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Cell Biochemistry and Biophysics

L Xue, D Su, D Li, W Gao, R Yuan, W Pang
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
July 30, 2019: Cell Biochemistry and Biophysics
Feng Gao, Xinyang Hu, Xiaojie Xie, Xianbao Liu, Jianan Wang
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 15, 2019: Cell Biochemistry and Biophysics
Mo-Han Zhang, Xue-Sen Fang, Jun-Yu Guo, Zheng Jin
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
June 4, 2019: Cell Biochemistry and Biophysics
Musunuru Suneel Kumar Reddy, Uma V Manjappara
Satiety peptides convey information about short-term energy reserves in the gut to the hypothalamus and aid in regulation of appetite and food intake. Obestatin is one such gastro peptide that has been shown to upregulate glycerolipid metabolism and PPARγ signalling. Obestatin brings about moderate reduction in circulating and stored triglyceride levels and reduction in gain in body weight in mice. We wanted to test whether obestatin could be further potentiated by co-administration with nutraceuticals genistein and capsaicin that are well known to reduce triglyceride levels...
May 27, 2019: Cell Biochemistry and Biophysics
Chun-Hua Wang, Lu-Kai Wang, Chang-Chieh Wu, Mao-Liang Chen, Ming-Cheng Lee, Yi-Ying Lin, Fu-Ming Tsai
Phospholipase A and acyltransferase 4 (PLAAT4) is a member of the HREV107 tumor suppressor gene family. The expression of PLAAT4 has been shown to induce cell death; however, the underlying mechanism remains unknown. Here, we found that RPLP0, a ribosomal protein, can interact with PLAAT4, as determined by yeast two-hybrid screening, coimmunoprecipitation, and colocalization. The level of RPLP0 was suppressed in HtTA cervical cancer cells expressing PLAAT4. In PLAAT4-expressing or RPLP0-silenced cells, decreased cell viability and cell proliferation combined with increased cell death were observed...
May 26, 2019: Cell Biochemistry and Biophysics
Kwan Hyung Cho, Meong Cheol Shin, Kyoung Ah Min
Recently, due to their promising applications in biomedicine, magnetic iron oxide nanoparticles (MPs) have become one of the research hotspots in the nanomedicine field. Since various synthetic modifications have been widely applied to these nanoparticles for better targeting behaviors, it is meaningful to apply the optimal magnetic field condition for each case. This will enable creating a safe and efficient drug targeting using different types of MPs. In the present study, we aimed to find out any changes of transepithelial transport of polysaccharide-coated MPs by applying the continuous or the pulsatile magnetic field condition...
May 21, 2019: Cell Biochemistry and Biophysics
Carleton J C Hsia, Shanta M Messerli, W Keith Miskimins
No abstract text is available yet for this article.
May 15, 2019: Cell Biochemistry and Biophysics
Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusamy
Pancreatic cancer has a 5-year survival rate below 10% and the treatment options are limited. Signal transducer and activator of transcription (STAT3) is a constitutively expressed protein in human pancreatic cancers and is associated with their poor prognosis. Targeting of STAT3 signaling using novel therapeutic agents is a potential strategy for pancreatic cancer treatment. Diarylidenylpiperidone (DAP) compounds, such as H-4073 and HO-3867, have been shown to be STAT3 inhibitors in several human ovarian cancers...
May 14, 2019: Cell Biochemistry and Biophysics
Elaheh Kashani-Amin, Amirhossein Sakhteman, Bagher Larijani, Azadeh Ebrahim-Habibi
The structure of sweet taste receptor (STR), a heterodimer of class C G-protein coupled receptors comprising T1R2 and T1R3 molecules, is still undetermined. In this study, a new enhanced model of the receptor is introduced based on the most recent templates. The improvement, stability, and reliability of the model are discussed in details. Each domain of the protein, i.e., VFTM, CR, and TMD, were separately constructed by hybrid-model construction methods and then assembled to build whole monomers. Overall, 680 ns molecular dynamics simulation was performed for the individual domains, the whole monomers and the heterodimer form of the VFTM orthosteric binding site...
May 8, 2019: Cell Biochemistry and Biophysics
Srijanani Kannan, Sri Rahavi Boovarahan, Jeyashri Rengaraju, Priyanka Prem, Gino A Kurian
Our early studies have shown that sodium thiosulfate (STS) treatment attenuated the ischemia-reperfusion (IR)-induced injury in an isolated rat heart model by decreasing apoptosis, oxidative stress, and preserving mitochondrial function. Hydrogen sulfide, the precursor molecule is reported to have similar efficacy. This study aims to investigate the role of endogenous hydrogen sulfide in STS-mediated cardioprotection against IR in an isolated rat heart model. D, L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase was used as endogenous H2 S blocker...
May 7, 2019: Cell Biochemistry and Biophysics
Mo-Han Zhang, Xue-Sen Fang, Jun-Yu Guo, Zheng Jin
This study aimed to investigate the effect of AMPK on apoptosis and energy metabolism of gastric smooth muscle cells in diabetic rats and to explore the role of AMPK in the pathogenesis of diabetic gastroparesis (DGP). After establishment of a diabetic rat model, rats were divided into normal control (NC), 4-week (DM4W), 6-week (DM6W), and 8-week (DM8W) diabetic model groups. The gastric residual pigment ratio, intestinal transit rate, and intestinal propulsion rate in each group were detected to confirm the successful establishment of the DGP model...
April 9, 2019: Cell Biochemistry and Biophysics
Benjamaporn Supawat, Chatchanok Udomtanakunchai, Suchart Kothan, Montree Tungjai
Iodinated radiographic contrast media is used in cancer radiography for cancer diagnosis. The aim of this present study was to examine five iodinated radiographic contrast media (IRCM) (i.e., iohexol, iopamidol, iobitridol, ioxaglate, and iodixanol) in terms of their cytotoxicity, mitochondria membrane potential (ΔΨm), and P-glycoprotein function in multidrug resistant K562/Dox cancer cells and corresponding sensitive cancer cells. The cytotoxicity was determined by colorimetric resazurin reduction assay...
March 28, 2019: Cell Biochemistry and Biophysics
Arina L Dudylina, Marina V Ivanova, Konstantin B Shumaev, Enno K Ruuge
Since mitochondria are the main cellular source of reactive oxygen species, it is important to study the effect of dietary phenolic compounds on the level of ROS in these organelles. Using the EPR spectroscopy and TIRON probe, the ability of the investigated phenols (quercetin, rutin, caffeic acid, curcumin, and resveratrol) to scavenge superoxide anion radicals generated by isolated heart mitochondria of Wistar rats under variable oxygen partial pressure was studied. It was shown that during a 10 min incubation, caffeic acid in concentrations of 10-500 μM most effectively scavenged superoxide radicals formed in the complex III of the mitochondrial respiratory chain...
March 2019: Cell Biochemistry and Biophysics
Lawrence Berliner, Marija Raguz, Balaraman Kalyanaraman, Tadeusz Sarna
No abstract text is available yet for this article.
February 26, 2019: Cell Biochemistry and Biophysics
Kullappan Malathi, Sudha Ramaiah, Anand Anbarasu
Presently, there are no effective vaccines and anti-virals for the prevention and treatment of Hepatitis C virus infections and hence there is an urgent need to develop potent HCV inhibitors. In this study, we have carried out molecular docking, molecular dynamics and 3D-QSAR on heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone series using NS5B protein. Total of 41 quinolinone derivatives is used for molecular modeling study. The binding conformation and hydrogen bond interaction of the docked complexes were analyzed to model the inhibitors...
February 22, 2019: Cell Biochemistry and Biophysics
Evgeniya N Burgovа, Yana I Khristidis, Aleksandr V Kurkov, Vasak D Mikoyan, Anatoly B Shekhter, Leila V Adamyan, Peter S Timashev, Anatoly F Vanin
The possibility that binuclear dinitrosyl iron complexes with glutathione and cysteine (DNIC-GSН and B-DNIC-Cys) have a strong cytotoxic effect on the growth of endometrioid tumours (EMT) in rats with surgically induced experimental endometriosis established in our previous studies has been supported with experimental data. The increase in the DNIC-GSН or B-DNIC-Cys dose from 10 (in our previous studies) to 20 μmol/kg (after i/p administration to experimental rats) fully suppressed the growth of uterine tissues implanted onto the inner surface of the abdominal wall...
February 1, 2019: Cell Biochemistry and Biophysics
Negar Sedghi Aminabad, Masoud Farshbaf, Abolfazl Akbarzadeh
Nanomedicine is one of the growing fields that presents new techniques for cancer diagnosis and treatment. Gold nanoparticles (GNPs) are considered as an important class of nanomaterials that possess superior physicochemical properties that make them valuable in medical applications. Unique optical properties of GNPs and their utility in photothermal and radiotherapy have extended a new platform for early detection and treatment of cancer, lately. Nanostructures based on GNPs are nontoxic and biocompatible with a large surface area that makes it possible to modify their surface with different chemicals including different polymers, antibodies, and even drug molecules...
December 20, 2018: Cell Biochemistry and Biophysics
Alireza Mohammadkarim, Manijhe Mokhtari-Dizaji, Ali Kazemian, Hazhir Saberi, Mohammad Mehdi Khani, Mohsen Bakhshandeh
Exposure to ionizing radiation is unavoidable for noncancerous cells during the external radiotherapy process. Increasing the dose delivery fraction times leads to increasing the endothelial cell damage. Vascular abnormalities are commonly associated with the alternation of endothelium biomechanical properties. The goal of the present study was to quantify the elastic and viscoelastic properties of human umbilical vein endothelial cells (HUVECs) using the micropipette aspiration technique in conjunction with a theoretical model while an 8 Gy dose was given in four fractions...
December 18, 2018: Cell Biochemistry and Biophysics
Anjali M Prabhat, M Lakshmi Kuppusamy, Balázs Bognár, Tamás Kálai, Kálmán Hideg, Periannan Kuppusamy
The synthesis and antiproliferative effect of a novel curcumin analog, 4,4'-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with N-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined...
December 14, 2018: Cell Biochemistry and Biophysics
Fadaei Mehdi, Ghatreh Samani Keihan, Amini Seyed Asadollah, Farrokhi Effat
The high accumulation of lipid droplets in the cell is related to metabolic disorders, such as obesity. Perilipin 5 (Plin5), plays an important role in triglyceride hydrolysis in the lipid droplets. In this study, this protein has been evaluated in different tissues and conditions in mice. Fifty male mice were divided into 5 groups and treated for 45 days with Resveratrol, Metformin, strength training, and 4 °C cold. Brown adipose tissue (BAT), gastrocnemius skeletal muscle and heart were isolated for RNA extraction...
December 2018: Cell Biochemistry and Biophysics
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