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Journals Saudi Pharmaceutical Journal :...

Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society

https://read.qxmd.com/read/38873335/skin-anti-aging-potential-of-launaea-procumbens-extract-antioxidant-and-enzyme-inhibition-activities-supported-by-admet-and-molecular-docking-studies
#1
JOURNAL ARTICLE
Hanan Khojah, Shaima R Ahmed, Shahad Y Alharbi, Kholood K AlSabeelah, Hatham Y Alrayyes, Kadi B Almusayyab, Shahad R Alrawiliy, Raghad M Alshammari, Sumera Qasim
Aging is a natural process that occurs in all living organisms. Particularly, the skin embodies aging since it serves as a barrier between the body and its surroundings. Previously, we reported the wound healing effect of Launaea procumbens and identified compounds therein. The study aims to explore the skin anti-aging properties of the plant extract. To that effect, the antioxidant potential of L. procumbens methanolic extract (LPM) was assessed using two complementary DPPH and FRAP assays. The enzyme inhibitory effect of the extract on collagenase, elastase, hyaluronidase, and tyrosinase was evaluated to assess the direct skin anti-aging effects...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38873334/diuretic-effects-of-hecogenin-and-hecogenin-acetate-via-aldosterone-synthase-inhibition
#2
JOURNAL ARTICLE
Abdulmohsin J Alamoudi, Maria Nazeer, Nabi Shah, Saif Ullah, Meshal Alshamrani, Waleed Y Rizg, Osama M Ashour, Ashraf B Abdel-Naim, Abdul Jabbar Shah
Hecogenin (HEC) is a steroidal saponin found in many plant species and serves as a precursor for steroidal drugs. The diuretic effects of HEC and its derivative, hecogenin acetate (HA), remain largely unexplored. The present study aimed to explore the potential diuretic effects of HEC and HA compared to furosemide (FUR) and spironolactone (SPIR). Additionally, the study aimed to explore the underlying mechanism particularly focusing on aldosterone synthase gene expression. Fifty-four Sprague-Dawley rats were allocated into nine groups (Group 1-9)...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38868175/effects-of-novel-beta-lactam-mc-100093-and-ceftriaxone-on-astrocytic-glutamate-transporters-and-neuroinflammatory-factors-in-nucleus-accumbens-of-c57bl-6-mice-exposed-to-escalated-doses-of-morphine
#3
JOURNAL ARTICLE
Youssef Sari, Ghadeer M S Swiss, Fatin A Alrashedi, Kholoud A Baeshen, Sultan A Alshammari, Shakir D Alsharari, Nemat Ali, Abdullah F Alasmari, Ali Alhoshani, Alaa A Alameen, Wayne E Childers, Magid Abou-Gharbia, Fawaz Alasmari
Chronic exposure to opioids can lead to downregulation of astrocytic glutamate transporter 1 (GLT-1), which regulates the majority of glutamate uptake. Studies from our lab revealed that beta-lactam antibiotic, ceftriaxone, attenuated hydrocodone-induced downregulation of GLT-1 as well as cystine/glutamate antiporter (xCT) expression in central reward brain regions. In this study, we investigated the effects of escalating doses of morphine and tested the efficacy of novel synthetic non-antibiotic drug, MC-100093, and ceftriaxone in attenuating the effects of morphine exposure in the expression of GLT-1, xCT, and neuroinflammatory factors (IL-6 and TGF-β) in the nucleus accumbens (NAc)...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38841107/formulation-and-evaluation-of-fluconazole-nanosuspensions-in-vitro-characterization-and-transcorneal-permeability-studies
#4
JOURNAL ARTICLE
Basmah N Aldosari, Mohamed Abbas Ibrahim, Yara Alqahtani, Amal El Sayeh F Abou El Ela
The aim in this study was to develop and evaluate a nanofluconazole (FLZ) formulation with increased solubility and permeation rate using nanosuspensions. The FLZ nanosuspensions were stabilized using a variety of stabilizing agents and surfactants in various concentrations. The FLZ nanosuspension was characterized in vitro using particle size, zeta potential, X-ray powder diffraction (XRPD), and solubility. In addition, the ex vivo ocular permeation of FLZ through a goat cornea was analyzed. The results showed that the particle size of all nanosuspension formulations was in the nanometer range from 174...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38841106/effect-of-eugenol-on-cytochrome-p450-1a2-2c9-2d6-and-3a4-activity-in-human-liver-microsomes
#5
JOURNAL ARTICLE
Naif Fahad M Alharbi, Abdul Ahad, Yousef A Bin Jardan, Fahad I Al-Jenoobi
This study aimed to provide an understanding of the influence of eugenol on CYP1A2, 2C9, 2D6, and 3A4 in human liver microsomes (HLM). Specific substrate for CYP1A2, 2C9, 2D6, and 3A4 were incubated in HLM with or without eugenol. The formation of their respective metabolites was assessed with HPLC analytical methods. Eugenol at 1, 10 and 100 µM levels inhibited the activity of CYP1A2 and CYP2C9 by 23.38 %, 23.57 %, 39.80 % and 62.82 %, 63.27 %, 67.70 % respectively. While, CYP2D6 and CYP3A4 activity was decreased by 40...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38831925/%C3%AE-glucosidase-butyrylcholinesterase-and-acetylcholinesterase-inhibitory-activities-of-phenolic-compounds-from-carthamus-tinctorius-l-flowers-in-silico-and-in-vitro-studies
#6
JOURNAL ARTICLE
Jawaher A M Alotaibi, Alaa Sirwi, Ali M El-Halawany, Ahmed Esmat, Gamal A Mohamed, Sabrin R M Ibrahim, Abdulrahim A Alzain, Taher F Halawa, Martin Safo, Hossam M Abdallah
Chemical investigation of Carthamus tinctorius L. flowers resulted in isolation of seven metabolites that were identified as; p -Hydroxybenzoic acid ( 1 ), trans hydroxy cinnamic acid ( 2 ), kaempferol-6-C-glucoside ( 3 ), astragalin ( 4 ), cartormin ( 5 ), kaempferol-3- O -rutinoside ( 6 ), and kaempferol-3- O -sophoroside ( 7 ). Virtual screening of the isolated compounds against human intestinal α-glucosidase, acetylcholinesterase, and butyrylcholinesterase was carried out. Additionally, the antioxidant activity of the bioactive compounds was assessed...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38817822/formulation-development-and-evaluation-of-hyaluronic-acid-conjugated-liposomal-nanoparticles-loaded-with-regorafenib-and-curcumin-and-their-in-vitro-evaluation-on-colorectal-cancer-cell-lines
#7
JOURNAL ARTICLE
Sewar G Shnaikat, Ashok K Shakya, Sanaa K Bardaweel
Colorectal cancer is one of the major causes of global cancer, with chemotherapy and radiation therapy being effective but limited due to low specificity. Regorafenib, a multikinase inhibitor, provides hope to patients with metastatic colorectal cancer and was approved by the FDA in 2012. However, due to resistance issues and adverse events, its efficacy is compromised, necessitating further refinement. Meanwhile, curcumin, a compound of turmeric, exhibits anticancer effects through antioxidant and anti-inflammatory actions, induction of the apoptosis, arrest of cell cycle, inhibition of angiogenesis, and modulation of signaling pathways...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38817821/role-of-kdm2b-epigenetic-factor-in-regulating-calcium-signaling-in-prostate-cancer-cells
#8
JOURNAL ARTICLE
Evangelia Pantazaka, Saad Alkahtani, Saud Alarifi, Abdullah A Alkahtane, Christos Stournaras, Galatea Kallergi
KDM2B, a histone lysine demethylase, is expressed in a plethora of cancers. Earlier studies from our group, have showcased that overexpression of KDM2B in the human prostate cancer cell line DU-145 is associated with cell adhesion, actin reorganization, and improved cancer cell migration. In addition, we have previously examined changes of cytosolic Ca2+ , regulated by the pore-forming proteins ORAI and the Ca2+ sensing stromal interaction molecules (STIM), via store-operated Ca2+ entry (SOCE) in wild-type DU-145...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38817820/-baeckea-frutescens-l-promotes-wound-healing-by-upregulating-expression-of-tgf-%C3%AE-il-1-%C3%AE-vegf-and-mmp-2
#9
JOURNAL ARTICLE
Ihsan Safwan Kamarazaman, Ling Sui Kiong, Mohd Kamal Nik Hasan, Norlia Basherudin, Nur Aini Mohd Kasim, Aida Azlina Ali, Salfarina Ramli, Sandra Maniam, Richard Johari James, Pornchai Rojsitthisak, Hasseri Halim
Baeckea frutescens L. has been traditionally used for treating snakebites and is known to possess antifebrile and hemostatic properties. These properties are closely related to wound healing. This study aimed to evaluate the wound healing properties of B. frutescens leaves extract (BFLE) in vitro and in vivo. The in vitro study focused on proliferation, migration, and expression of TGF-β, IL-1β, VEGF, and MMP-2 genes and proteins. The in vivo study included excisional wound healing, histology, and tensile strength studies...
July 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38812945/preparing-a-novel-baicalin-loaded-microemulsion-based-gel-for-transdermal-delivery-and-testing-its-anti-gout-effect
#10
JOURNAL ARTICLE
Yingzhou Wang, Mingxue Liu, Junjie Li, Peipei Jiang, Di Han, Hongling Zhang, Lingyun Xu, Yinsheng Qiu
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of baicalin against GA. The preparation method and transdermal capability of B-MEG was screened and optimized using the central composite design, Franz diffusion cell experiments, and the split-split plot design. Skin irritation tests were performed in guinea pigs. The anti-gout effects were evaluated using mice...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38812944/development-of-a-microcantilever-based-biosensor-for-detecting-programmed-death-ligand-1
#11
JOURNAL ARTICLE
Tajweed Neairat, Mahmoud Al-Gawati, Qura Tul Ain, Abdulaziz K Assaifan, Aws Alshamsan, Abdulaziz Alarifi, Abdullah N Alodhayb, Khalid E Alzahrani, Hamad Albrithen
The ongoing global concern of cancer worldwide necessitates the development of advanced diagnostic and therapeutic strategies. The majority of recent detection strategies involve the employment of biomarkers. A critical biomarker for cancer immunotherapy efficacy and patient prognosis is Programmed Death Ligand 1 (PD-L1), which is a key immune checkpoint protein. PD-L1 can be particularly linked to cancer progression and therapy response. Current detection methods, such as enzyme-linked immunosorbent assay (ELISA), face limitations like high cost, time consumption, and complexity...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38812943/the-concomitant-use-of-ultra-short-beta-blockers-with-vasopressors-and-inotropes-in-critically-ill-patients-with-septic-shock-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
JOURNAL ARTICLE
Khalid Al Sulaiman, Hadeel A Alkofide, Mashael E AlFaifi, Sarah S Aljohani, Abdullah F Al Harthi, Rahaf A Alqahtani, Ashwaq M Alanazi, Lama H Nazer, Abdulrahman I Al Shaya, Ohoud Aljuhani
BACKGROUND: Septic shock is associated with systemic inflammatory response, hemodynamic instability, impaired sympathetic control, and the development of multiorgan dysfunction that requires vasopressor or inotropic support. The regulation of immune function in sepsis is complex and varies over time. However, activating Beta-2 receptors and blocking Beta-1 receptors reduces the proinflammatory response by influencing cytokine production. Evidence that supports the concomitant use of ultra short beta-blockers with inotropes and vasopressors in patients with septic shock is still limited...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38799001/role-of-diosmin-in-preventing-doxorubicin-induced-cardiac-oxidative-stress-inflammation-and-hypertrophy-a-mechanistic-approach
#13
JOURNAL ARTICLE
Abdullah F AlAsmari, Mohammed M Al-Shehri, Nasser Algarini, Nada A Alasmari, Alabid Alhazmi, Mohammed AlSwayyed, Metab Alharbi, Fawaz Alasmari, Nemat Ali
Chemotherapeutic drugs, such as doxorubicin (Dox), are commonly used to treat a variety of malignancies. However, Dox-induced cardiotoxicity limits the drug's clinical applications. Hence, this study intended to investigate whether diosmin could prevent or limit Dox-induced cardiotoxicity in an animal setting. Thirty-two rats were separated into four distinct groups of controls, those treated with Dox (20 mg/kg, intraperitoneal, i.p.), those treated with diosmin 100 mg plus Dox, and those treated with diosmin 200 mg plus Dox...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38799000/streptomyces-isolate-som013-a-potential-agent-against-microbial-resistance-and-gastric-ulcers
#14
JOURNAL ARTICLE
Kizito Eneye Bello, Ahmad Adebayo Irekeola, Ahmad A Alshehri
The menace of microbial resistance and re-emerging disease is still a problem for healthcare givers globally, and the need for newer sources of potent antibiotics has become paramount. This study investigated the antimicrobial and antiulcer activities of Streptomyces isolate SOM013. Streptomyces isolates were cultivated and purified following standard microbiological protocols. Secondary metabolites were recovered and characterized from Streptomyces isolate SOM013 via broth fermentation and extraction. Varying concentrations (0...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38798999/evaluation-of-factors-affecting-pharmacists-and-pharmacy-technicians-satisfaction-towards-practicing-ce-activities-in-saudi-arabia
#15
JOURNAL ARTICLE
Raniah Aljadeed, Rana Aljadeed, Wasmeah Alsamti, Hadeel Alharbi, Rand Alturki, Haya Almalag, Lobna Aljuffali, Jawza Alsabhan, Noha AlAloola, Hadeel Alkofide, Rihaf Alfaraj, Njoud Altuwaijri, Nora Alkhudair, Lamya Alnaim, Ghada Bawazeer
BACKGROUND: Continuing education (CE) is an essential requirement for pharmacy professionals to stay abreast with the evolving knowledge and skills of the practice and meet the regulatory mandate. The purpose of this research is to assess factors affecting the satisfaction of pharmacists and pharmacy technicians towards CE practices in Saudi Arabia. MATERIAL AND METHODS: A self-administered survey instrument was developed following an extensive literature search...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38774811/trend-of-pharmaceuticals-3d-printing-in-the-middle-east-and-north-africa-mena-region-an-overview-regulatory-perspective-and-future-outlook
#16
JOURNAL ARTICLE
Riyad F Alzhrani, Mohammed Y Alyahya, Mohammed S Algahtani, Rawan A Fitaihi, Essam A Tawfik
The traditional method of producing medicine using the "one-size fits all" model is becoming a major issue for pharmaceutical manufacturers due to its inability to produce customizable medicines for individuals' needs. Three-dimensional (3D) printing is a new disruptive technology that offers many benefits to the pharmaceutical industry by revolutionizing the way pharmaceuticals are developed and manufactured. 3D printing technology enables the on-demand production of personalized medicine with tailored dosage, shape and release characteristics...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38766274/%C3%AE-glucosidase-inhibitory-potential-of-oroxylum-indicum-using-molecular-docking-molecular-dynamics-and-in-vitro-evaluation
#17
JOURNAL ARTICLE
Samhita Bhaumik, Alekhya Sarkar, Sudhan Debnath, Bimal Debnath, Rajat Ghosh, Magdi E A Zaki, Sami A Al-Hussain
BACKGROUND: According to the International Diabetes Federation, there will be 578 million individuals worldwide with diabetes by 2030 and 700 million by 2045. One of the promising drug targets to fight diabetes is α-glucosidase (AG), and its inhibitors may be used to manage diabetes by reducing the breakdown of complex carbohydrates into simple sugars. The study aims to identify and validate potential AG inhibitors in natural sources to combat diabetes. METHODS: Computational techniques such as structure-based virtual screening and molecular dyncamic simulation were employed to predict potential AG inhibitors from compounds of Oroxylum indicum ...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38766273/a-novel-source-of-biologically-active-compounds-the-leaves-of-serbian-herbaceous-peonies
#18
JOURNAL ARTICLE
Petar Batinić, Aleksandra Jovanović, Dejan Stojković, Natalija Čutović, Ilija Cvijetić, Uroš Gašić, Tamara Carević, Gökhan Zengin, Aleksandar Marinković, Tatjana Marković
In order to gain further insight into how various extraction techniques (maceration, microwave-, and ultrasound-assisted extractions) affect the chemical profile and biological activities of leaf extracts from Paeonia tenuifolia L., Paeonia peregrina Mill., and Paeonia officinalis L., this research was performed. The targeted chemical characterization of the extracts was achieved using the Ultra-High-Performance-Liquid-Chromatography-Linear-Trap-Mass-Spectrometry OrbiTrap instrumental technique, while Fourier Transform Infrared Spectroscopy was conducted to investigate the structural properties of the examined leaf extracts...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38757071/human-plasma-derived-exosomes-impact-of-active-and-passive-drug-loading-approaches-on-drug-delivery
#19
JOURNAL ARTICLE
Rabia Gul, Hamid Bashir, Muhammad Sarfraz, Ahson Jabbar Shaikh, Yousef A Bin Jardan, Zahid Hussain, Muhammad Hassham Hassan Bin Asad, Faisal Gulzar, Bo Guan, Imran Nazir, Muhammad Imran Amirzada
The aim of the current study was to explore the potential of human plasma-derived exosomes as versatile carriers for drug delivery by employing various active and passive loading methods. Exosomes were isolated from human plasma using differential centrifugation and ultrafiltration method. Drug loading was achieved by employing sonication and freeze thaw methods, facilitating effective drug encapsulation within exosomes for delivery. Each approach was examined for its effectiveness, loading efficiency and ability to preserve membrane stability...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38757070/patient-satisfaction-with-private-community-pharmacies-versus-pharmacies-in-primary-health-care-centers-in-saudi-arabia
#20
JOURNAL ARTICLE
Ali M Alzahrani, Abdulrhman A Alzhrani, Holly C Felix, Khulud K Alharbi, Muhammad Waseem Shahzad, Turky J Arbaein, Sarah S Monshi
INTRODUCTION: Saudi Arabia has begun reforming its government-run health care system to increase efficiency and reduce costs. One effort is the adoption of an electronic prescribing system (Wasfaty) and outsourcing pharmaceutical services from government-run clinics to community pharmacies (CP). This study aims to compare satisfaction with pharmaceutical services offered in the two systems. MATERIALS AND METHODS: This cross-sectional observational study used existing survey data collected from patients (≥15 years of age) visiting government primary health care centers from January 2022 to June 2022...
June 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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