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Journal of Biological Inorganic Chemistry: JBIC

Justyna Polaczek, Łukasz Orzeł, Grażyna Stochel, Rudi van Eldik
The Commentary is in answer to the comment of a reader that objected against the use of the term 'nitroxylcobalamin' in two recent reports in JBC from our group. We use this opportunity to explain to the reader where this terminology originated from.
April 12, 2019: Journal of Biological Inorganic Chemistry: JBIC
Patrícia Ferreira Espuri, Larissa Luiza Dos Reis, Eduardo de Figueiredo Peloso, Vanessa Silva Gontijo, Fábio Antônio Colombo, Juliana Barbosa Nunes, Carine Ervolino de Oliveira, Eduardo T De Almeida, Débora E S Silva, Jessica Bortoletto, Daniel Fonseca Segura, Adelino V G Netto, Marcos José Marques
A new series of silver compounds could be of interest on designing new drugs for the treatment of leishmaniasis. The compounds [Ag(phen)(imzt)]NO3 (1), [Ag(phen)(imzt)]CF3 SO3 (2), [Ag(phen)2 ](BF4 )·H2 O (3), [Ag2 (imzt)6 ](NO3 )2 (4), and imzt have been synthesized and evaluated in vitro for antileishmanial activity against Leishmania. (L.) amazonensis (La) and L. (L.) chagasi (Lc), and two of them were selected for in vivo studies. In addition to investigating the action on Leishmania, their effects on the hydrogen peroxide production and cysteine protease inhibition have also been investigated...
April 4, 2019: Journal of Biological Inorganic Chemistry: JBIC
Carlson Alexander, N U Prajith, P V Priyanka, A Nithyakumar, N Arockia Samy
The synthesis and characterization of the dinucleating ligands 1,2-bis(2-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenoxy)ethane (L1) and 1,2-bis(2-(1H-imidazo[4,5-f][1, 10]phenanthrolin-2-yl)phenoxy)hexane (L2) and their dinuclear complexes [Pt2 (L1)Cl4 ] (1) and [Pt2 (L2)Cl4 ] (2) and the in vitro cytotoxicity of the complexes against HeLa, HepG2, and MCF-7 cell lines are reported. Ligand L1 crystallizes in the orthorhombic system with the space group Pbca. The complexes 1 and 2 undergo aquation following first-order kinetics...
April 3, 2019: Journal of Biological Inorganic Chemistry: JBIC
Sahar Hajebi, Masoud Homayouni Tabrizi, Mahboobeh Nakhaei Moghaddam, Farzaneh Shahraki, Soheyla Yadamani
Based on recent researches, bio synthesized silver nanoparticles (Ag-NPs) seem to have the potential in declining angiogenesis and oxidative stress. In the current study, rapeseed flower pollen (RFP) water extract was triggered to synthesize RFP-silver nanoparticles (RFP/Ag-NPs). Moreover, antioxidant, antiangiogenesis and cytotoxicity of the RFP/Ag-NPs against MDA-MB-231, MCF7 and carcinoma cell lines and normal human skin fibroblast HDF were compared. Results indicated that RFP/Ag-NPs have a peak at 430 nm, spherical shape and an average size of 24 nm...
March 29, 2019: Journal of Biological Inorganic Chemistry: JBIC
Saad El-Din Hassan, Amr Fouda, Ahmed A Radwan, Salem S Salem, Mohammed G Barghoth, Mohamed A Awad, Abdullah M Abdo, Mamdouh S El-Gamal
In this study, two endophytic actinomycetes isolates Oc-5 and Acv-11, were isolated from healthy leaves of medicinal plant Oxalis corniculata L. These isolates were identified as Streptomyces zaomyceticus Oc-5 and Streptomyces pseudogriseolus Acv-11 using 16S rRNA gene sequence. Biomass extract of these strains were used as a greener attempt for synthesis of copper oxide nanoparticles (CuO-NPs). The synthesized NPs were characterized by UV-Vis spectroscopy, Fourier transform infra-red (FT-IR) spectroscopy, X-ray diffraction (XRD)' transmission electron microscopy (TEM), energy dispersive X-ray (EDX) and X-ray photoelectron spectroscopy (XPS)...
March 26, 2019: Journal of Biological Inorganic Chemistry: JBIC
Claire M Weekley, Gloria Jeong, Michael E Tierney, Farjaneh Hossain, Aung Min Maw, Anu Shanu, Hugh H Harris, Paul K Witting
In the original article there were errors in the methods section. Thus, within Table 1: (i) the primer sequence pair for SOD-2 was incorrectly cited; (ii) the primer sequence pair used for SOD 1 was incorrect and did not target the gene of interest. Additional experiments were performed with correctly designed SOD1 primer pair and the outcomes documented here.
March 25, 2019: Journal of Biological Inorganic Chemistry: JBIC
Büşra Kaya, Zehra Kübra Yılmaz, Onur Şahin, Belma Aslim, Ümmügülsüm Tükenmez, Bahri Ülküseven
One iron(III) and two manganese(III) complexes based on thiosemicarbazone were synthesized and characterized using analytical and spectroscopic data. The crystallographic analysis showed the square pyramid structures of the complexes. Electronic spectra analysis was performed to determine the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were examined by gel electrophoresis (pBR322 DNA). The cytotoxicity of the complexes was determined against human cervical carcinoma (HeLa) and human colorectal adenocarcinoma (HT-29) cell lines by MTT assay...
March 20, 2019: Journal of Biological Inorganic Chemistry: JBIC
Sidhali U Parsekar, Manohar Singh, Durga P Mishra, P K Sudhadevi Antharjanam, Aditya P Koley, Manjuri Kumar
We report the synthesis, crystal structures and biological activities of two dinuclear Cu(II) complexes [Cu(o-phen)LCu(OAc)] (1) and [Cu(o-phen)LCu(o-phen)](OAc) (2), where o-phen = 1,10-phenanthroline, H3 L = o-HOC6 H4 C(H)=N-NH-C(OH)=N-N=C(H)-C6 H4 OH-o, and OAc=CH3 COO- . Both compounds display strong and broad X-band EPR spectra at RT in their powder state confirming that these are paramagnetic. The intercalative DNA binding of the compounds as revealed from spectrophotometric studies was found to be consistent with the results of fluorescence spectroscopic studies for ethidium bromide displacement assay as well as enhanced viscosity of DNA in the presence of these compounds...
March 18, 2019: Journal of Biological Inorganic Chemistry: JBIC
V A Timoshnikov, T Kobzeva, O Y Selyutina, N E Polyakov, G J Kontoghiorghes
Copper ions can catalyze the production of free oxygen radicals (•OH and •OOH) similar to iron ions. The capacity to initiate oxidative damage is most commonly attributed to Cu-induced toxicity in copper-related diseases where there is an increase in copper levels and also when Cu homeostasis and regulation are disrupted. An antioxidant/chelator inhibiting Cu-induced oxidative damage could play a significant role in the treatment of such Cu-related diseases. Deferiprone has high affinity for copper binding and can be considered for the potential treatment of copper toxicity and overloading conditions, such as Wilson's disease...
March 13, 2019: Journal of Biological Inorganic Chemistry: JBIC
Alejandro K Samhan-Arias, Cristina M Cordas, Marta S Carepo, Luisa B Maia, Carlos Gutierrez-Merino, Isabel Moura, José J G Moura
Recently, we observed that at extreme alkaline pH, cytochrome b5 (Cb5 ) acquires a peroxidase-like activity upon formation of a low spin hemichrome associated with a non-native state. A functional characterization of Cb5 , in a wide pH range, shows that oxygenase/peroxidase activities are stimulated in alkaline media, and a correlation between tyrosine ionization and the attained enzymatic activities was noticed, associated with an altered heme spin state, when compared to acidic pH values at which the heme group is released...
March 5, 2019: Journal of Biological Inorganic Chemistry: JBIC
(no author information available yet)
No abstract text is available yet for this article.
February 14, 2019: Journal of Biological Inorganic Chemistry: JBIC
Marijana Pavlović, Stefan Nikolić, Nevenka Gligorijević, Biljana Dojčinović, Sandra Aranđelović, Sanja Grgurić-Šipka, Siniša Radulović
Three new ruthenium(II)-arene complexes with pyrido[2',3':5,6]pyrazino[2,3-f][1, 10]phenanthroline (ppf) of general formula: C1 ([(ƞ6 -benzene)Ru(ppf)Cl]PF6 , C2 ([(ƞ6 -toluene)Ru(ppf)Cl]PF6 ) and C3 ([(ƞ6 -p-cymene)Ru(ppf)Cl]PF6 ) have been synthesized. The structures of complexes were determined by elemental analysis, IR, ESI-MS, as well as with 1 H and 13 C NMR spectroscopy. Cytotoxic activity has been evaluated in three different human neoplastic cell lines (A549, A375, LS 174T) and in one human non-tumor cell line (MRC-5), by the MTT assay...
February 14, 2019: Journal of Biological Inorganic Chemistry: JBIC
Danijela Maksimović-Ivanić, Mirna Bulatović, David Edeler, Christian Bensing, Igor Golić, Aleksandra Korać, Goran N Kaluđerović, Sanja Mijatović
Extraordinary progress in medicinal inorganic chemistry in the past few years led to the rational design of novel platinum compounds, as well as nonplatinum metal-based antitumor agents, including organotin compounds, whose activity is not based on unrepairable interaction with DNA. To overcome poor solubility and toxicity problems that limited the application of these compounds numerous delivering systems were used (Lila et al. in Biol Pharm Bull 37:206-211, 2014; Yue and Cao in Curr Cancer Drug Targets 16:480-488, 2016; Duan et al...
February 13, 2019: Journal of Biological Inorganic Chemistry: JBIC
Aleksey Aleshintsev, Erik Eppinger, Janosch A D Gröning, Andreas Stolz, Rupal Gupta
Gentisate 1,2-dioxygenases (GDOs) are non-heme iron enzymes that catalyze the oxidation of dihydroxylated aromatic substrate, gentisate (2,5-dihydroxybenzoate). Salicylate 1,2-dioxygenase (SDO), a member of the GDO family, performs the ring scission of monohydroxylated substrates such as salicylate, thereby oxidizing a broader range of substrates compared to GDOs. Although the two types of enzymes share a high degree of sequence similarity, the origin of substrate specificity between SDO and GDOs is not understood...
February 2, 2019: Journal of Biological Inorganic Chemistry: JBIC
Paolo Ascenzi, Alessandra di Masi, Giovanna De Simone, Magda Gioia, Massimo Coletta
Haptoglobin (Hp) binds human hemoglobin (Hb), contributing to prevent extra-erythrocytic Hb-induced damage. Hp forms preferentially complexes with αβ dimers, displaying heme-based reactivity. Here, kinetics and thermodynamics of fluoride and azide binding to ferric human Hb (Hb(III)) complexed with the human Hp phenotypes 1-1 and 2-2 (Hp1-1:Hb(III) and Hp2-2:Hb(III), respectively) are reported (pH 7.0 and 20.0 °C). Fluoride binds to Hp1-1:Hb(III) and Hp2-2:Hb(III) with a one-step kinetic and equilibrium behavior...
January 31, 2019: Journal of Biological Inorganic Chemistry: JBIC
Supaporn Khamchun, Kanyarat Sueksakit, Sakdithep Chaiyarit, Visith Thongboonkerd
Fibronectin, an extracellular matrix (ECM) protein, has been thought to be involved in pathogenic mechanisms of kidney stone disease, especially calcium oxalate (CaOx) type. Nevertheless, its precise roles in modulation of CaOx crystal remained unclear. We thus performed a systematic evaluation of effects of fibronectin on CaOx monohydrate (COM) crystal (the major causative chemical crystal in kidney stone formation) in various stages of kidney stone pathogenesis, including crystallization, crystal growth, aggregation, adhesion onto renal tubular cells, and invasion through ECM in renal interstitium...
January 30, 2019: Journal of Biological Inorganic Chemistry: JBIC
Gehui Gong, Jufei Xu, Xiangyi Huang, Weihong Du
The abnormal aggregation and deposition of human islet amyloid polypeptide (hIAPP) are implicated in the pathogeny of type 2 diabetes mellitus (T2DM). Many aromatic ring-containing Ru complexes inhibit the aggregation of hIAPP. A new Ru complex Ru(bipy)(met)2 ·3H2 O (1), where bipy is 2,2'-bipyridine and met is methionine, was synthesized and employed to resist the fibril formation of hIAPP and to promote the biocompatibility of metal complexes. Two polypyridyl Ru complexes, namely [Ru(bipy)3 ]Cl2 (2) and Ru(bipy)2 Cl2 (3), were used for comparison...
January 30, 2019: Journal of Biological Inorganic Chemistry: JBIC
J F Cadavid-Vargas, C Villa-Pérez, M C Ruiz, I E León, G C Valencia-Uribe, D B Soria, S B Etcheverry, A L Di Virgilio
The aim of this work was to study the antitumor effects and the mechanisms of toxic action of a series of 6-methoxyquinoline (6MQ) complexes in vitro. The Cu(II) and Zn(II) complexes (Cu6MQ and Zn6MQ) are formulated as M(6MQ)2 Cl2 ; the Co(II) and Ag(I) compounds (Co6MQ and Ag6MQ) are ionic with formulae [Ag(6MQ)2 ]+ NO3 - and H(6MQ)+ [Co(6MQ)Cl3 ]- (where H(6MQ)+ is the protonated ligand). We found that the copper complex, outperformed the Co(II), Zn(II) and Ag(I) complexes with a lower IC50 (57.9 µM) in A549 cells exposed for 24 h...
January 30, 2019: Journal of Biological Inorganic Chemistry: JBIC
Julia J Griese, Ramona Kositzki, Michael Haumann, Martin Högbom
R2-like ligand-binding oxidases (R2lox) assemble a heterodinuclear Mn/Fe cofactor which performs reductive dioxygen (O2 ) activation, catalyzes formation of a tyrosine-valine ether cross-link in the protein scaffold, and binds a fatty acid in a putative substrate channel. We have previously shown that the N-terminal metal binding site 1 is unspecific for manganese or iron in the absence of O2 , but prefers manganese in the presence of O2 , whereas the C-terminal site 2 is specific for iron. Here, we analyze the effects of amino acid exchanges in the cofactor environment on cofactor assembly and metalation specificity using X-ray crystallography, X-ray absorption spectroscopy, and metal quantification...
January 28, 2019: Journal of Biological Inorganic Chemistry: JBIC
Pavel Štarha, Zdeněk Trávníček, Ján Vančo, Zdeněk Dvořák
4-Azaindole (1H-pyrrolo[3,2-b]pyridine; 4aza) and its N1-alkylated derivative N1-isopropyl-4-azaindole (1-(propan-2-yl)-1H-pyrrolo[3,2-b]pyridine; ip4aza) have been used for the preparation of the cis-diiodido-platinum(II) complexes cis-[Pt(4aza)2 I2 ] (1), cis-[PtI2 (ip4aza)2 ] (2), cis-[Pt(4aza)I2 (NH3 )] (3) and cis-[PtI2 (ip4aza)(NH3 )] (4). The prepared complexes were thoroughly characterized (e.g., multinuclear NMR spectroscopy and ESI mass spectrometry) and their in vitro cytotoxicity was assessed at human ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R) and colon carcinoma (HT-29) cell lines, where they showed, in some cases, significantly higher activity than the used reference-drug cisplatin...
March 2019: Journal of Biological Inorganic Chemistry: JBIC
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