Sandhya Pruthi, Dietlind L Wahner-Roedler, Carolyn J Torkelson, Stephen S Cha, Lori S Thicke, Jennifer H Hazelton, Brent A Bauer
OBJECTIVE: To evaluate the effectiveness of vitamin E, evening primrose oil (EPO), and the combination of vitamin E and EPO for pain control in women with cyclical mastalgia. PROCEDURE: A double-blind, randomized, placebo-controlled trial was conducted at two U.S. academic medical centers. Eighty-five women with premenstrual cyclical breast discomfort were enrolled. Participants were randomly assigned to one of four six-month oral treatments: vitamin E (1,200 IU per day), EPO (3,000 mg per day), vitamin E (1,200 IU per day) plus EPO (3,000 mg per day), or double placebo...
April 2010: Alternative Medicine Review: a Journal of Clinical Therapeutic