journal
MENU ▼
Read by QxMD icon Read
search

Journal of Cutaneous Medicine and Surgery

journal
https://read.qxmd.com/read/30742778/treating-to-target-s-with-interleukin-17-inhibitors
#1
Charles W Lynde, Jennifer Beecker, Jan Dutz, Cathy Flanagan, Lyn C Guenther, Wayne Gulliver, Kim Papp, Proton Rahman, Dalton Sholter, Gordon E Searles
BACKGROUND: The treat-to-target (T2T) strategy has become established in several medical specialties as a key guidance to optimal therapeutic decision making. T2T may be effective in the assessment of the biologic class of agents called interleukin (IL)-17 inhibitors, which are emerging as a safe and effective treatment option for autoimmune inflammatory conditions such as plaque psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS). OBJECTIVE: The objective of this article is to use a T2T approach for the evaluation of the effectiveness and safety of IL-17 inhibitors in the management of patients with plaque psoriasis, PsA, and AS...
February 11, 2019: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30688532/a-qualitative-analysis-of-canadian-indoor-tanning-policies
#2
Pavandeep Gill, Sunil Kalia
BACKGROUND: The International Agency for Research on Cancer classifies artificial tanning devices as Group 1 human carcinogens. Studies have shown that use of indoor tanning before age 35 can increase the risk of melanoma development by 75%. It has therefore been recommended that indoor tanning use be restricted in individuals younger than age 18. OBJECTIVES: This study aims to review the state of provincial indoor tanning policies, especially in regards to use by youth across Canada, and what strategies are being implemented to enforce them...
January 28, 2019: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30688081/the-use-of-janus-kinase-inhibitors-in-alopecia-areata-a-review-of-the-literature
#3
Erika L Crowley, Shamone C Fine, Kathleen Kwan Katipunan, Melinda J Gooderham
Alopecia areata (AA) is a chronic, immune-mediated disorder that targets hair follicle epithelium, thereby restricting hair growth in localized patches. Although several therapies for AA have been tested, responses with traditional therapies have been limited. In recent years, numerous reports have been published of patients with AA responding to Janus kinase (JAK) inhibitors. This literature review aims to describe AA pathophysiology, explore how and why JAK inhibitors can be used for AA treatment, and review published case reports, case series, and open-label studies published to date...
January 28, 2019: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30658534/combination-therapies-for-hidradenitis-suppurativa-a-retrospective-chart-review-of-31-patients
#4
Meghan L McPhie, Alanna C Bridgman, Mark G Kirchhof
BACKGROUND: Although a variety of medical and surgical interventions exist for the treatment of hidradenitis suppurativa (HS), it remains a challenging disease to manage because of its variable presentation and unpredictable clinical course. Apart from the combination of clindamycin and rifampin, the success of other combination therapies is largely unknown. OBJECTIVES: The goal of our study was to examine the clinical utility of various combination therapies for the treatment of HS...
January 18, 2019: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30654637/ointment-pseudo-cheilitis-a-disease-distinct-from-factitial-cheilitis-a-series-of-13-patients-from-s%C3%A3-o-paulo-brazil
#5
Marcello Menta Simonsen Nico, Alexandre Jack Dwan, Silvia Vanessa Lourenço
BACKGROUND: The terms exfoliative cheilitis, factitial cheilitis, and morsicatio labiorum are used to describe self-inflicted lesions of the lip. OBJECTIVE: Here we report and analyze clinical, pathological, and therapeutic data on 13 patients with a form of factitial cheilitis that we believe should be considered a separate entity. RESULTS: Eight patients were male and 5 patients were female. All patients reported pain and presented with crusts consisting of dried saliva and topical medications adherent to the surface of the lips...
January 17, 2019: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30606055/the-efficacy-of-platelet-rich-plasma-in-the-field-of-hair-restoration-and-facial-aesthetics-a-systematic-review-and-meta-analysis
#6
Aditya K Gupta, Sarah G Versteeg, Jeffrey Rapaport, Amelia K Hausauer, Neil H Shear, Vincent Piguet
As a promising alternative to traditional treatment, platelet-rich plasma (PRP) is being used to encourage hair growth through the release of growth factors and cytokines. In addition to hair restoration, PRP's multifactorial capabilities can also be used to treat aging skin, facial scarring, and acne. The purpose of this review is to critically examine the success of PRP in the field of dermatology, with specific attention to the role of PRP in hair restoration. Where possible, meta-analyses were used to evaluate the efficacy of PRP...
January 4, 2019: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30556424/margin-controlled-staged-surgical-excision-in-the-treatment-of-high-risk-basal-cell-carcinomas-of-the-head-and-neck-region
#7
Ayse Nigar Durmus Ucar, Fatma Nihal Durmus Kocaaslan, Andac Salman, Cuyan Demirkesen, Filiz Erdem Bayram, Mehmet Bayramicli
BACKGROUND: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low. OBJECTIVES: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative...
December 17, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30556421/distinction-of-condylomata-acuminata-from-vulvar-vestibular-papules-or-pearly-penile-papules-using-ki-67-immunostaining
#8
Kerry M Gardner, Richard I Crawford
BACKGROUND: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. However, these lesions can be clinically confused with condylomata acuminata induced by human papillomavirus (HPV), which have medical and social implications. OBJECTIVE: Because HPV infection is known to induce expression of proliferation markers, we propose that Ki-67 be used to differentiate condylomata acuminata from vulvar vestibular papules or pearly penile papules on pathologic examination...
December 17, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30556414/psoriasis-and-atopic-dermatitis-resistant-to-topical-treatment-responds-rapidly-to-topical-desoximetasone-spray
#9
Latrice Hogue, Leah A Cardwell, Catherine Roach, Kayla H Felix, Elias Oussedik, Irma Richardson, Steven R Feldman
PURPOSE: Topical corticosteroids (TS) are a treatment for atopic dermatitis (AD) and psoriasis (Ps). We assessed whether use of a TS under conditions designed to enhance adherence would be effective in patients who "failed" TS in the outpatient setting. METHODS: Individuals with treatment-resistant Ps or AD were recruited (AD, n = 12; Ps, n = 12). Six participants were randomized to each of 2 groups of desoximetasone 0.25% spray alone (n = 6) or desoximetasone spray plus twice-daily phone call reminders to use the medication...
December 17, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30463418/vaccination-guidelines-for-patients-with-immune-mediated-disorders-on-immunosuppressive-therapies
#10
Kim A Papp, Boulos Haraoui, Deepali Kumar, John K Marshall, Robert Bissonnette, Alain Bitton, Brian Bressler, Melinda Gooderham, Vincent Ho, Shahin Jamal, Janet E Pope, A Hillary Steinhart, Donald C Vinh, John Wade
BACKGROUND: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient population remain suboptimal. OBJECTIVES: To evaluate the safety and efficacy of vaccines in individuals exposed to immunosuppressive therapies and provide evidence-based clinical practice recommendations. METHODS: A literature search for vaccination safety and efficacy in patients on immunosuppressive therapies (2009-2017) was conducted...
November 21, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30463416/comparison-of-management-guidelines-for-moderate-to-severe-plaque-psoriasis-a-review-of-phototherapy-systemic-therapies-and-biologic-agents
#11
Arvin Ighani, Arun C R Partridge, Neil H Shear, Charles Lynde, Wayne P Gulliver, Cathryn Sibbald, Patrick Fleming
INTRODUCTION: Many international guidelines for management of psoriasis exist and most have variations in grading evidence quality, strength of recommendations, and dosing. The objective of our review is to compare international guidelines published in the United Kingdom, Canada, Europe, and the United States for the management of moderate-to-severe plaque psoriasis. METHODS: We conducted a literature review on systemic therapies and phototherapy for moderate-to-severe plaque psoriasis in adult patients...
November 21, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30449146/ixekizumab-interleukin-17a-antagonist-12-week-efficacy-and-safety-outcomes-in-real-world-clinical-practice
#12
Jorge R Georgakopoulos, Michelle Phung, Arvin Ighani, Jensen Yeung
BACKGROUND: Current knowledge of the efficacy and safety of ixekizumab is limited to data from phase III randomized controlled trials (RCTs). A gap exists in our understanding of treatment outcomes of this newly available biologic in real-world clinical practice. OBJECTIVE: This study explores the efficacy and safety of ixekizumab in non-RCT patients to compare real-world outcomes to those reported in RCTs. METHODS: We conducted a multicentre, retrospective chart review of patients treated with ixekizumab therapy for moderate-to-severe plaque psoriasis...
November 18, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30445821/aesthetic-dermatologic-surgery-training-in-canadian-residency-programs
#13
Brandon Worley, Luvneet Verma, Jillian Macdonald
BACKGROUND: The public and other physicians expect dermatologists to be experts on aesthetic dermatology services. In Canada, current challenges may limit residents from achieving competency in aesthetic dermatology during their training. This may adversely affect patient safety, create medicolegal risks, and deter graduates from offering aesthetic procedures. OBJECTIVES: The objective of this article is to characterize the curriculum, hands-on learning opportunities, and perceptions of aesthetic dermatologic training in Canadian dermatology residency training programs...
November 16, 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30439301/approach-to-the-assessment-and-management-of-adult-patients-with-atopic-dermatitis-a-consensus-document-section-iv-treatment-options-for-the-management-of-atopic-dermatitis
#14
Gurbir Dhadwal, Lorne Albrecht, Robert Gniadecki, Yves Poulin, Jensen Yeung, Chih-Ho Hong, Melinda J Gooderham
The objectives of therapy for atopic dermatitis (AD) are to reduce skin inflammation and pruritus, restore skin barrier function, and improve quality of life (QoL). Treatments can be classified as moisturizing and basic care, topical therapy, phototherapy, and systemic therapy. In this review, we summarize the treatments for AD and recommendations for their use.
November 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30439300/approach-to-the-assessment-and-management-of-adult-patients-with-atopic-dermatitis-a-consensus-document-section-v-consensus-statements-on-the-assessment-and-management-of-adult-patients-with-moderate-to-severe-atopic-dermatitis
#15
Chih-Ho Hong, Melinda J Gooderham, Lorne Albrecht, Robert Bissonnette, Gurbir Dhadwal, Robert Gniadecki, Parbeer Grewal, Mark G Kirchhof, Ian Landells, Perla Lansang, Chuck W Lynde, Kim A Papp, Yves Poulin, Gordon Sussman, Irina Turchin, Marni Wiseman, Jensen Yeung
This document is a concise, current, and practical guide for dermatologists and other health care providers managing adult patients with moderate-to-severe atopic dermatitis (AD). The recommendations made here are based on a consensus of specialists with extensive experience managing patients with AD. Topics reviewed in this publication include AD pathophysiology, assessment, comorbidities, and treatment options.
November 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30439299/approach-to-the-assessment-and-management-of-adult-patients-with-atopic-dermatitis-a-consensus-document-section-i-pathophysiology-of-atopic-dermatitis-and-implications-for-systemic-therapy
#16
Mark G Kirchhof, Ian Landells, Chuck W Lynde, Melinda J Gooderham, Chih-Ho Hong
Atopic dermatitis (AD) is a chronic, relapsing, and remitting inflammatory skin disease whose onset typically occurs early in life. AD pathophysiology includes genetic, immune, and environmental factors contributing to chronic inflammation. A rapidly evolving understanding of the pathogenesis of AD has led to the development of several treatment options for AD in adults, including topicals, phototherapy, and systemic therapies. Here, we provide a concise summary of AD pathophysiology with a focus on implications for systemic therapy...
November 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30439298/approach-to-the-assessment-and-management-of-adult-patients-with-atopic-dermatitis-a-consensus-document
#17
Melinda J Gooderham, Chih-Ho Hong, Lorne Albrecht, Robert Bissonnette, Gurbir Dhadwal, Robert Gniadecki, Parbeer Grewal, Mark G Kirchhof, Ian Landells, Perla Lansang, Chuck W Lynde, Kim A Papp, Yves Poulin, Gordon Sussman, Irina Turchin, Marni Wiseman, Jensen Yeung
BACKGROUND: Atopic dermatitis (AD) is a chronic, relapsing, and remitting inflammatory skin disease with complex pathophysiology, primarily driven by type 2 inflammation. Existing guidelines often do not reflect all current therapeutic options and guidance on the practical management of patients with AD is lacking. OBJECTIVES: To develop practical, up-to-date guidance on the assessment and management of adult patients with AD. METHODS: An expert panel of 17 Canadian experts, including 16 dermatologists and 1 allergist, with extensive clinical experience managing moderate-to-severe AD reviewed the available literature from the past 5 years using a defined list of key search terms...
November 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30439297/approach-to-the-assessment-and-management-of-adult-patients-with-atopic-dermatitis-a-consensus-document-section-ii-tools-for-assessing-the-severity-of-atopic-dermatitis
#18
Melinda J Gooderham, Robert Bissonnette, Parbeer Grewal, Perla Lansang, Kim A Papp, Chih-Ho Hong
Clinicians rely on clinical measures to define the severity of atopic dermatitis and assess outcomes of therapy. These measures can be objective (ie, physician assessments of disease severity) or subjective (ie, patient-reported symptoms and quality of life outcomes). In this review, the most commonly used tools for assessing atopic dermatitis severity in adult patients are presented and compared. These include Eczema Area and Severity Index (EASI); SCORing Atopic Dermatitis (SCORAD); Physician Global Assessment (PGA); body surface area (BSA); Atopic Dermatitis Severity Index (ADSI); Six Area, Six Sign Atopic Dermatitis (SASSAD); Patient Oriented Eczema Measure (POEM); Dermatology Life Quality Index (DLQI); and pruritus Numerical Rating Scale (NRS)...
November 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30439296/approach-to-the-assessment-and-management-of-adult-patients-with-atopic-dermatitis-a-consensus-document-section-iii-evaluation-of-atopic-dermatitis-patients-for-comorbidities
#19
Chih-Ho Hong, Gordon Sussman, Irina Turchin, Marni Wiseman, Melinda J Gooderham
Atopic dermatitis (AD) is often associated with other atopic diseases, including asthma, allergic rhinitis, atopy-associated eye disorders, and eosinophilic esophagitis. Depression and anxiety are also comorbidities to AD that significantly affect quality of life and should be screened for in patients with AD. Links to other comorbidities such as cardiovascular disease and malignancy are considered inconclusive, but patient counselling and screening may be appropriate in some patients. This article highlights practical recommendations for the recognition and management of atopic and nonatopic comorbidities commonly associated with AD...
November 2018: Journal of Cutaneous Medicine and Surgery
https://read.qxmd.com/read/30322310/looking-for-a-treatment-for-hailey-hailey-disease-the-importance-of-being-consistent-in-case-reports
#20
Massimo Micaroni
No abstract text is available yet for this article.
November 2018: Journal of Cutaneous Medicine and Surgery
journal
journal
32629
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"