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Journals Allergology International : Of...

Allergology International : Official Journal of the Japanese Society of Allergology

https://read.qxmd.com/read/36890018/clinical-features-of-igg4-related-disease-with-bronchial-asthma
#21
LETTER
Sayaka Tsuzuki, Toshihiko Komai, Aya Nishiwaki, Terumi Kamisawa, Hirofumi Shoda, Keishi Fujio, Keigo Setoguchi
No abstract text is available yet for this article.
March 6, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/37010996/il-33-induced-keratoconjunctivitis-is-mediated-by-group-2-innate-lymphoid-cells-in-mice
#22
JOURNAL ARTICLE
Yuka Hosotani, Koubun Yasuda, Makoto Nagai, Kiyofumi Yamanishi, Nobuo Kanazawa, Fumi Gomi, Yasutomo Imai
BACKGROUND: Interleukin-33 (IL-33) is involved in type 2 innate immunity by inducing type 2 cytokines, such as IL-5 and IL-13, through the activation of group 2 innate lymphoid cells (ILC2s) or T helper 2 (Th2) cells. We previously reported that mice overexpressing IL-33 (IL-33Tg) in the cornea and conjunctiva spontaneously develop atopic keratoconjunctivitis-like inflammation. Despite previous studies, it is not fully understood what types of immune cells contribute to the disease process of IL-33-induced keratoconjunctivitis...
April 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/37010995/the-dual-aspects-of-igd-in-the-development-of-tolerance-and-the-pathogenesis-of-allergic-diseases
#23
REVIEW
Naohiro Itoh, Yusei Ohshima
The cell-surface form of IgD is co-expressed with IgM on mature, naïve B cells as B-cell receptors. The secreted IgD antibody (Ab) is found in relatively modest concentrations in the blood and other body fluids as it has a relatively short serum half-life. IgD Abs produced in the upper-respiratory mucosa presumably participate in host defense against pathogens. The allergen-mediated cross-linkage of basophil-bound IgD Ab enhances type 2 cytokine secretion; IgD Ab may also interfere with IgE-mediated basophil degranulation, suggesting dual and opposing roles of IgD Ab in allergen sensitization and the development of allergen immune tolerance...
April 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/37003621/the-latest-findings-on-ilc2s-from-bench-to-bedside
#24
EDITORIAL
Kazuyo Moro
No abstract text is available yet for this article.
April 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36868950/questionnaire-for-diagnosing-asthma-copd-overlap-in-copd-development-of-aco-screening-questionnaire-aco-q
#25
JOURNAL ARTICLE
Yuki Suzuki, Hiroyuki Nagase, Hikaru Toyota, Sho Ohyatsu, Konomi Kobayashi, Yuri Takeshita, Yuuki Uehara, Saya Hattori, Mana Ishizuka, Hirokazu Sakasegawa, Michio Kuramochi, Tadashi Kohyama, Naoya Sugimoto
BACKGROUND: The considerable prevalence and worse outcomes of asthma-COPD overlap (ACO) in COPD have been reported, and optimal introduction of ICS is essential for ACO. However, diagnostic criteria for ACO consist of multiple laboratory tests, which is challenging during this COVID-19 era. The purpose of this study was to create a simple questionnaire to diagnose ACO in patients with COPD. METHODS: Among 100 COPD patients, 53 were diagnosed with ACO based on the Japanese Respiratory Society Guidelines for ACO...
March 1, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36858856/efficacy-pharmacokinetics-and-safety-of-subcutaneous-c1-esterase-inhibitor-as-prophylaxis-in-japanese-patients-with-hereditary-angioedema-results-of-a-phase-3-study
#26
JOURNAL ARTICLE
Tomoo Fukuda, Keiko Yamagami, Kimito Kawahata, Yuzo Suzuki, Yoshihiro Sasaki, Takashi Miyagi, Iris Jacobs, John-Philip Lawo, Fiona Glassman, Hideto Akama, Michihiro Hide, Isao Ohsawa
BACKGROUND: Hereditary angioedema (HAE) is a rare and potentially life-threatening genetic disorder characterized by recurrent attacks of angioedema. HAE types I and II result from deficient or dysfunctional C1-esterase inhibitor (C1-INH). This Phase 3 study assessed the efficacy, pharmacokinetics (PK), and safety of subcutaneous (SC) C1-INH in Japanese patients with HAE. METHODS: The prospective, open-label, multicenter, single-arm Phase 3 study recruited patients with HAE types I or II to an initial run-in period, followed by a 16-week treatment period where patients received 60 IU/kg C1-INH (SC) twice weekly...
February 27, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36842916/ilc2s-in-skin-disorders
#27
REVIEW
Yasutomo Imai
The activation of group 2 innate lymphoid cells (ILC2s) is controlled by various tissue-derived factors, including cytokines, whereas T cells respond to foreign antigens. This review discusses the tissue-specific properties of ILC2s in skin and their involvement in human skin diseases. In a steady state, cutaneous ILC2s contribute to tissue homeostasis. In the keratinocytes of patients with atopic dermatitis (AD), the inflammatory cytokine interleukin-33 (IL-33) is overexpressed. ILC2s are stimulated by IL-33-stimulated basophils through IL-4 to produce type 2 cytokines, such as IL-5 and IL-13...
February 24, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36813678/serine-phosphate-group-in-casein-phosphopeptide-is-crucial-for-ige-binding-to-%C3%AE-s1-casein
#28
LETTER
Michihiro Naito, Teruaki Matsui, Komei Ito, Hidehiko Izumi
No abstract text is available yet for this article.
February 20, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36740498/individual-multidisciplinary-clinical-phenotypes-of-nasal-and-ocular-symptoms-in-hay-fever-crowdsourced-cross-sectional-study-using-allersearch
#29
JOURNAL ARTICLE
Takenori Inomata, Jaemyoung Sung, Kenta Fujio, Masahiro Nakamura, Yasutsugu Akasaki, Ken Nagino, Yuichi Okumura, Masao Iwagami, Keiichi Fujimoto, Nobuyuki Ebihara, Masahiro Nakamura, Akie Midorikawa-Inomata, Hurramhon Shokirova, Tianxiang Huang, Kunihiko Hirosawa, Maria Miura, Mizu Ohno, Yuki Morooka, Nanami Iwata, Yuma Iwasaki, Akira Murakami
BACKGROUND: Multidisciplinary efforts to prospectively collect and analyze symptoms of hay fever are limited. We aimed to identify the characteristics of nasal and ocular symptoms of hay fever, using the AllerSearch smartphone application. METHODS: This mobile health-based prospective observational study using the AllerSearch smartphone application was conducted between February 1, 2018, and May 1, 2020. Individuals who downloaded AllerSearch from Japan and provided comprehensive self-assessments (including 17 items related to quality of life [QoL]-related items) were included...
February 3, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36725444/effect-of-birth-season-on-allergic-rhinitis-and-cedar-pollinosis-considering-allergen-and-vitamin-d-exposure-the-japan-environment-and-children-s-study-jecs
#30
JOURNAL ARTICLE
Reiji Kojima, Ryoji Shinohara, Megumi Kushima, Sayaka Horiuchi, Sanae Otawa, Kunio Miyake, Hiroshi Yokomichi, Yuka Akiyama, Tadao Ooka, Zentaro Yamagata
BACKGROUND: The relationship between the season of birth, allergen sensitization, and allergic rhinitis have been inconsistent, and there are no studies that simultaneously consider vitamin D and allergen exposure. This study aimed to determine the associations between the season of birth, house dust mite (HDM) and Japanese cedar pollen (JCP) sensitization, and allergic rhinitis and pollinosis, while taking vitamin D levels and allergen exposure into account. METHODS: This study included 4323 participants in the Sub-Cohort Study of the Japan Environment and Children's Study...
January 30, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36646561/crossing-the-valley-of-death-toward-translational-research-regarding-ilc2
#31
REVIEW
Takuya Yashiro, Kazuyo Moro
Group 2 innate lymphoid cells (ILC2s) are tissue-resident innate lymphoid cells that express the transcription factor GATA3 as a master regulator, which leads to the production of large amounts of type 2 cytokines, such as IL-5 and IL-13. ILC2s are activated by epithelial cell-derived cytokines, including IL-33 and IL-25, and play a key role in parasite expulsion, allergic responses, tissue repair, and metabolism. In the first five years after the discovery of ILC2s, research mainly focused on their function through cytokine receptors...
January 14, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36642622/small-airway-dysfunction-in-asthma-based-on-oscillometry
#32
LETTER
Toshihiro Shirai, Keita Hirai, Yasuhiro Gon
No abstract text is available yet for this article.
January 13, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36641300/efficacy-and-safety-of-omalizumab-in-adult-patients-with-wheat-dependent-exercise-induced-anaphylaxis-reduction-of-in%C3%A2-vitro-basophil-activation-and-allergic-reaction-to-wheat
#33
JOURNAL ARTICLE
Yuko Chinuki, Kunie Kohno, Michihiro Hide, Keiko Hanaoka, Takahiro Okabe, Atsushi Fukunaga, Yoshiko Oda, Atsuko Adachi, Tsukasa Ugajin, Hiroo Yokozeki, Ritsuro Suzuki, Akiko Sugiyama, Reiko Kishikawa, Osamu Yamasaki, Eishin Morita
BACKGROUND: In patients with wheat-dependent exercise-induced anaphylaxis (WDEIA), anaphylactic shock occurs frequently, therefore avoidance of wheat products is recommended. We aimed to evaluate efficacy and safety of long-term omalizumab treatment for adult patients with WDEIA. METHODS: In this phase 2, multicentre single-arm trial, 20 adult patients with WDEIA were enrolled (UMIN 000019250). All patients were administered 150-600 mg of omalizumab subcutaneously and evaluations (basophil activation and blood examination) were performed at regular intervals during administration period (0-48 weeks) and observation period (48-68 weeks)...
January 12, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36635146/lncrna-fam239a-modulates-t-helper-cell-responses-via-tyrosine-phosphatase-shp2-in-allergic-rhinitis
#34
LETTER
Yumei Li, Zhen Liu, Yakui Mou, Yanyan Yang, Yujuan Yang, Qi Sun, Hao Song, Yu Zhang, Xicheng Song
No abstract text is available yet for this article.
January 10, 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36681418/rapid-progress-in-molecular-targeted-therapy-for-allergic-diseases
#35
EDITORIAL
Hiroyuki Nagase
No abstract text is available yet for this article.
January 2023: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36588001/current-situation-of-anaphylaxis-in-japan-data-from-the-anaphylaxis-registry-of-training-and-teaching-facilities-certified-by-the-japanese-society-of-allergy-secondary-publication
#36
JOURNAL ARTICLE
Sakura Sato, Noriyuki Yanagida, Komei Ito, Yoshitaka Okamoto, Hirohisa Saito, Masami Taniguchi, Makoto Nagata, Hirokuni Hirata, Masao Yamaguchi, Ruby Pawankar, Motohiro Ebisawa
BACKGROUND: Anaphylaxis is a potentially fatal severe systemic hypersensitivity reaction that causes symptoms in multiple organs such as the skin, respiratory tract, and gastrointestinal tract; however, no nationwide epidemiological survey on anaphylaxis has been conducted in Japan. This survey aimed to elucidate the triggers and treatment of anaphylaxis in Japan. METHODS: Between February 2015 and October 2017, we prospectively collected clinical data on the triggers and treatment of patients who developed anaphylaxis or were admitted to the emergency room with anaphylaxis in the training and teaching facilities of the Japanese Society of Allergology...
December 30, 2022: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36586746/blood-eosinophil-count-variability-in-chronic-obstructive-pulmonary-disease-and-severe-asthma
#37
JOURNAL ARTICLE
Yuki Abe, Masaru Suzuki, Hirokazu Kimura, Kaoruko Shimizu, Nozomu Takei, Akira Oguma, Machiko Matsumoto-Sasaki, Houman Goudarzi, Hironi Makita, Masaharu Nishimura, Satoshi Konno
BACKGROUND: Blood eosinophils are essential biomarkers that vary substantially over time in patients with COPD and asthma. However, no study has identified the changes and effects in the changes of the blood eosinophil counts over time in both diseases. This study aimed to demonstrate blood eosinophil variability in patients with COPD and severe asthma based on these backgrounds. METHODS: A total of 172 patients with COPD from the Hokkaido COPD cohort study and 96 patients with severe asthma from the Hokkaido Severe Asthma Cohort Study, whose blood eosinophil counts were measured annually over a 3-year period, were analyzed...
December 29, 2022: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36586745/calcium-ionophore-activated-platelets-induce-eosinophil-extracellular-trap-formation
#38
JOURNAL ARTICLE
Myeong Seong Sim, Hye Jeong Kim, Ikhyeon Bae, Chun Kim, Hun Soo Chang, Youngwoo Choi, Dong-Hyun Lee, Hae-Sim Park, Il Yup Chung
BACKGROUND: Platelets play a modulatory role in inflammatory response by secreting a vast array of granules and disintegrating into membrane-bound microparticles upon activation. The interplay between eosinophils and platelets is postulated to be implicated in the pathology of allergic airway inflammation. In this study, we investigated whether activated platelets can induce eosinophil extracellular trap (EET) formation, a cellular process by which activated eosinophils release net-like DNA fibers...
December 29, 2022: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36585333/group-2-innate-lymphoid-cells-in-human-asthma
#39
REVIEW
Arifumi Iwata, Yosuke Toda, Hiroki Furuya, Hiroshi Nakajima
Asthma is characterized by increased airway hyperresponsiveness, reversible airflow limitation, and remodeling due to allergic airway inflammation. Asthma has been proposed to be classified into various phenotypes by cluster analyses integrating clinical information and laboratory data. Recently, asthma has been classified into two major endotypes, Type 2-high and Type 2-low asthma, and various subtypes based on the underlying molecular mechanisms. In Type 2-high asthma, Th2 cells, together with group 2 innate lymphoid cells (ILC2s), produce type 2 cytokines such as IL-4, IL-5, IL-9, and IL-13, which play crucial roles in causing airway inflammation...
December 28, 2022: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/36543689/biologics-for-severe-asthma-the-real-world-evidence-effectiveness-of-switching-and-prediction-factors-for-the-efficacy
#40
REVIEW
Hiroyuki Nagase, Maho Suzukawa, Keiji Oishi, Kazuto Matsunaga
Biologics have been a key component of severe asthma treatment, and there are currently biologics available that target IgE, IL-5, IL-4/IL-13, and TSLP. Randomized controlled trials have established clinical evidence, but a significant portion of patients with severe asthma in real-life settings would have been excluded from those trials. Therefore, real-world research is necessary, and there is a growing body of information about the long-term efficacy and safety of biologics. Multiple clinical phenotypes of severe asthma exist, and it is crucial to choose patients based on their phenotypes...
December 19, 2022: Allergology International: Official Journal of the Japanese Society of Allergology
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