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Journals Saudi Pharmaceutical Journal :...

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society

https://read.qxmd.com/read/38435847/new-flavonoids-with-multiple-bronchodilator-activity-pathways-from-tephrosia-purpurea-l-pers-growing-in-saudi-arabia
#21
JOURNAL ARTICLE
Maged S Abdel-Kader, Abdulaziz S Saeedan, Najeeb U Rehman, Hayder M Faqihi, Gamal A Soliman
Total extract of Tephrosia purpurea ( T. purpurea ) expressed potent ex-vivo bronchodilator effect in isolated Guinea pigs' tracheal muscles. Fractionation of T. purpurea total extract ( TPTE) using liquid-liquid technique followed by ex-vivo bronchodilator testing indicated that the activity was trapped to the chloroform (CHCl3 ) soluble fraction. Phytochemical study of the CHCl3 fraction guided by ex-vivo bronchodilator activity led to the isolation of 7 active flavones of which compounds 1 ( epi- Tephroapollin G), 3 (Acetyltephroapollin C), 4 (4''-Dehydroxytephroapollin E), and 5 ( epi- Tephroapollin F) were new...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38426034/a-content-quality-and-optimization-analysis-of-youtube-as-a-source-of-patient-information-for-bipolar-disorder
#22
JOURNAL ARTICLE
Jawza F Alsabhan, Haya M Almalag, Norah O Abanmy, Yara I Aljadeed, Reema H Alhassan, Awatif B Albaker
BACKGROUND: The goal of this study was to identify and evaluate the use of Arabic YouTube videos on BD as a resource for patient education. METHODS: A cross-sectional evaluation of YouTube videos as a source of information for patients with BD in Arabic was performed. The study was observational and, because it did not involve human subjects, it followed the STROBE guidelines whenever possible. The quality of the videos was assessed using the validated DISCERN instrument...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38414783/exploring-the-topic-structure-and-abuse-trends-of-new-psychoactive-substance-since-the-21st-century-from-a-bibliometric-perspective
#23
JOURNAL ARTICLE
Xiaolong Hou, Jifen Wang, Ying Zhang, Yufan Zhang, Jianyang Shangguan, Ge Qin, Boxu Chen, Zhenjun Jia, Duo Qi Xu
Nowadays, NPS abuse are continuing to expand in terms of harm and scope, due to its cheap and easy to manufacture anywhere in the world. This study reviewed articles related to seven heavily abused NPS to analyze the structure and trends of NPS abuse. A total of 2476 articles were retrieved based on the search strategy for bibliometric analysis. A significant trend of research in recent years was the increasing number of research on synthetic opioids and designer benzodiazepines, but synthetic cannabinoid and synthetic cathinone still dominate, which were mainly concerned with the development of metabolic models and determining methods as well as their abuse characteristics and reasons...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38414782/an-analysis-of-the-intention-of-female-pharmacy-students-to-work-in-community-pharmacy-settings-in-saudi-arabia-using-the-theory-of-planned-behavior
#24
JOURNAL ARTICLE
Ahmed M Alshehri, Wafa H Alqahtani, Aljoharah A Moaili, Yasser S Almogbel, Ziyad S Almalki, Abdullah K Alahmari, Ahmed A Albassam, Nehad J Ahmed
OBJECTIVE: This study aimed to determine the intention of female Saudi pharmacy students to work in community pharmacies and the factors associated with this intention. METHODS: This cross-sectional study was conducted between April 2022 and June 2022 and included female students from pharmacy colleges in Saudi Arabia. The survey was created based on the Theory of Planned Behavior. It included items that measure student intentions, attitudes, subjective norms, and perceived behavioral control regarding working in community pharmacies in Saudi Arabia...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38414781/physicochemical-and-biological-properties-of-encapsulated-boesenbergia-rotunda-extract-with-different-wall-materials-in-enhancing-antioxidant-mineralogenic-and-osteogenic-activities-of-mc3t3-e1-cells
#25
JOURNAL ARTICLE
Safiah Saah, Dalad Siriwan, Piyapat Trisonthi, Sawitree Dueramae
Boesenbergia rotunda  (L.) comprises bioactive compounds with biological and pharmacological properties, especially flavonoid compounds with osteoblastogenesis-stimulating potential. However, the application of  B. rotunda  in the food and pharmaceutical industry is restricted by its low solubility and stability. Encapsulation becomes an alternative to overcome these restrictions. The purpose study was to encapsulate  B. rotunda  extract by freeze-drying and to investigate the effects of different wall materials (maltodextrin (MD), gum arabic (GA), and their combination (MDGA)) and extract contents on the physicochemical, bioactive properties and in vitro enhancement of osteogenesis of MC3T3-E1 cells of the obtained encapsulates...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38405043/exploring-the-effectiveness-of-pharmacy-curriculum-in-saudi-arabia-in-developing-leadership-skills-among-pharmacy-students-from-their-perspective-a-mixed-methods-study
#26
JOURNAL ARTICLE
Majid Ali, Aseel Alsreaya, Abdulrahman Alqarzi, Yazeed Alzahrani, Ibrahim Alhomood, Abdulaziz Alruhaimi, Abdulrahman Hijri, Ahmed Mobarki, Mohammed Najie, Mohammed Mashyakhi, Abdullwahab Bajawi
INTRODUCTION: Leadership is an important component of pharmacy education. This study helps identify the strengths and limitations of the pharmacy curriculum in developing leadership skills among pharmacy students in Saudi Arabia and suggest how to improve the curriculum to better prepare them to become effective leaders in the healthcare profession. METHODS: This study employed a mixed-methods research design with a sequential exploratory design. Phase I involved semi-structured interviews with student leaders of pharmacy student clubs/societies from different universities in Saudi Arabia...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38405042/assessing-mental-health-among-students-in-the-uae-a-cross-sectional-study-utilizing-the-dass-21-scale
#27
JOURNAL ARTICLE
Samer O Alalalmeh, Omar E Hegazi, Moyad Shahwan, Nageeb Hassan, Ghala Rashid Humaid Alnuaimi, Raghd F Alaila, Ammar Jairoun, Yomna Tariq Hamdi, Mina Thamer Abdullah, Roaa Mohammed Abdullah, Samer H Zyoud
BACKGROUND: The escalating worldwide concerns for mental health, significantly amplified by the COVID-19 pandemic, necessitates understanding the impact on vulnerable populations, such as university students. This study aims to investigate the prevalence and implications of depression, anxiety, and stress among university students in the United Arab Emirates (UAE) using the Depression, Anxiety, and Stress Scale-21 Items (DASS-21). METHODS: This study utilized convenience sampling to investigate the mental health of undergraduates in UAE universities using a bilingual DASS-21 questionnaire via Google Forms...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38405041/improvement-of-comorbid-anxiety-and-depression-in-patients-with-migraine-treated-with-injectable-preventive-calcitonin-gene-related-peptide-antagonists-review-of-clinical-evidence
#28
REVIEW
Abubker Omaer, Abdulrazaq Albilali, Reem Bamogaddam, Fares Almutairi, Raghad Alsaif, Osama Almohammadi, Abdullah A Alhifany
BACKGROUND: Migraine is often associated with depression and anxiety, leading to a diminished quality of life. Calcitonin gene-related peptide (CGRP) antagonists have shown promise in treating migraines, but their effects on concurrent depression and anxiety have not been clarified. METHODS: A literature review was conducted on ClinicalTrials.gov, PubMed, Ovid Medline, and EMBASE focusing on phase 3 clinical trials, post-hoc analysis studies, and real-world evidence (RWE) published in the past 5 years...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38405040/nmda-receptor-modulation-by-esculetin-investigating-behavioral-biochemical-and-neurochemical-effects-in-schizophrenic-mice-model
#29
JOURNAL ARTICLE
Iqra Khalid, Uzma Saleem, Bashir Ahmad, Mohammed F Hawwal, Ramzi A Mothana
Schizophrenia, a global mental health disorder affecting approximately 1 % of the population, is characterized by neurotransmitter dysregulation, particularly dopamine, serotonin, and glutamate. Current antipsychotic therapies, despite their efficacy, are accompanied by adverse effects, which has motivated researchers to investigate more secure substitutes. This study examines the potential antipsychotic effects of esculetin, a natural coumarin derivative recognized for its wide-ranging pharmacological activities (anti-inflammatory, antioxidant, anti-pathogenic, anticancer, and neuroprotective), in animal model of schizophrenia induced by ketamine...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38384478/chemical-profile-and-biological-properties-of-the-piper-corcovadense-c-dc-essential-oil
#30
JOURNAL ARTICLE
Bruno Henrique Fontoura, Ellen Cristina Perin, Ana Paula Buratto, Jucemar Francisco Schreiner, Kamyla Menezes Cavalcante, Sirlei Dias Teixeira, Daiane Manica, Rafael Antônio Narzetti, Gilnei Bruno da Silva, Margarete Dulce Bagatini, Tatiane Luiza Cadorin Oldoni, Solange Teresinha Carpes
The essential oil from Piper corcovadense D.DC. (EOPc), an important plant belonging to the Piperaceae family, which is commonly found in the northern region of Brazil and poorly explored scientifically, was used in this study. Thus, the EOPc was characterized chemically by Gas Chromatography/Mass Spectrometry (GC/MS) and the antioxidant and antimicrobial activities and their potential effects on cutaneous melanoma (SK-MEL-28) and healthy peripheral blood mononuclear (PBMC) cells were determined. The major compounds identified in the EOPc were: trans-sesquisabinene hydrate, trans-caryophyllene, β-pinene, trans-β-farnesene, 14-hydroxycaryophyllene, limonene and p -cymene...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38384477/challenges-and-insights-methamphetamine-analysis-in-post-mortem-putrefied-human-tissues-in-a-hot-climate
#31
JOURNAL ARTICLE
Ahmed Alasmari, Amani Alhejaili, Hassan Alharbi, Mansour Alzahrani, Torki Zughaibi
BACKGROUND: The production and distribution of methamphetamine (meth) is often associated with illegal and clandestine laboratories, posing significant challenges for law enforcement and public health efforts. Global concern is growing over meth-related fatalities, as its high potential for abuse and detrimental impact on health make it an important issue in the realm of substance abuse and addiction. This concern has notably increased in Saudi Arabia, where the hot climate adds complexity to the analysis due to challenges posed by putrefaction...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38384476/optimized-ribociclib-nanostructured-lipid-carrier-for-the-amelioration-of-skin-cancer-inferences-from-ex-vivo-skin-permeation-and-dermatokinetic-studies
#32
JOURNAL ARTICLE
Mohammed F Aldawsari, Mohammad Azhar Kamal, Mohamed F Balaha, Talha Jawaid, Mohammed Jafar, Sana Hashmi, Majid Ahmad Ganaie, Aftab Alam
Current research focuses on explicitly developing and evaluating nanostructured lipidic carriers (NLCs) for the chemotherapeutic drug Ribociclib (RCB) via the topical route to surmount the inherent bioavailability shortcomings. The absolute oral bioavailability has not been determined, but using a physiologically based pharmacokinetic model it was predicted that 65.8 % of the standard dose of RCB (600 mg) would be absorbed mainly in the small intestine. RCB-NLCs were produced using the solvent evaporation method, and Box-Behnken Design (BBD) was employed to optimize composition...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38380162/a-comprehensive-quality-control-and-cost-comparison-study-of-branded-and-generic-angiotensin-receptor-blockers
#33
JOURNAL ARTICLE
Arvind Kumar Sharma, Shruti Rastogi, Faraat Ali, Anuj Prakash Yadav, Ramesh K Goyal
This study was designed to assess both the quality and cost aspects of various branded and generic formulations of angiotensin receptor blockers, specifically Irbesartan, Losartan Potassium, Olmesartan Medoxomil, Telmisartan, and Valsartan. The collected samples underwent distinct quality evaluations using the methods outlined in different global Pharmacopoeias (British Pharmacopoeia/European Pharmacopoeia, Indian Pharmacopoeia and United States Pharmacopoeia). These drugs were characterized using Fourier-Transform Infrared Spectroscopy and Nuclear Magnetic Resonance techniques, while their quality and concentration were analysed using High Performance Liquid Chromatography...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38380161/muslim-pilgrims-knowledge-attitudes-and-practices-regarding-complementary-and-alternative-medicine-cam-a-study-conducted-during-hajj-season
#34
JOURNAL ARTICLE
Aljawharah A Alqathama, Rizwan Ahmad
Complementary and alternative medicine (CAM) has attracted much interest, and its prevalence in both developed and developing countries has increased. During the Hajj season, millions of Muslims from many different countries travel to Makkah for the pilgrimage. In dealing with health issues during the holy season, many pilgrims prefer to self-medicate with traditional remedies instead of visiting medical practitioners, which could affect the efforts of state healthcare organizations to maintain overall public health during this mass gathering...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38370133/consensus-methodology-to-investigate-the-crucial-referral-criteria-to-pharmacist-led-counseling-clinics-in-makkah-city
#35
JOURNAL ARTICLE
Sarah M Khayyat
AIM: Identifying and prioritizing criteria for referring patients to a counseling clinic managed by hospital pharmacists in the tertiary care setting in Saudi Arabia (SA). METHOD: A two-phase consensus Delphi methodological approach was adopted in this study. Data was collected from physicians and pharmacists from different specialties working in different hospitals in Makkah City. In Phase 1, semi-structured interviews were conducted with physicians and pharmacists to discuss and develop the initial list of potential referral criteria for post-discharge counseling...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38362039/the-anti-urolithiatic-effect-of-the-roots-of-saussurea-costus-falc-lipsch-agonist-ethylene-glycol-and-magnesium-oxide-induced-urolithiasis-in-rats
#36
JOURNAL ARTICLE
Naima Mammate, Fatima Ezzahra El Oumari, Hamada Imtara, Salim Belchkar, Ramzi A Mothana, Hinde E L Fatemi, Mohammed Danouche, Sara Er-Rahmani, Nabil Boucetta, Omar M Noman, Mahmoud Tarayrah, Tarik Sqalli Houssaini
Phytotherapy, which involves the use of plant extracts and natural compounds for medicinal purposes, is indeed a promising alternative for managing urinary lithiasis. Many plants have been studied for their potential to prevent and treat kidney stones, and they may offer a more natural and potentially less harmful approach compared to conventional treatments. Additionally, phytotherapy may be more cost-effective. The aim of the present study was to investigate the antilithic potential of extracts and essential oils of Saussurea costus (Falc) Lipsch in two in vivo models, one on ethylene glycol-induced calcium oxalate crystal formation and the other to assess the effects of these extracts on magnesium oxide-induced struvite crystal formation...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38357701/design-synthesis-molecular-docking-and-in-vitro-studies-of-2-mercaptoquinazolin-4-3-h-ones-as-potential-anti-breast-cancer-agents
#37
JOURNAL ARTICLE
Manal A Alossaimi, Yassine Riadi, Ghaida N Alnuwaybit, Shadab Md, Huda Mohammed Alkreathy, Engy Elekhnawy, Mohammed H Geesi, Safar M Alqahtani, Obaid Afzal
Triple-negative breast cancer (TNBC) comprises 10 % to 20 % of breast cancer, however, it is more dangerous than other types of breast cancer, because it lacks druggable targets, such as the estrogen receptors (ER) and the progesterone receptor (PR), and has under expressed receptor tyrosine kinase, ErbB2. Present targeted therapies are not very effective and other choices include invasive procedures like surgery or less invasive ones like radiotherapy and chemotherapy. This study investigated the potential anticancer activity of some novel quinazolinone derivatives that were designed on the structural framework of two approved anticancer drugs, Ispinesib (KSP inhibitor) and Idelalisib (PI3Kδ inhibitor), to find out solutions for TNBC...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38352238/preparation-and-in-vivo-evaluation-of-nano-sized-cubosomal-dispersion-loaded-with-ruta-graveolens-extracts-as-a-novel-approach-to-reduce-asthma-mediated-lung-inflammation
#38
JOURNAL ARTICLE
Mohammad H Alyami, Dalia I Hamdan, Heba M A Khalil, Mohamed A A Orabi, Nora M Aborehab, Nada Osama, Mai M Abdelhafez, Abdulaziz Mohsen Al-Mahallawi, Hamad S Alyami
Asthma is a chronic disease affecting people of all ages. Asthma medications are associated with adverse effects restricting their long-term usage, demanding newer alternative therapies. This study aimed to investigate the anti-asthmatic properties of Ruta graveolens extract and its prepared nano-cubosomal dispersion (Ruta-ND). Firstly, the R. graveolens methanolic extract exhibited higher anti-inflammatory activity on Lipopolysaccharide (LPS)-activated BEAS-2B cells. To ensure best bioavailability and hence best cellular uptake, R...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38348290/potentially-active-aspirin-derivative-to-release-nitric-oxide-in-vitro-in-vivo-and-in-silico-approaches
#39
JOURNAL ARTICLE
Amruta M Amritkar, Afzal Hussain, Mohammad A Altamimi, Sumel Ashique, Mohd Usman Mohd Siddique, Sushil Burle, Anwar R Shaikh, Sameer N Goyal, Zahid R Bhat
The series of newer salicylate derivatives incorporating nitroxy functionality were synthesized and evaluated for their potential effect in gastrointestinal (GI) related toxicity produced by aspirin. The synthesized compounds (5a-j) were subjected to %NO (nitric oxide) release study, in-vitro anti-inflammatory potential, % inhibition of carrageenan-induced paw edema and the obtained results were validated by in-silico studies including molecular docking, MD simulations and in-silico ADME (absorption, distribution, metabolism, and elimination) calculations...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38348289/establishing-competency-based-internship-program-through-participatory-action-research-in-a-private-pharmacy-college-in-the-eastern-province-of-saudi-arabia
#40
JOURNAL ARTICLE
Luma Ameer, Nousheen Aslam, Sherihan Ghosn, Jenan Al-Matouq, Zahra Al-Mousa, Safyah Alasfour, Manal Suroor, Yousif Hassan Amin
OBJECTIVES: To use Participatory Action Research (PAR) methodology to develop a competency-based training (CBT) program for Bachelor of Pharmacy interns at Mohammed Al-Mana College for Medical Sciences (MACHS), Dammam, Saudi Arabia, based on the International Pharmaceutical Federation (FIP) Global Competency Framework. METHODS: The MACHS Pharmacy Department Training Unit developed a competency-based training (CBT) framework over 6 cohorts of interns based on the FIP Global Competency Framework using the Participatory Action Research (PAR) methodology...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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