Keiichi Ohata, Takeshi Sugaya, Hanh Nhung Nguyen, Yuri Hatanaka, Kinuko Uno, Marika Tohma, Tsuyoshi Oikawa, Hiroshi Nagabukuro, Kanako Kuniyeda, Atsuko Kamijo-Ikemori, Noriko Suzuki-Kemuriyama, Dai Nakae, Eisei Noiri, Katsuhiro Miyajima
AIM: Urinary liver-type fatty acid binding protein (L-FABP) has potential utility as an early prognostic biomarker ahead of traditional severity scores in coronavirus disease 2019 and sepsis, however, the mechanism of elevated urinary L-FABP in the disease has not been clearly elucidated. We investigated the background mechanisms of urinary L-FABP excretion through non-clinical animal model focusing on histone, which is one of the aggravating factors in these infectious diseases. METHODS: Male Sprague-Dawley rats were placed in central intravenous catheters, and these rats were given a continuous intravenous infusion of 0...
April 19, 2023: Nephrology