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Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society

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https://read.qxmd.com/read/30766442/employing-a-plga-tpgs-based-nanoparticle-to-improve-the-ocular-delivery-of-acyclovir
#1
Musaed Alkholief, Hammam Albasit, Adel Alhowyan, Sultan Alshehri, Mohammad Raish, Mohd Abul Kalam, Aws Alshamsan
Delivering drugs via the ocular route has always been a challenge for poorly soluble drugs. The various anatomical and physiological barriers in the eye cavity hinder the residence of drugs within the corneal and precorneal regions. In this study, the nanosystem that could sufficiently deliver the poorly soluble Acyclovir topically via ocular route. Our nanosystem is composed of the biocompatible PLGA polymer stabilized with TPGS which possess a high emulsifying capacity and is also known as P-gp inhibitor...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766441/antibacterial-activity-of-biosynthesized-gold-nanoparticles-using-biomolecules-from-lignosus-rhinocerotis-and-chitosan
#2
Haliza Katas, Chei Sin Lim, Ahmad Yasser Hamdi Nor Azlan, Fhataheya Buang, Mohd Fauzi Mh Busra
A simple, cost-effective, and environmentally friendly method is needed for synthesizing metal nanoparticles, including gold nanoparticles (AuNPs). In this study, AuNPs were synthesized with Lignosus rhinocerotis sclerotial extract (LRE) and chitosan (CS) as reducing and stabilizing agents, respectively. Different LRE concentrations from cold and hot water extraction (CWE and HWE, respectively) were used to reduce chloroauric acid (HAuCl4 ) to form AuNPs. Positively charged chitosan stabilized AuNPs (CS-AuNPs) mediated by LRE exhibited a surface plasmon resonance (SPR) band at 533 nm...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766440/students-perception-of-an-industry-based-approach-problem-based-learning-pbl-and-their-performance-in-drug-delivery-courses
#3
Mumtaz Hussain, Shariza Sahudin, Nor Hayati Abu Samah, Nor Khaizan Anuar
Objective: To investigate students perception of an industry based approach problem based learning (PBL) and their performance in drug delivery courses in pharmaceutics. Methods: PBL was implemented within two drug delivery courses in 2015, in anticipation that the use of formulation or industrial instead of clinical or pharmacy practice based triggers, would open up student interest and understanding towards learning pharmaceutics in relation to industrial pharmacy...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766439/dissolution-and-bioavailability-improvement-of-bioactive-apigenin-using-solid-dispersions-prepared-by-different-techniques
#4
Sultan M Alshehri, Faiyaz Shakeel, Mohamed A Ibrahim, Ehab M Elzayat, Mohammad Altamimi, Kazi Mohsin, Osaid T Almeanazel, Musaed Alkholief, Abdullah Alshetaili, Bader Alsulays, Fars K Alanazi, Ibrahim A Alsarra
Apigenin (APG) is a poorly soluble bioactive compound/nutraceutical which shows poor bioavailability upon oral administration. Hence, the objective of this research work was to develop APG solid dispersions (SDs) using different techniques with the expectation to obtain improvement in its in vitro dissolution rate and in vivo bioavailability upon oral administration. Different SDs of APG were prepared by microwave, melted and kneaded technology using pluronic-F127 (PL) as a carrier. Prepared SDs were characterized using "thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier transform infra-red (FTIR) spectrometer, powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM)"...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766438/knowledge-attitudes-and-use-of-anabolic-androgenic-steroids-among-male-gym-users-a-community-based-survey-in-riyadh-saudi-arabia
#5
Fares F Alharbi, Islam Gamaleddin, Samar F Alharbi, Omar Almodayfer, Fahad Allohidan, Mohammed Alghobain, Asaad Arafah, Khaled Al-Surimi
Recreational use of anabolic-androgenic steroids (AAS) is a growing worldwide public health concern. However, studies assessing the level of awareness and knowledge of its effects on health are fairly limited, especially in developing countries, including Saudi Arabia. This community-based cross-sectional study was conducted to assess knowledge, attitudes and practices among male gym members toward AAS in Riyadh (Saudi Arabia) from March to October 2016. Twenty gyms were randomly selected from four different geographical regions (clusters) within Riyadh...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766437/psychotropic-drug-prescribing-correlates-of-disorganized-speech-in-asians-with-schizophrenia-the-reap-ap-study
#6
Yong Chon Park, Min-Soo Lee, Tian-Mei Si, Helen F K Chiu, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Pichet Udomratn, Kok Yoon Chee, Andi J Tanra, Golam Rabbani, Afzal Javed, Samudra Kathiarachchi, Win Aung Myint, Tran Van Cuong, Kang Sim, Shu-Yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka Shinfuku, Seon-Cheol Park
Background: Although disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large samples of schizophrenia patients. Objective: We aimed to examine the prevalence of disorganized speech and its correlates in terms of psychotropic drug prescribing, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766436/are-dietary-supplements-containing-plant-derived-ingredients-safe-microbiologically
#7
Jolanta Dlugaszewska, Magdalena Ratajczak, Dorota Kamińska, Marzena Gajecka
Dietary supplements, particularly those containing ingredients of natural origin, may contain microbiological contaminants, both bacterial and fungal. The present study evaluated the microbiological purity of selected dietary supplements containing plant-based ingredients before their release to the market, as well as raw materials of plant origin which are used in the production of such supplements. A total of 122 samples of supplements and 30 materials of plant origin were studied, with 92.1% exhibiting different degrees of bacterial contamination...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766435/practices-awareness-and-attitudes-toward-self-medication-of-analgesics-among-health-sciences-students-in-riyadh-saudi-arabia
#8
Mohammed Al Essa, Abdulmajeed Alshehri, Mohammed Alzahrani, Rami Bustami, Shazia Adnan, Atheer Alkeraidees, Amjad Mudshil, Jawaher Gramish
Background: Self-medication is a common practice among health sciences students in Saudi Arabia. It is known that inappropriate selfmedication may harm individuals due to increasing the risk of drug misuse or delaying a hospital visit by masking some symptoms. Thus, the aim of our study is to investigate and assess practices, awareness and attitudes toward analgesics self-medication among health science students in Riyadh, Saudi Arabia. Methods: This is a cross-sectional study in a form of electronic survey that was conducted among health sciences students from different universities in Riyadh, Saudi Arabia in 2016...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766434/assessment-of-the-risk-of-qt-interval-prolongation-associated-with-potential-drug-drug-interactions-in-patients-admitted-to-intensive-care-units
#9
Flávia Medeiros Fernandes, Aryelle Mayara da Silva Paulino, Bruna Camelo Sedda, Eliane Pereira da Silva, Rand Randall Martins, Antonio Gouveia Oliveira
Objectives: To evaluate the relationship between drug interactions and QT-interval prolongation in patients admitted to a general intensive care unit (ICU). Methods: This study was approved by the Institutional Review Board and written informed consent was obtained from all patients. From May 2015 to July 2016, all patients over 18 years-old admitted to the ICU for more than 24 h and in whom the QT-interval on the ECG could be read were prospectively included in this observational, cross-sectional study...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766433/attitude-and-knowledge-of-saudi-community-pharmacists-towards-use-of-proton-pump-inhibitors
#10
Abdulaziz Alhossan, Ziyad Alrabiah, Sultan Alghadeer, Salmeen Bablghaith, Syed Wajid, Mohammed Al-Arifi
Introduction: Proton pump inhibitors (PPIs) effectively suppress acid secretion and play an important role in peptic ulcer disease and gastroesophageal reflux disease . There is a real concern about the overutilization of PPIs, which will lead to significant high cost and undesirable outcomes . Despite that most of PPIs are classified as prescribed medications, yet most of their users take them without prescription in Saudi Arabia. Therefore, it was important to understand community pharmacists practice in dealing with PPIs and to evaluate their despising pattern of these medications...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766432/effect-of-hydroxylated-solvents-on-the-active-constituents-of-salvadora-persica-root-siwak
#11
Maged S Abdel-Kader, Khalid S Al Shahrani, Mohammed H Alqarni, Mohammed A Salkini, Elsadig H Khamis, Hazem A Ghabbour, Saleh I Alqasoumi
Previously, the antimicrobial activity of Salvadora persica was traced to benzyl isothiocyanate. In the present study known inactive compounds were isolated from extracts obtained by different solvents including β -amyrin, β -sitosterol, stigmasterol glucoside, benzyl cyanide and sulphur. However, some inactive compounds were present only in the ethanol and methanol extracts. This observation indicated that these compounds most likely are artifacts resulted from interaction with the solvents used in extraction...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766431/identifying-treatment-related-problems-and-associated-factors-among-hospitalized-post-stroke-patients-through-medication-management-review-a-multi-center-study
#12
Iman A Basheti, Shahnaz Mohammed Ayasrah, Muayyad Ahmad
Background: Stroke is a major cause of disability and one of the leading causes of death among the elderly. Treatment related problems can lead to undesirable consequences. The Medication Management Review (MMR) service is aimed at identifying, resolving and preventing TRPs, subsiding the undesirable outcomes associated with TRPs. Objectives: To explore the types, frequencies and severity of TRPs amongst post-stroke patients recruited through hospitals via conducting the MMR service by clinical pharmacists in Jordan...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766430/vitamin-d-status-in-relation-to-age-bone-mineral-density-of-the-spine-and-femur-in-obese-saudi-females-a-hospital-based-study
#13
Tarfa Ibrahim Albrahim, Manal Abdulaziz Binobead
The aim of the present study was to evaluate the association between Bone mineral density in lumber spine and femoral neck with serum total levels of vitamin D, sun exposure and Consumption of vitamin D Supplement in obese Saudi females aged between 30 and 54 years old. Recent attention to the high prevalence of osteoporosis and its association with low vitamin D levels in adults has raised the importance of vitamin D evaluation. A low level of vitamin D is considered to be one of the most important risk factors for osteoporosis...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766429/-cassia-grandis-lf-nanodispersion-is-a-hypoglycemic-product-with-a-potent-%C3%AE-glucosidase-and-pancreatic-lipase-inhibitor-effect
#14
Ariadna Lafourcade Prada, Hady Keita, Tatiane Pereira de Souza, Emerson Silva Lima, Leonard Domingo Rosales Acho, Márcia de Jesus Amazonas da Silva, José Carlos Tavares Carvalho, Jesus Rafael Rodriguez Amado
Purpose: This study aimed to evaluate the hypoglycemic effect, antioxidant, α-glucosidase and lipase inhibitory activity, and the cytotoxicity of the Cassia grandis nanodispersion (CgND). Methods: The hypoglycemic effect was evaluated in alloxan-induced diabetic mice. The particle size, polydispersion index, ζ-potential, and conductivity, as well as the drug-loaded content, were monitored in shelf-live, along a year. The delivery profile was evaluated in simulated intestinal fluids at pH 6...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766428/utilizing-mixer-torque-rheometer-in-the-prediction-of-optimal-wet-massing-parameters-for-pellet-formulation-by-extrusion-spheronization
#15
Mohamed A Ibrahim, Gamal M Zayed, Fahd M Alsharif, Wael A Abdelhafez
In this study, we aimed to optimize theophylline pellet formulations using a two-factor three-level full-factorial design (32 ) by monitoring the concentration of two pellet excipients, polyvinyl pyrrolidone K30 (PVP) binder solution (X1) and the hydrophilic excipient mannitol (X2). Their impact on pellet characteristics (responses) were evaluated. Increasing PVP concentration in the binder solution resulted in an increase in the wet mass torque value. The effect of mannitol, however, was antagonistic. Moreover, the pellet particle size was significantly influenced by the level of mannitol, PVP solution, and quadratic effect of mannitol...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766427/exploring-healthcare-professionals-perceptions-of-medication-errors-in-an-adult-oncology-department-in-saudi-arabia-a-qualitative-study
#16
Waleed Alharbi, Jennifer Cleland, Zoe Morrison
Objective: Adverse events which result from medication errors are considered to be one of the most frequently encountered patient safety issues in clinical settings. We undertook a qualitative investigation to identify and explore factors relating to medication error in an adult oncology department in Saudi Arabia from the perspective of healthcare professionals. Methods: This was a qualitative study conducted in an adult oncology department in Saudi Arabia. After obtaining required ethical approvals and written consents from the participants, semi-structured interviews and focus group discussions were carried out for data collection...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766426/influence-of-chitosan-coating-on-the-oral-bioavailability-of-gold-nanoparticles-in-rats
#17
Ahmed Alalaiwe, Paul Carpinone, Saad Alshahrani, Bader Alsulays, Mohammed Ansari, Mohammed Anwer, Sultan Alshehri, Abdullah Alshetaili
Gold nanoparticles are one of the most extensively investigated metallic nanoparticles for several applications. It is less toxic than other metallic nanolattices. The exceptional electrical and thermal conductivity of gold make it possible to be administered as non-invasive radiofrequency irradiation therapy that produces sufficient heat to kill tumor cells. Nanoparticles are generally administered intravenously instead of orally due to negligible oral absorption and cellular uptake. This study evaluated the oral bioavailability of gold nanoparticles coated with chitosan (C-AuNPs), a natural mucoadhesive polymer...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766425/comparative-evaluation-of-cytotoxic-antimicrobial-and-antioxidant-activities-of-the-crude-extracts-of-three-plectranthus-species-grown-in-saudi-arabia
#18
Ramzi A Mothana, Jamal M Khaled, Ali A El-Gamal, Omar M Noman, Ashok Kumar, Mohamed F Alajmi, Adnan J Al-Rehaily, Mansour S Al-Said
Natural products from medicinal plants represent major resource of novel therapeutic substances for combating serious diseases including cancers and microbial infections. The genus Plectranthus (Family: Labiatae) represents a large and widespread group of species with a diversity of traditional uses in treatment of various ailments. Therefore, this research study aimed to evaluate the cytotoxic, antimicrobial and antioxidant activities of three Plectranthus species growing in Saudi Arabia namely P. cylindraceus Hocst...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30766424/knowledge-and-attitude-towards-dentist-industry-relationship-and-their-association-with-own-behavior-among-dentists-working-in-saudi-arabia
#19
Abdulaziz M Albaker, Fahad D Alosaimi
Objectives: To examine the knowledge and attitude towards dentist-industry relationship including accepting gifts, influence on decisions, and accuracy of given information among dentists working in Saudi Arabia. In addition, to examine the association of such knowledge and attitude of dentists' behavior with industry, including sorts of interaction and accepting industrial gifts. Methods: A cross-sectional study was conducted among dental practitioners working in the private and governmental hospitals located in the various regions of Saudi Arabia...
February 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/30662318/quantification-of-the-constituents-of-the-traditional-korea-medicine-samryeongbaekchul-san-and-assessment-of-its-antiadipogenic-effect
#20
Chang-Seob Seo, Sae-Rom Yoo, Soo-Jin Jeong, Hyekyung Ha
Samryeongbaekchul-san (SBS) is a traditional herbal formula, which is used for the treatment of dyspepsia, chronic gastritis, and anorexia in Korea. To evaluate the quality of SBS decoction by quantifying its main constituents simultaneously using high-performance liquid chromatography coupled with photodiode array (HPLC-PDA) detection, and secondly to determine the antiadipogenic effect of SBS decoction. The main constituents in a 10-μL injection volume of the decoction were separated on Gemini C18 and Luna NH2 columns (both 250 mm × 4...
January 2019: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
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