Irina I Faingold, Anastasia V Smolina, Yulia V Soldatova, Darya A Poletaeva, Anastasia A Balakina, Tatyana E Sashenkova, Uguljan Yu Allayarova, Tatyana R Prikhodchenko, Svetlana V Blokhina, Lyudmila A Makartseva, David A Areshidze, Vladislav N Varfolomeev, Denis V Mishchenko, Raisa A Kotelnikova
Oxidative stress (OS) plays a key role in the development of cardiovascular diseases (CVD) in three major ways: reactive oxygen species (ROS)-induced reduction of nitric oxide (NO) bioavailability, ROS-induced inflammation and ROS-induced mitochondrial dysfunction. Oxidation of lipid molecules under the action of ROS leads to damage to membrane structures, changes the functioning of membrane-bound enzymes, and impairs membrane permeability and stability. An increase in OS results in the occurrence of endothelial dysfunction and drug tolerance, side effects, requiring discontinuation of drugs...
December 8, 2023: Cell Biochemistry and Biophysics