Vandit Shah, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Abhijit Konnur, Sishir Gang, Sachchida Nand Pandey
BACKGROUND: Accurate genetic diagnosis of end-stage renal disease patients with a family history of renal dysfunction is very essential. It not only helps in proper prognosis, but becomes crucial in designating donor for live related renal transplant. We here present a case of family with deleterious mutations in INF2 and ROBO2 and its importance of genetic testing before preparing for kidney transplantation. CASE PRESENTATION: We report the case of a 29-year-female with end-stage renal disease and rapidly progressive renal failure...
September 29, 2023: Nephrology
Ahmet Burak Dirim, Tugba Kalayci, Seda Safak, Nurane Garayeva Guller, Ozgur Akin Oto, Ayse Serra Artan, Sukru Ozturk, Halil Yazici
No abstract text is available yet for this article.
September 22, 2023: Nephrology
Ayse Serra Artan, Ahmet Burak Dirim, Halil Yavuzkilic, Erol Demir, Ozgur Akin Oto, Nurana Guller, Seda Safak, Halil Yazici, Aydin Turkmen
AIM: Increased venous thrombosis and arterial embolism rates are observed in the general population during or after COVID-19. Data regarding the kidney transplant population are scarce. In this study, we aim to investigate the thrombotic complications and risk factors associated with thrombotic complications in kidney transplant patients. METHODS: This retrospective observational study included adult kidney transplant recipients diagnosed with COVID-19 between March 2020 and June 2022...
September 20, 2023: Nephrology
Maria Gabriela Motta Guimarães, Fernanda Pinheiro Martin Tapioca, Leonardo Matos Peixoto, Sheila Nunes Freitas Teixeira, Luiz Carlos Santana Passos
Despite its rare frequency, a pleuroperitoneal communication is a well-documented complication for patients on peritoneal dialysis. It occurs in ~2% of continuous ambulatory peritoneal dialysis, with uncertain incidence for those on automated peritoneal dialysis. We report a case of a 30-year-old female patient with end-stage kidney disease with sudden dyspnea 2 days after starting automated peritoneal dialysis. Her chest x-ray revealed a significant pleural effusion on the right side. A thoracocentesis was performed, with a pleural glucose/plasma glucose of 1...
September 20, 2023: Nephrology
Shu Ling Fan, Anthony Landgren, Irene Ruderman
Syphilis is a known cause of membranous nephropathy. We describe a case of a patient presenting with nephrotic syndrome whose renal biopsy demonstrated a 'full house' immunohistochemical pattern with positive IgG, IgM, C1q, IgA, C3c, and C4d staining. He was treated with immunosuppressive agents for minimal change nephropathy and subsequently class V lupus nephritis, before syphilis infection was confirmed. Following treatment with a single dose of intramuscular benzathine penicillin there was complete and rapid resolution of nephrotic syndrome...
September 18, 2023: Nephrology
Ching-I Cheng, Woan-Jean Lin, Hui-Ting Liu, Yi-Ting Chen, Chih-Kang Chiang, Kung-Yu Hung
PURPOSE: Coronavirus disease pandemic makes high requirements in delivering remote and efficient communication, and patient education. Because of the increases of digital and social media applications in Taiwan, we aim to apply Artificial Intelligence of LINE Chatbot to improve the self-care ability of patients undergoing peritoneal dialysis. MATERIALS AND METHODS: We conducted the project since 1 May 2021 to 30 April 2022. We designed an automatically replied Chatbot system, and divided into six scopes of interaction interfaces, including peritoneal dialysis technique operation video, clinical reminder, home caring, hospital registration service, dietary guideline, and Automatic Peritoneal dialysis guidance...
September 12, 2023: Nephrology
Li Lei, Sheng Zhang, Rui Hou, Pei Dong
AIM: This study aimed to explore the effect and related mechanisms of LncRNA 152 in acute kidney injury (AKI). METHODS: QRT-PCR was used to detect the expression of LncRNA 152, FGF23 and Klotho in the serum of patients with AKI. Subsequently, Sprague Dawley (SD) rats were induced into AKI animal model by lipopolysaccharide (LPS). Then, H&E staining was performed to observe the pathological changes in the rat kidney tissues; qRT-PCR to detect the expression of LncRNA 152, FGF23 and Klotho in the rat kidney tissues; biochemical assay and ELISA to assess the levels of renal function indexes and inflammatory factors in rat serum, as well as oxidative stress indexes in kidney tissues; and western blot to measure the protein expressions of FGF23, Klotho, p-p38 and p38 in rat kidney tissues...
September 12, 2023: Nephrology
Sanjiv Jasuja, Maurizio Gallieni, Vivekanand Jha, Tushar Vachharajani, A K Bhalla, Jackson Tan, Cheih Suai Tan, Nabin Bahadur Basnet, Nalaka Herath, Ha Phan Hai An, Yong Soo Kim, Yaeni Kim, Krishnaswamy SampathKumar, Manisha Sahay, Raja Ramachandran, Suceena Alexander, Vinant Bhargava, J Balasubramaniam, David Voss, Fredeick E Ogbac, Atma Gunawan, Bak Leong Goh, Chih-Ching Lin, Jamshaid Khan, Ibrahim Shiham, Haroon Ayub, Min Aung Hein, Sarwar Iqbal, Nattachai Srisawat, Bihu Gao, Cherian Sajiv, Catherine Wilkinson, Thim Pichthida, D S Rana, Gaurav Sagar, Anupam Bahl, Samir Tawakley, Mragank Gaur
AIM: This cross-sectional survey aimed to determine the prevalence of Interventional Nephrology (IN) practice amongst nephrologists in the Asia-Pacific Region (APR), specifically related to dialysis access (DA). METHODS: The Association of VA and intervenTionAl Renal physicians (AVATAR) Foundation from India conducted a multinational online survey amongst nephrologists from the Asia-Pacific to determine the practice of IN in the planning, creation, and management of dialysis access...
September 11, 2023: Nephrology
Jiaying Zhang, Rongyun Su, Yinghui Wang, Honggang Wang, Shan Li, Xue Yang, Gang Liu
Acute kidney injury is a severe disease that is closely associated with substantial morbidity and mortality. The most common cause of AKI is renal ischemia-reperfusion injury. Mesenchymal stem cells (MSCs) have previously been shown to have renoprotective effects. However, extracellular vesicles secreted by MSCs are thought to be the key for the therapeutic effects of MSCs. This study investigated whether small EVs derived from ACE2-modified human umbilical cord MSCs could alleviate RIRI and explored their underlying molecular mechanisms METHODS: A lentivirus carrying an ACE2 overexpression vector was constructed and used to infect MSCs...
September 4, 2023: Nephrology
Kübra Kaynar, Beyhan Güvercin, Sedanur Demir, Murat Şahin, Sevdegül Mungan
No abstract text is available yet for this article.
August 27, 2023: Nephrology
Sara Stoler, Sebastiaan J van Hal, Steve Chadban, Thomas Le, Paul Torzillo, Rose-Marie Scarlato, Kate Wyburn, Griffith B Perkins, Tina Marinelli
We present the case of a recent ABO incompatible kidney transplant recipient with persistent SARS-CoV-2 infection and pneumonitis. Serial whole genome sequencing confirmed intra-host viral evolution, which was used as a surrogate to confirm active viral replication and support re-treatment with antivirals, late in the course of infection. A prolonged course of remdesivir combined with immunosuppression modulation resulted in successful clearance of virus and clinical improvement. The diagnostic process undertaken in this case provides a useful guide for other clinicians when approaching similar patients...
August 27, 2023: Nephrology
Kai-Yu Hu, Chia-Ter Chao, Shih-I Chen, Chin-Chung Shu, Kuan-Yu Hung
No abstract text is available yet for this article.
August 26, 2023: Nephrology
Esther Huimin Leow, Siew Le Chong, Ee Shien Tan, Ai Ling Koh, Breana Wen Min Cham, Celeste Jia Ying Yap, Yong Hong Ng
Adenine phosphoribosyl transferase (APRT) deficiency is an autosomal recessive disorder and a rare cause of urolithiasis due to mutations in APRT (OMIM #102600). APRT deficiency results in increased urinary excretion of 2,8-dihydroxyadenine (DHA) which can cause urolithiasis and kidney failure. However, with prompt diagnosis, patients with APRT deficiency can be treated with xanthine oxidoreductase inhibitors which decrease urinary DHA excretion and improve outcomes. We report a pair of siblings, an 11-year-old brother and his 14-year-old sister with compound heterozygous variants c...
August 24, 2023: Nephrology
Sijia Yu, Qiang Li, Yibo He, CongZhuo Jia, Guoxiao Liang, Hongyu Lu, Wanying Wu, Jin Liu, Yong Liu, Jiyan Chen
AIM: Cardiac biomarkers' predictive value of contrast-associated acute kidney injury (CA-AKI) remains unclear. We analysed whether creatine kinase isoenzyme-MB (CKMB), cardiac troponin I (cTnI) and preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) are tied to CA-AKI patients undergoing cardiac catheterization. METHODS: In the multi-center study, we included 3553 people underwent cardiac catheterization for analysis. CA-AKI was defined as the absolute increase of over 0...
August 24, 2023: Nephrology
Lucy McMullen, Douglas Drak, Gopal Basu, P Toby Coates, David J Goodman, Alison Graver, Nicole Isbel, Wai H Lim, Grant Luxton, Frederika Sciberras, Nigel D Toussaint, Germaine Wong, David M Gracey
Kidney transplantation in people living with HIV (PLWHIV) is occurring with increasing frequency. Limited international data suggest comparable patient and graft survival in kidney transplant recipients with and without HIV. All PLWHIV aged ≥18 years who received a kidney transplant between 2000 and 2020 were identified by retrospective data initially extracted from Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), with additional HIV-specific clinical data extracted from linked local health-care records...
August 21, 2023: Nephrology
Takuya Maeda, Hiroaki Io, Kazuaki Hara, Junichiro Nakata, Masanori Ishizaka, Yuki Shimizu, Yuka Shirotani, Haruna Fukuzaki, Yusuke Suzuki
Laparoscopy provides extensive data for the decannulation of a peritoneal dialysis catheter and is being increasingly used to diagnose encapsulating peritoneal sclerosis. However, there are few reports on the methods of decannulation of peritoneal dialysis catheters. In this study, we examined the laparoscopic findings and postoperative complications of patients undergoing peritoneal dialysis catheter removal. A total of 119 laparoscopic decannulations of peritoneal dialysis catheters were performed between 2003 and 2018 at the Juntendo University Hospital and Juntendo University Nerima Hospital...
August 21, 2023: Nephrology
Tomoharu Watanabe, Kayaho Maeda, Noritoshi Kato, Hiroshi Seko, Masahiro Sugimura, Yuka Sato, Akihiro Ryuge, Sawako Kato, Kenji Kadomatsu, Shoichi Maruyama, Tomoki Kosugi
AIM: Irrespective of the cause, albumin/proteinuria induces tubulointerstitial damage and accelerates the progression of kidney diseases. Our series of studies demonstrated that proteinuria, an independent prognostic factor for chronic kidney disease (CKD), is correlated with urinary basigin/CD147 (Bsg) levels. We examined the morphology and origin of Bsg in the tubular lumen through the effects of filtered glucose and protein solutes on the tubules. METHODS: Diabetic kidney disease (DKD) patients (N = 50) were treated with spironolactone 25 mg for 4 weeks or by conservative treatment...
August 10, 2023: Nephrology
Ming-Yen Lin, Chia-Te Liao, Ming-Huang Lin, Hsiao-Ting Wu, Mai-Szu Wu, Yung-Ho Hsu, Chih-Cheng Hsu
The world healthcare system is actively seeking possible solutions for the rapid growth of kidney disease threats. The Taiwan Renal Data System (TWRDS) was central in assisting kidney health and care policymaking to reduce end-stage kidney disease incidence and mortality. This article summarizes the TWRDS framework, recent applications, and developments to provide new insights for some international researchers to promote planetary kidney health. The TWRDS originated in 1987 for the accreditation and quality monitoring of dialysis units and was connected with enriched health claim databases after the implementation of universal national health insurance in Taiwan in 1995...
August 7, 2023: Nephrology
Elenjickal Elias John, Sanjeet Roy, Jeethu Joseph Eapen, Reka Karuppusami, Nisha Jose, Selvin Sundar Raj Mani, Joseph Johny, Rizwan Alam, Sabina Yusuf, Athul Thomas, Anna T Valson, Vinoi George David, Santosh Varughese, Suceena Alexander
AIM: Diabetic patients are prone to infections, thus making them a unique cohort at risk of developing bacterial infection-related glomerulonephritis (IRGN). METHODS: In total, 1693 adult diabetic patients underwent kidney biopsy between 2005 and 2021 at our tertiary care hospital in South India. Of these, 121 consecutive cases which met criteria of bacterial IRGN were included in this study. RESULTS: The mean age of the cohort was 53.1 ± 10...
July 26, 2023: Nephrology
Esra Karabag Yilmaz, Memnune Nur Cebi, Iremnaz Karahan, Seha Saygılı, Ruveyda Gulmez, Ebru Burcu Demirgan, Cansu Durak, Fatih Aygun, Fatih Ozaltin, Salim Caliskan, Nur Canpolat
A limited number of cases of thrombotic microangiopathy (TMA) have previously been reported in association with COVID-19. Our report describes two cases of TMA associated with COVID-19, one of which was successfully treated with eculizumab. The first case was a 23-month-old girl, and the second case was a 9-month-old boy. PCR tests for SARS-CoV-2 were positive in both cases, and laboratory results showed microangiopathic haemolytic anaemia, thrombocytopenia, and acute kidney injury. No known aetiology for TMA was found in either case...
July 23, 2023: Nephrology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.