Xue Wang, Junnan Liu, Anca Azoitei, Tim Eiseler, Sabine Meessen, Wencheng Jiang, Xi Zheng, Arika W Makori, Markus Eckstein, Arndt Hartmann, Stephan Stilgenbauer, Mohamed Elati, Meike Hohwieler, Alexander Kleger, Axel John, Friedemann Zengerling, Felix Wezel, Christian Bolenz, Cagatay Günes
We have recently shown that loss of ORP3 leads to aneuploidy induction and promotes tumor formation. However, the specific mechanisms by which ORP3 contributes to ploidy-control and cancer initiation and progression is still unknown. Here, we report that ORP3 is highly expressed in ureter and bladder epithelium while its expression is downregulated in invasive bladder cancer cell lines and during tumor progression, both in human and in mouse bladder cancer. Moreover, we observed an increase in the incidence of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced invasive bladder carcinoma in the tissue-specific Orp3 knockout mice...
September 22, 2023: Cellular and Molecular Life Sciences: CMLS