journal
https://read.qxmd.com/read/38878101/deciphering-the-role-of-exosomal-non-coding-rna-ncrna-in-drug-resistance-of-gastrointestinal-tumors-an-updated-review
#1
REVIEW
Nafiseh Tashakori, Maryam Armanfar, Anahita Mashhadi, Adil Tawfeeq Mohammed, Manal Morad Karim, Abbas Hameed Abdul Hussein, Mohaned Adil, Sajad Ataei Azimi, Fatemeh Abedini
One of the most prevalent types of cancer worldwide today is gastric intestinal (GI) tumors. To guarantee their lives, people with a developed GI require palliative care. This covers the application of targeted medicines in addition to chemotherapy treatments including cisplatin, 5-fluorouracil, oxaliplatin, paclitaxel, and pemetrexed. Because of the evidence of drug resistance emerging in poor patient outcomes and prognoses, determining the exact process of medication resistance is motivated. Besides, it is noteworthy that exosomes and noncoding RNAs, like microRNAs and long non-coding RNAs (lncRNAs), produced from tumor cells are implicated in both GI medication resistance and the carcinogenesis and development of GI disease...
June 15, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38878100/farrerol-alleviates-diabetic-cardiomyopathy-by-regulating-ampk-mediated-cardiac-lipid-metabolic-pathways-in-type-2-diabetic-rats
#2
JOURNAL ARTICLE
Jia Tu, Qiaoling Liu, Huirong Sun, Luzhen Gan
Diabetic cardiomyopathy (DCM) is a prevalent complication of diabetes mellitus characterized by cardiac dysfunction and myocardial remodeling. Farrerol (FA), an active ingredient in Rhododendron with various pharmacological activities, has an unclear specific role in DCM. Therefore, this study aims to investigate the effects of FA on DCM rats and elucidate its mechanism. The type 2 diabetes mellitus (T2DM) model was induced in adult male Sprague-Dawley rats by administering a high-fat diet for 8 weeks along with STZ injection...
June 15, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38878099/mirna-133a-3p-attenuates-renal-tubular-epithelial-cell-injury-via-targeting-malm1-and-suppressing-the-notch-signaling-pathway-in-diabetic-nephropathy
#3
JOURNAL ARTICLE
Yuting Li, Peng Tan, Qianpan Liu, Man Liu, Yue Wang, Weixin Kong, Huaixin Sun, Xiang Shao
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes characterized by structural and functional changes of kidneys. Human renal tubular epithelial (HK-2) cells are important for kidney recovery post injury and usually used for establishment of DN cell models. The study explored the role of microRNA (miR)-133a-3p in DN cell model and animal model. A cell model for DN was established via high glucose (HG) stimulation to HK-2 cells. Cell viability and apoptotic rate were measured by cell counting kit 8 and flow cytometry...
June 15, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38877336/sfxn3-is-a-prognostic-marker-and-promotes-the-growth-of-acute-myeloid-leukemia
#4
JOURNAL ARTICLE
Fengbo Jin, Limei He, Jing Wang, Yu Zhang, Mingzhen Yang
Acute myeloid leukemia (AML) is a heterogeneous disease with rapid progression and frequent mutations. Sideroflexin3 (SFXN3) has been shown to be involved in various neurodegenerative diseases. However, the role of SFXN3 in AML remains unclear. The level and prognostic value of SFXN3 were assessed in pan-cancer, especially AML, based on the data obtained from the TCGA database. The effect and mechanism of SFXN3 in AML were measured by fluorescence-activated cell sorting (FACS), qRT-PCR, western blotting in vitro and in vivo...
June 14, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38877335/brucine-suppresses-malignant-progression-of-prostate-cancer-by-decreasing-sarcosine-accumulation-via-downregulation-of-gnmt-in-the-glycine-sarcosine-metabolic-pathway
#5
JOURNAL ARTICLE
Long Miao, Yang Liu, Wei Chen, Chao Gao, Yijing Zhang, Jin Wei, Xiliang Cao
Prostate cancer (PCa) remains a leading cause of cancer-related incidence and mortality in men. Disruptions in amino acid (AA) metabolism contribute to the disease progression, with brucine, a glycine antagonist, exhibiting antitumor effects. This study explores the antitumor impact of brucine on PCa and investigates its mechanisms in regulating AA metabolic pathways. The study employed the PCa cell line DU-145, characterized by high sarcosine (Sar) levels, for various assays including Cell Counting Kit-8 (CCK8), wound healing, Transwell, 5-Ethynyl-2'-deoxyuridine (EDU), TdT mediated dUTP Nick End Labeling (TUNEL), flow cytometry, Western blot, and ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
June 14, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38874840/inhibition-of-asap1-modulates-the-tumor-immune-microenvironment-and-suppresses-lung-cancer-metastasis-via-the-p-stat3-signaling-pathway
#6
JOURNAL ARTICLE
Hongye Zhao, Yongcun Liu, Yunfan Wu, Jingge Cheng, Yishuai Li
ADP ribosylation factor guanylate kinase 1 (ASAP1), a key protein regulating cell migration and invasion, has attracted extensive attention in oncological research in recent years. This study aims to explore the effects of ASAP1 inhibition on lung cancer metastasis and its potential mechanisms, particularly how it modulates the tumor immune microenvironment through the p-STAT3 signaling pathway. In this study, shRNA technology was employed to specifically inhibit ASAP1 expression in lung cancer cell lines A549, NCI-H1299, and PC-9...
June 14, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38872051/n-6-methyladenosine-m-6-a-writer-wtap-potentiates-hepatocellular-carcinoma-immune-evasion-and-aerobic-glycolysis
#7
JOURNAL ARTICLE
Fatao Yu, Yuling Feng, Qing Wang, Jian Sun
Hepatocellular carcinoma (HCC) is one of most prevalent malignant tumors with poor prognosis and a high mortality rate. Recent research indicates that N6 -methyladenosine (m6 A) and tumor immunotherapy are important factors in HCC. More research is still needed to fully understand the profound roles that m6 A writer Wilms tumor 1-associated protein (WTAP) and CD8+ T cells play in the antitumor immunity that prevents HCC from progressing. According to the findings of our investigation, WTAP was significantly elevated in HCC cells and was associated with a poor prognosis...
June 13, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38869687/unveiling-therapeutic-frontiers-don-drp-104-as-innovative-plasma-kallikrein-inhibitors-against-carcinoma-associated-hereditary-angioedema-shocks-a-comprehensive-molecular-dynamics-exploration
#8
JOURNAL ARTICLE
Ernest Oduro-Kwateng, Mahmoud E S Soliman
Human plasma kallikrein (PKa) is a member of the serine protease family and serves as a key mediator of the kallikrein-kinin system (KKS), which is known for its regulatory roles in inflammation, vasodilation, blood pressure, and coagulation. Genetic dysregulation of KKS leads to Hereditary Angioedema (HAE), which is characterized by spontaneous, painful swelling in various body regions. Importantly, HAE frequently coexists with various cancers. Despite substantial efforts towards the development of PKa inhibitors for HAE, there remains a need for bifunctional agents addressing both anti-cancer and anti-HAE aspects, especially against carcinoma-associated comorbid HAE conditions...
June 13, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38869686/effect-of-fenugreek-oil-on-healing-of-experimentally-induced-buccal-mucosal-ulcer-by-immunohistochemical-evaluation-of-ki-67-expression
#9
JOURNAL ARTICLE
Sarah A Omran, Ban A Ghani
Wound healing involves multiple populations of cells, the extracellular matrix, and soluble mediators' actions like growth factors and cytokines. Wound care was the target of many research, utilizing new therapy techniques and the progression of acute and chronic wound treatments with techniques involving plants to improve healing and decrease the side effects of drugs. When fenugreek is applied to an ulcer, its anti-inflammatory components are released, reducing unnecessary inflammation and accelerating the healing process...
June 13, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38858307/assessment-of-biological-damage-induced-during-multidetector-computed-tomography-mdct-examination
#10
JOURNAL ARTICLE
Amarja Pandurang Laad, Tamizh Selvan Gnanasekaran, Shashi Kumar Shetty, Savin Kotekar Vidyan, Sayali Satish Chodankar, Suchetha Kumari Nalilu, Vishakh Radhakrishna
Computed tomography (CT) is known for its non-invasiveness, fast procedure, and also for providing detailed diagnostic information to physicians. It also utilises low-dose-rate ionising radiation (X-rays) as a source for imaging. Multidetector computed tomography (MDCT) is an advanced system that uses iodinated contrast media for more accurate diagnostic results. Studies suggest using these contrasts will lead to greater radiation adsorption with significant DNA damage. No studies have been taken comparing the physical dose with the biological effect...
June 10, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38856833/theoretical-and-experimental-study-of-the-interaction-of-protonophore-uncouplers-and-decoupling-agents-with-functionally-active-mitochondria
#11
JOURNAL ARTICLE
Victor N Samartsev, Konstantin N Belosludtsev, Evgenia K Pavlova, Svetlana I Pavlova, Alena A Semenova, Mikhail V Dubinin
The purpose of this work was to quantitatively characterize the effectiveness of oxidative phosphorylation uncouplers and decoupling agents in functionally active mitochondria, taking into account their content in the hydrophobic region of the inner membrane of these organelles. When conducting theoretical studies, it is accepted that uncouplers and decouplers occupy part of the volume of mitochondria to exhibit their activity, which is defined as the effective volume. The following quantities characterizing the action of these reagents are considered: (1) concentrations of reagents that cause double stimulation of mitochondrial respiration in state 4 ( <mml:math xmlns:mml="https://www...
June 10, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38856832/clinoleic-impairs-ros-production-and-phagocytosis-in-m1-macrophages-without-affecting-m1-differentiation
#12
JOURNAL ARTICLE
Yi-Sheng Tsai, Hsuan-Te Yeh, Ming-Shan Chen, Hui-Ju Chang, Wen-Chun Lin, Shew-Meei Sheu
Lipid emulsions are the primary source of calories and fatty acids that are used to provide essential energy and nutrients to patients suffering from severe intestinal failure and critical illness. However, their use has been linked to adverse effects on patient outcomes, notably affecting immune defenses and inflammatory responses. ClinOleic is a lipid emulsion containing a mixture of olive oil and soybean oil (80:20). The effect of ClinOleic on the differentiation of M1 macrophages remains unclear. In this study, we isolated human monocytes and added ClinOleic to differentiation culture media to investigate whether it affects monocyte polarization into M1 macrophages and macrophage functions, such as reactive oxygen species (ROS) production and phagocytosis...
June 10, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38850406/phenolic-contents-antioxidant-activities-lcms-profiles-of-mespilus-germanica-leaf-extract-and-effects-on-mrna-transcription-levels-of-apoptotic-autophagic-and-necrotic-genes-in-mcf7-and-a549-cancer-cell-lines
#13
JOURNAL ARTICLE
Gül Görmez, Veysel Yüksek, Ayşe Usta, Semiha Dede, Selçuk Gümüş
Cancer, defined by the continuous, uncontrollable proliferation of cells in the human body, is a disease with a rapidly increasing incidence and mortality rate. Scientists are looking for novel ways to cure and prevent this sneaky disease because of the toxicity of contemporary chemotherapy and the cancer cells' resilience to anticancer drugs. Determining the effect of herbal medicines, which do not have as harmful side effects as synthetic drugs, on cancer cell lines is an essential preliminary study in the production of effective drugs against cancer...
June 8, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38849695/long-non-coding-rna-pcat19-suppresses-cell-proliferation-and-angiogenesis-in-coronary-artery-disease-through-interaction-with-gcnt2
#14
JOURNAL ARTICLE
Yuan Zhou, Lei Zhang, Jiongchao Guo, Min Chen, Huangsheng Zheng, Bingfeng Zhou
LncRNAs involvement in heart disease, however, the effect of lncRNA prostate cancer-associated transcript 19 (PCAT19) in coronary artery disease (CAD) remains unclear. In the current study, we aimed to verify the role of PCAT19 in CAD. We first investigated the differentially expressed lncRNAs in different Genes Expression Omnibus (GEO) database. We then detected lncRNAs expression in healthy volunteers and acute myocardial infarction (AMI) patients by qRT‑PCR. The correlation of PCAT19 and Glucosaminyl (N-Acetyl) Transferase 2 (GCNT2) was analyzed...
June 7, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38849694/advances-in-the-study-of-etiology-and-molecular-mechanisms-of-sensorineural-hearing-loss
#15
REVIEW
Cairong He, Hongcun Gai, Wen Zhao, Haiqin Zhang, Lin Lai, Chenyu Ding, Lin Chen, Jie Ding
Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a complex interplay of genetic and environmental factors, with its underlying mechanisms remaining unclear. Several pathological factors are believed to contribute to SNHL, including genetic factors, ion homeostasis, cell apoptosis, immune inflammatory responses, oxidative stress, hormones, metabolic syndrome, human cytomegalovirus infection, mitochondrial damage, and impaired autophagy. These factors collectively interact and play significant roles in the onset and progression of SNHL...
June 7, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38847942/a-kernelized-classification-approach-for-cancer-recognition-using-markovian-analysis-of-dna-structure-patterns-as-feature-mining
#16
JOURNAL ARTICLE
Vijay Kalal, Brajesh Kumar Jha
Nucleotide-based molecules called DNA and RNA are essential for several biological processes that affect both normal and cancerous cells. They contain the critical genetic material needed for normal cell growth and functioning. The DNA structure patterns that make up the genetic code affect cells' growth, behavior, and control. Different DNA structure patterns indicate different physiological effects in the cell. Knowledge of these patterns is necessary to identify the molecular origins of cancer and other disorders...
June 7, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38847941/raman-spectroscopy-of-blood-serum-for-essential-thrombocythemia-diagnosis-correlation-with-genetic-mutations-and-optimization-of-laser-wavelengths
#17
LETTER
Aynur Aday, Ayşe Gül Bayrak, Suat Toraman, İpek Yönal Hindilerden, Meliha Nalçacı, Joanna Depciuch, Jozef Cebulski, Zozan Guleken
Essential thrombocythemia (ET) is a type of myeloproliferative neoplasm that increases the risk of thrombosis. To diagnose this disease, the analysis of mutations in the Janus Kinase 2 (JAK2), thrombopoietin receptor (MPL), or calreticulin (CALR) gene is recommended. Disease poses diagnostic challenges due to overlapping mutations with other neoplasms and the presence of triple-negative cases. This study explores the potential of Raman spectroscopy combined with machine learning for ET diagnosis. We assessed two laser wavelengths (785, 1064 nm) to differentiate between ET patients and healthy controls...
June 7, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38847940/intermittent-fasting-regulates-metabolic-homeostasis-and-improves-cardiovascular-health
#18
REVIEW
Rawan Diab, Lina Dimachkie, Omar Zein, Ali Dakroub, Ali H Eid
Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has also been rising. Recent research has focused on modalities aimed at reducing obesity. Several modalities have been suggested including behavioral and dietary changes, medications, and bariatric surgery. These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities...
June 7, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38839699/iguratimod-alleviates-experimental-sj%C3%A3-gren-s-syndrome-by-inhibiting-nlrp3-inflammasome-activation
#19
JOURNAL ARTICLE
Qi Zhang, Xi-Rui Yang, Yao Deng
Iguratimod (T-614) is a compound widely used as anti-rheumatic drug. This study investigated the effect and underlying mechanism of T-614 on experimental Sjögren's syndrome (ESS). ESS mice model was established by injection of submandibular gland protein. Mice were randomly divided into control, experimental Sjögren's syndrome (ESS), ESS + T-614 (10 mg/kg), ESS + T-614 (20 mg/kg), and ESS + T-614 (30 mg/kg) groups. Human submandibular gland (HSG) were cultured with 0, 0...
June 5, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38837011/multi-omics-analysis-revealed-that-the-ccn-family-regulates-cell-crosstalk-extracellular-matrix-and-immune-escape-leading-to-a-poor-prognosis-of-glioma
#20
JOURNAL ARTICLE
Jingyan Gu, Wenjie Tong, Xu Wang, Lianping Gu, Wei Wang, Tingting Zang, Meiqing Lou, Yaohua Liu
The CCN family is a group of matricellular proteins associated with the extracellular matrix. This study aims to explore the role of the CCN family in glioma development and its implications in the tumor microenvironment. Through analysis of bulk RNA-seq cohorts, correlations between CCN family expression and glioma subtypes, patient survival, and bioactive pathway enrichment were investigated. Additionally, single-cell datasets were employed to identify novel cell subgroups, followed by analyses of cell communication and transcription factors...
June 5, 2024: Cell Biochemistry and Biophysics
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