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Journals Saudi Pharmaceutical Journal :...

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society

https://read.qxmd.com/read/38799000/streptomyces-isolate-som013-a-potential-agent-against-microbial-resistance-and-gastric-ulcers
#21
JOURNAL ARTICLE
Kizito Eneye Bello, Ahmad Adebayo Irekeola, Ahmad A Alshehri
The menace of microbial resistance and re-emerging disease is still a problem for healthcare givers globally, and the need for newer sources of potent antibiotics has become paramount. This study investigated the antimicrobial and antiulcer activities of Streptomyces isolate SOM013. Streptomyces isolates were cultivated and purified following standard microbiological protocols. Secondary metabolites were recovered and characterized from Streptomyces isolate SOM013 via broth fermentation and extraction. Varying concentrations (0...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38798999/evaluation-of-factors-affecting-pharmacists-and-pharmacy-technicians-satisfaction-towards-practicing-ce-activities-in-saudi-arabia
#22
JOURNAL ARTICLE
Raniah Aljadeed, Rana Aljadeed, Wasmeah Alsamti, Hadeel Alharbi, Rand Alturki, Haya Almalag, Lobna Aljuffali, Jawza Alsabhan, Noha AlAloola, Hadeel Alkofide, Rihaf Alfaraj, Njoud Altuwaijri, Nora Alkhudair, Lamya Alnaim, Ghada Bawazeer
BACKGROUND: Continuing education (CE) is an essential requirement for pharmacy professionals to stay abreast with the evolving knowledge and skills of the practice and meet the regulatory mandate. The purpose of this research is to assess factors affecting the satisfaction of pharmacists and pharmacy technicians towards CE practices in Saudi Arabia. MATERIAL AND METHODS: A self-administered survey instrument was developed following an extensive literature search...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38774811/trend-of-pharmaceuticals-3d-printing-in-the-middle-east-and-north-africa-mena-region-an-overview-regulatory-perspective-and-future-outlook
#23
JOURNAL ARTICLE
Riyad F Alzhrani, Mohammed Y Alyahya, Mohammed S Algahtani, Rawan A Fitaihi, Essam A Tawfik
The traditional method of producing medicine using the "one-size fits all" model is becoming a major issue for pharmaceutical manufacturers due to its inability to produce customizable medicines for individuals' needs. Three-dimensional (3D) printing is a new disruptive technology that offers many benefits to the pharmaceutical industry by revolutionizing the way pharmaceuticals are developed and manufactured. 3D printing technology enables the on-demand production of personalized medicine with tailored dosage, shape and release characteristics...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38766274/%C3%AE-glucosidase-inhibitory-potential-of-oroxylum-indicum-using-molecular-docking-molecular-dynamics-and-in-vitro-evaluation
#24
JOURNAL ARTICLE
Samhita Bhaumik, Alekhya Sarkar, Sudhan Debnath, Bimal Debnath, Rajat Ghosh, Magdi E A Zaki, Sami A Al-Hussain
BACKGROUND: According to the International Diabetes Federation, there will be 578 million individuals worldwide with diabetes by 2030 and 700 million by 2045. One of the promising drug targets to fight diabetes is α-glucosidase (AG), and its inhibitors may be used to manage diabetes by reducing the breakdown of complex carbohydrates into simple sugars. The study aims to identify and validate potential AG inhibitors in natural sources to combat diabetes. METHODS: Computational techniques such as structure-based virtual screening and molecular dyncamic simulation were employed to predict potential AG inhibitors from compounds of Oroxylum indicum ...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38766273/a-novel-source-of-biologically-active-compounds-the-leaves-of-serbian-herbaceous-peonies
#25
JOURNAL ARTICLE
Petar Batinić, Aleksandra Jovanović, Dejan Stojković, Natalija Čutović, Ilija Cvijetić, Uroš Gašić, Tamara Carević, Gökhan Zengin, Aleksandar Marinković, Tatjana Marković
In order to gain further insight into how various extraction techniques (maceration, microwave-, and ultrasound-assisted extractions) affect the chemical profile and biological activities of leaf extracts from Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L., this research was performed. The targeted chemical characterization of the extracts was achieved using the Ultra-High-Performance-Liquid-Chromatography-Linear-Trap-Mass-Spectrometry OrbiTrap instrumental technique, while Fourier Transform Infrared Spectroscopy was conducted to investigate the structural properties of the examined leaf extracts...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38757071/human-plasma-derived-exosomes-impact-of-active-and-passive-drug-loading-approaches-on-drug-delivery
#26
JOURNAL ARTICLE
Rabia Gul, Hamid Bashir, Muhammad Sarfraz, Ahson Jabbar Shaikh, Yousef A Bin Jardan, Zahid Hussain, Muhammad Hassham Hassan Bin Asad, Faisal Gulzar, Bo Guan, Imran Nazir, Muhammad Imran Amirzada
The aim of the current study was to explore the potential of human plasma-derived exosomes as versatile carriers for drug delivery by employing various active and passive loading methods. Exosomes were isolated from human plasma using differential centrifugation and ultrafiltration method. Drug loading was achieved by employing sonication and freeze thaw methods, facilitating effective drug encapsulation within exosomes for delivery. Each approach was examined for its effectiveness, loading efficiency and ability to preserve membrane stability...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38757070/patient-satisfaction-with-private-community-pharmacies-versus-pharmacies-in-primary-health-care-centers-in-saudi-arabia
#27
JOURNAL ARTICLE
Ali M Alzahrani, Abdulrhman A Alzhrani, Holly C Felix, Khulud K Alharbi, Muhammad Waseem Shahzad, Turky J Arbaein, Sarah S Monshi
INTRODUCTION: Saudi Arabia has begun reforming its government-run health care system to increase efficiency and reduce costs. One effort is the adoption of an electronic prescribing system (Wasfaty) and outsourcing pharmaceutical services from government-run clinics to community pharmacies (CP). This study aims to compare satisfaction with pharmaceutical services offered in the two systems. MATERIALS AND METHODS: This cross-sectional observational study used existing survey data collected from patients (≥15 years of age) visiting government primary health care centers from January 2022 to June 2022...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38746850/the-ethanol-extract-of-cocoa-pod-husk-minimizes-hyperalgesia-and-blood-glucose-levels-in-diabetic-neuropathy-model-through-transient-receptor-protein-vanilloid-trpv-1
#28
JOURNAL ARTICLE
Fifteen Aprila Fajrin, Diana Holidah, Heni Nurhidayah, Putri Suci Wulansari, Didik Pudji Restanto, Lailatul Azkiyah, Yuli Witono, Ari Satia Nugraha
Oxidative stress accumulation becomes a pathophysiological factor in diabetic neuropathy (DN), activating TRPV-1. Resveratrol in cocoa pod husk exhibits antioxidant activity that could be beneficial in DN. This study examined how the ethanol extract of cocoa pod husk (EECPH) affects DN in mice by targeting TRPV-1. Cocoa pod husk was extracted using 96 % ethanol with remaceration. The antioxidant activity was measured using DPPH. Mice were induced using alloxan 210 mg/kg BW i.p. At day 14, mice were randomized into seven groups: normal, diabetic, gabapentin 100 mg/kg BW, metformin 250 mg/kg BW, and EECPH (doses 250, 500, and 750 mg/kg BW)...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38737808/intra-peritoneal-lavage-of-zingiber-officinale-rhizome-and-its-active-constituent-gingerol-impede-inflammation-angiogenesis-and-fibrosis-following-post-operative-peritoneal-adhesion-in-male-rats
#29
JOURNAL ARTICLE
Roghayeh Yahyazadeh, Vafa Baradaran Rahimi, Seyed Ahmad Mohajeri, Milad Iranshahy, Maede Hasanpour, Vahid Reza Askari
Post-operative peritoneal adhesions (PA) are a common and important clinical problem. In this study, we focused on the ameliorative efficacy of ginger and gingerol compounds on surgical-induced peritoneal adhesion, and their strategies that disrupted the PA formation pathways to suppress their incidence. First, liquid chromatography-mass spectrometry (LC-MS) was established to separate and identify several chemical groups of ginger rhizome extract. In the next steps, male Wistar albino rats were randomly selected and divided into various groups, namely sham, control, ginger extract (0...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38737807/in-vitro-antimicrobial-anticancer-evaluation-and-in-silico-studies-of-mannopyranoside-analogs-against-bacterial-and-fungal-proteins-acylation-leads-to-improved-antimicrobial-activity
#30
JOURNAL ARTICLE
Md Ahad Hossain, Shahin Sultana, Mohammed M Alanazi, Hanine Hadni, Ajmal R Bhat, Imtiaj Hasan, Sarkar M A Kawsar
Carbohydrate analogs are an important, well-established class of clinically useful medicinal agents that exhibit potent antimicrobial activity. Thus, we explored the various therapeutic potential of methyl α-D-mannopyranoside (MαDM) analogs, including their ability to synthesize and assess their antibacterial, antifungal, and anticancer properties; additionally, molecular docking, molecular dynamics simulation, and ADMET analysis were performed. The structure of the synthesized MαDM analogs was ascertained by spectroscopic techniques and physicochemical and elemental analysis...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38726227/formulation-of-silymarin-surface-modified-vesicles-in-vitro-characterization-to-cell-viability-assessment
#31
JOURNAL ARTICLE
Syed Sarim Imam, Sultan Owaid Alshammari, Sultan Alshehri, Wael A Mahdi, Mohamed H Al-Agamy
Silymarin (SLR) is a poorly water-soluble bioactive compound with a wide range of therapeutic activities. Nanosized silymarin vesicles (F1-F6) were prepared by the solvent evaporation rehydration method. The silymarin vesicles were evaluated for vesicle size, surface charge, entrapment efficiency, and drug release studies. The optimized SLR lipid vesicle (F3) was further modified with the addition of the cationic polymer chitosan. After that, the modified vesicle (F3C1) was assessed for permeation flux, antimicrobial activity, cell viability, and molecular docking studies...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38726226/biocompatible-gelatin-coated-ferrite-nanoparticles-a-magnetic-approach-to-advanced-drug-delivery
#32
JOURNAL ARTICLE
Varda Shakeel, Iftikhar Hussain Gul, Peter John, Attya Bhatti
Nanotechnology has transformed drug delivery, offering opportunities to enhance treatment outcomes while minimizing adverse effects. This study focuses on gelatin-coated cobalt and manganese ferrite nanoparticles for potential drug delivery applications. The synthesis involved a co-precipitation method, and the nanoparticles were characterized using various techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy, and vibrating sample magnetometer (VSM)...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38716111/the-use-of-complementary-and-alternative-medicine-for-functional-gastrointestinal-disorders-among-the-saudi-population
#33
JOURNAL ARTICLE
Salmeen D Babelghaith, Ibrahim Sales, Wajid Syed, Mohamed N Al-Arifi
BACKGROUND AND OBJECTIVE: Complementary and alternative medicine (CAM) is a common practice among patients, who experience functional gastrointestinal disorders (FGID). Among the Saudi population, less is known about CAM use for FGID. Therefore, this study aimed to determine the prevalence of CAM utilization for FGID amongst the Saudi population and determine the types of CAM used for treatment. METHOD: A cross-sectional study was carried out in Riyadh, Saudi Arabia during February 2023 through social media platforms using questionnaires adopted from the literature...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38707207/apixaban-and-clopidogrel-in-a-fixed-dose-combination-formulation-and-in-vitro-evaluation
#34
JOURNAL ARTICLE
Ni'meh Al-Shami, Hani Naseef, Feras Kanaze
Fixed-dose combination (FDC) products represent a novel, safe, and cost-effective formulation. Combined use of anticoagulant and antiplatelet medications is common among comorbid cardiovascular patients. This study aimed to formulate FDC tablets for Apixaban and Clopidogrel, as prophylaxis and treatment of thrombo-embolic events. FDC tablets were developed by combining small tablets of Immediate-Release Clopidogrel 75 mg and Extend-Release Apixaban 5 mg through direct compression and wet granulation...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38699598/pharmacological-p38-mapk-inhibitor-sb203580-enhances-aml-stem-cell-line-kg1a-chemosensitivity-to-daunorubicin-by-promoting-late-apoptosis-cell-growth-arrest-in-s-phase-and-mir-328-3p-upregulation
#35
JOURNAL ARTICLE
Sara Bahattab, Ali Assiri, Yazeid Alhaidan, Thadeo Trivilegio, Rehab AlRoshody, Sarah Huwaizi, Bader Almuzzaini, Abir Alamro, Manal Abudawood, Zeyad Alehaideb, Sabine Matou-Nasri
Acute myeloid leukaemia (AML) is characterized by uncontrolled proliferation of myeloid progenitor cells and impaired maturation, leading to immature cell accumulation in the bone marrow and bloodstream, resulting in hematopoietic dysfunction. Chemoresistance, hyperactivity of survival pathways, and miRNA alteration are major factors contributing to treatment failure and poor outcomes in AML patients. This study aimed to investigate the impact of the pharmacological p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 on the chemoresistance potential of AML stem cell line KG1a to the therapeutic drug daunorubicin (DNR)...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38699597/statistical-modeling-optimization-and-characterization-of-andrographolide-loaded-emulgel-for-its-therapeutic-application-on-skin-cancer-through-enhancing-its-skin-permeability
#36
JOURNAL ARTICLE
N V L Sirisha Mulukuri, Sujeet Kumar, Moumita Dhara, Gupta Dheeraj Rajesh, Pankaj Kumar
Andrographolide is a natural diterpene lactone with multiple biological effects. In the present study, a total of 11 andrographolide-loaded emulgels (ANG 1- ANG 11) were prepared by emulsification and solvent evaporation method using flaxseed oil and xanthan gum in different ratios, as suggested by the Design-Expert software. A 2-factor-5-level design was employed with different responses including spreadability, extrudability, viscosity, and drug release after 1 h (h) and 24 h. Based on the Design-Expert software response, the optimized emulgel ANG 12 was formulated and evaluated...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38690211/advancing-liposome-technology-for-innovative-strategies-against-malaria
#37
REVIEW
Andang Miatmoko, Rifda Tarimi Octavia, Tamasa Araki, Takeshi Annoura, Retno Sari
This review discusses the potential of liposomes as drug delivery systems for antimalarial therapies. Malaria continues to be a significant cause of mortality and morbidity, particularly among children and pregnant women. Drug resistance due to patient non-compliance and troublesome side effects remains a significant challenge in antimalarial treatment. Liposomes, as targeted and efficient drug carriers, have garnered attention owing to their ability to address these issues. Liposomes encapsulate hydrophilic and/or hydrophobic drugs, thus providing comprehensive and suitable therapeutic drug delivery...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38690210/the-utility-of-serum-glucose-potassium-ratio-as-a-predictive-factor-for-haemorrhagic-transformation-stroke-recurrence-and-mortality-among-ischemic-stroke-patients
#38
JOURNAL ARTICLE
Faisal F Alamri, Daniyah A Almarghalani, Eman A Alraddadi, Abdullah Alharbi, Hajar S Algarni, Oyoon M Mulla, Abdullah M Alhazmi, Turki A Alotaibi, Deema H Beheiry, Abdullah S Alsubaie, Ahmed Alkhiri, Yasser Alatawi, Mohammad S Alzahrani, Alqassem Y Hakami, Aser Alamri, Khalid Al Sulaiman
BACKGROUND AND OBJECTIVE: Glucose-Potassium Ratio (GPR) has emerged as a biomarker in several pathophysiological conditions. However, the association between GPR and long-term outcomes in stroke patients has not been investigated. Our study evaluated the applicability of baseline GPR as a predictive prognostic tool for clinical outcomes in ischemic stroke patients. METHODS: The multicenter retrospective cohort study included acute-subacute adult ischemic stroke patients who had their baseline serum GPR levels measured...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38690209/therapeutic-and-pharmacological-prospects-of-nutmeg-seed-a-comprehensive-review-for-novel-drug-potential-insights
#39
REVIEW
Sawsan S Al-Rawi, Ahmad Hamdy Ibrahim, Heshu Jalal Ahmed, Zhikal Omar Khudhur
BACKGROUND AND OBJECTIVES: For centuries, plant seed extracts have been widely used and valued for their benefits. They have been used in food, perfumes, aromatherapy, and traditional medicine. These natural products are renowned for their therapeutic properties and are commonly used in medicinal treatments. Their significant pharmacological profiles provide an excellent hallmark for the prevention or treatment of various diseases. In this study, we comprehensively evaluated the biological and pharmacological properties of nutmeg seeds and explored their efficacy in treating various illnesses...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38690208/special-issues-in-forensic-toxicology-in-the-middle-east-and-north-africa-mena-region-the-importance-of-toxicology-amid-mena-drug-challenges
#40
JOURNAL ARTICLE
Ahmed Ibrahim Al-Asmari, Fawaz Alasmari, Sary Alsanea
No abstract text is available yet for this article.
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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