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Hematology (Amsterdam, Netherlands)

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https://read.qxmd.com/read/30472933/notice-of-duplicate-publication
#1
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No abstract text is available yet for this article.
November 24, 2018: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30758269/analysis-of-long-non-coding-rna-expression-in-hemophilia-a-patients
#2
Niloofar Naderi, Ali Namvar, Nooshin Amani, Nikoo Nasoohi, Azam Bolhassani
OBJECTIVES: Hemophilia A (HA) is an inherited and rare X-linked bleeding disorder which is caused by mutations of the factor VIII gene (FVIII). Long non-coding RNAs (lncRNAs) are non-protein coding sequence transcripts containing more than 200 nucleotides and have potential in diagnosis, prevention and treatment of cancers and inherited bleeding disorders like thalassemia. The goal of this study was to determine the relationship between the expression of lncRNAs and the incidence of hemophilia A in Iranian population...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30757960/minimal-residual-disease-level-predicts-outcome-in-adults-with-ph-negative-b-precursor-acute-lymphoblastic-leukemia
#3
Nicola Gökbuget, Hervé Dombret, Sebastian Giebel, Monika Bruggemann, Michael Doubek, Robin Foà, Dieter Hoelzer, Christopher Kim, Giovanni Martinelli, Elena Parovichnikova, Alessandro Rambaldi, Josep-Maria Ribera, Marieke Schoonen, Julia M Stieglmaier, Gerhard Zugmaier, Renato Bassan
OBJECTIVES: Detectable minimal residual disease (MRD) after therapy for acute lymphoblastic leukemia (ALL) is the strongest predictor of hematologic relapse. This study evaluated outcomes of patients with B-cell precursor ALL with MRD of ≥10-4 Methods: Study population was from ALL study groups in Europe managed in national study protocols 2000-2014. MRD was measured by polymerase chain reaction or flow cytometry. Patients were age ≥15 years at initial ALL diagnosis. Patients were excluded if exposed to blinatumomab within 18 months of baseline or prior alloHSCT...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30727851/gdf11-is-increased-in-patients-with-aplastic-anemia
#4
Xifeng Dong, Yu Han, Iruni Roshanie Abeysekera, Zonghong Shao, Huaquan Wang
OBJECT: To explore the critical role of growth differentiation factor 11 (GDF11) in the pathobiology of aplastic anemia (AA). METHODS: We have examined the serum GDF11 levels for 79 AA patients and 30 healthy controls. A total of 79 AA patients, which included 29 new diagnosed (untreated) cases, 14 cases with no response, 21 partial remission (PR) cases and 15 complete remission (CR) cases after immunosuppressive therapy (IST). GDF11 serum levels were assessed by an enzyme-linked immunosorbent assay...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30669960/correlation-between-rbc-changes-and-coagulation-parameters-in-high-altitude-population
#5
Rong Zhang, Xiaochuan Yu, Yuanzhen Shen, Chunhui Yang, Fengjuan Liu, Shengliang Ye, Xi Du, Li Ma, Haijun Cao, Zongkui Wang, Changqing Li
OBJECTIVE: To explore the correlations between RBCs indexes and the basic coagulation parameters, and provide data for further studies on high altitude-induced thrombotic disease. METHODS: A total of eligible 433 volunteers were divided into different groups according to HGB concentration and HCT, respectively. PT, APTT, TT and Fbg were measured by clotting assays. HGB content, HCT and PLT count were assessed by automated hematology analyzer. RESULTS: APTT and PT were significantly higher in group 4 (high HGB or HCT groups) (p < 0...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30665334/long-non-coding-rnas-malat1-miat-and-anril-gene-expression-profiles-in-beta-thalassemia-patients-a-cross-sectional-analysis
#6
Abeer Fakhr-Eldeen, Eman A Toraih, Manal S Fawzy
OBJECTIVES: Beta-thalassemia (β-thal) is one of the most common genetic disorders worldwide. Multiple genetic and epigenetic mechanisms could be implicated in the pathogenesis and/or phenotype variations. We sought to explore the serum expression profile of three disease-related long non-coding RNAs (lncRNAs) in a sample of Egyptian β-thal patients with correlation to the patients' clinicolaboratory data. METHODS: Fifty consecutive β-thal patients and 50 unrelated controls were enrolled in the study...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30665323/denosumab-effects-on-serum-levels-of-the-bone-morphogenetic-proteins-antagonist-noggin-in-patients-with-transfusion-dependent-thalassemia-and-osteoporosis
#7
Ersi Voskaridou, Ioannis Ntanasis-Stathopoulos, Dimitrios Christoulas, Linda Sonnleitner, Athanasios Papaefstathiou, Maria Dimopoulou, Albert Missbichler, Nikolaos Kanellias, Konstantina Repa, Athanasios Papatheodorou, Melpomeni Peppa, Gerhard Hawa, Evangelos Terpos
INTRODUCTION: Noggin is an antagonist of bone morphogenetic proteins (BMPs) and has a strong effect on osteogenesis. Osteoporosis is a common complication of transfusion dependent beta-thalassemia (TDT) and denosumab has been recently emerged as a promising therapeutic option. This was a post hoc investigation of serum noggin levels among TDT patients with osteoporosis who participated in a randomized, placebo-control, phase 2b study. METHODS: Patients received either 60 mg denosumab (n = 32) or placebo (n = 31) every 6 months for 12 months...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30661482/therapeutic-options-for-adult-patients-with-previously-treated-immune-thrombocytopenia-a-systematic-review-and-network-meta-analysis
#8
Ran Yang, Lin Lin, Hao Yao, Ou Ji, Qun Shen
OBJECTIVES: The great majority of adult patients with immune thrombocytopenia (ITP) who fail to respond to first-line medication or who relapse following response require additional treatment. Although broad guidelines currently exist for second-line and subsequent therapies, none to date have been prescriptive. The purpose of this systematic review and network meta-analysis was to establish a clinically relevant ranking of the efficacy and safety of medications for adults (≥18 years old) with previously treated ITP...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30661467/differentially-expressed-plasma-proteins-of-%C3%AE-thalassemia-hemoglobin-e-patients-in-response-to-curcuminoids-vitamin-e-antioxidant-cocktails
#9
Jirawan Panachan, Daranee Chokchaichamnankit, Churat Weeraphan, Chantragan Srisomsap, Patarabutr Masaratana, Suneerat Hatairaktham, Narumol Panichkul, Jisnuson Svasti, Ruchaneekorn W Kalpravidh
OBJECTIVE: Iron overload and oxidative stress are the major causes of serious complications and mortality in thalassemic patients. Our previous work supports the synergistic effects of antioxidant cocktails (curcuminoids or vitamin E, N-acetylcysteine, and deferiprone) in treatment of β-thalassemia/Hb E patients. This further 2-DE-based proteomic study aimed to identify the plasma proteins that expressed differentially in response to antioxidant cocktails. METHODS: Frozen plasma samples of ten normal subjects and ten β-thalassemia/Hb E patients at three-time points (baseline, month 6, and month 12) were reduced the dynamic range of proteome using ProteoMiner kit and separated proteins by two-dimensional gel electrophoresis...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30558524/international-sentinel-site-surveillance-of-patients-with-transfusional-hemosiderosis-treated-with-deferasirox-in-actual-practice-setting
#10
Amal El-Beshlawy, Baba Inusa, David Beneitez Pastor, Blanca Xicoy, Maria Soledada Duran Nieto, Andreas Bruederle, Amin Azmon, Geralyn Gilotti, Mohsen Elalfy
OBJECTIVE: The study evaluates the long-term deferasirox treatment of adult and pediatric patients with chronic transfusional iron overload in clinical practice. METHODS: In this non-interventional study, patients were observed for up to 3 years from initiation of deferasirox treatment both prospectively and retrospectively for up to 1 year prior to enrollment. The primary end points were the proportion of patients with ≥1 notable increase in serum creatinine (SCr), and ≥1 notable increase in alanine aminotransferase (ALT)...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30558522/long-term-safety-and-efficacy-of-deferasirox-in-patients-with-myelodysplastic-syndrome-aplastic-anemia-and-other-rare-anemia-in-taiwan
#11
MULTICENTER STUDY
Bor-Sheng Ko, Ming-Chih Chang, Tzeon-Jye Chiou, Te-Kau Chang, Yeu-Chin Chen, Sheng-Fung Lin, Cheng-Shyong Chang, Yin-Che Lu, Su-Peng Yeh, Tsai-Yun Chen, Wei-Shou Hwang
OBJECTIVE: Patients with myelodysplastic syndromes (MDS), aplastic anemia (AA) or other rare anemia require chronic blood transfusions which can lead to iron overload and subsequent excess iron-mediated complications. Intensive iron chelation with deferasirox could remove excess iron and can alleviate these events; however, the long-term safety and efficacy in Chinese population are not clearly characterized. This study examined the long-term efficacy and safety of deferasirox in a real-world setting in Taiwan...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30479190/efficacy-and-safety-of-bispecific-t-cell-engager-bite-antibody-blinatumomab-for-the-treatment-of-relapsed-refractory-acute-lymphoblastic-leukemia-and-non-hodgkin-s-lymphoma-a-systemic-review-and-meta-analysis
#12
Jian Yu, Wen Wang, He Huang
OBJECTIVES: Multiple clinical trials have been conducted to investigate the therapeutic effects of blinatumomab on acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL). We did a meta-analysis including 8 clinical trials to verify the efficacy and safety of blinatumomab in patients with relapsed/refractory ALL and NHL. METHODS: We searched and investigated all relevant publications from PubMed, Web of Science, Embase, and ClinicalTrials.gov. The primary endpoint was complete remission (CR)...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30479187/risk-factors-for-hospitalizations-and-readmissions-among-individuals-with-sickle-cell-disease-results-of-a-u-s-survey-study
#13
MULTICENTER STUDY
Robert M Cronin, Jane S Hankins, Jeannie Byrd, Brandi M Pernell, Adetola Kassim, Patricia Adams-Graves, Alexis Thompson, Karen Kalinyak, Michael DeBaun, Marsha Treadwell
OBJECTIVE: Hospital admissions are significant events in the care of individuals with sickle cell disease (SCD) due to associated costs and potential for quality of life compromise. METHODS: This cross-sectional cohort study evaluated risk factors for admissions and readmissions between October 2014 and March 2016 in adults with SCD (n = 201) and caregivers of children with SCD (n = 330) at six centres across the U.S. Survey items assessed social determinants of health (e...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30479186/prevalence-and-clinical-significances-of-red-cell-alloimmunization-and-red-cell-bound-immunoglobulin-g-in-polytransfused-patients-with-thalassemias
#14
Anchalee Thedsawad, Orathai Taka, Wanchai Wanachiwanawin
The study was to determine the prevalence and clinical significances of red blood cell (RBC)-bound IgG as detected by flow cytometry in polytransfused patients with thalassemias. Relationship of the presence of RBC-bound IgG with RBC alloimmunization was also evaluated. This study included 59 polytransfused patients with β-thalassemia disease. We studied the frequency of RBC autoantibodies and alloimmunization. Direct Coombs test and flow cytometry were performed to detect the presence of RBC autoantibodies while RBC alloantibodies were detected by antibody screening and identification assays...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30458690/the-use-of-octagam-and-gammanorm-in-immunodeficiency-associated-with-hematological-malignancies-a-prospective-study-from-21-french-hematology-departments
#15
Omar Benbrahim, Jean-François Viallard, Sylvain Choquet, Bruno Royer, Frédéric Bauduer, Olivier Decaux, Jean-Charles Crave, Yann Fardini, Pierre Clerson, Vincent Lévy
OBJECTIVE: Immunoglobulin replacement therapy (IgRT) is increasingly used in secondary immunodeficiency (SID) related to hematological malignancies (HM) to prevent infections. Study's objective was to document prospectively the efficacy and safety of IgRT in patients with HM-associated SID. METHODS: Non-interventional, prospective French longitudinal study. RESULTS: One-hundred and sixty patients starting IgRT for HM-associated SID (myeloma: 54 cases, chronic lymphoid leukemia: 54, aggressive non-Hodgkin B-cell lymphoma: 19, indolent non-Hodgkin B-cell lymphoma: 29, and Hodgkin disease: 4...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30453843/noninvasive-assessment-and-risk-factors-of-liver-fibrosis-in-patients-with-thalassemia-major-using-shear-wave-elastography
#16
Murtadha Al-Khabori, Shahina Daar, Said A Al-Busafi, Humoud Al-Dhuhli, AlGhalya A Alumairi, Moez Hassan, Sara Al-Rahbi, Umaima Al-Ajmi
OBJECTIVES: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). METHODS: All patients with TM over the age of 10 years were included in the study. RESULTS: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30322352/adamts-13-activity-reduction-in-plasma-of-acute-myeloid-leukemia-predicts-poor-prognosis-after-bone-marrow-transplantation
#17
Chen Liu, Man Han, Lei Zhao, Mengjie Zhu, Qinzhu Xu, Ying Song, Hui Wang
OBJECTIVE: This research aimed to explore the significance of low activity of ADAMTS-13 in acute myeloid leukemia (AML) after bone morrow transplantation (BMT), and to evaluate the disease progress and prognosis of the patients with low or normal activity of ADAMTS-13 after BMT. METHODS: 46 AML patients were included in our research. ADAMTS-13 activity was measured before BMT. Their medical indicators were recorded one month after BMT. All the patients were followed up and their disease progression was evaluated afterwards...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30303041/relationship-between-genetic-polymorphism-of-mthfr-c677t-and-lower-extremities-deep-venous-thrombosis
#18
Jiasheng Xu, Kexin Li, Weimin Zhou
OBJECTIVE: To investigate the association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and the formation of lower extremities deep venous thrombosis, and to evaluate the etiology of deep venous thrombosis. METHODS: Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30198830/plasma-fibrinogen-level-as-possible-prognostic-biomarker-in-diffuse-large-b-cell-lymphoma
#19
Amira Mohamed Foad Shehata, Amira I Aldesoky, Suzy F Gohar
OBJECTIVES: Although many studies have assessed numerous molecular and immunohistochemical prognostic markers for diffuse large Bcell lymphoma (DLBCL), there is always a need for simple widely available markers. This study was planned to illustrate the clinical significance of baseline plasma fibrinogen levels in DLBCL patients. METHODS: We prospectively investigated 76 DLBCL patients treated with rituximab plus cyclophosphamide, vincristine, doxorubicin and hostacortine between August 2015 and February 2018...
December 2019: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/30010502/contributions-of-a-regional-approach-to-document-hematologic-disease-in-mexico-a-10-year-experience-in-an-open-population
#20
José Carlos Jaime-Pérez, Goel Treviño-Reyna, Patrizia Aguilar-Calderón, Olga G Cantú-Rodríguez, Luis Javier Marfil-Rivera, David Gómez-Almaguer
OBJECTIVES: To demonstrate the importance of regional efforts to register features and report frequency of hematology diseases in the context of incomplete national registries. METHODS: Frequencies and salient characteristics of hematologic diseases in Northeast Mexico were documented in a reference center at a tertiary care university hospital during the decade 2005-2015. Disease categories were grouped by age, sex and diagnosis. Age group distribution followed WHO guidelines in years as children (0-17), adults (18-64) and elders (+65)...
December 2018: Hematology (Amsterdam, Netherlands)
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