...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38205814/serum-indicators-in-functional-high-risk-multiple-myeloma-patients-undertaking-proteasome-inhibitors-therapy-a-retrospective-study
#14
JOURNAL ARTICLE
Linquan Zhan, Dai Yuan, Xueling Ge, Mei Ding, Jianhong Wang, Xiangxiang Zhou, Xin Wang
OBJECTIVES: Multiple myeloma (MM) is a class of malignant plasma cell diseases. An increasing application of autologous stem cell transplantation (ASCT) and anti-myeloma agents represented by proteasome inhibitors (PIs) has improved the response rates and survival of MM patients. Patients progressing within 12 months were recently categorized with functional high-risk (FHR), which could not be clarified by existing genetic risk factors, with poor outcomes. Our study aimed to investigate clinical indices related to FHR and seek prognostic roles in transplant-eligible MM patients...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38197452/insights-into-the-role-of-jak2-i724t-variant-in-myeloproliferative-neoplasms-from-a-unique-cohort-of-new-zealand-patients
#15
JOURNAL ARTICLE
Christopher Puli'uvea, Tracey Immanuel, Taryn N Green, Peter Tsai, Peter R Shepherd, Maggie L Kalev-Zylinska
OBJECTIVES: This study aimed to compile bioinformatic and experimental information for JAK2 missense variants previously reported in myeloproliferative neoplasms (MPN) and determine if germline JAK2 -I724T, recently found to be common in New Zealand Polynesians, associates with MPN. METHODS: For all JAK2 variants found in the literature, gnomAD_exome allele frequencies were extracted and REVEL scores were calculated using the dbNSFP database. We investigated the prevalence of JAK2 -I724T in a cohort of 111 New Zealand MPN patients using a TaqMan assay, examined its allelic co-occurrence with JAK2 -V617F using Oxford Nanopore sequencing, and modelled the impact of I724T on JAK2 using I-Mutant and ChimeraX software...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38193467/quality-assessment-of-the-preparation-and-storage-of-leukocyte-depleted-pooled-platelet-concentrates
#16
JOURNAL ARTICLE
Feng Chen, Xiaoqing Dai, Azhong Li, Yinhong Zheng, Wei Hu
OBJECTIVE: To explore the feasibility of using a disposable platelet storage bag containing a leukocyte filter to prepare leukocyte-depleted pooled platelet concentrates with the buffy coat method. METHODS: 150 bags of whole blood samples (400 mL/bag) were stored overnight at 22 ± 2°C, and buffy coats were separated on Day 2, then 5 units of ABO homotypic buffy coat and 1 unit of plasma were pooled into a disposable platelet storage bag containing a leukocyte filter to prepare leukocyte-depleted pooled platelet concentrates and stored in a Platelet Agitator...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38186217/understanding-thrombosis-the-critical-role-of-oxidative-stress
#17
REVIEW
Peiming Li, Xueru Ma, Guofei Huang
Thrombosis, a leading contributor to global health burden, is a complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), can significantly impair the function of these cells, thus instigating a cascade of events leading to thrombus formation. In this review, we comprehensively explore the role of oxidative stress within these cells, and its mechanistic contribution to thrombogenesis, and the application of oxidative therapy in inhibiting thrombosis...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38186215/a-combined-immune-and-exosome-related-risk-signature-as-prognostic-biomakers-in-acute-myeloid-leukemia
#18
JOURNAL ARTICLE
Zenghui Fang, Jiali Fu, Xin Chen
OBJECTIVES: Acute myeloid leukemia (AML) is one of the common hematological diseases with low survival rates. Studies have highlighted the dysregulated expression of immune-related and exosome-related genes (ERGs) in cancers. Nevertheless, it remains to be determined whether combining these genes have a prognostic significance in AML. METHODS: Immune-ERG profiles for 151 AML patients from TCGA were analyzed. A risk model was constructed and optimized through the combination of univariate Cox regression and LASSO regression analysis...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38156735/high-vs-regular-dose-recombinant-human-thrombopoietin-plus-cyclosporine-a-in-patients-with-newly-diagnosed-non-severe-aplastic-anemia-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
Yuan Yang, Qinglin Hu, Chen Yang, Miao Chen, Bing Han
BACKGROUND: Cyclosporine A (CsA) and regular doses of recombinant human thrombopoietin (rhTPO) can accelerate platelet recovery in patients with non-severe aplastic anemia (NSAA). However, it is unclear whether CsA plus rhTPO at a higher dose can further increase the efficacy. METHODS: Data from patients with newly diagnosed NSAA, who had been treated with CsA in combination with different doses of rhTPO between February 2021 and August 2021 at Peking Union Medical College Hospital, were reviewed...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38149670/advancing-the-understanding-of-venetoclax-in-t-11-14-positive-multiple-myeloma-a-comprehensive-review-of-clinical-evidence-and-future-prospects
#20
REVIEW
Abdullah AlZahrani, Nada Alsuhebany, Imran K Tailor, Abdullah M Alrajhi
Venetoclax is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (BCL2), as a targeted therapy for multiple myeloma (MM) patients. It was initially approved by the United States Food and Drug Administration for the treatment of chronic lymphocytic leukemia in April 2016 and later for acute myeloid leukemia in October 2020. However, venetoclax is used as an off-label in a subset group of relapsed and refractory multiple myeloma (RRMM) patients with the presence of translocation t(11;14). Preclinical and clinical studies have highlighted the potential of venetoclax in the management of MM patients, with a specific focus on t(11;14) as a predictive biomarker for initiating venetoclax-based treatment...
December 2024: Hematology (Amsterdam, Netherlands)
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