journal
https://read.qxmd.com/read/38965970/identifying-hub-genes-related-to-vascular-endothelial-cell-permeability-through-bioinformatics-and-verification
#1
JOURNAL ARTICLE
Yunjiang Zheng, Qianyi Chen, Lei Cao, Lili Zhao, Yi Tang, Zhihan Liu
BACKGROUND: In this study, we aimed to identify the hub genes responsible for increased vascular endothelial cell permeability. METHODS: We applied the weighted Gene Expression Omnibus (GEO) database to mine dataset GSE178331 and ob-tained the most relevant high-throughput sequenced genes for an increased permeability of vascular endothelial cells due to inflammation. We constructed two weighted gene co-expression network analysis (WGCNA) networks, and the differential expression of high-throughput sequenced genes related to endothelial cell permeability were screened from the GEO database...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965969/clinical-characteristics-of-lung-abscess-caused-by-streptococcus-constellatus-infection
#2
JOURNAL ARTICLE
YouMing Zhu, Jie Jiang, Tao Jiang, TingTing Hu, YiLing Gan
BACKGROUND: This study aimed to understand the clinical characteristics of pulmonary abscess caused by Streptococcus constellatus infection. METHODS: The clinical manifestations, laboratory examination, drug sensitivity, chest CT manifestations, and treatment and prognosis of patients with pulmonary abscess caused by Streptococcus constellatus infection were retrospectively collected and analyzed. RESULTS: A total of 9 cases of pulmonary abscess caused by Streptococcus constellatus infection were confirmed; one case was confirmed by traditional cultures, while metagenomic next-generation sequencing (mNGS) confirmed the other 8 cases...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965968/measurement-of-natriuretic-peptides-in-patients-with-suspected-heart-failure-to-prevent-overuse-of-echocardiography-a-pilot-study
#3
JOURNAL ARTICLE
Francois-Xavier Goudot, Marie Paugam, Nabil Bendaoud, Cedric Desbene, Mohamed B El-Sayed, Pierre-Olivier Schismanoff, Christophe Meune
BACKGROUND: European Society of Cardiology (ESC) guidelines recommend measuring natriuretic peptides (BNP or NT-proBNP) in patients with suspected heart failure (HF) as a first-line tool. HF should be ruled-out if concen-trations of NT-proBNP are below 300 ng/L and 125 ng/L for acute HF and chronic HF, respectively. METHODS: Patients with suspected HF referred for transthoracic echocardiography (TTE) were enrolled; NT-pro-BNP concentrations were obtained from medical charts (measurement < 48 hours) or prospectively measured on the day of TTE...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965967/combined-intracoronary-prourokinase-thrombolysis-on-myocardial-perfusion-and-vascular-endothelial-function-in-stemi
#4
JOURNAL ARTICLE
ShuHuan Che, XiaoHu Guo, ZhiHui Lei, ShuSheng Lin
BACKGROUND: This study aimed to investigate the effects of intracoronary prourokinase thrombolysis combined with emergency percutaneous coronary intervention (PCI) on myocardial perfusion and vascular endothelial function in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: A total of 104 patients with STEMI were collected from August 2020 to August 2022, and were divided into control group and observation group in a random manner...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965966/a-case-of-false-decrease-of-plasma-d-dimer
#5
JOURNAL ARTICLE
Minggang Lu, Liangfeng Hu, Lihong Zhang, Ye Yang
BACKGROUND: D-dimer, a specific product of cross-linked fibrin degradation, is of great clinical value in the early diagnosis of thrombotic diseases and in monitoring the efficacy of thrombolysis; therefore, the accuracy of D-dimer test results is crucial. METHODS: This article reports a case of a patient with disseminated intravascular coagulation (DIC) who experienced a false decrease in D-dimer due to the hook effect. RESULTS: The three D-dimer test results for DIC patients were 1...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965965/mirror-syndrome-combined-with-postpartum-hemolytic-uremic-syndrome
#6
JOURNAL ARTICLE
Ning Luo, Hong J Li, Zhu Lin, Yin Li, Hong M Gao
BACKGROUND: Mirror syndrome is a rare disease characterized by "triple edema", while Hemolytic Uremic Syndrome (PHUS) is a serious disease that occurs within a short period of time after the end of pregnancy, with a low prevalence and poor prognosis, and it is even rarer for both to occur in the same patient. METHODS: We report a case of mirror syndrome combined with PHUS and analyze the clinical data to improve the understanding of the disease. RESULTS: The patient presented clinically with "triple edema" and was diagnosed with mirror image syndrome...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965964/analysis-of-differences-in-neonatal-sepsis-caused-by-streptococcus-agalactiae-and-escherichia-coli
#7
JOURNAL ARTICLE
Chengwen Que, Huiyu Chen, Huahong Qiu, Hui Zhong
BACKGROUND: Streptococcus agalactiae (GBS) and Escherichia coli (E. coli) are the main pathogenic bacteria in neonatal sepsis. Therefore, the clinical characteristics, nonspecific indicators, and drug susceptibilities of these two bacteria were studied. METHODS: In total, 81 and 80 children with sepsis caused by GBS and E. coli infection, respectively, admitted to the neonatal department of our hospital between May 2012 and July 2023, were selected, and the clinical characteris-tics of the two groups were analyzed...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965963/application-of-rhd-blood-group-to-simulate-antibody-identification-test-in-immunohematology-education
#8
JOURNAL ARTICLE
Yingying Niu, Jiang Wang, Yuxin Wang, Honghui Long, Danting Wang, Chunyan Huang
BACKGROUND: Immunohematology skill education is an important part of the transfusion medicine professional training. We tried to solve the difficulty of obtaining suitable and sufficient positive samples in the immunohematology education. METHODS: Different identification panels and panel cells were created by RhD-positive red blood cells (RBCs) and RhD-negative RBCs, according to the underlying antibodies. Diluted anti-D reagent was used as simulated plasma for identification...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965962/two-cases-of-false-elevation-of-mchc
#9
JOURNAL ARTICLE
Gangfeng Li, Mingging Lu, Qian Wang, Tao Lu
BACKGROUND: Mean corpuscular hemoglobin concentration (MCHC) is one of the parameters detected by blood cell analyzers, often used together with mean corpuscular volume (MCV) and mean corpuscular hemoglobin content (MCH) as diagnostic indicators for anemia classification. It has important clinical value in early detection of the cause of anemia and the underlying etiology of anemia. Therefore, the accuracy of MCHC results is of great significance for the diagnosis and treatment of diseases...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965961/systemic-lupus-erythematosus-complicated-with-mycobacterium-leprae-infection-a-rare-case-report
#10
JOURNAL ARTICLE
Daohong Zhou, Shuang Tang, Jinmi Li
BACKGROUND: In December 2023, our hospital confirmed a case of systemic lupus erythematosus complicated with Mycobacterium leprae infection. The patient has extensive patchy erythema on the back and face, with obvious itching. There are multiple subcutaneous masses on both hands, some of which are accompanied by tenderness, wave sensation, and other symptoms. The patient's mother has a history of leprosy and close contact with the patient. The patient tested positive for syphilis antibodies 2 years ago and did not receive formal treatment...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965960/a-case-of-intravenous-ivig-interfering-with-serological-test-results-of-hbv
#11
JOURNAL ARTICLE
Dan Zhang, Debao Yu
BACKGROUND: Since Imbach [1] first reported the use of high-dose intravenous immunoglobulin (IVIg) in the treatment of idiopathic thrombocytopenic purpura (ITP) in children, indications for IVIg therapy have been increaseing. At present, IVIg infusion has become an important means of clinical treatment. The phenomenon of anti-HBs and anti-HBc elevation caused by IVIg infusion in patients has been reported in journals, but similar reports in journals related to laboratory diagnosis are rare...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965959/the-effect-of-preoperative-anemia-on-the-odds-of-allogeneic-blood-transfusion-and-patient-outcomes-in-colorectal-neoplasm-patients
#12
JOURNAL ARTICLE
Dongmei Yang, Chunxia Chen, Fu Cheng, Chunyan Huang, Zhenglian Luo, Li Qin, Bin Tan
BACKGROUND: The optimal preoperative hemoglobin (Hb) value of colorectal neoplasm patients is still being debated. This study aimed at determining the effect of preoperative anemia on patient outcomes and allogeneic blood transfusion (ABT). METHODS: This retrospective cohort study enrolled colorectal neoplasm patients, that underwent surgery, from January 1, 2012, to December 31, 2021. The primary outcomes were the association between anemia and average length of stay (ALOS) and the odds of ABT...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965958/hb-guigang-%C3%AE-90-fg2-lys%C3%A2-asn-hba1-c-273g%C3%AB-t-a-novel-%C3%AE-globin-chain-variant
#13
JOURNAL ARTICLE
Guichun Gan, Weibin Li, Jialiang Huang, Lihong Zheng, Teng Li, Youqiong Li
BACKGROUND: New hemoglobin (Hb) variants are constantly being updated as assays are developed and the testing population expands. Here, we report a novel Hb variant, named Hb Guigang. METHODS: Hemoglobin (Hb) analysis was analyzed by capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC). Glycated hemoglobin was performed by CE and HPLC. Routine genetic analysis was done with Gap-PCR and PCR-reverse dot-blot hybridization. The hemoglobin variant was identified by Sanger sequencing...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965957/combined-application-of-multiple-techniques-in-prenatal-diagnosis-of-a-fetus-with-turner-syndrome
#14
JOURNAL ARTICLE
Weiping Chen, Tao Zhang
BACKGROUND: The clinical features of Turner syndrome (TS) involve multiple organ system dysplasia, among which growth retardation and gonadal dysplasia are the most important clinical phenotypes. METHODS: G banding karyotype analysis, chromosome microarray (CMA), and fluorescence in situ hybridization (FISH) were used for prenatal diagnosis of fetal chromosomes. RESULTS: The result of fetal chromosome karyotype analysis was 46,XX. CMA showed arr[GRCh38]Xp22...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965956/involvement-of-the-laboratory-department-in-mdt-discussion-for-the-diagnosis-of-unexplained-leukocytosis
#15
JOURNAL ARTICLE
Ying Liang, Yue Chen, Ying Zhou, Hui Peng, Linyi Ma, Yali Wang, Shi Min Wu
BACKGROUND: This paper reports the diagnostic process of a case involving an 86-year-old male patient who was admitted with cough, sputum, and fever, accompanied by persistent leukocytosis. METHODS: Through a multidisciplinary team (MDT) discussion, the laboratory department identified elevated ferritin levels, prompting clinical consideration of potential malignancy. RESULTS: Further investigations confirmed the diagnosis of thyroid cancer with multiple lung metastases...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965955/frequency-of-duffy-kidd-lewis-and-rh-blood-group-antigens-and-phenotypes-among-donors-in-the-al-ahsa-region-saudi-arabia
#16
JOURNAL ARTICLE
Fahd A Kuriri, Abdulrahman Ahmed, Fahad Alhumud, Fehaid Alanazi, Ezeldine K Abdalhabib
BACKGROUND: In Al-Ahsa, Saudi Arabia, the high consanguinity rates contribute to the prevalence of inherited hemoglobinopathies such as sickle cell disease and thalassemia, which frequently require blood transfusions. These transfusions carry the risk of alloimmunization, necessitating a precise blood component matching to mitigate health risks. Local antigen frequency data is vital for optimizing transfusion practices and enhancing the safety of these medical procedures for the Al-Ahsa population...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965954/the-effects-of-different-blood-sample-and-anticoagulant-types-on-quantitative-tests-of-b-type-natriuretic-peptide
#17
JOURNAL ARTICLE
Liangping Yin, Qian Wang, Zhikui Jiang, Xiufang Meng, Yuying Wang
BACKGROUND: BNP is a sensitive and widely used biomarker for an early diagnosis of heart failure. Currently, most commercial BNP detection products use EDTA plasma samples. The aim of this study was to evaluate the clinical performance of the BNP test by using whole blood samples compared to plasma samples, and to evaluate the effect of the anticoagulant type on the BNP test result. METHODS: In total, 106 patients with different BNP levels from the Dahua Hospital volunteered for this study...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965953/relationship-between-vitamin-d-concentration-and-lipid-concentration-in-patients-with-nafld-in-the-hulunbuir-region-of-china
#18
JOURNAL ARTICLE
Shihua Zhang, Xiaoyu Jia, Zhanzhu Dong, Xia Li, Xin Li, Hongyan Ge, Chunyu Li
BACKGROUND: We aimed to characterize the relationship between the serum 25-hydroxyvitamin D concentration and the circulating lipid concentrations of patients with NAFLD in the Hulunbuir region of China. METHODS: One hundred fifty-six patients, who were diagnosed with NAFLD in the Physical Examination Department of the Second Clinical College of Inner Mongolia University for the Nationalities between January 2021 and March 2023, were recruited as NAFLD group, and 160 healthy people were recruited as a control group during the same period...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965952/prognostic-factors-and-clinical-outcomes-in-patients-with-blast-phase-chronic-myeloid-leukemia
#19
JOURNAL ARTICLE
Jian Huang, Haining Guan
BACKGROUND: Given the low incidence of patients with advanced chronic myeloid leukemia (CML), comprehensive clinical characteristics and outcomes of cohort studies of patients diagnosed with blast phase chronic myeloid leukemia (BP-CML) are limited. We examined the clinical features of blast phase CML, including the TKI selection, treatment response, and whether they have had hematopoietic stem cell transplantation (HSCT) or not. METHODS: We performed a retrospective cohort study, including BP-CML patients diagnosed in our center from January 2013 to December 2022...
July 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38965951/prevalence-of-four-sexually-transmitted-infection-pathogens-detected-in-urine-and-genital-tract-secretion-in-hangzhou-china
#20
JOURNAL ARTICLE
Xiaoxia Wang, Chunyan Zhong, Xia Zhao, Qin Song
BACKGROUND: Sexually transmitted infections (STIs) increase gradually and have become a public health problem in the world. UU, CT, NG, and MG are four common STI pathogens. Our retrospective study analyzed the clinical situation and the laboratory data of patients infected with the four pathogens. The prevalence of the four pathogens, detected in urine and genital tract secretion, was studied in Hangzhou, China. METHODS: A total of 3,168 male and female patients were randomly selected from February 2023 to February 2024...
July 1, 2024: Clinical Laboratory
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