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Allergology International : Of...
Allergology International : Official Journal of the Japanese Society of Allergology
#21
LETTER
Sayaka Hamaguchi, Kiwako Yamamoto-Hanada, Erika Ogawa, Satoko Uematsu, Shima Ohnishi, Yushi Ito, Kenji Toyokuni, Miori Sato, Tatsuki Fukuie, Yukihiro Ohya, Ichiro Nomura
No abstract text is available yet for this article.
May 9, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#22
JOURNAL ARTICLE
Takashi Haraguchi, Tatsuo Horiuchi, Tomonori Takazawa, Kazuhiro Nagumo, Masaki Orihara, Shigeru Saito
BACKGROUND: Diagnosing perioperative anaphylaxis (POA) is often challenging. Although a guideline recommends measuring tryptase rather than histamine, there is little evidence for this. We aimed to examine the diagnostic performance and appropriate timing of tryptase and histamine measurements for diagnosing anaphylaxis, and the association between Hypersensitivity Clinical Scoring Scheme (HCSS) scores and elevated biomarkers. METHODS: We measured tryptase and histamine levels thrice: 30 min, 2 h, and at least 24 h after an anaphylactic event for patients with suspected anaphylaxis, and at the induction of general anesthesia and 30 min and 2 h after the start of surgery for control patients without a reaction...
May 8, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#23
REVIEW
Ana M Jaramillo, Eszter K Vladar, Fernando Holguin, Burton F Dickey, Christopher M Evans
Mucus provides a protective barrier that is crucial for host defense in the lungs. However, excessive or abnormal mucus can have pathophysiological consequences in many pulmonary diseases, including asthma. Patients with asthma are treated with agents that relax airway smooth muscle and reduce airway inflammation, but responses are often inadequate. In part, this is due to the inability of existing therapeutic agents to directly target mucus. Accordingly, there is a critical need to better understand how mucus hypersecretion and airway plugging are affected by the epithelial cells that synthesize, secrete, and transport mucus components...
April 30, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#24
JOURNAL ARTICLE
Kento Kawakita, Hideaki Kouzaki, Takuya Murao, Yoshihito Kubo, Tatsuji Nishiguchi, Keigo Nakamura, Hiroyuki Arai, Koji Matsumoto, Ichiro Tojima, Shino Shimizu, Takeshi Shimizu
BACKGROUND: Basal cell hyperplasia is commonly observed in nasal polyp epithelium of eosinophilic chronic rhinosinusitis (eCRS). We examined the function and mechanisms of basal cell hyperplasia in the pathophysiology of eCRS. METHODS: We found that normal human bronchial epithelial (NHBE) cells obtained basal cell characteristics when cultured with PneumaCult™-Ex Plus Medium. Most of the cells passaged three times expressed basal cell surface markers CD49f and CD271 by flow cytometry, and basal cell nuclear marker p63 by immunohistochemical staining...
April 25, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#25
JOURNAL ARTICLE
Maho Suzukawa, Ken Ohta, Masahiro Sugimoto, Nobuharu Ohshima, Nobuyuki Kobayashi, Hiroyuki Tashimo, Yasushi Tanimoto, Junko Itano, Goro Kimura, Shohei Takata, Takako Nakano, Takafumi Yamashita, Satoshi Ikegame, Kentaro Hyodo, Masahiro Abe, Kenji Chibana, Yosuke Kamide, Kazunori Sasaki, Hiroya Hashimoto
BACKGROUND: Asthma is characterized by phenotypes of different clinical, demographic, and pathological characteristics. Identifying the profile of exhaled volatile organic compounds (VOCs) in asthma phenotypes may facilitate establishing biomarkers and understanding asthma background pathogenesis. This study aimed to identify exhaled VOCs that characterize severe asthma phenotypes among patients with asthma. METHODS: This was a multicenter cross-sectional study of patients with severe asthma in Japan...
April 23, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#26
JOURNAL ARTICLE
Monami Hara, Hisato Suzuki, Daisuke Hayashi, Wataru Morii, Takako Nakamura, Kaori Kiyoki, Hideki Hara, Ryota Ishii, Emiko Noguchi, Hidetoshi Takada
BACKGROUND: Intestinal bacteria may play a role in the development of food allergies. This study aimed to analyze and compare the gut microbiota of food-allergic children with that of healthy children of the same age. METHODS: Stool samples were collected from one-and-a-half-year-old food-allergic (FA group, n = 29) and healthy controls (HC group, n = 19). A questionnaire was provided to examine the children's birth, dietary, medical, and social histories...
April 9, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#27
REVIEW
Misaki Arima, Keisuke Ito, Tomoe Abe, Tsuyoshi Oguma, Koichiro Asano, Manali Mukherjee, Shigeharu Ueki
Eosinophilic inflammation is primarily characterized by type 2 immune responses against parasitic organisms. In the contemporary human being especially in developed countries, eosinophilic inflammation is strongly associated with allergic/sterile inflammation, and constitutes an undesired immune reaction. This situation is in stark contrast to neutrophilic inflammation, which is indispensable for the host defense against bacterial infections. Among eosinophilic inflammatory disorders, massive accumulation of eosinophils within mucus is observed in certain cases, and is often linked to the distinctive clinical finding of mucus with high viscosity...
April 8, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#28
JOURNAL ARTICLE
Hung-Chih Hsu, Wen-Hung Chung, Yung-Chang Lin, Tsai-Sheng Yang, John Wen-Cheng Chang, Chia-Hsun Hsieh, Shuen-Iu Hung, Chun-Wei Lu, Jen-Shi Chen, Wen-Chi Chou, Chuang-Wei Wang
BACKGROUND: Oxaliplatin is commonly used to treat gastrointestinal malignancies. However, its applications are limited due to potential adverse drug reactions (ADRs), particularly severe anaphylactic shock. There is no method to predict or prevent ADRs caused by oxaliplatin. Therefore, we aimed to investigate the genetic HLA predisposition and immune mechanism of oxaliplatin-induced ADRs. METHODS: A retrospective review was performed for 154 patients with ADRs induced by oxaliplatin during 2016-2021 recorded in our ADR notification system...
April 8, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#29
LETTER
Chio Sakai, Masashi Matsuyama, Masayuki Nakajima, Sosuke Matsumura, Mizu Nonaka, Naoki Arai, Kenya Kuramoto, Kazufumi Yoshida, Yuko Morishima, Masafumi Muratani, Nobuyuki Hizawa
No abstract text is available yet for this article.
April 5, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#30
REVIEW
Masayuki Akashi, Sachiko Kaburagi, Naoki Kajita, Hideaki Morita
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy with gastrointestinal symptoms such as vomiting and diarrhea. The development of international consensus guidelines for the diagnosis and management of FPIES in 2017 enabled us to compare patients worldwide, regardless of geographic variation in disease features. As a result, it has become clear that there is heterogeneity among patients with FPIES or that there are cases that partly fit the diagnostic criteria for FPIES but have different characteristics...
April 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#31
LETTER
Makiko Kido-Nakahara, Daisuke Onozuka, Kenji Izuhara, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Ryo Saito, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Masutaka Furue, Norito Katoh, Takeshi Nakahara
No abstract text is available yet for this article.
April 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#32
REVIEW
Carmen Venegas Garrido, Manali Mukherjee, Sarah Svenningsen, Parameswaran Nair
Airway mucus is a hydrogel with unique biophysical properties due to its primary water composition and a small proportion of large anionic glycoproteins or mucins. The predominant mucins in human mucus, MUC5AC and MUC5B, are secreted by specialized cells within the airway epithelium both in normal conditions and in response to various stimuli. Their relative proportions are correlated with specific inflammatory responses and disease mechanisms. The dysregulation of mucin expression is implicated in numerous respiratory diseases, including asthma, COPD, and cystic fibrosis, where the pathogenic role of mucus has been extensively described yet often overlooked...
March 13, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#33
JOURNAL ARTICLE
Tomoko Tajiri, Motohiko Suzuki, Hirono Nishiyama, Yoshiyuki Ozawa, Ryota Kurokawa, Norihisa Takeda, Keima Ito, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Yuta Mori, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Masaya Takemura, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Kenji Izuhara, Akio Niimi
BACKGROUND: Dupilumab has clinical effects in patients with moderate-to-severe asthma. When considering interleukin (IL)-4 and IL-13 signaling, effects of dupilumab on airway mucus hypersecretion and airway remodeling are expected, but they have been reported in only a few short-term studies. Its efficacy for airway hyperresponsiveness (AHR) remains unknown. We comprehensively assessed the efficacy of dupilumab, especially for subjective and objective measures of airway mucus hypersecretion and airway dimensions in moderate-to-severe asthmatic patients...
March 11, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#34
EDITORIAL
Kenji Matsumoto
No abstract text is available yet for this article.
March 9, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#35
JOURNAL ARTICLE
Yusuke Hayashi, Naoya Tanabe, Hisako Matsumoto, Kaoruko Shimizu, Ryo Sakamoto, Tsuyoshi Oguma, Hironobu Sunadome, Atsuyasu Sato, Susumu Sato, Toyohiro Hirai
BACKGROUND: Associations of fractional exhaled nitric oxide (FeNO) with airway wall remodeling and mucus plugs remain to be explored in smokers and nonsmokers with asthma. Ultra-high-resolution computed tomography (U-HRCT), which allows accurate structural quantification of airways >1 mm in diameter, was used in this study to examine whether higher FeNO was associated with thicker walls of the 3rd to 6th generation airways and mucus plugging in patients with asthma. METHODS: The retrospective analyses included consecutive former smokers and nonsmokers with asthma who underwent U-HRCT in a hospital...
February 24, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#36
JOURNAL ARTICLE
Hyun Seung Lee, Heung-Woo Park
BACKGROUND: Although it has been reported that cellular senescence is important in the pathogenesis of asthma, the differential effects of diesel exhaust particle (DEP)-induced cellular senescence on the development of asthma according to age have not been thoroughly studied. METHODS: We first confirmed that DEP induced cellular senescence in mouse lungs, and then that DEP-induced cellular senescence followed by intranasal instillation of a low-dose house dust mite (HDM) allergen resulted in murine asthma...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#37
JOURNAL ARTICLE
Minori Sasakura, Hitoshi Urakami, Kota Tachibana, Kenta Ikeda, Ken-Ichi Hasui, Yoshihiro Matsuda, Ko Sunagawa, Daisuke Ennishi, Shuta Tomida, Shin Morizane
BACKGROUND: Selective activator protein (AP)-1 inhibitors are potentially promising therapeutic agents for atopic dermatitis (AD) because AP-1 is an important regulator of skin inflammation. However, few studies have investigated the effect of topical application of AP-1 inhibitors in treating inflammatory skin disorders. METHODS: Immunohistochemistry was conducted to detect phosphorylated AP-1/c-Jun expression of skin lesions in AD patients. In the in vivo study, 1 % T-5224 ointment was topically applied for 8 days to the ears of 2,4 dinitrofluorobenzene challenged AD-like dermatitis model mice...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#38
JOURNAL ARTICLE
Syuji Yonekura, Yoshitaka Okamoto, Fumiya Yamaide, Taiji Nakano, Kiyomi Hirano, Urara Funakoshi, Sawako Hamasaki, Tomohisa Iinuma, Toyoyuki Hanazawa, Naoki Shimojo
BACKGROUND: This study aimed to clarify the diagnostic and predictive factors for perennial allergic rhinitis (PAR) onset in children by analyzing the results of the Chiba High-risk Birth Cohort for Allergy study, which examined newborns with a family history of allergies. METHODS: Overall, 306 pregnant women were recruited. Their newborns were examined by otolaryngologists and pediatric allergists at 1, 2, and 5 years of age. Participants with clinical and laboratory data available at all consultation points were considered eligible...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#39
LETTER
Fumiya Nihashi, Kazuki Furuhashi, Ryo Horiguchi, Yoshihiro Kitahara, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Takafumi Suda
No abstract text is available yet for this article.
February 9, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
#40
JOURNAL ARTICLE
Hitomi Ikegami-Tanaka, Naoya Yasokawa, Koji Kurose, Shonosuke Tajima, Masaaki Abe, Shigeki Katoh, Yoshihiro Kobashi, Toru Oga
BACKGROUND: Asthma and obstructive sleep apnea (OSA) are prevalent chronic respiratory disorders, which often coexist and interact with each other. Obesity is an important risk factor shared by them. The rate of obesity is lower in Japan versus Western countries. Hence, the co-existence of asthma and OSA has not been investigated in Japan. METHODS: Ninety-seven outpatients with asthma were recruited. Patients wore a portable monitor for sleep study. Background data, pulmonary function, blood tests, and patient-reported outcomes including gastroesophageal reflux disease, sleepiness, sleep quality, asthma control, cough and respiratory symptoms, and health status, were assessed...
February 9, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
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