journal
Journals Cellular and Molecular Life Sc...

Cellular and Molecular Life Sciences : CMLS

https://read.qxmd.com/read/37740130/loss-of-orp3-induces-aneuploidy-and-promotes-bladder-cancer-cell-invasion-through-deregulated-microtubule-and-actin-dynamics
#1
JOURNAL ARTICLE
Xue Wang, Junnan Liu, Anca Azoitei, Tim Eiseler, Sabine Meessen, Wencheng Jiang, Xi Zheng, Arika W Makori, Markus Eckstein, Arndt Hartmann, Stephan Stilgenbauer, Mohamed Elati, Meike Hohwieler, Alexander Kleger, Axel John, Friedemann Zengerling, Felix Wezel, Christian Bolenz, Cagatay Günes
We have recently shown that loss of ORP3 leads to aneuploidy induction and promotes tumor formation. However, the specific mechanisms by which ORP3 contributes to ploidy-control and cancer initiation and progression is still unknown. Here, we report that ORP3 is highly expressed in ureter and bladder epithelium while its expression is downregulated in invasive bladder cancer cell lines and during tumor progression, both in human and in mouse bladder cancer. Moreover, we observed an increase in the incidence of N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced invasive bladder carcinoma in the tissue-specific Orp3 knockout mice...
September 22, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37728789/critical-functions-of-extracellular-matrix-in-brain-metastasis-seeding
#2
REVIEW
Arseniy E Yuzhalin, Dihua Yu
Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance of brain ECM in both physiological and pathological conditions should not be underestimated. Brain metastasis is a serious complication of cancer, and recent findings highlighted the contribution of ECM in brain metastasis development. In this review, we provide a comprehensive outlook on how ECM proteins promote brain metastasis seeding. In particular, we discuss (1) disruption of the blood-brain barrier in brain metastasis; (2) role of ECM in modulating brain metastasis dormancy; (3) regulation of brain metastasis seeding by ECM-activated integrin signaling; (4) functions of brain-specific ECM protein reelin in brain metastasis...
September 20, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37728691/human-cd34-derived-complete-plasmacytoid-and-conventional-dendritic-cell-vaccine-effectively-induces-antigen-specific-cd8-t-cell-and-nk-cell-responses-in-vitro-and-in-vivo
#3
JOURNAL ARTICLE
Jesper van Eck van der Sluijs, Diede van Ens, Jolanda Brummelman, Daan Heister, Aastha Sareen, Lisa Truijen, Dorette S van Ingen Schenau, Mirjam H M Heemskerk, Marieke Griffioen, Michel G D Kester, Nicolaas P M Schaap, Joop H Jansen, Anniek B van der Waart, Harry Dolstra, Willemijn Hobo
Allogeneic stem cell transplantation (alloSCT) can be curative for hemato-oncology patients due to effective graft-versus-tumor immunity. However, relapse remains the major cause of treatment failure, emphasizing the need for adjuvant immunotherapies. In this regard, post-transplantation dendritic cell (DC) vaccination is a highly interesting strategy to boost graft-versus-tumor responses. Previously, we developed a clinically applicable protocol for simultaneous large-scale generation of end-stage blood DC subsets from donor-derived CD34+ stem cells, including conventional type 1 and 2 DCs (cDC1s and cDC2s), and plasmacytoid DCs (pDCs)...
September 20, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37728633/correction-catalytic-antibodies-in-arrhythmogenic-cardiomyopathy-patients-cleave-desmoglein%C3%A2-2-and-n-cadherin-and-impair-cardiomyocyte-cohesion
#4
Sunil Yeruva, Konstanze Stangner, Anna Jungwirth, Matthias Hiermaier, Maria Shoykhet, Daniela Kugelmann, Michael Hertl, Shohei Egami, Norito Ishii, Hiroshi Koga, Takashi Hashimoto, Michael Weis, Britt-Maria Beckmann, Ruth Biller, Dominik Schüttler, Stefan Kääb, Jens Waschke
No abstract text is available yet for this article.
September 20, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37726569/real-time-heterogeneity-of-supramolecular-assembly-of-amyloid-precursor-protein-is-modulated-by-an-endocytic-risk-factor-picalm
#5
JOURNAL ARTICLE
Vivek Belapurkar, H S Mahadeva Swamy, Nivedita Singh, Shekhar Kedia, Subba Rao Gangi Setty, Mini Jose, Deepak Nair
Recently, the localization of amyloid precursor protein (APP) into reversible nanoscale supramolecular assembly or "nanodomains" has been highlighted as crucial towards understanding the onset of the molecular pathology of Alzheimer's disease (AD). Surface expression of APP is regulated by proteins interacting with it, controlling its retention and lateral trafficking on the synaptic membrane. Here, we evaluated the involvement of a key risk factor for AD, PICALM, as a critical regulator of nanoscale dynamics of APP...
September 20, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37718345/carboplatin-induced-upregulation-of-pan-%C3%AE-tubulin-and-class-iii-%C3%AE-tubulin-is-implicated-in-acquired-resistance-and-cross-resistance-of-ovarian-cancer
#6
JOURNAL ARTICLE
Margareta Pernar Kovač, Vanja Tadić, Juran Kralj, George E Duran, Alessia Stefanelli, Darija Stupin Polančec, Sanja Dabelić, Niko Bačić, Maja T Tomicic, Petra Heffeter, Branimir I Sikic, Anamaria Brozovic
Resistance to platinum- and taxane-based chemotherapy represents a major obstacle to long-term survival in ovarian cancer (OC) patients. Here, we studied the interplay between acquired carboplatin (CBP) resistance using two OC cell models, MES-OV CBP and SK-OV-3 CBP, and non-P-glycoprotein-mediated cross-resistance to paclitaxel (TAX) observed only in MES-OV CBP cells. Decreased platination, mesenchymal-like phenotype, and increased expression of α- and γ-tubulin were observed in both drug-resistant variants compared with parental cells...
September 17, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37715850/plant-derived-cell-penetrating-microprotein-%C3%AE-astratide-am1-targets-akt-signaling-and-alleviates-insulin-resistance
#7
JOURNAL ARTICLE
Bamaprasad Dutta, Shining Loo, Antony Kam, James P Tam
Insulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the underlying molecular mechanisms involving insulin resistance would be desirable. Our laboratory recently identified a proteolytic-resistant cystine-dense microprotein from huáng qí (Astragalus membranaceus) called α-astratide aM1, which shares high sequence homology to leginsulins. Here we show that aM1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the PI3K/Akt signaling pathway independent of the insulin receptor leading to translocation of glucose transporter GLUT4 to the cell surface to promote glucose uptake...
September 16, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37715829/reciprocal-negative-feedback-regulation-of-atf6%C3%AE-and-pten-promotes-prostate-cancer-progression
#8
JOURNAL ARTICLE
Tingting Feng, Ru Zhao, Hanwen Zhang, Feifei Sun, Jing Hu, Meng Wang, Mei Qi, Ling Liu, Lin Gao, Yabo Xiao, Junhui Zhen, Weiwen Chen, Lin Wang, Bo Han
Phosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inactivation of PTEN leads to abnormal activation of PI3K/AKT pathway. However, results from clinical trials with AKT inhibitors in PCa have been largely disappointing. Identification of novel regulators of PTEN in PTEN-dysfunctional PCa is urgently needed. Here we demonstrated that the expression level of PTEN is inversely correlated with the signature score of unfolded protein response (UPR) in PCa...
September 16, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37704889/revolutionizing-control-strategies-against-mycobacterium-tuberculosis-infection-through-selected-targeting-of-lipid-metabolism
#9
REVIEW
Hagyu Kim, Sung Jae Shin
Lipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy macrophages accumulate lipids in granulomas, providing metabolic adaptation and survival strategies for Mtb against multiple stresses. Host-derived lipid species, including triacylglycerol and cholesterol, can also contribute to the development of drug-tolerant Mtb, leading to reduced efficacy of antibiotics targeting the bacterial cell wall or transcription...
September 14, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37698644/correction-comparative-study-of-prph2-d2-loop-mutants-reveals-divergent-disease-mechanism-in-rods-and-cones
#10
Larissa Ikelle, Mustafa Makia, Tylor Lewis, Ryan Crane, Mashal Kakakhel, Shannon M Conley, James R Birtley, Vadim Y Arshavsky, Muayyad R Al-Ubaidi, Muna I Naash
No abstract text is available yet for this article.
September 12, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37690046/upregulation-of-hdac9-in-hippocampal-neurons-mediates-depression-like-behaviours-by-inhibiting-anxa2-degradation
#11
JOURNAL ARTICLE
Yunjian Dai, Taofeng Wei, Yuwen Huang, Yun Bei, Haoran Lin, Zexu Shen, Lingyan Yu, Mingdong Yang, Huimin Xu, Wei He, Zheng Lin, Haibin Dai
Major depressive disorder (MDD) is a pervasive and devastating mental disease. Broad spectrum histone deacetylase (HDAC) inhibitors are considered to have potential for the treatment of depressive phenotype in mice. However, due to its non-specific inhibition, it has extensive side effects and can not be used in clinical treatment of MDD. Therefore, finding specific HDAC subtypes that play a major role in the etiology of MDD is the key to develop corresponding specific inhibitors as antidepressants in the future...
September 10, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37689602/identification-of-sodium-channel-toxins-from-marine-cone-snails-of-the-subgenera-textilia-and-afonsoconus
#12
JOURNAL ARTICLE
Kirsten L McMahon, Henrik O'Brien, Christina I Schroeder, Jennifer R Deuis, Dhananjeyan Venkatachalam, Di Huang, Brad R Green, Pradip K Bandyopadhyay, Qing Li, Mark Yandell, Helena Safavi-Hemami, Baldomero M Olivera, Irina Vetter, Samuel D Robinson
Voltage-gated sodium (NaV ) channels are transmembrane proteins that play a critical role in electrical signaling in the nervous system and other excitable tissues. µ-Conotoxins are peptide toxins from the venoms of marine cone snails (genus Conus) that block NaV channels with nanomolar potency. Most species of the subgenera Textilia and Afonsoconus are difficult to acquire; therefore, their venoms have yet to be comprehensively interrogated for µ-conotoxins. The goal of this study was to find new µ-conotoxins from species of the subgenera Textilia and Afonsoconus and investigate their selectivity at human NaV channels...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37689587/tgf%C3%AE-signaling-links-early-life-endocrine-disrupting-chemicals-exposure-to-suppression-of-nucleotide-excision-repair-in-rat-myometrial-stem-cells
#13
JOURNAL ARTICLE
Maria Victoria Bariani, Yan-Hong Cui, Mohamed Ali, Tao Bai, Sandra L Grimm, Cristian Coarfa, Cheryl L Walker, Yu-Ying He, Qiwei Yang, Ayman Al-Hendy
Environmental exposure to endocrine-disrupting chemicals (EDCs) is linked to the development of uterine fibroids (UFs) in women. UFs, non-cancerous tumors, are thought to originate from abnormal myometrial stem cells (MMSCs). Defective DNA repair capacity may contribute to the emergence of mutations that promote tumor growth. The multifunctional cytokine TGFβ1 is associated with UF progression and DNA damage repair pathways. To investigate the impact of EDC exposure on TGFβ1 and nucleotide excision repair (NER) pathways, we isolated MMSCs from 5-month-old Eker rats exposed neonatally to diethylstilbestrol (DES), an EDC, or to vehicle (VEH)...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688664/energetics-and-dynamics-of-the-proton-shuttle-of-carbonic-anhydrase-ii
#14
JOURNAL ARTICLE
Heiner N Raum, Suzanne Zoë Fisher, Ulrich Weininger
Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton. His64-mediated proton shuttling between the active site and the bulk solvent is rate limiting. Here we investigate the protonation behavior of His64 as well as its structural and dynamic features in a pH dependent way. We derive two pKa values for His64, 6.25 and 7.60, that we were able to assign to its inward and outward conformation. Furthermore, we show that His64 exists in both conformations equally, independent of pH...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688662/metformin-induces-tolerogenicity-of-dendritic-cells-by-promoting-metabolic-reprogramming
#15
JOURNAL ARTICLE
Xianmei Liu, Peng Yu, Yujun Xu, Yun Wang, Jin Chen, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu, Yuannong Ye, Yi Jia, Weijuan Yao, Jinhua Long, Zhu Zeng
Dendritic cells (DCs) can mediate immune responses or immune tolerance depending on their immunophenotype and functional status. Remodeling of DCs' immune functions can develop proper therapeutic regimens for different immune-mediated diseases. In the immunopathology of autoimmune diseases (ADs), activated DCs notably promote effector T-cell polarization and exacerbate the disease. Recent evidence indicates that metformin can attenuate the clinical symptoms of ADs due to its anti-inflammatory properties. Whether and how the therapeutic effects of metformin on ADs are associated with DCs remain unknown...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688644/synapses-do-not-facilitate-prion-like-transfer-of-alpha-synuclein-a-quantitative-study-in-reconstructed-unidirectional-neural-networks
#16
JOURNAL ARTICLE
Josquin Courte, Ngoc Anh Le, Teng Pan, Luc Bousset, Ronald Melki, Catherine Villard, Jean-Michel Peyrin
Alpha-synuclein (aSyn) aggregation spreads between cells and underlies the progression of neuronal lesions in the brain of patients with synucleinopathies such as Parkinson's diseases. The mechanisms of cell-to-cell propagation of aggregates, which dictate how aggregation progresses at the network level, remain poorly understood. Notably, while prion and prion-like spreading is often simplistically envisioned as a "domino-like" spreading scenario where connected neurons sequentially propagate protein aggregation to each other, the reality is likely to be more nuanced...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688617/functions-of-the-rip-kinase-family-members-in-the-skin
#17
REVIEW
Corinne Urwyler-Rösselet, Giel Tanghe, Michael Devos, Paco Hulpiau, Yvan Saeys, Wim Declercq
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress signals. In response to several extracellular and/or intracellular stimuli, RIP kinases engage signaling cascades leading to the activation of NF-κB and mitogen-activated protein kinases, cell death, inflammation, differentiation and Wnt signaling and can have kinase-dependent and kinase-independent functions. Although it was previously suggested that seven RIPKs are part of the RIPK family, phylogenetic analysis indicates that there are only five genuine RIPKs...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688612/the-origin-of-brain-malignancies-at-the-blood-brain-barrier
#18
REVIEW
Brennan McDonald, Kathrin Barth, Mirko H H Schmidt
Despite improvements in extracranial therapy, survival rate for patients suffering from brain metastases remains very poor. This is coupled with the incidence of brain metastases continuing to rise. In this review, we focus on core contributions of the blood-brain barrier to the origin of brain metastases. We first provide an overview of the structure and function of the blood-brain barrier under physiological conditions. Next, we discuss the emerging idea of a pre-metastatic niche, namely that secreted factors and extracellular vesicles from a primary tumor site are able to travel through the circulation and prime the neurovasculature for metastatic invasion...
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688601/why-are-neuromelanin-containing-dopaminergic-neurons-lost-in-idiopathic-parkinson-s-disease
#19
LETTER
Sandro Huenchuguala, Juan Segura-Aguilar
No abstract text is available yet for this article.
September 9, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37684532/cyclin-d1-cdk4-regulates-neuronal-activity-through-phosphorylation-of-gabaa-receptors
#20
JOURNAL ARTICLE
Neus Pedraza, Ma Ventura Monserrat, Francisco Ferrezuelo, Jordi Torres-Rosell, Neus Colomina, Federico Miguez-Cabello, Javier Picañol Párraga, David Soto, Esperanza López-Merino, Celia García-Vilela, José A Esteban, Joaquim Egea, Eloi Garí
Nuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves to the cytoplasm at the onset of differentiation in neuronal precursors. However, cytoplasmic functions and targets of Ccnd1 in post-mitotic neurons are unknown. Here we identify the α4 subunit of gamma-aminobutyric acid (GABA) type A receptors (GABAA Rs) as an interactor and target of Ccnd1-Cdk4. Ccnd1 binds to an intracellular loop in α4 and, together with Cdk4, phosphorylates the α4 subunit at threonine 423 and serine 431...
September 8, 2023: Cellular and Molecular Life Sciences: CMLS
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