Journals Cellular and Molecular Life Sc...

Cellular and Molecular Life Sciences : CMLS
Yingzhen Du, Jialei Li, Zhe Dai, Yuxin Chen, Yao Zhao, Xiaoman Liu, Tian Xia, Pingjun Zhu, Yijin Wang
The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage during many pathological conditions, the regulatory signals influencing MQC disruption during septic cardiomyopathy (SC) remain unclear. This study aimed to investigate the involvement of pyruvate kinase M2 (PKM2) and prohibitin 2 (PHB2) interaction followed by MQC impairment in the pathogenesis of SC. We utilized LPS-induced SC models in PKM2 transgenic (PKM2TG ) mice, PHB2S91D -knockin mice, and PKM2-overexpressing HL-1 cardiomyocytes...
June 10, 2024: Cellular and Molecular Life Sciences: CMLS
Vanajothi Ramar, Shanchun Guo, Breanna Hudson, Azam Khedri, Alyssa A Guo, Jason Li, Mingli Liu
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor; GBM's inevitable recurrence suggests that glioblastoma stem cells (GSC) allow these tumors to persist. Our previous work showed that FOSL1, transactivated by the STAT3 gene, functions as a tumorigenic gene in glioma pathogenesis and acts as a diagnostic marker and potential drug target in glioma patients. Accumulating evidence shows that STAT3 and NF-κB cooperate to promote the development and progression of various cancers...
June 10, 2024: Cellular and Molecular Life Sciences: CMLS
Xingyue Fu, Jiaqi Zhang, Keke Sun, Meiqi Zhang, Shuyan Wang, Meng Yuan, Wenguang Liu, Xianlu Zeng, Xueqing Ba, Yueshuang Ke
Post-transcriptional regulation of cytokine/chemokine mRNA turnover is critical for immune processes and contributes to the mammalian cellular response to diverse inflammatory stimuli. The ubiquitous RNA-binding protein human antigen R (HuR) is an integral regulator of inflammation-associated mRNA fate. HuR function is regulated by various post-translational modifications that alter its subcellular localization and ability to stabilize target mRNAs. Both poly (ADP-ribose) polymerase 1 (PARP1) and p38 mitogen-activated protein kinases (MAPKs) have been reported to regulate the biological function of HuR, but their specific regulatory and crosstalk mechanisms remain unclear...
June 9, 2024: Cellular and Molecular Life Sciences: CMLS
Jessica A Haley, Sreekanth H Chalasani
Animals have evolved to seek, select, and exploit food sources in their environment. Collectively termed foraging, these ubiquitous behaviors are necessary for animal survival. As a foundation for understanding foraging, behavioral ecologists established early theoretical and mathematical frameworks which have been subsequently refined and supported by field and laboratory studies of foraging animals. These simple models sought to explain how animals decide which strategies to employ when locating food, what food items to consume, and when to explore the environment for new food sources...
June 8, 2024: Cellular and Molecular Life Sciences: CMLS
Neus P Lorite, Sonia Apostolova, Marta Guasch-Vallés, Aaron Pryer, Fernando Unzueta, Raimundo Freire, Roger Solé-Soler, Neus Pedraza, Xavier Dolcet, Eloi Garí, Neus Agell, Elaine M Taylor, Neus Colomina, Jordi Torres-Rosell
The Smc5/6 complex is a highly conserved molecular machine involved in the maintenance of genome integrity. While its functions largely depend on restraining the fork remodeling activity of Mph1 in yeast, the presence of an analogous Smc5/6-FANCM regulation in humans remains unknown. We generated human cell lines harboring mutations in the NSE1 subunit of the Smc5/6 complex. Point mutations or truncations in the RING domain of NSE1 result in drastically reduced Smc5/6 protein levels, with differential contribution of the two zinc-coordinating centers in the RING...
June 7, 2024: Cellular and Molecular Life Sciences: CMLS
Jose C Casas-Martinez, Afshin Samali, Brian McDonagh
Mitochondria and the endoplasmic reticulum (ER) have a synergistic relationship and are key regulatory hubs in maintaining cell homeostasis. Communication between these organelles is mediated by mitochondria ER contact sites (MERCS), allowing the exchange of material and information, modulating calcium homeostasis, redox signalling, lipid transfer and the regulation of mitochondrial dynamics. MERCS are dynamic structures that allow cells to respond to changes in the intracellular environment under normal homeostatic conditions, while their assembly/disassembly are affected by pathophysiological conditions such as ageing and disease...
June 7, 2024: Cellular and Molecular Life Sciences: CMLS
Kelong Ma, Rundong Shu, Hongtao Liu, Jinli Ge, Jiayang Liu, Qian Lu, Jiaqi Fu, Xiaoyun Liu, Jiazhang Qiu
Protein ubiquitination is one of the most important posttranslational modifications (PTMs) in eukaryotes and is involved in the regulation of almost all cellular signaling pathways. The intracellular bacterial pathogen Legionella pneumophila translocates at least 26 effectors to hijack host ubiquitination signaling via distinct mechanisms. Among these effectors, SidC/SdcA are novel E3 ubiquitin ligases with the adoption of a Cys-His-Asp catalytic triad. SidC/SdcA are critical for the recruitment of endoplasmic reticulum (ER)-derived vesicles to the Legionella-containing vacuole (LCV)...
June 5, 2024: Cellular and Molecular Life Sciences: CMLS
Liang Wang, Hoi Ying Tsang, Ziyi Yan, Sari Tojkander, Katarzyna Ciuba, Konstantin Kogan, Xiaonan Liu, Hongxia Zhao
Contractile actomyosin bundles play crucial roles in various physiological processes, including cell migration, morphogenesis, and muscle contraction. The intricate assembly of actomyosin bundles involves the precise alignment and fusion of myosin II filaments, yet the underlying mechanisms and factors involved in these processes remain elusive. Our study reveals that LUZP1 plays a central role in orchestrating the maturation of thick actomyosin bundles. Loss of LUZP1 caused abnormal cell morphogenesis, migration, and the ability to exert forces on the environment...
June 4, 2024: Cellular and Molecular Life Sciences: CMLS
Ligang Fan, Hongtao You, Xiao Jiang, Yixuan Niu, Zhengxin Chen, Huibo Wang, Yuan Xu, Peng Zhou, Li Wei, Tianwei Jiang, Danni Deng, Lian Xue, Ya Peng, Wei Xing, Naiyuan Shao
BACKGROUND: The high degree of intratumoral genomic heterogeneity is a major obstacle for glioblastoma (GBM) tumors, one of the most lethal human malignancies, and is thought to influence conventional therapeutic outcomes negatively. The proneural-to-mesenchymal transition (PMT) of glioma stem cells (GSCs) confers resistance to radiation therapy in glioblastoma patients. POLD4 is associated with cancer progression, while the mechanisms underlying PMT and tumor radiation resistance have remained elusive...
June 3, 2024: Cellular and Molecular Life Sciences: CMLS
Andrea Álvarez-Sánchez, Johanna Grinat, Paula Doria-Borrell, Maravillas Mellado-López, Érica Pedrera-Alcócer, Marta Malenchini, Salvador Meseguer, Myriam Hemberger, Vicente Pérez-García
The glycosylphosphatidylinositol (GPI) biosynthetic pathway in the endoplasmic reticulum (ER) is crucial for generating GPI-anchored proteins (GPI-APs), which are translocated to the cell surface and play a vital role in cell signaling and adhesion. This study focuses on two integral components of the GPI pathway, the PIGL and PIGF proteins, and their significance in trophoblast biology. We show that GPI pathway mutations impact on placental development impairing the differentiation of the syncytiotrophoblast (SynT), and especially the SynT-II layer, which is essential for the establishment of the definitive nutrient exchange area within the placental labyrinth...
May 31, 2024: Cellular and Molecular Life Sciences: CMLS
Signe Simonsen, Caroline K Søgaard, Johan G Olsen, Marit Otterlei, Birthe B Kragelund
DNA replication is a tightly coordinated event carried out by a multiprotein replication complex. An essential factor in the bacterial replication complex is the ring-shaped DNA sliding clamp, β-clamp, ensuring processive DNA replication and DNA repair through tethering of polymerases and DNA repair proteins to DNA. β -clamp is a hub protein with multiple interaction partners all binding through a conserved clamp binding sequence motif. Due to its central role as a DNA scaffold protein, β-clamp is an interesting target for antimicrobial drugs, yet little effort has been put into understanding the functional interactions of β-clamp...
May 30, 2024: Cellular and Molecular Life Sciences: CMLS
Yan Wang, Ziwei Kuang, Xueqi Xing, Yumei Qiu, Jie Zhang, Dandan Shao, Jiaxin Huang, Chunsun Dai, Weichun He
Four-and-a-half LIM domains protein 2 (FHL2) is an adaptor protein that may interact with hypoxia inducible factor 1α (HIF-1α) or β-catenin, two pivotal protective signaling in acute kidney injury (AKI). However, little is known about the regulation and function of FHL2 during AKI. We found that FHL2 was induced in renal tubular cells in patients with acute tubular necrosis and mice model of ischemia-reperfusion injury (IRI). In cultured renal proximal tubular cells (PTCs), hypoxia induced FHL2 expression and promoted the binding of HIF-1 to FHL2 promoter...
May 30, 2024: Cellular and Molecular Life Sciences: CMLS
Delan N Alasaadi, Roberto Mayor
Cell fate determination, a vital process in early development and adulthood, has been the focal point of intensive investigation over the past decades. Its importance lies in its critical role in shaping various and diverse cell types during embryonic development and beyond. Exploration of cell fate determination started with molecular and genetic investigations unveiling central signaling pathways and molecular regulatory networks. The molecular studies into cell fate determination yielded an overwhelming amount of information invoking the notion of the complexity of cell fate determination...
May 30, 2024: Cellular and Molecular Life Sciences: CMLS
Orest V Matveichuk, Anna Ciesielska, Aneta Hromada-Judycka, Natalia Nowak, Ichrak Ben Amor, Gabriela Traczyk, Katarzyna Kwiatkowska
No abstract text is available yet for this article.
May 30, 2024: Cellular and Molecular Life Sciences: CMLS
Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang
Aspergillus ochraceus is the traditional ochratoxin A (OTA)-producing fungus with density-dependent behaviors, which is known as quorum sensing (QS) that is mediated by signaling molecules. Individual cells trend to adapt environmental changes in a "whole" flora through communications, allowing fungus to occupy an important ecological niche. Signals perception, transmission, and feedback are all rely on a signal network that constituted by membrane receptors and intracellular effectors. However, the interference of density information in signal transduction, which regulates most life activities of Aspergillus, have yet to be elucidated...
May 29, 2024: Cellular and Molecular Life Sciences: CMLS
Weifeng Sun, Weixin Wu, Xinyu Fang, Xinna Ge, Yongning Zhang, Jun Han, Xin Guo, Lei Zhou, Hanchun Yang
The pulmonary endothelium is a dynamic and metabolically active monolayer of endothelial cells. Dysfunction of the pulmonary endothelial barrier plays a crucial role in the acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), frequently observed in the context of viral pneumonia. Dysregulation of tight junction proteins can lead to the disruption of the endothelial barrier and subsequent leakage. Here, the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) served as an ideal model for studying ALI and ARDS...
May 28, 2024: Cellular and Molecular Life Sciences: CMLS
Susanne J van Veluw, Helene Benveniste, Erik N T P Bakker, Roxana O Carare, Steven M Greenberg, Jeffrey J Iliff, Sylvie Lorthois, William E Van Nostrand, Gabor C Petzold, Andy Y Shih, Matthias J P van Osch
The brain's network of perivascular channels for clearance of excess fluids and waste plays a critical role in the pathogenesis of several neurodegenerative diseases including cerebral amyloid angiopathy (CAA). CAA is the main cause of hemorrhagic stroke in the elderly, the most common vascular comorbidity in Alzheimer's disease and also implicated in adverse events related to anti-amyloid immunotherapy. Remarkably, the mechanisms governing perivascular clearance of soluble amyloid β-a key culprit in CAA-from the brain to draining lymphatics and systemic circulation remains poorly understood...
May 27, 2024: Cellular and Molecular Life Sciences: CMLS
Xin Shen, Mengjun Ma, Rujia Mi, Jiahao Zhuang, Yihui Song, Wen Yang, Hongyu Li, Yixuan Lu, Biao Yang, Yinliang Liu, Yanfeng Wu, Huiyong Shen
Chemoresistance is the main obstacle in the clinical treatment of osteosarcoma (OS). In this study, we investigated the role of EF-hand domain-containing protein 1 (EFHD1) in OS chemotherapy resistance. We found that the expression of EFHD1 was highly correlated with the clinical outcome after chemotherapy. We overexpressed EFHD1 in 143B cells and found that it increased their resistance to cell death after drug treatment. Conversely, knockdown of EFHD1 in 143BR cells (a cisplatin-less-sensitive OS cell line derived from 143B cells) increased their sensitivity to treatment...
May 25, 2024: Cellular and Molecular Life Sciences: CMLS
Fang Sui, Guanjie Wang, Juan Liu, Mengmeng Yuan, Pu Chen, Yao Yao, Shaoqiang Zhang, Meiju Ji, Peng Hou
BRAFV600E represents a constitutively active onco-kinase and stands as the most prevalent genetic alteration in thyroid cancer. However, the clinical efficacy of small-molecule inhibitors targeting BRAFV600E is often limited by acquired resistance. Here, we find that nerve/glial antigen 2 (NG2), also known as chondroitin sulfate proteoglycan 4 (CSPG4), is up-regulated in thyroid cancers, and its expression is increased with tumor progression in a BRAFV600E -driven thyroid cancer mouse model. Functional studies show that NG2 knockout almost does not affect tumor growth, but significantly improves the response of BRAF-mutant thyroid cancer cells to BRAF inhibitor PLX4720...
May 25, 2024: Cellular and Molecular Life Sciences: CMLS
Shai Kellner, Shai Berlin
N-methyl-D-aspartate receptors (NMDARs emerging from GRIN genes) are tetrameric receptors that form diverse channel compositions in neurons, typically consisting of two GluN1 subunits combined with two GluN2(A-D) subunits. During prenatal stages, the predominant channels are di-heteromers with two GluN1 and two GluN2B subunits due to the high abundance of GluN2B subunits. Postnatally, the expression of GluN2A subunits increases, giving rise to additional subtypes, including GluN2A-containing di-heteromers and tri-heteromers with GluN1, GluN2A, and GluN2B subunits...
May 25, 2024: Cellular and Molecular Life Sciences: CMLS
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