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Pathology Oncology Research: POR

Tomofumi Naruse, Souichi Yanamoto, Kohei Okuyama, Keisuke Ohmori, Hiroki Tsuchihashi, Kohei Furukawa, Shin-Ichi Yamada, Masahiro Umeda
While neoadjuvant chemotherapy (NAC) for patients with oral tongue squamous cell carcinoma (OTSCC) may improve tumor microenvironment, it may lead to local immune suppression caused by residual cancer cells. The efficacy of NAC is therefore controversial. In our study, we investigated tumor microenvironments after NAC using immune checkpoint molecules, and evaluated the association between tumor microenvironments, clinicopathological factors and outcomes. We reviewed the records of 121 patients who underwent radical surgery for OTSCC between April 2001 and March 2015...
February 14, 2019: Pathology Oncology Research: POR
Huining Liu, Qifan Yin, Guang Yang, Peng Qie
Surgical resection is the most effective treatment for early stage lung adenocarcinoma. However, the rate of 5-year postoperative recurrence reaches 30%, Spread Through Air Spaces(STAS) is a recently described novel invasive pattern of lung cancer, According to the 2015 WHO classification. STAS is defined as"micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumor, However, the prognostic role of STAS in lung cancer is not known, The aim of the current study is to evaluate the association between STAS and clinical outcome of lung cancer patients after surgical resection through a meta-analysis...
February 14, 2019: Pathology Oncology Research: POR
Li Tan, Yinying Wu, Xiaowei Ma, Yanli Yan, Shuai Shao, Jiaxin Liu, Hailin Ma, Rui Liu, Linyan Chai, Juan Ren
Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation have different clinicopathological characteristics compared with EGFR wild type NSCLC. A growing number of studies focused on the relevance between EGFR mutation status and brain metastases (BM) in NSCLC, but it remains controversial. Therefore, this study performed a comprehensive meta-analysis to untangle this issue. Several electronic databases including Pubmed, Embase, Web of science and Cochrane database were thoroughly searched...
February 14, 2019: Pathology Oncology Research: POR
Jie Ying, Xiaoyan Qiu, Yu Lu, Miaomiao Zhang
Suppressor of cytokine signaling1 (SOCS1), as a member of SOCS family, has been widely studied in recent years. It has been found that SOCS1 not only participates in cell signaling, but also in ubiquitination mediated protein degradation process. Both of these two functions play an important role in the growth and proliferation of cells. Therefore, researchers speculated that SOCS1 also played an important role in tumors. This review mainly focuses on the structure, transcriptional regulation and functions of SOCS1 protein, and finally describes the possible clinical role of SOCS1 protein in tumors...
February 13, 2019: Pathology Oncology Research: POR
Miriam Victoria Martín-Manzo, Carlos Lara, Cruz Vargas-de-Leon, Julio Carrero, Gloria Queipo, Miguel Fonseca-Sanchez, Nancy R Mejia-Dominguez, David Kershenobich, Srinivas Mummidi, Alejandro Zentella-Dehesa, Joselin Hernandez
Epidemiological evidence points to a link between insulin resistance (IR) and breast cancer (BrCA). Insulin plays a role in CD8+ T cells (CD8T) differentiation and function and affects adipocytokines levels. CD8T activity in BrCA is associated with favorable outcome; while PD1 and TIM3 are markers of CD8T exhaustion and play critical roles in the negative regulation of T cell responses. Patients with (BrCA) have high expression levels of PD1 on circulating. Therefore, we hypothesized that BrCA and IR could affect PD1 and/or TIM3 expression on circulating CD8T...
February 13, 2019: Pathology Oncology Research: POR
Ghada Mohamed, Soha Talima, Lili Li, Wenbin Wei, Zbigniew Rudzki, Rasha Mahmoud Allam, William Simmons, Qian Tao, Paul G Murray
SLIT2 has been classified as a major tumour suppressor gene due to its frequent inactivation in different cancer types. However, alterations of SLIT2 expression and relation to patient outcomes in diffuse large B cell lymphoma (DLBCL) remain undefined. The aim of this study was to investigate the expression and the methylation status of SLIT2 gene as well as its relation to patient outcomes in DLBCL. Immunohistochemical (IHC) staining was carried out to detect the expression of SLIT2 in a series of 108 DLBCL cases...
February 9, 2019: Pathology Oncology Research: POR
Zsolt Mervai, Andrea Reszegi, Ildikó Miklya, József Knoll, Zsuzsa Schaff, Ilona Kovalszky, Kornélia Baghy
BPAP is a potent enhancer substance with catecholaminergic and serotoninergic activity in the brain. It was discovered that it is also effective against certain types of experimental cancers, showing the most promising results in case of lung cancer. That is why we tested its efficacy in two different doses in a newly developed EGFR wild type mouse lung adenocarcinoma xenograft model. Experiments were conducted on FVB/N and SCID mouse strains treated with low and high dose of BPAP. Body weight, survival, and tumor volumes were recorded...
February 8, 2019: Pathology Oncology Research: POR
Subrata Kar, Dwijesh Dutta Majumder
This study aims to detect the abnormal growth of tissue in cervix region for diagnosis of cervical cancer using Pap test of patients. The proposed methodology classifies cervical cancer for pattern recognition either benign or malignant stages using shape and neuro-fuzzy based diagnostic model. In this experiment, firstly the authors segment Pap smear images of cervical cells using fuzzy c-means clustering algorithm and shape theory to classify them according to the presence of abnormality of the cells. Secondly the features extraction process is performed in the part of nucleus and cytoplasm on the squamous and glandular cells and the authors used input variables such as cytoplasm area (CA), cytoplasm circularity (CC), nucleus area (NA), nucleus circularity (NC), nucleus-cytoplasm ratio (NCR), and maximum nucleus brightness (MNB) in fuzzy tools and used fuzzy rules to evaluate the cervical cancer risk status as an output variable...
February 6, 2019: Pathology Oncology Research: POR
Zheng Liu, Ming Yang, Song Wang, Hai-Peng Chen, Xu Guan, Zhi-Xun Zhao, Zheng Jiang, Ji-Chuan Quan, Run-Kun Yang, Xi-Shan Wang
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. GGN is a germ cell-specific gene, but its function in CRC has been rarely reported to date. The aim of this study was to investigate the potential role of GGN in CRC tumorigenesis. Therefore, in this study, we examined the expression of GGN in CRC cell lines and tissues and its effects on cellular proliferation and apoptosis. We then explored the underlying mechanism. Our results showed that GGN was significantly overexpressed in both CRC cell lines and tissues...
February 5, 2019: Pathology Oncology Research: POR
Sándor Sipka, Boglárka Brugós, Gabriella Czifra, Zoltán Griger, Norbert Balogh, Tünde Tarr, Gábor Papp, Tamás Bíró, Margit Zeher
We aimed to answer the question whether the decreased expression of protein kinase C (PKC) isoenzymes in the peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE) is inherited or not. For this reason we examined the expression of PKC isoenzymes in a European white girl with acute SLE and in her healthy mother and father simultaneously in summer and winter during one year using western blotting and densitometry. We found that in the father the expression of PKC isoenzymes did not differ from that of eight healthy controls included women and men...
February 4, 2019: Pathology Oncology Research: POR
Chiraz Mehemmai, Farid Cherbal, Yosr Hamdi, Abdelmoumene Guedioura, Wassila Benbrahim, Rabah Bakour, Sonia Abdelhak
Breast cancer is currently the leading cause of cancer morbidity and mortality among Algerian women. In this study, we aimed to investigate the mutation spectrum of BRCA1 and BRCA2 genes in hereditary breast/ovarian cancer (HBOC) families from the Aures region (eastern Algeria). High risk breast/ovarian cancer families were selected from overall 1162 consecutive patients collected from cancer registry of anticancer center of Batna. Breast cancers were diagnosed between 2011 and 2015. Recurrent mutations on BRCA1 and BRCA2 previously found in Algerian patients were screened using PCR-direct sequencing in 113 HBOC families...
February 4, 2019: Pathology Oncology Research: POR
Jianguo Zhang, Jianzhong Zhang, Wenqi Chen, Huiyu Li, Meiying Li, Lisha Li
Sex determining region Y-box 2 (Sox2) is a transcription factor that is essential for maintaining self-renewal or pluripotency of undifferentiated embryonic stem cells. The expression and distribution of Sox2 in tumor tissues have been extensively recorded, which are related to the progression and metastasis of tumor. However, a complete mechanistic understanding of Sox2 regulation and function remains to be studied. Herein, we show new potential properties of Sox2 regulation and functions from bioinformatics analysis...
February 2, 2019: Pathology Oncology Research: POR
Ali Yaghobi Joybari, Payam Azadeh, Siamak Babaei, Farnaz Hosseini Kamal
We decided to compare pathologic complete response (pCR) and disease-free survival (DFS) in rectal adenocarcinoma patients who received neoadjuvant chemoradiotherapy (CRT) with capecitabine plus oxaliplatin (XELOX) or capecitabine (Xeloda). In this study, patients with non-metastatic locally advanced rectal cancer (tumor stages of T2, T3, or T4) with or without lymph node involvement were retrospectively included. Patients received concomitant radiation (50.4-54 Gy external beam radiation in 28 to 30 fractions) and neoadjuvant therapy as either Xeloda (capecitabine, 2500 mg/m2 concomitantly with radiation therapy) (42patients) or XELOX [(oxaliplatin (50 mg/m2 intravenously once a week for five weeks) and capecitabine)] (72 patients)...
February 2, 2019: Pathology Oncology Research: POR
K Hema Shree, Pratibha Ramani, Herald Sherlin, Gheena Sukumaran, Gifrrina Jeyaraj, K R Don, Archana Santhanam, Abilasha Ramasubramanian, R Sundar
Whole saliva is mainly composed of fluid produced by major and minor salivary glands. Major salivary glands including parotid, submandibular, and sublingual glands, are known to secrete fluid transported from serum as well as surrounding glandular tissues [1]. Beside the secretions from salivary glands, oral mucosa, periodontium, as well as oral microflora also contribute to the final content of whole saliva [1]. Whole saliva therefore represents a complex balance among local and systemic sources [2]. This allows for the application of saliva in the diagnosis not only for salivary gland disorders but also for oral diseases and systemic conditions [2]...
February 2, 2019: Pathology Oncology Research: POR
Gergely Varga, Zsolt Nagy, Judit Demeter, Szabolcs Kosztolányi, Árpád Szomor, Hussain Alizadeh, Beáta Deák, Tamás Schneider, Márk Plander, Tamás Szendrei, László Váróczy, Árpád Illés, Árpád Bátai, Mónika Pető, Gábor Mikala
Ixazomib-Revlimid-Dexamethasone is an all-oral treatment protocol for multiple myeloma with a manageable tolerability profile which was available through a named patient program for Hungarian patients from December 2015 to April 2017. We analyzed the clinical characteristics and survival of 77 patients treated at 7 centers within this program. The majority of patients responded, we found complete response in 9, very good partial response in 8, partial response in 32, minor response or stable disease in 13 and progressive disease in 11 patients...
February 2, 2019: Pathology Oncology Research: POR
Xinwei Li, Xueying Xu, Keng Chen, Haijian Wu, Yirong Wang, Shuxu Yang, Kun Wang
Primary central nervous system lymphoma (PCNSL) is an aggressive and rare subtype of non-Hodgkin lymphoma, arising exclusively in the CNS with a poor prognosis. Previous evidence has proved that MGMT was a promising target involving in TMZ resistance of PCNSL. Our study described a new miR-370-mediated mechanism of MGMT regulation in PCNSL. We first showed that miR-370 was downregulated in PCNSL tissues, while MGMT was inversely overexpressed. It was also observed that miR-370 suppressed the expression of MGMT...
February 2, 2019: Pathology Oncology Research: POR
Beata Smolarz, Magdalena M Michalska, Dariusz Samulak, Hanna Romanowicz, Luiza Wójcik
Ovarian cancer is one of the most common types of cancer in women. The repair system via homologous recombination repairs double-strand breaks (DSB) of DNA, which are the most mortal for cell, out of all DNA damages. The genes, which encode the double-strand break repairing proteins, are highly polymorphic and, taking into account the significance of the repaired defects for cancer development, it seems important to learn the role of the polymorphisms in ovarian cancer development. The aim of the study was to determine the relationship between DNA repair genes via homologous recombination (HR) and modulation of the risk of ovarian cancer...
February 2, 2019: Pathology Oncology Research: POR
Noemi Eiro, Juan Francisco Carrión, Sandra Cid, Alejandro Andicoechea, José Luis García-Muñiz, Luis O González, Francisco J Vizoso
Current clinical-pathologic stratification factors do not allow clear identification of high-risk stage II colorectal cancer (CRC) patients. Therefore, the identification of additional prognostic markers is desirable. Toll-like receptor (TLR)-4 is activated during tumorigenesis and matrix metalloproteases (MMPs) are involved in invasion and metastasis. We aimed to evaluate the expression and clinical relevance of TLR4, MMP11 and MMP13 for patients with stage II CRC. Immunohistochemistry was used to study the expression of TLR4, MMP11 and MMP13 in 96 patients with stage II CRC...
February 1, 2019: Pathology Oncology Research: POR
Jianying Jin, Qunyi Guo, Jingjing Xie, Dan Jin, Yanan Zhu
The study aimed to investigate the reason of HCT116 cell resistance to MEK inhibitor, and the combination treatment effects of MEK inhibitor AZD6244 and JAK2/STAT3 inhibitor AG490 on colon cancer in vitro and in vivo, including cell viability, apoptosis, and explore the partial mechanisms focused on AZD6244 promoted the activation of JAK2-STAT3 pathways. In vitro, we examined the HCT116 cell viability by CCK8, cell apoptosis by flow cytometry; Western blot measured p-ERK, p-JAK2, p-STAT3 and STAT3 expression...
January 31, 2019: Pathology Oncology Research: POR
Milica Lj Stojkovic Lalosevic, Vesna M Coric, Tatjana D Pekmezovic, Tatjana P Simic, Marija S Pljesa Ercegovac, Aleksandra R Pavlovic Markovic, Zoran V Krivokapic
Glutathione-S transferases (GSTs) are xenobiotic-conjugation enzymes involved in the detoxification process of heterocyclic aromatic amines and polycyclic aromatic hydrocarbons, widely recognized risk factors of colorectal cancer (CRC) development. Polymorphism in GSTs often leads to alteration or complete lack of enzyme activity, which might have an effect on CRC carcinogenesis. Aim of this study was to investigate GST gene variants as risk factors in patients with CRC. A total of 523 CRC patients administered for surgical resection and 400 matched controls were included...
January 29, 2019: Pathology Oncology Research: POR
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