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Deidra C Crews, Aminu K Bello, Gamal Saadi
No abstract text is available yet for this article.
February 6, 2019: Nephrology
Nicholas A Gray, Li Zuo, Daqing Hong, Smyth Brendan, Jun Min, Janak De Zoysa, Kha Vo, Kirsten Howard, Jing Wang, Chunlai Lu, Zhangsuo Liu, Alan Cass, Vlado Perkovic, Meg Jardine
AIM: To compare quality of life (QOL) of caregivers of dialysis patients with the cared for patients and population norms. METHODS: The ACTIVE Dialysis study randomised participants to extended (median 24 hours/week) or standard (median 12 hours/week) haemodialysis hours for 12 months. A subgroup of participants and their nominated caregivers completed QOL questionnaires including the EuroQOL-5 Dimension-3 Level (EQ5D-3L), Short Form-36 (SF-36, also allowing estimation of the SF-6D), as well as a bespoke questionnaire and the Personal Wellbeing Index (PWI)...
February 5, 2019: Nephrology
Ferah Armutcu, Kadir Demircan, Umran Yildirim, Mehmet Namuslu, Murat Yagmurca, Hüseyin Tu Gbreve Rul Celik
AIM: Renal fibrosis is a common cause of renal dysfunction with chronic kidney diseases. This process is characterized by excessive production of extracellular matrix (ECM) or inhibition of ECM degradation. ADAMTS proteinases, which are widely presented in mammals, have very critical roles in ECM remodeling. We aimed to study the role of ADAMTS proteinases and some of the ECM markers in the pathogenesis of renal fibrosis, and to investigate the effects of hypoxia upon these biomarkers...
February 4, 2019: Nephrology
Hye Eun Yoon, Young Joo Kwon, Seok Joon Shin, So-Young Lee, Sangho Lee, Su-Hyun Kim, Eun Young Lee, Sug Kyun Shin, Yong-Soo Kim
AIM: Bioimpedance spectroscopy (BIS) allows volume status to be assessed objectively. This study evaluated the effect of BIS-guided fluid management on residual kidney function (RKF), volume status, and cardiovascular events in peritoneal dialysis (PD) patients. METHODS: A multicenter, prospective, randomized, controlled trial was conducted over 12 months in 2013-2017. Non-anuric PD patients (urine volume ≥500 mL/day) were randomized to clinical method-guided management (n = 98) or BIS-guided management (n = 103)...
January 31, 2019: Nephrology
Emily Duncanson, Kathryn Dansie, Talia Gutman, Allison Tong, Martin Howell, Shilpanjali Jesudason, Donna Reidlinger, Amber Williamson, Nicole Scholes-Robertson, Lisa Murphy, Carmel M Hawley, Jonathan C Craig, David W Johnson, Stephen McDonald
Involving consumers (patients, carers and family members) across all stages of research is gaining momentum in the nephrology community. Scientific meetings present a partnership opportunity with consumers for dissemination of research findings. The Better Evidence And Translation - Chronic Kidney Disease (BEAT-CKD) research collaboration, in partnership with Kidney Health Australia, convened two consumer sessions at the 54th Australian and New Zealand Society of Nephrology Annual Scientific Meeting held in September 2018...
January 29, 2019: Nephrology
Joey Junarta, Vivekanand Jha, Debasish Banerjee
Patients with chronic kidney disease (CKD) experience excess cardiovascular morbidity and mortality that is unexplained by traditional cardiovascular risk factors. Vitamin D deficiency is highly prevalent in CKD and is associated with increased cardiovascular mortality in both the general population and in CKD patients. Vitamin D supplementation is a reasonably safe and simple intervention and meta-analyses of observational studies have suggested that vitamin D supplementation in CKD improves cardiovascular mortality...
January 26, 2019: Nephrology
I-Kuan Wang, Tsung-Hsun Tsai, Shih-Shang Chang, Shih-Yi Lin, Tzung-Hai Yen, Cheng-Li Lin, Fung-Chang Sung
AIMS: Dialysis patients with atrial fibrillation (AF) are at 1.72-fold increased mortality risk. This study investigated whether peritoneal dialysis (PD) patients using icodextrin were at a reduced risk of AF. METHODS: From the Taiwan National Health Insurance database, we identified 4040 icodextrin users and 3517 non-users among 7557 patients newly diagnosed with end-stage renal disease undergoing PD f rom 2005 to 2011. The incidence of AF was compared between PD patients with and without icodextrin treatment by the end of 2011, with the hazard ratio (HR) of AF measured using Cox proportional hazards regression models...
January 24, 2019: Nephrology
Bianca Davidson, Debbie Nel, Erika Jones, Kathryn Manning, Ruan Spies, Raphaela Bohmer, Aadil Omar, Samantha Ash, Nicola Wearne
INTRODUCTION: South Africa continues to be burdened by human immunodeficiency virus [HIV] and tuberculosis [TB]. In Cape Town, the epidemic of HIV-TB co-infection is as high as 70%. Granulomatous interstitial nephritis [GIN] has increased in frequency on renal biopsy. This study aimed to determine GIN prevalence and causes in HIV positive patients as well as renal outcomes, patient survival and associated factors. METHOD: This observational cohort study reviewed HIV positive renal biopsies for GIN from 2005-2012...
January 20, 2019: Nephrology
Kevan R Polkinghorne, Rory Wolfe, Kim M Jachno, James B Wetmore, John J McNeil, Mark R Nelson, Christopher M Reid, Anne M Murray
The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD-EPIeGFR ) and Berlin Initiative Study 1 (BIS1eGFR ) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants. GFR was estimated using CKD-EPI and BIS1 equations. CKD was defined as eGFR <60 mL/min/1...
January 20, 2019: Nephrology
Sree Krishna Venuthurupalli, Helen Healy, Robert Fassett, Anne Cameron, Zaimin Wang, Wendy Elizabeth Hoy
BACKGROUND: Chronic Kidney Disease, Queensland (CKD.QLD) is a multidisciplinary, collaborative research platform for CKD in Queensland. All public renal services contribute towards the CKD Registry, including Toowoomba Hospital which is a referral hospital for Darling Downs Health (DDH) serving largely regional population in Queensland. We aim to present the profile of the CKD cohort recruited to CKD.QLD Registry from Toowoomba Hospital, the first comprehensive report on pre-dialysis population from regional Australia METHODS: Study subjects were patients in the DDH service who consented to be included in the CKD...
January 20, 2019: Nephrology
Yeoungjee Cho, Benedicte Sautenet, Talia Gutman, Gopala Rangan, Jonathan C Craig, Albert Cm Ong, Arlene Chapman, Curie Ahn, Helen Coolican, Juliana Tze-Wah Kao, Ron Gansevoort, Ronald D Perrone, Tess Harris, Vicente Torres, York Pei, Peter G Kerr, Jessica Ryan, David W Johnson, Andrea K Viecelli, Claire Geneste, Hyunsuk Kim, Yaerim Kim, Yun Kyu Oh, Armando Teixeira-Pinto, Charlotte Logeman, Martin Howell, Angela Ju, Karine E Manera, Allison Tong
AIM: Patients with autosomal dominant polycystic kidney disease (ADPKD) are at increased risk of premature mortality, morbidities and complications, which severely impair quality of life. However, patient-centred outcomes are not consistently reported in trials in ADPKD, which can limit shared decision-making. We aimed to identify outcomes important to patients and caregivers and the reasons for their priorities. METHODS: Nominal group technique was adopted involving patients with ADPKD and caregivers who were purposively selected from eight centres across Australia, France and the Republic of Korea...
January 20, 2019: Nephrology
Min Woo Kang, Ho Jun Chin, Kwon-Wook Joo, Ki Young Na, Sejoong Kim, Seung Seok Han
BACKGROUND: Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid and the risk of acute kidney injury (AKI) and mortality remains unresolved in hospitalized patients. METHODS: Data from 18,444 hospitalized patients were retrospectively reviewed. The odds ratio (OR) for AKI and the hazard ratio (HR) for all-cause mortality were calculated based on the uric acid quartiles after adjustment for multiple variables...
January 15, 2019: Nephrology
Lingfei Zhao, Chenxia Hu, Jun Cheng, Ping Zhang, Hua Jiang, Jianghua Chen
AIM: Hemoglobin (Hb) variability has been reported to be associated with mortality in dialysis patients in some but not all studies. We aimed to establish the prognostic significance of Hb variability with all-cause mortality in hemodialysis patients through this meta-analysis. METHODS: The Medline, Embase, Cochrane Library and Web of Science databases were searched for studies assessing the association between Hb variability and all-cause mortality in hemodialysis patients after adjustment for other covariates...
January 15, 2019: Nephrology
Akira Ashida, Tatsuya Shoji, Shiho Honda, Rei Iio, Chihiro Iga, Terumasa Hayashi, Kenichi Satomura, Yoshiharu Tsubakihara
AIM: School urine screening has been established in several countries of Asia, including Japan, Korea, and Taiwan. In Osaka prefectural schools, the urine screening system had some problematic issues including an unclear referral procedure for students with abnormal urinary findings. Therefore, the school urine screening system was reviewed and restructured in 2004. The aim of this study was to assess the improvement in school urine screening through evaluation of the restructured Osaka prefectural school urinary screening system...
January 11, 2019: Nephrology
Martin J Wolley, Carmel M Hawley, David W Johnson, Mark R Marshall, Matthew A Roberts
BACKGROUND: Haemodialysis is usually started at a frequency of three times a week, with occasional patients starting twice weekly ("incremental dialysis"). Incremental haemodialysis may preserve residual kidney function and has been associated with reduced mortality. In this study we report prevalence and outcomes of incremental dialysis in Australia and New Zealand. METHODS: The cohort was all adults starting renal replacement therapy with haemodialysis in Australia and New Zealand 2004 - 2015...
January 10, 2019: Nephrology
R Ramachandran, J Bharati, I Rao, A W Kashif, R Nada, R Minz, K L Gupta, H S Kohli
AIM: A significant proportion of patients with minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are either steroid dependent (SD) or resistant (SR), requiring long-term calcineurin inhibitors (CNIs) use. Rituximab has more favourable safety profile. The present study was undertaken to evaluate the efficacy and safety of rituximab in CNI dependent patients. METHODS: This was a prospective observational study conducted from July 2014 to February 2018...
December 26, 2018: Nephrology
Heng-Chih Pan, Chiao-Yin Sun, I-Wen Wu, Tien-Ling Tsai, Chi-Chin Sun, Chin-Chan Lee
AIM: Previous investigations have shown that end-stage renal disease is associated with an increased risk of malignancies. The aim of this study was to explore the association between end-stage renal disease in patients undergoing maintenance haemodialysis and the incidence of malignancies according to age. METHODS: We analysed a nationwide cohort retrieved from Taiwan's National Health Insurance Research Database to study the incidence of malignancies in patients who were and were not receiving haemodialysis...
December 24, 2018: Nephrology
Koji Eguchi, Yuichiro Izumi, Yushi Nakayama, Hideki Inoue, Takahiro Marume, Naomi Matsuo, Akiko Hiramatsu, Makoto Ono, Yutaka Kakizoe, Takashige Kuwabara, Hiroshi Nonoguchi, Masashi Mukoyama
AIM: Metabolic acidosis occurs due to insufficient urinary ammonium excretion as chronic kidney disease (CKD) advances. Because obese subjects tend to have excessive consumption of protein and sodium chloride, they are prone to chronic acid-loading and may therefore be predisposed to acid-induced kidney injury. We investigated the involvement of obesity in ammoniagenesis within damaged kidneys. METHODS: In the clinical study, urinary ammonium excretion was compared between 13 normal-weight and 15 overweight/obese CKD outpatients whose creatinine clearance was higher than 25 ml/min...
December 23, 2018: Nephrology
Ken Ohara, Takahiro Masuda, Takuya Murakami, Toshimi Imai, Hiromichi Yoshizawa, Saki Nakagawa, Mari Okada, Atsushi Miki, Akihiro Myoga, Taro Sugase, Chuji Sekiguchi, Yasuharu Miyazawa, Akito Maeshima, Tetsu Akimoto, Osamu Saito, Shigeaki Muto, Daisuke Nagata
AIM: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic properties. We recently reported that an SGLT2 inhibitor ameliorated extracellular fluid expansion with a transient increase in urinary Na+ excretion. However, the effects of SGLT2 inhibitors on fluid distribution in comparison to conventional diuretics remain unclear. METHODS: Forty chronic kidney disease (CKD) patients with fluid retention (average estimated glomerular filtration rate 29...
December 22, 2018: Nephrology
Sibei Tao, Siying Tao, Yiming Cheng, Jing Liu, Liang Ma, Ping Fu
BACKGROUND: Chronic kidney disease (CKD) is a worldwide public health problem. Although accumulated data suggested that probiotic supplements played roles in CKD, the results remained controversial. Here we performed a meta-analysis to assess the effects of probiotic supplements on the CKD progression. METHODS: A systematic search was conducted via the PubMed, Embase, and Cochrane databases until September 2018. Randomized controlled trials (RCTs) with control receiving placebo, evaluating the effects of probiotic supplements on CKD were included...
December 18, 2018: Nephrology
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