Georgia M Wells, Kirsty Young, Marie J Haskell, Anne J Carter, Dylan N Clements
Mobility is an essential aspect of a dog's daily life. It is defined as the ability to move freely and easily and deviations from an animals' normal mobility capabilities are often an indicator of disease, injury or pain. When a dog's mobility is compromised, often functionality (ability to perform activities of daily living; ADL), is also impeded, which can diminish an animal's quality of life. Given this, it is necessary to understand the extent to which conditions impact a dog's physiological ability to freely move around their environment to carry out ADL, a concept termed functional mobility...
April 18, 2024: Veterinary Journal
Makoto Ujike, Tohru Suzuki
The generation of genetically engineered recombinant viruses from modified DNA/RNA is commonly referred to as reverse genetics, which allows the introduction of desired mutations into the viral genome. Reverse genetics systems (RGSs) are powerful tools for studying fundamental viral processes, mechanisms of infection, pathogenesis and vaccine development. However, establishing RGS for coronaviruses (CoVs) and toroviruses (ToVs), which have the largest genomes among vertebrate RNA viruses, is laborious and hampered by technical constraints...
April 17, 2024: Veterinary Journal
H B Carslake, G L Pinchbeck, C M Argo, A H A Dugdale, C M McGowan
Glucagon-like peptide-1 (GLP-1), the principal incretin in horses, may play a role in the pathophysiology of insulin dysregulation (ID). This study aimed to describe its concentration in response to three preserved forages and four dynamic tests for ID in ponies. Twelve adult ponies of mixed ID status were given a meal of hay, soaked hay or haylage, an in-feed oral glucose test (OGT), oral sugar test (OST), an oral test using a proprietary breakfast cereal (WEET) or a combined glucose-insulin tolerance test (CGIT) weekly in a randomised cross-over study...
April 9, 2024: Veterinary Journal
Emi N Barker, Conor O'Halloran, Danièlle A Gunn-Moore
Canine mycobacterial disease was first recognised over 100 years ago but is now an emerging concern. All reported cases of tuberculous disease in dogs have been caused by infection with one of three Mycobacterium tuberculosis-complex (MTBC) organisms (M. tuberculosis, Mycobacterium bovis, and Mycobacterium microti). Molecular PCR and interferon-gamma release assays offer alternative or complementary diagnostic pathways to that of specialist culture, which is limited by availability, sensitivity, and the time it takes to get a result...
April 8, 2024: Veterinary Journal
Kristopher Hughes, Claire Moore, Sophie Woods, Edwina Wilkes
Point-of-care (POC) glucometry is commonly used in horses; however, measurement error with this method when analysing hypoglycaemic samples (<4mmol/L) is unknown. The objective of this study was to determine the precision and accuracy of glucometry in hypoglycaemic horses in comparison to a laboratory method of glucose measurement (LAB). Repeatability coefficients were 0.47mmol/L for POC and 0.09mmol/L for LAB, and coefficients of variation were 10% and 2.11%, for the POC and LAB methods, respectively. Systemic bias with the POC method was present, with a mean bias of -0...
April 8, 2024: Veterinary Journal
Mike Farrell, Rob Adams, Dirsko Jf von Pfeil
We are writing to express our interest in the article entitled "Laboratory safety evaluation of bedinvetmab, a canine anti-nerve growth factor monoclonal antibody, in dogs", published in the October, 2021 issue of The Veterinary Journal, Volume 276, 105733, by Krautmann and others.
April 3, 2024: Veterinary Journal
M Menard, M Kurtz, A Duclos, J Vial, C Maurey, M Canonne-Guibert, V Fabres, D Rosenberg, M Coyne, R Murphy, C Trumel, R Lavoue, G Benchekroun
Serum symmetric dimethylarginine (SDMA) and patterns of urinary protein separated by sodium dodecyl sulfate agarose gel electrophoresis (SDS-AGE) have not been investigated as biomarkers in dogs with ACTH-dependent hyperadrenocorticism (ADHAC). This exploratory prospective study aimed to evaluate SDMA, serum creatinine (sCR), and SDS-AGE in dogs with ADHAC with and without proteinuria (ADHAC-P and ADHAC-nP, respectively). Thirty-five pet dogs classified as ADHAC-P (n=16), ADHAC-nP (n=6) and healthy (n=13) were included...
April 3, 2024: Veterinary Journal
Hannah E Michael, Catherine M McGowan, Heli K Hyytiäinen
Postural assessment is an important part of the veterinary evaluation of a dog's neuromusculoskeletal function. It forms an important part of the clinical examination by physiotherapists and specialists in veterinary rehabilitation and sports medicine and is well researched in humans, which has allowed treatment approaches to be developed and validated. This narrative review aims to complement the veterinary literature, which largely quantifies the impact of various conditions on posture, by synthesising the physiotherapy literature, to help translate the use of postural assessment as a basis for the development and validation of treatment techniques to improve outcomes in dogs...
April 3, 2024: Veterinary Journal
L J Walter, J D Stack, K Winderickx, H M S Davies, O Simon, S H Franklin
Sacroiliac dysfunction (SID) is a condition seen in horses associated with poor performance that affects hind limb gait and impulsion. The condition comprises pain and dysfunction but there lacks clarity around the aetiopathogenesis and whether SID encompasses abnormal joint pathology, abnormal joint movement, abnormal regional biomechanical function, joint laxity and pain, or various combinations of these that may vary over time. Clinical assessment remains challenging for equine clinicians due to the deep location of the sacroiliac joint (SIJ) and surrounding structures which limits access for palpation, diagnostic imaging and joint-specific injection...
March 29, 2024: Veterinary Journal
M Pirolo, M Menezes, M Poulsen, V Søndergaard, P Damborg, A C Poirier, R La Ragione, M Schjærff, L Guardabassi
Staphylococcus pseudintermedius is the most common cause of pyoderma in dogs. We validated a point-of-care (PoC) test based on colorimetric loop-mediated isothermal amplification (LAMP) for rapid S. pseudintermedius identification and susceptibility testing for first line antimicrobials for systemic treatment of canine pyoderma, i.e., lincosamides, first generation cephalosporins and amoxicillin clavulanate. Newly designed LAMP primers targeting clinically relevant resistance genes were combined with a previously validated set of primers targeting spsL for species identification...
March 26, 2024: Veterinary Journal
J Hamilton, E Jimenez, P Zarei, J Lection, R Sorto, E Hovingh, M Martinez, S Bas, A A Barragan
The objectives of this study were to assess: 1) differences in the metabolic status, systemic inflammation, daily milk yield, and daily rumination time between Holstein dairy cows with different vaginal discharge scores (VDS) in the first 7±3 DIM, and 2) effects of intrauterine dextrose infusion on metabolic status, systemic inflammation, daily milk yield and daily rumination time in dairy cows with VDS4 and VDS5. Cows (n=641) from a farm located in central Pennsylvania were screened at 7±3 DIM (study d 0) to assess vaginal discharge scores...
March 22, 2024: Veterinary Journal
Cuicui Jiao, Di Liu, Hongli Jin, Pei Huang, Haili Zhang, Yuanyuan Li, Hualei Wang
Feline viral rhinotracheitis (FVR) is caused by the feline herpesvirus-1 (FHV-1), which commonly results in upper respiratory symptoms, and can result in death in the kittens and weak cats. Rabies is an infectious disease with zoonotic characteristics highly relevant to public health and also poses a serious threat to cats. Vaccines are the most effective method to control the spread of both FHV-1 and RABV and have the advantage that they produce long-term specific immune responses. In this study, we constructed a bivalent vaccine against FVR and RABV simultaneously...
March 17, 2024: Veterinary Journal
B P Monteiro, C Otis, R Nitulescu, E Troncy
Quantitative sensory testing (QST) allows the study of pain mechanisms, patient phenotyping, and response to therapy. The goals of this study were to conduct a systematic review of the use of QST in dogs with musculoskeletal disease including osteoarthritis (OA), and to assess, by means of a meta-analysis, the ability of QST to differentiate affected dogs from healthy controls. The study protocol was registered; three bibliographic databases were screened. Studies involving QST in healthy dogs and those with musculoskeletal disease were included...
March 14, 2024: Veterinary Journal
Penelope Banchi, Lotte Spanoghe, Dominiek Maes, Jane Morrell, Ann Van Soom
The microbiome of the reproductive tract is an area of research in full development. Specifically, the microbiome may be involved in reproductive health, disease, and pregnancy outcomes, as has been shown in humans and animals, including dogs. The aim of the present review was to summarize current knowledge on the microbiome of the canine reproductive tract, to expose the controversial role that some bacterial agents may play in canine subfertility, and to highlight future research perspectives. This review discussed whether the use of antimicrobials in dogs is appropriate to increase reproductive performance and to treat subfertility without proper diagnosis, and the possible use of probiotics to modulate the reproductive canine microbiome...
March 12, 2024: Veterinary Journal
Miao-Zhan Wei, Lan Chen, Rong Zhang, Ze Chen, Yan-Juan Shen, Bi-Jun Zhou, Kai-Gong Wang, Chun-Lan Shan, Er-Peng Zhu, Zhen-Tao Cheng
Vaccination is the most effective means of preventing and controlling porcine epidemic diarrhea (PED). Conventional vaccines developed from porcine epidemic diarrhea virus (PEDV) GI-a subtypes (CV777 and SM98) have played a vital role in preventing classical PED. However, with the emergence of PEDV mutants in 2010, conventional PEDV GI-a subtype-targeting vaccines no longer provide adequate protection against PEDV GII mutants, thereby making novel-type PED vaccine development an urgent concern to be addressed...
March 11, 2024: Veterinary Journal
N Capion, A M Rinken, C Christensen, K Dahl-Pedersen, K Bach
Corkscrew claw (CC) in dairy cattle is increasingly reported in dairy herds. CC is a progressive deformity of the claw capsule with uncertain aetiology and pathogenesis. Genetics and specific environmental factors are suspected of contributing to the development of this irreversible condition. CC has been found in lame cows; however, the cause and effect has not been established. To perform analysis of risk factors, treatment and pathogenesis, a definition of severity scores is called for. The aim of this study was to measure and analyse CC characteristics from photos of cows' feet to describe and evaluate a scoring system for CC...
March 8, 2024: Veterinary Journal
P I Schimites, L T Mangini, J C Gasparotto, I G Franco, T S Alves, M L Biaggio, N P Mangini, G C Freitas, B P Floriano, A V Soares
The purpose of this study was to assess sedation, emesis and cardiovascular effects of dexmedetomidine alone or combined with acepromazine in healthy cats. Fourteen male cats aged 0.9 ± 0.5 years and weighing 3.7 ± 0.7kg were randomly assigned to one of two experimental groups: GD, dexmedetomidine 5µg/kg; and GDA, dexmedetomidine 5µg/kg with acepromazine 0.03mg/kg, all intramuscularly. Measurements were recorded at baseline, at 20minutes and then at 10-minute intervals following sedation and included heart rate (HR), respiratory rate (FR ), systolic arterial pressure (SAP), rectal temperature (RT), number of episodes of emesis and sedation score (0-4)...
March 8, 2024: Veterinary Journal
M E Herrera-Linares, B Rico-Pérez, D Yaffy, R Fernández-Parra, C Llanos, C Parra-Martínez, M E Herrera-Gutiérrez, S Sanchis-Mora
This study describes a transversal (TV) ultrasound-guided erector spinae plane (ESP) block technique over the transverse process of T12. And evaluates the distribution of the dye and affected nerves branches compared to a longitudinal (LNG) approach over the transverse process of T12 in canine cadavers. Secondly, it also compares de anatomy and dimensions of the transverse processes of T12 with T9 and T5. For this double-masked, cadaveric experimental study, 12 adult Beagle cadavers were injected with 0.6mL/kg of dye/contrast...
March 5, 2024: Veterinary Journal
Gilad Segev, Jonathan D Foster, Thierry Francey, Catherine Langston, Ariane Schweighauser, Larry D Cowgill
Intermittent hemodialysis (IHD) is an advanced adjunctive standard of care for severe acute kidney injury (AKI) and other indications. Most animals with AKI are managed medically, however, when the disease is severe, medical management may not control the consequences of the disease, and animals with a potential for renal recovery may die from the consequences of uremia before recovery has occurred. Extracorporeal therapies aid the management of AKI by expanding the window of opportunity for recovery of sufficient kidney function to become dialysis independent...
March 3, 2024: Veterinary Journal
S Franz, L Hofer, A M Dadak
Endoscopy in bovine internal medicine has come a long way from the first profound research papers in the 1980s to its present-day use. This paper reviews the progress in the 2000s and identifies the main application fields for diagnostic and therapeutic use. Inclusion criteria for scientific papers and reports encompassed focus on endoscopic examination techniques in cattle in the field of internal medicine and publication in a peer reviewed journal (case report/review/original research paper/short communication)...
March 2, 2024: Veterinary Journal
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