journal
https://read.qxmd.com/read/38965950/mycobacterium-infection-of-abscess-with-hemoptysis-as-the-initial-manifestation
#21
JOURNAL ARTICLE
Jingshan Bai, Wanyang Xu, Wenrui Li, Xiaoning Zhang, Kunyang Li, Yutao Zhou
BACKGROUND: Mycobacterium abscessus is a new pathogen in recent years, which belongs to non-tuberculosis mycobacterium. Mycobacterium abscessus is widely involved in many nosocomial infections and secondary aggravation of genetic respiratory diseases. Mycobacterium abscessus is naturally resistant to most antibiotics and is difficult to treat. We report a case of mycobacterium abscessus infection with hemoptysis as the first manifestation. METHODS: Bronchoscopy, next-generation sequencing (NGS)...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965949/clinical-characteristics-and-diagnosis-of-nonaccelerating-mds-mpn-u-patient-with-granulocyte-dysplasia
#22
REVIEW
Nana Jin, Shang Li
BACKGROUND: The goal was to improve the clinical cognition of nonaccelerating myelodysplastic/myeloproliferative neoplasms-unclassifiable (MDS/MPN-U) and avoid misdiagnosis or delayed diagnosis. METHODS: The clinical manifestations, laboratory indicators, histopathology, and therapeutic effects of a patient with nonaccelerating MDS/MPN-U were analyzed and the relevant literature was reviewed. RESULTS: Blood routine: white blood cell 98.48 x 109/L, red blood cell 3...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965948/respiratory-viruses-co-detection-on-a-multiplex-rt-pcr-panel-a-comparative-clinical-study
#23
COMPARATIVE STUDY
Qute Choi, Hyun Jin Kim
BACKGROUND: The FilmArray Respiratory Panel RP 2.1 plus (FilmArray RP) is a point-of-care syndromic panel for respiratory pathogens. Although highly valuable in the clinical settings, the co-detection of pathogens in FilmArray RP may confound result interpretation. METHODS: Nasopharyngeal swab specimens collected from patients with respiratory symptoms were analyzed by comparing co-detection results from FilmArray RP with those of Allplex Respiratory Panels (Allplex RP: Power-Chek for SARS-CoV-2)...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965947/a-rare-case-of-autoimmune-hemolytic-anemia-caused-by-autoantibody-with-mimicking-anti-d-and-anti-c-specificity
#24
JOURNAL ARTICLE
Yang Liyan, Zhang Yu, Feng Jing
BACKGROUND: Most of the autoantibodies that cause autoimmune hemolytic anemia (AIHA) are non-specific. Autoantibodies expressing alloantibody specificity are rare. METHODS: We present the case of a 4-year-old boy with no history of blood transfusion or underlying medical conditions who developed AIHA caused by autoantibody with mimicking anti-D and anti-C specificity. RESULTS: Following treatment with methylprednisolone sodium succinate and transfusion of red blood cells with negative antigens for D and C, along with administration of human immunoglobulin, the patient's condition gradually improved...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965946/easynat-mtc-assay-a-rapid-method-to-detect-mycobacterium-tuberculosis-in-respiratory-specimens
#25
JOURNAL ARTICLE
Ying Zheng, Qing-Yong Wang
BACKGROUND: This study aimed to effectively evaluate the diagnostic performance of the EasyNAT Mycobacterium tuberculosis complex (MTC) assay for tuberculosis (TB) detection from sputum. METHODS: The retrospectively analyzed data was collected from September 1, 2021, to November 1, 2023, in our hospital. RESULTS: Forty EasyNAT-positive sputum specimens were simultaneously detected using the GeneXpert MTB/ rifampicin (RIF) assay. The concordance rate between the EasyNAT and GeneXpert MTB/RIF assays was 100%...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965945/ferritin-and-serum-iron-in-a-causal-relationship-with-estrogen-receptor-negative-breast-cancer-a-two-sample-mendelian-randomization-study
#26
JOURNAL ARTICLE
Yi Lu, Liumei Lin, Jun Shen
BACKGROUND: The aim of this study was to explore the causal relationship between different serum iron statuses (ferritin, transferrin, transferrin saturation, and serum iron) and the occurrence of estrogen receptor (ER)-positive or ER-negative breast cancer. METHODS: The summary data on serum iron status exposure were gathered from the IEU OpenGWAS Project, the UK Biobank, and other databases. Concurrently, the summary data for ER+ and ER- breast cancer are sourced from the Breast Cancer Association Consortium (BCAC)...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965944/assessing-the-accuracy-of-self-specimen-collection-in-hpv-testing-implications-for-clinical-laboratory-practice
#27
LETTER
Pathum Sookaromdee, Viroj Wiwanitkit
No abstract text is available yet for this article.
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965943/determination-of-reference-intervals-of-some-biochemistry-tests-by-the-bhattacharya-and-hoffmann-methods
#28
JOURNAL ARTICLE
Cengiz Aydin, Bagnu Orhan, Cahide Güldür
BACKGROUND: Clinical laboratory tests are being evaluated with reference intervals (RI). Therefore, it is important that each laboratory determines and classifies its own reliable RI for each test to ensure an accurate and effective interpretation. The proposed method for determining RI is the "direct" approach, but it is a difficult, troublesome, time-consuming, and expensive method. An alternative approach is the "indirect" approach. In this study, we aimed to compare the RI values determined by the indirect method from the Calcium (Ca), Magnesium (Mg), Phosphate (P), 25-Hydroxy Vitamin D (25(OH)D), and Parathyroid hormone (PTH) test results with the RI provided by the manufacturer...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965942/first-case-of-septic-shock-caused-by-cetobacterium-somerae
#29
JOURNAL ARTICLE
Min Young Lee, Myeong Hee Kim, Woo In Lee, So Young Kang
BACKGROUND: Cetobacterium somerae rarely causes infection in humans. Most studies on C. somerae have analyzed its role in the intestinal system of freshwater fish. METHODS: Herein, we report a case of septic shock caused by C. somerae in an elderly patient. RESULTS: Blood culture revealed growth of a gram-negative, rod-shaped anaerobic bacterium, which was identified as C. somerae through MALDI-TOF analyses. Although C. somerae is a resident species in the gut, it can cause systemic infection, which can be fatal...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965941/molecular-detection-of-salmonella-typhi-isolated-from-patients-undergoing-gallbladder-cholecystectomy-in-baghdad
#30
JOURNAL ARTICLE
Maryam K Ali, Jaafar S Shia
BACKGROUND: Salmonella typhi is a specific strain of the Salmonella bacterium, responsible for triggering typhoid fever; a significant public health concern in developing nations. OBJECTIVE: The current study aimed to identify the bacteria from the gallbladder, taken during cholecystectomies of patients, by isolating Salmonella typhi and by using microscopic characteristics, biochemical and polymerase chain reaction (PCR) tests. METHODS: A total of 120 specimens were collected from the Baghdad Teaching Hospital, Iraq...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965940/a-novel-and-simple-method-for-a-differentiation-of-alcohol-types
#31
JOURNAL ARTICLE
Alper Gümüş, Burak Gümüş, Ali K Erenler, Uğur Çom, Mehmet Şahin, Mehmet N Sutaşir
BACKGROUND: Alcohol poisoning is a significant global problem that has become an epidemic. The determination of the alcohol type is hereby essential as it may affect the course of the treatment; however, there is no routine laboratory diagnostic method for alcohol types other than for ethanol. In this study, we aimed to define a simple method for alcohol type differentiation by utilizing a combination of breathalyzer and spectrophotometrically measured serum ethanol results. METHODS: A breathalyzer and spectrophotometry were used to measure four different types of alcohol: ethanol, isopropanol, methanol, and ethylene glycol...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868895/pseudo-elevation-of-tsh-and-acth-caused-by-heterophilic-antibodies-a-case-report-and-literature-review
#32
REVIEW
Hong-Gang Sun, Xiu-Ping Xu, Li-Qin He
BACKGROUND: TSH and ACTH are crucial hormones for diagnosing thyroid and adrenal diseases, and incorrect test reports can cause significant harm to patients. METHODS: The TSH and ACTH levels on the testing system of our laboratory were measured using "sandwich" assays. The patient had heterophilic antibodies in their body, causing a false increase in TSH and ACTH levels. RESULTS: TSH on the Abbott platform was 59.7 μIU/mL and on the Roche platform it was 4...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868894/lumbar-spine-infected-by-mycobacterium-tuberculosis-and-cryptococcus-neoformans-a-rare-case-report
#33
JOURNAL ARTICLE
Yun Xing, Qiu Zhong, Min Li, Yuansu Jiang, Baihui Zheng
BACKGROUND: In July 2023, our hospital confirmed one case of lumbar spine infected complicated by Mycobacterium tuberculosis and Cryptococcus neoformans. The patient was admitted due to lower back pain for 1 year and a hard lump for 3 months. Symptoms and signs: Dressing can be seen fixed on the lower back, with severe bleeding. When the dressing is removed, a hard and protruding lump with a size of 6 cm x 8 cm, a sinus tract can be seen near the mass, with a slightly red wound and a sinus depth of about 3 cm...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868893/the-importance-of-rapid-laboratory-diagnosis-of-acute-promyelocytic-leukemia
#34
JOURNAL ARTICLE
Debao Yu, Dan Zhang
BACKGROUND: Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia [1,2], the onset of the disease is insidious and the disease progresses rapidly, and failure to detect it in time or missing the best time to seek medical treatment is likely to cause secondary cerebral hemorrhage and lead to early death (ED: deaths occur in the first 30 days post diagnosis) [3-5]. METHODS: A patient with APL was rapidly identified by peripheral blood image, fibrinogen (FIB), and D-dimer within 24 hours...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868892/the-variation-of-rhd-blood-group-in-different-periods-in-a-patient-with-systemic-lupus-erythematosus
#35
JOURNAL ARTICLE
Minggang Lu, Fen Ye, Ying Wang
BACKGROUND: Autoimmune hemolytic anemia disease often produces a large number of various autoantibodies, and some autoantibodies may be related to Rh blood group. In rare cases, autoantibodies can specifically target Rh antigen, thus interfering with the identification of Rh blood group. METHODS: A case of systemic lupus erythematosus (SLE) with inconsistent RhD blood group identification results in different periods was reported and the reasons were analyzed. RESULTS: Some autoantibodies can completely block D antigen on red blood cells, resulting in no redundant D sites on red blood cells binding to reagent anti D...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868891/neglected-mycobacterium-avium-complex-infection-in-a-patient-with-prolonged-pneumonia
#36
JOURNAL ARTICLE
Hong L Ji, Xin R Li, Jia F Luo, Cheng X Nie, Hong Q Ren, Yan L Ge, Ai S Fu
BACKGROUND: Non-tuberculous mycobacterial pulmonary infections (NTM-PD) are becoming increasingly common in clinical practice, and early detection and accurate determination of the infecting pathogen is crucial for subsequent treatment. We report a case of NTM-PD in a healthy middle-aged female with Mycobacterium tuberculosis complex group (MAC) infection confirmed by mNGS examination. METHODS: Appropriate laboratory tests, chest CT scan, bronchoscopic alveolar lavage fluid (BALF) examination, and macrogenomic next-generation sequencing (mNGS) were performed to establish the diagnosis...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868890/a-rare-case-report-of-b-cell-acute-lymphoblastic-leukemia-with-ep300-znf384-fusion-gene
#37
LETTER
Xue Wu, Xiaofeng Yang, Yingying Chen, Zhihua Zhang, XinhongYang
No abstract text is available yet for this article.
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868889/organizing-pneumonia-due-to-secondary-invasive-pulmonary-mycosis-and-cytomegalovirus-infection-in-a-patient-with-lymphoma
#38
JOURNAL ARTICLE
Jia F Luo, Xin R Li, Hong L Ji, Cheng X Nie, Yan L Ge, Ai S Fu
BACKGROUND: Reactivation of cytomegalovirus is more common in lymphoma patients undergoing hematopoietic stem cell transplantation, but reactivation of cytomegalovirus due to chemotherapy for lymphoma has rarely been reported. We report a case of a lymphoma patient with secondary pulmonary fungal infection and cytomegalovirus infection after chemotherapy, which ultimately led to organizing pneumonia. METHODS: Percutaneous lung biopsy, Next Generation Sequencing (NGS)...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868888/one-case-of-drug-resistant-invasive-fungal-infection-after-myelodysplastic-syndrome-chemotherapy
#39
JOURNAL ARTICLE
Yingying Chen, Xinhong Yang, Xue Wu, Yingwei Wu, Yan Li
BACKGROUND: The aim of this study was to evaluate the therapeutic regimen of a patient with myelodysplastic syndrome (MDS) who developed invasive fungal infections caused by drug-resistant Candida tropicalis after chemotherapy and to investigate the effect of drug treatment. METHODS: We referred to the Diagnostic Criteria and Treatment Principles of invasive fungal diseases in patients with hematological diseases and malignant tumors (2013, fourth revised edition) and the Expert Consensus on Clinical Application of Posaconazole (2022 Edition)...
June 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38868887/diagnostic-evaluation-of-polycythemia-vera-at-high-altitude
#40
JOURNAL ARTICLE
Husain Y Alkhaldy, Abdullah M Algarni, Noha Eisa, Hassan Y Asiri, Hassan A Alasiri, Mohammed Assiri, Sultan Alasmari, Mohammed Makkawi, Ayel Yahya
BACKGROUND: Polycythemia is a common medical problem, frequently acquired and reactive to secondary conditions. High-altitude-associated hypoxia contributes to the greater prevalence of polycythemia at altitude. Primary clonal polycythemia vera (PV), even though it is rare, requires a different therapeutic approach. Suspicion of PV usually drives the diagnostic workup of polycythemia. METHODS: In this retrospective lab record study, we collected all JAK2 tests requested over a three-year period...
June 1, 2024: Clinical Laboratory
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