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Cell Biochemistry and Biophysics

Kwan Hyung Cho, Meong Cheol Shin, Kyoung Ah Min
Recently, due to their promising applications in biomedicine, magnetic iron oxide nanoparticles (MPs) have become one of the research hotspots in the nanomedicine field. Since various synthetic modifications have been widely applied to these nanoparticles for better targeting behaviors, it is meaningful to apply the optimal magnetic field condition for each case. This will enable creating a safe and efficient drug targeting using different types of MPs. In the present study, we aimed to find out any changes of transepithelial transport of polysaccharide-coated MPs by applying the continuous or the pulsatile magnetic field condition...
May 21, 2019: Cell Biochemistry and Biophysics
Carleton J C Hsia, Shanta M Messerli, W Keith Miskimins
No abstract text is available yet for this article.
May 15, 2019: Cell Biochemistry and Biophysics
Jesse M Mast, Dan Tse, Kevin Shee, M Lakshmi Kuppusamy, Maciej M Kmiec, Tamás Kálai, Periannan Kuppusamy
Pancreatic cancer has a 5-year survival rate below 10% and the treatment options are limited. Signal transducer and activator of transcription (STAT3) is a constitutively expressed protein in human pancreatic cancers and is associated with their poor prognosis. Targeting of STAT3 signaling using novel therapeutic agents is a potential strategy for pancreatic cancer treatment. Diarylidenylpiperidone (DAP) compounds, such as H-4073 and HO-3867, have been shown to be STAT3 inhibitors in several human ovarian cancers...
May 14, 2019: Cell Biochemistry and Biophysics
Elaheh Kashani-Amin, Amirhossein Sakhteman, Bagher Larijani, Azadeh Ebrahim-Habibi
The structure of sweet taste receptor (STR), a heterodimer of class C G-protein coupled receptors comprising T1R2 and T1R3 molecules, is still undetermined. In this study, a new enhanced model of the receptor is introduced based on the most recent templates. The improvement, stability, and reliability of the model are discussed in details. Each domain of the protein, i.e., VFTM, CR, and TMD, were separately constructed by hybrid-model construction methods and then assembled to build whole monomers. Overall, 680 ns molecular dynamics simulation was performed for the individual domains, the whole monomers and the heterodimer form of the VFTM orthosteric binding site...
May 8, 2019: Cell Biochemistry and Biophysics
Srijanani Kannan, Sri Rahavi Boovarahan, Jeyashri Rengaraju, Priyanka Prem, Gino A Kurian
Our early studies have shown that sodium thiosulfate (STS) treatment attenuated the ischemia-reperfusion (IR)-induced injury in an isolated rat heart model by decreasing apoptosis, oxidative stress, and preserving mitochondrial function. Hydrogen sulfide, the precursor molecule is reported to have similar efficacy. This study aims to investigate the role of endogenous hydrogen sulfide in STS-mediated cardioprotection against IR in an isolated rat heart model. D, L-propargylglycine (PAG), an inhibitor of cystathionine γ-lyase was used as endogenous H2 S blocker...
May 7, 2019: Cell Biochemistry and Biophysics
Mo-Han Zhang, Xue-Sen Fang, Jun-Yu Guo, Zheng Jin
This study aimed to investigate the effect of AMPK on apoptosis and energy metabolism of gastric smooth muscle cells in diabetic rats and to explore the role of AMPK in the pathogenesis of diabetic gastroparesis (DGP). After establishment of a diabetic rat model, rats were divided into normal control (NC), 4-week (DM4W), 6-week (DM6W), and 8-week (DM8W) diabetic model groups. The gastric residual pigment ratio, intestinal transit rate, and intestinal propulsion rate in each group were detected to confirm the successful establishment of the DGP model...
April 9, 2019: Cell Biochemistry and Biophysics
Benjamaporn Supawat, Chatchanok Udomtanakunchai, Suchart Kothan, Montree Tungjai
Iodinated radiographic contrast media is used in cancer radiography for cancer diagnosis. The aim of this present study was to examine five iodinated radiographic contrast media (IRCM) (i.e., iohexol, iopamidol, iobitridol, ioxaglate, and iodixanol) in terms of their cytotoxicity, mitochondria membrane potential (ΔΨm), and P-glycoprotein function in multidrug resistant K562/Dox cancer cells and corresponding sensitive cancer cells. The cytotoxicity was determined by colorimetric resazurin reduction assay...
March 28, 2019: Cell Biochemistry and Biophysics
Lawrence Berliner, Marija Raguz, Balaraman Kalyanaraman, Tadeusz Sarna
No abstract text is available yet for this article.
February 26, 2019: Cell Biochemistry and Biophysics
Kullappan Malathi, Sudha Ramaiah, Anand Anbarasu
Presently, there are no effective vaccines and anti-virals for the prevention and treatment of Hepatitis C virus infections and hence there is an urgent need to develop potent HCV inhibitors. In this study, we have carried out molecular docking, molecular dynamics and 3D-QSAR on heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone series using NS5B protein. Total of 41 quinolinone derivatives is used for molecular modeling study. The binding conformation and hydrogen bond interaction of the docked complexes were analyzed to model the inhibitors...
February 22, 2019: Cell Biochemistry and Biophysics
Evgeniya N Burgovа, Yana I Khristidis, Aleksandr V Kurkov, Vasak D Mikoyan, Anatoly B Shekhter, Leila V Adamyan, Peter S Timashev, Anatoly F Vanin
The possibility that binuclear dinitrosyl iron complexes with glutathione and cysteine (DNIC-GSН and B-DNIC-Cys) have a strong cytotoxic effect on the growth of endometrioid tumours (EMT) in rats with surgically induced experimental endometriosis established in our previous studies has been supported with experimental data. The increase in the DNIC-GSН or B-DNIC-Cys dose from 10 (in our previous studies) to 20 μmol/kg (after i/p administration to experimental rats) fully suppressed the growth of uterine tissues implanted onto the inner surface of the abdominal wall...
February 1, 2019: Cell Biochemistry and Biophysics
Negar Sedghi Aminabad, Masoud Farshbaf, Abolfazl Akbarzadeh
Nanomedicine is one of the growing fields that presents new techniques for cancer diagnosis and treatment. Gold nanoparticles (GNPs) are considered as an important class of nanomaterials that possess superior physicochemical properties that make them valuable in medical applications. Unique optical properties of GNPs and their utility in photothermal and radiotherapy have extended a new platform for early detection and treatment of cancer, lately. Nanostructures based on GNPs are nontoxic and biocompatible with a large surface area that makes it possible to modify their surface with different chemicals including different polymers, antibodies, and even drug molecules...
December 20, 2018: Cell Biochemistry and Biophysics
Alireza Mohammadkarim, Manijhe Mokhtari-Dizaji, Ali Kazemian, Hazhir Saberi, Mohammad Mehdi Khani, Mohsen Bakhshandeh
Exposure to ionizing radiation is unavoidable for noncancerous cells during the external radiotherapy process. Increasing the dose delivery fraction times leads to increasing the endothelial cell damage. Vascular abnormalities are commonly associated with the alternation of endothelium biomechanical properties. The goal of the present study was to quantify the elastic and viscoelastic properties of human umbilical vein endothelial cells (HUVECs) using the micropipette aspiration technique in conjunction with a theoretical model while an 8 Gy dose was given in four fractions...
December 18, 2018: Cell Biochemistry and Biophysics
Anjali M Prabhat, M Lakshmi Kuppusamy, Balázs Bognár, Tamás Kálai, Kálmán Hideg, Periannan Kuppusamy
The synthesis and antiproliferative effect of a novel curcumin analog, 4,4'-disulfonyldiarylidenyl piperidone, are reported. The design of the molecule is based on the fusion of an antiproliferative segment, namely diarylidenyl piperidone (DAP), with N-hyroxypyrroline, which is known to metabolically convert to nitroxide and protect healthy cells. Cellular uptake, metabolic conversion, cytotoxicity and antiproliferative effect of the DAP derivative against HCT-116 human colon cancer cells have been determined...
December 14, 2018: Cell Biochemistry and Biophysics
Fadaei Mehdi, Ghatreh Samani Keihan, Amini Seyed Asadollah, Farrokhi Effat
The high accumulation of lipid droplets in the cell is related to metabolic disorders, such as obesity. Perilipin 5 (Plin5), plays an important role in triglyceride hydrolysis in the lipid droplets. In this study, this protein has been evaluated in different tissues and conditions in mice. Fifty male mice were divided into 5 groups and treated for 45 days with Resveratrol, Metformin, strength training, and 4 °C cold. Brown adipose tissue (BAT), gastrocnemius skeletal muscle and heart were isolated for RNA extraction...
December 2018: Cell Biochemistry and Biophysics
Yan Mi, Dehong Tan, Yin He, Xin Zhou, Qian Zhou, Shujuan Ji
Melatonin exists as an active ingredient in several foods and has been reported to inhibit fatty liver disease in animals; however, its molecular mechanisms are not well elucidated. Herein, we explored effects of melatonin on lipid accumulation induced by oleic acid in HepG2 cells and characterized the underlying molecular mechanisms. Pretreatment with melatonin (0.1-0.3 mM) significantly inhibited accumulation of triglyceride and cholesterol induced by incubating HepG2 cells with high concentrations of oleic acid (oleic acid overload) (p < 0...
December 2018: Cell Biochemistry and Biophysics
Carleton J C Hsia, W Keith Miskimins
No abstract text is available yet for this article.
December 2018: Cell Biochemistry and Biophysics
Francisco Correa, Natalia Pavón, Mabel Buelna-Chontal, Natalia Chiquete-Félix, Luz Hernández-Esquivel, Edmundo Chávez
Several studies have demonstrated that the mitochondrial membrane switches from selective to non-selective permeability because of its improved matrix Ca2+ accumulation and oxidative stress. This process, known as permeability transition, evokes severe dysfunction in mitochondria through the opening of a non-specific pore, whose chemical nature is still under discussion. There are some proposals regarding the components of the pore structure, e.g., the adenine nucleotide translocase and dimers of the F1 Fo-ATP synthase...
December 2018: Cell Biochemistry and Biophysics
Sangeeta Soni, Buddhi Prakash Jain, Richa Gupta, Sudhaker Dharavath, Karunakar Kar, Sneha Sudha Komath, Shyamal K Goswami
SG2NA was first discovered as nuclear autoantigen in lung and bladder cancer patient. It was named SG2NA as its expression increases during S to G2 phase of cell cycle. SG2NA/Striatin3 was classified as a member of Striatin family along with Straitin and Zinedin due to its structural and functional relatedness. At the molecular level, SG2NA is characterized by the presence of multiple protein-protein interaction domains viz., a caveolin binding motif, a coiled coil structure, Ca2+ -calmodulin binding domain and a large WD-40 repeat domain in the same order from amino to the carboxyl termini...
December 2018: Cell Biochemistry and Biophysics
Alexander N Tikhonov, Witold K Subczynski
In this review, we consider the applications of electron paramagnetic resonance (EPR) methods to the study of the relationships between the electron transport and oxygen-exchange processes in photosynthetic systems of oxygenic type. One of the purposes of this article is to encourage scientists to use the advantageous EPR oximetry approaches to study oxygen-related electron transport processes in photosynthetic systems. The structural organization of the photosynthetic electron transfer chain and the EPR approaches to the measurements of molecular oxygen (O2 ) with O2 -sensitive species (nitroxide spin labels and solid paramagnetic particles) are briefly reviewed...
November 20, 2018: Cell Biochemistry and Biophysics
Balaraman Kalyanaraman, Gang Cheng, Jacek Zielonka, Brian Bennett
Oxidants formed from oxidative and nitrative metabolism include reactive oxygen species (ROS) such as superoxide, hydrogen peroxide/lipid hydroperoxides and reactive nitrogen species (RNS) (e.g., peroxynitrite [ONOO- ] and nitrogen dioxide), and reactive halogenated species (e.g., hypochlorous acid [HOCl]). Increasingly, ROS and RNS are implicated in tumorigenesis as well as tumor growth, progression, and metastasis. Recently, ROS were implicated in drug resistance, metabolic reprogramming, and T-cell metabolism in immunotherapy...
September 26, 2018: Cell Biochemistry and Biophysics
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