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International Journal of Tuberculosis and Lung Disease

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https://read.qxmd.com/read/30688210/first-description-of-mycobacterium-tuberculosis-and-m-canettii-concomitant-infection-report-of-two-cases
#1
N Paleiron, C Soler, M O Hassan, D Andriamanantena, R Vong, C Pourcel, J-B Roseau
<h2>SUMMARY</h2>We report the first two cases of tuberculous coinfection with Mycobacterium tuberculosis and M. canettii . Both patients were young Djiboutian females with pulmonary tuberculosis (TB). One had a miliary pattern with concomitant human immunodeficiency virus infection. Both recovered completely with a standard four-drug anti-tuberculosis treatment regimen. Due to the different natural reservoirs and routes of infection of these two strains, our study supports the common belief that multiple strains of infection in TB are related to superinfection rather than concomitant infection...
January 24, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30940300/discordant-rifampicin-susceptibility-results-are-associated-with-xpert-%C3%A2-mtb-rif-probe-b-and-probe-binding-delay
#2
R H Berhanu, K Schnippel, R Kularatne, C Firnhaber, K R Jacobson, C R Horsburgh, C K Lippincott
SETTING: Xpert® MTB/RIF is the first-line diagnostic test for Mycobacterium tuberculosis and rifampicin (RIF) resistance in South Africa. OBJECTIVE: To describe the rates of Xpert RIF resistance not confirmed on follow-up testing, as well as the patient and test characteristics associated with discordant results. DESIGN: Retrospective review of patients with isolates showing Xpert RIF resistance. Line-probe assay, phenotypic drug susceptibility testing or repeat Xpert were all considered confirmatory tests of RIF resistance...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871670/hear-this-audiometry-testing-saves-the-hearing-of-a-patient-with-drug-resistant-tuberculosis
#3
E Tesema, F Wares, A Bedru, C Negeri, Y Molla, A Kassa, B Ayele, H Siraj, F Tsegaye
No abstract text is available yet for this article.
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871669/-provider-barriers-to-the-uptake-of-isoniazid-preventive-therapy-among-people-living-with-hiv-in-ethiopia
#4
J Lai, Z Dememew, D Jerene, A Abashawl, B Feleke, A M Teklu, A Ruff
SETTING: Sixty-seven government health facilities providing tuberculosis (TB) and human immunodeficiency virus (HIV) services across Ethiopia. OBJECTIVE: To examine clinician barriers to implementing isoniazid preventive therapy (IPT) among people living with HIV. DESIGN: A cross-sectional study to evaluate the provider-related factors associated with high IPT coverage at the facility level. RESULTS: On bivariate analysis, the odds of high IPT implementation were lower when clinicians felt patients were negatively affected by the side effects of IPT (OR 0...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871668/spatial-epidemiology-of-tuberculosis-in-the-high-burden-counties-of-kisumu-and-siaya-western-kenya-2012-2015
#5
P M Sifuna, C Ouma, H Atieli, J Owuoth, D Onyango, B Andagalu, J Cowden
BACKGROUND: Effective management of tuberculosis (TB) and reduction of TB incidence relies on knowledge of where, when and to what degree the disease is present. METHODS: In a retrospective cross-sectional study, we analysed the spatial distribution of notified TB incidence from 1 January 2012 and 31 December 2015 in Siaya and Kisumu Counties, Western Kenya. TB data were obtained from the Division of Leprosy, Tuberculosis and Lung Disease, Nairobi, Kenya, as part of an approved TB case detection study...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871667/high-prevalence-and-incidence-of-tuberculosis-in-people-living-with-the-hiv-in-mandalay-myanmar-2011-2017
#6
K H Phyo, M M Oo, A D Harries, S Saw, T K Aung, J Moe, S S Thuya, Y Y Mon, A C Min, N N Naing, M S Kyi, S T Aung, H N Oo
SETTING: Two human immunodeficiency virus (HIV) clinics providing antiretroviral therapy (ART), Mandalay, Myanmar. OBJECTIVE: To assess prevalent TB at enrolment, incident TB during follow-up and associated risk factors in adult people living with HIV (PLHIV) between 2011 and 2017. DESIGN: Cohort study using secondary data. RESULTS: Of 11 777 PLHIV, 2911 (25%) had prevalent TB at or within 6 weeks of enrolment. Independent risk factors for prevalent TB were being male or single/widowed, daily alcohol consumption, CD4 count 200 cells/μl and anaemia...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871666/effect-of-neonatal-bacille-calmette-gu%C3%A3-rin-on-the-tuberculin-skin-test-reaction-in-the-first-2-years-of-life
#7
T Kurtz, A C Feil, L S Nascimento, P de Oliveira Abreu, M C Scotta, L A Pinto
SETTING: Latent tuberculous infection (LTBI) is an important reservoir of disease reactivation that is sufficient to generate new cases for decades. The tuberculin skin test (TST) is an important tool to diagnose LTBI; however, neonatal bacille Calmette-Guérin (BCG) vaccination may impact interpretation of TST data. OBJECTIVES: To analyse the effect of the neonatal BCG vaccine on TST reaction in the first 2 years of life in children with no identified contact with tuberculosis (TB)...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871665/contacts-of-underserved-tuberculosis-patients-have-higher-odds-of-tb-disease-in-north-west-england-a-cohort-study
#8
T Wingfield, P MacPherson, P Sodha, A Tucker, J Mithoo, S B Squire, P Cleary
OBJECTIVE: To investigate the association between patients' social risk factors and the risk of tuberculous infection and TB disease among their contacts in England. DESIGN: This was a cohort study of all TB cases from North West England diagnosed between 27 March 2012 and 28 June 2016. The social risk factors of TB cases were evaluated to estimate their need for enhanced case management (ECM), from 0 (standard of care) to 3 (intensive social support). RESULTS: A total of 2139 cases and their 10 019 contacts met the eligibility criteria...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871664/risk-factors-for-unfavourable-treatment-outcomes-among-rifampicin-resistant-tuberculosis-patients-in-tajikistan
#9
M Makhmudova, Z Maxsumova, A Rajabzoda, A Makhmadov, S van den Hof, V Mirtskhulava
SETTING: Tajikistan is among the 30 countries with the highest multidrug-resistant tuberculosis (MDR-TB) burden. OBJECTIVE: To investigate the risk factors for unfavourable treatment outcomes among rifampicin-resistant (RR)/MDR-TB patients. DESIGN: Retrospective medical chart review of RR/MDR-TB patients enrolled for treatment in 2012-2013. RESULTS: Of 601 RR/MDR-TB patients, 58 (9.7%) had pre-extensively drug-resistant TB (pre-XDR-TB; i...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871663/ipt-in-people-living-with-hiv-in-myanmar-a-five-fold-decrease-in-incidence-of-tb-disease-and-all-cause-mortality
#10
N T T Kyaw, A M V Kumar, K W Y Kyaw, S Satyanarayana, M J Magee, A C Min, J Moe, Z Z Aung, T K Aung, M M Oo, K T Soe, H N Oo, S T Aung, A D Harries
SETTING: Myanmar, a country with a high human immunodeficiency virus-tuberculosis (HIV-TB) burden, where the tuberculin skin test or interferon-gamma release assays are not routinely available for the diagnosis of latent tuberculous infection. OBJECTIVE: To assess the effect of isoniazid (INH) preventive therapy (IPT) on the risk of TB disease and mortality among people living with HIV (PLHIV). DESIGN: A retrospective cohort study of routinely collected data on PLHIV enrolled into care between 2009 and 2014...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871662/initiation-of-anti-tuberculosis-treatment-in-children-following-gastric-aspirate-testing-botswana-2008-2012
#11
T Q Lo, L Matlhare, K Mugisha, T D Lere, A Ho-Foster, R Boyd, J Cavanaugh, R Ncube, A P Steenhoff, T Arscott-Mills
SETTING: Diagnosing pediatric tuberculosis (TB) is difficult; to improve diagnosis , gastric aspiration (GA) was performed in 121 Botswana health facilities. OBJECTIVE: To describe treatment initiation and outcomes in children with a positive GA result and those treated empirically. METHODS: Children with smear or culture-positive GA or those clinically diagnosed were referred for anti-tuberculosis treatment. Treatment initiation and outcomes were assessed from February 2008 to December 2012 using name-based matching algorithms of the GA database; treatment initiation was captured in the electronic TB registry...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871661/hiv-related-tuberculosis-mortality-risk-in-persons-without-vs-with-culture-confirmed-disease
#12
B Crabtree-Ramírez, C Jenkins, K Jayathilake, G Carriquiry, V Veloso, D Padgett, E Gotuzzo, C Cortes, F Mejia, C C McGowan, S Duda, B E Shepherd, T R Sterling
BACKGROUND: Tuberculosis (TB) diagnosis in human immunodeficiency virus (HIV) positive persons is difficult, particularly in resource-limited settings. The relationship between TB culture status and mortality in HIV-positive persons treated for TB is unclear. METHODS: We evaluated HIV-positive adults treated for TB at or after their first HIV clinic visit in Argentina, Brazil, Chile, Honduras, Mexico or Peru from 2000 to 2015. Anti-tuberculosis treatment included 2 months of isoniazid, rifampicin (RMP)/rifabutin (RBT), pyrazinamide ± ethambutol, followed by continuation phase treatment with isoniazid + RMP/RBT...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871660/-nat2-variants-and-toxicity-related-to-anti-tuberculosis-agents-a-systematic-review-and-meta-analysis
#13
M Richardson, J Kirkham, K Dwan, D J Sloan, G Davies, A L Jorgensen
BACKGROUND: Tuberculosis (TB) patients receiving anti-tuberculosis treatment may experience serious adverse drug reactions (ADRs) such as hepatotoxicity. Variants of the N -acetyltransferase 2 ( NAT2 ) gene may increase the risk of experiencing such toxicity events. OBJECTIVE: To provide a comprehensive evaluation of the evidence base for associations between NAT2 variants and anti-tuberculosis drug-related toxicity. METHOD: This was a systematic review and meta-analysis...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871659/point-of-care-hba-1c-level-for-diabetes-mellitus-management-and-its-accuracy-among-tuberculosis-patients-a-study-in-four-countries
#14
P Huangfu, Y V Laurence, B Alisjahbana, C Ugarte-Gil, A-L Riza, G Walzl, R Ruslami, D A J Moore, M Ioana, S McAllister, K Ronacher, R C Koesoemadinata, D Grint, S Kerry, J Coronel, S T Malherbe, U Griffiths, H M Dockrell, P C Hill, R van Crevel, F Pearson, J A Critchley
BACKGROUND: Diabetes mellitus (DM) is common among tuberculosis (TB) patients and often undiagnosed or poorly controlled. We compared point of care (POC) with laboratory glycated haemoglobin (HbA1c ) testing among newly diagnosed TB patients to assess POC test accuracy, safety and acceptability in settings in which immediate access to DM services may be difficult. METHODS: We measured POC and accredited laboratory HbA1c (using high-performance liquid chromatography) in 1942 TB patients aged 18 years recruited from Peru, Romania, Indonesia and South Africa...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871658/tb-or-not-tb-challenges-in-diagnosing-and-treating-maternal-and-neonatal-tuberculosis
#15
C P Macias, I Monedero-Recuero
We present the case of a pregnant woman who died from disseminated tuberculosis (TB), and the difficulties encountered in diagnosing TB disease in her newborn. We discuss the burden of maternal and neonatal TB and the need for a different approach, one that is not solely based on bacteriologic evidence which, in most cases, tends to be inconclusive. We also explore the difficulties physicians and national TB programs face in managing and developing effective policies for these two highly vulnerable and neglected populations...
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871657/spatial-epidemiology-for-tuberculosis-surveillance-a-relevant-add-on-to-routine-surveillance
#16
D Nguenha, J I Garcia, J F Cowan, A L Garcia-Basteiro
No abstract text is available yet for this article.
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871656/another-aetiology-for-tuberculosis-beyond-the-mycobacterium
#17
A P Santos, G B Migliori
No abstract text is available yet for this article.
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30871655/the-mortality-rates-for-tuberculosis-remain-high-even-in-high-income-countries
#18
Y-S Kwon, W-J Koh
No abstract text is available yet for this article.
March 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30808463/key-features-to-consider-in-revising-the-model-list-of-essential-in-vitro-diagnostics-a-tb-perspective
#19
Khairunisa Suleiman, Kathleen England, Erica Lessem, Lindsay McKenna
No abstract text is available yet for this article.
February 1, 2019: International Journal of Tuberculosis and Lung Disease
https://read.qxmd.com/read/30808462/-ulk1-polymorphisms-confer-susceptibility-to-pulmonary-tuberculosis-in-a-chinese-population
#20
R-R Zhang, L Liang, W-W Chen, C Wen, B-S Wan, L-L Luo, Y-L Zhao, J Chen, J Yue
OBJECTIVE: The autophagy pathway is a critical process in Mycobacterium tuberculosis infection, and can be regulated by uncoordinated 51-like kinase 1 (ULK1). We investigated the associations between single-nucleotide polymorphisms (SNPs) in ULK1 and risk of tuberculosis (TB) in a Chinese Han population. DESIGN: We recruited 380 pulmonary tuberculosis (PTB) cases, 242 extra-pulmonary tuberculosis (EPTB) cases and 606 healthy controls from a Chinese Han population and sequenced ULK1 ...
February 1, 2019: International Journal of Tuberculosis and Lung Disease
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