Ana P P Rödel, José A M de Carvalho, Karla N Pereira, Yasmin S das Neves, Caroline S Teixeira, Rafael N Moresco
No abstract text is available yet for this article.
May 1, 2023: Clinical Laboratory
JiMo Jian, XinLu Wang, HongYuan Hao, ChunYan Ji, ChengLu Yuan, Fei Lu
BACKGROUND: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the abnormal proliferation of myeloid hematopoietic cells and it is urgently needed to develop new molecular biomarkers to predict clinical outcomes and improve therapeutic effects. METHODS: The differentially expressed genes were identified by comparing TCGA with GETx data. Univariate LASSO and multivariate cox regression analysis were performed to identify prognosis-associated pseudogenes...
May 1, 2023: Clinical Laboratory
H Bencharef, F Hidki, A Lahmoudi, C Pongo, M Chemsi, M Lehlimi, A Habzi, S Benomar, B Oukkache
BACKGROUND: Congenital protein C deficiency is a rare hereditary thrombophilia, neonatal purpura fulminans is the most serious form of this deficit. The purpose of this observation is two-fold. The first is the need to make an early diagnosis in order to improve the prognosis. The second, is to discuss the need. In case of extensive purpura fulminans in the neonatal period, the search for a deficiency in anticoagulant factor, in particular the dosage of protein C, in the newborn and in both parents...
May 1, 2023: Clinical Laboratory
Lu-Qing Zheng, Qing-Yong Wang
BACKGROUND: The latest region-specific panel of mycoplasma species is often crucial for providing insights into local mycoplasma epidemiology and updating clinical practice guidance. METHODS: We retrospectively reviewed reports of 4,166 female outpatients detected by the mycoplasma identification verification and antibiotic susceptibility kit from the last five years. RESULTS: Among them, > 73.3% of cases with Ureaplasma urealyticum or Mycoplasma hominis single infection or co-infection with both species were susceptible to three tetracyclines and one macrolide (josamycin)...
May 1, 2023: Clinical Laboratory
Yanmei Fan, Lijuan Jiang, Nan Wang, Xiaoyan Liu, Liqin Zhang
BACKGROUND: Defined as rare large azurophilic cytoplasmic inclusions, Pseudo-Chediak-Higashi granules mimic those in granulocytes cytoplasm of Chediak-Higashi syndrome. Rare cases of hematopoietic and lymphoid tissues tumors showed Pseudo-Chediak-Higashi inclusions in cytoplasm, some of which presented with unusual morphological characteristics. METHODS: Herein, we report the first case, in which rare pseudo-Chediak-Higashi inclusions were observed in therapy-related acute myeloid leukemia with myelodysplasia-related changes (t-AML-MRC)...
May 1, 2023: Clinical Laboratory
Sang-Yeob Lee, Min-Chul Cho, Yong-Han Cha, Chan Ho Park, Jung-Taek Kim, Jun-Il Yoo
BACKGROUND: One of the most dangerous side effects of joint replacement for the hip, knee, shoulder, and elbow is prosthesis joint infection (PJI). Polymerase chain reaction (PCR) has been considered a promising method for PJI diagnosis due to its short diagnostic time and high sensitivity. Although several PCR methods such as multiplex PCR and broad-range PCR are useful diagnostic methods for detecting microorganisms causing PJI, values of different PCR methods for the diagnosis of PJI remain unclear...
May 1, 2023: Clinical Laboratory
Gangfeng Li, Yi Feng, Tao Lu, Lihong Zhang
BACKGROUND: Insulin autoimmune syndrome (IAS) is a rare condition in which spontaneous severe hypoglycemia without previous exposure to exogenous insulin, and is characterized by hyperinsulinemia and high titers of insulin autoantibodies (IAA). METHODS: This paper reports a case of IAS with false insulin test results due to the hook effect. RESULTS: The patient's blood samples were collected at 0, 30, 60, 120, 180 minutes for measurement of serum insulin after a 3-hour oral glucose tolerance test (OGTT)...
May 1, 2023: Clinical Laboratory
Nasrin K Valian, Behzad Houshmand, Mohammadreza T Ardakani, Shima Mahmoudi
BACKGROUND: No systematic review/meta-analysis has been conducted on the microbiological profile associated with the occurrence of periodontitis in patients with HIV. The aim of this study was to evaluate the prevalence of identified bacteria in HIV-infected patients with periodontal disease. METHODS: Three English electronic databases (MEDLINE (via PubMed), SCOPUS, and Web of Science) were searched systematically from the beginning to February 13, 2021. The frequency of each identified bacteria in HIV-infected patients with periodontal disease was extracted...
May 1, 2023: Clinical Laboratory
Hongxia Wang, Keyu Liu, Wenjun Liu, Julue Huang, Faquan Lin
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening syndrome led by a highly stimulated but invalid immune response, and Talaromyces marneffei (T. marneffei) is an opportunistic infection with high mortality commonly among acquired immunodeficiency syndrome (AIDS) patients. METHODS: Here is a rare case, in which secondary HLH is caused by dual infections of T. marneffei and cytomega-lovirus (CMV). A 15 year old man with a 20-day history of fatigue and intermittent fever (maximum 41...
May 1, 2023: Clinical Laboratory
Tobias Schupp, Kathrin Weidner, Jonas Rusnak, Schanas Jawhar, Jan Forner, Floriana Dulatahu, Lea M Brück, Ursula Hoffmann, Maximilian Kittel, Thomas Bertsch, Ibrahim Akin, Michael Behnes
BACKGROUND: Studies investigating the diagnostic and prognostic value of D-dimer levels and the disseminated intravascular coagulation (DIC) score in sepsis or septic shock commonly include preselected subgroups of patients or were published prior to the current sepsis-3 criteria. Therefore, this study investigates the diagnostic and prognostic impact of D-dimer levels and the DIC score in patients with sepsis and septic shock. METHODS: Consecutive patients with sepsis and septic shock enrolled in the prospective and monocentric "MARSS" registry from 2019 to 2021 were included...
May 1, 2023: Clinical Laboratory
Nan Xu, Xudong Yang, Yanping Zhang, Qian He, Yan Geng, Youqiong Li
BACKGROUND: There are occasional unexpected detections in HbA1c tests. Here, we described a novel β-globin gene mutation and its hematological phenotype. METHODS: The proband is a 60-year-old woman who was admitted to the hospital for two weeks due to chest pain. Complete blood count, fasting blood glucose, and glycated hemoglobin tests were performed before admission. High-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) were used to detect HbA1c...
May 1, 2023: Clinical Laboratory
Turan Turhan, Muhammed F Kilinckaya
BACKGROUND: Reference intervals (RI) are an essential section of the information that medical laboratories present to clinicians to facilitate the management process of the patient. Thyroid-stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3) are the most valuable and cost-effective parameters of thyroid functions. According to the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), Clinical and Laboratory Standards Institute (CLSI), and American Thyroid Association (ATA), every laboratory should determine own RI on own population and method...
May 1, 2023: Clinical Laboratory
Minggang Lu, Lihong Zhang, Fen Ye, Guojian Shen, Ying Wang
BACKGROUND: In clinical practice, thrombocytopenia is very dangerous for patients, because it has the risk of bleeding and may cause serious adverse consequences. Therefore, timely and accurate identification of spurious platelet counts is very important to improve patient safety. METHODS: This study reported a case of spurious platelet counts in a patient with influenza B virus. RESULTS: Leukocyte fragmentation is responsible for the inaccurate platelet detection results by resistance method in this influenza B patient...
May 1, 2023: Clinical Laboratory
Hong Q Ren, Qian Zhao, Wen Yang, Jiao Jiang, Ai S Fu, Yan L Ge
BACKGROUND: Infectious pulmonary diseases caused by nontuberculous mycobacteria (NTM) are becoming more common in clinical work, and early detection of the bacterium and its early identification are prerequisites for accurate treatment. METHODS: By reporting a case of confirmed NTM infection in a patient with connective tissue disease-associated interstitial lung fibrosis, a joint literature analysis was performed to improve clinicians' understanding of NTM and the clinical application of targeted next-generation sequencing (tNGS)...
May 1, 2023: Clinical Laboratory
Tobias Schupp, Michael Behnes, Ibrahim Akin, Thomas Bertsch
No abstract text is available yet for this article.
May 1, 2023: Clinical Laboratory
Zhongchan Lao, Gengcai Ding, Fengjuan Yang, Liang Liang, Youqiong Li
BACKGROUND: Many new variants are constantly detected by capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC). Here, we described a novel α-globin gene mutation. METHODS: The proband was a 46-year-old male who came to the hospital with his wife for pre-conception thalassemia screening. Hematological parameters were obtained from a complete blood count. Hb analysis was performed by CE and HPLC. Routine genetic analysis was carried out by Gap-polymerase chain reaction (Gap-PCR) and PCR and reverse dot-blot (PCR-RDB)...
May 1, 2023: Clinical Laboratory
Oytip Nathalang, Kamphon Intharanut, Dollapak Apipongrat, Plaiwan Suttanon
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease commonly found among elderly populations. Multiple risk factors, including non-clinical and genetic factors, contribute to the etiology and pathogenesis of OA. This study aimed to investigate the association between the human leukocyte antigen (HLA) class II alleles and knee OA occurrence in a Thai population. METHODS: HLA-DRB1 and -DQB1 alleles in 117 patients with knee OA and 84 controls were determined using the PCR with sequence-specific primer (PCR-SSP) method...
May 1, 2023: Clinical Laboratory
Ruimin Li, Yiping Wu, Xiaofang Zhang, LihuaWang, Shuang Huo
BACKGROUND: The goal was to study the role of the morphology, immunophenotype, karyotype and fusion gene expression in a patient with diagnosis of AML1-ETO positive acute myeloid leukemia. METHODS: A case of AML1-ETO positive acute myeloid leukemia morphologically similar to chronic myelogenous leukemia was reported. The results of the morphology, immunophenotype, karyotype and fusion gene expression were analyzed by reviewing relevant literature. RESULTS: The patient was a young boy, at the age of 13, with clinical manifestations of intermittent fatigue and fever...
May 1, 2023: Clinical Laboratory
Kun-Long Du, Wen-Tong Ji, Quan-Hang Jiang, Yao Wang
BACKGROUND: Altered anti-CD25 antibody levels in plasma have been observed in patients with various solid malignancies. The present study aimed to determine whether circulating anti-CD25 antibody levels were altered in bladder cancer (BC). METHODS: An enzyme-linked immunosorbent assay was developed in-house to detect plasma IgG antibodies against three CD25-derived linear peptide antigens in 132 patients with BC and 120 control subjects. RESULTS: The Mann-Whitney U-test indicated that the plasma levels of anti-CD25a (Z = -10...
May 1, 2023: Clinical Laboratory
Shimin Wu, Jiangqin Song, Fuying Hu, Huashun Li, Youjun Tian, Weijia Cheng, Ying Liang, Qian Luo
BACKGROUND: Mucor infection cannot be ignored in patients with pulmonary shadowing with cavitation. This paper reports a case of mucormycosis during the COVID-19 pandemic in Hubei Province, China. METHODS: An anesthesiology doctor was initially diagnosed as COVID-19 due to changes in lung imaging. After anti-infective, anti-viral, and symptomatic supportive treatment, some of symptoms were relieved. But some symptoms -'chest pain and discomfort', accompanied by chest sulking and short breath after activities, did not ease...
May 1, 2023: Clinical Laboratory
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