Hamidreza Soleimani, Ali Nasrollahizadeh, Mohsen Hajiqasemi, Mandana Ebrahimzade, Homa Taheri, Pouya Ebrahimi, Haleh Ashraf, Marc D Samsky, Kaveh Hosseini
Different interventions have been evaluated for the treatment of depression in heart failure (HF) patients. However, clear and established recommendations are lacking. PubMed, Scopus, and Web of Science databases were systematically searched for randomized controlled trials (RCT) evaluating the effect of various treatment options on depression scores in heart failure patients. The primary outcome was a change in depression scores presented as standardized mean difference (SMD). A Bayesian network for meta-analysis was constructed...
April 13, 2024: Heart Failure Reviews
Xu Huang, Yi Shen, Yiwei Liu, Hao Zhang
A ventricular assist device (VAD) is a form of mechanical circulatory support that uses a mechanical pump to partially or fully take over the function of a failed heart. In recent decades, the VAD has become a crucial option in the treatment of end-stage heart failure in adult patients. However, due to the lack of suitable devices and more complicated patient profiles, this therapeutic approach is still not widely used for pediatric populations. This article reviews the clinically available devices, adverse events, and future directions of design and implementation in pediatric VADs...
March 26, 2024: Heart Failure Reviews
Abedin Teimourizad, Abdosaleh Jafari, Firooz Esmaeilzadeh
No abstract text is available yet for this article.
March 25, 2024: Heart Failure Reviews
Matteo Lisi, Giovanni Andrea Luisi, Maria Concetta Pastore, Giulia Elena Mandoli, Giovanni Benfari, Federica Ilardi, Alessandro Malagoli, Simona Sperlongano, Michael Y Henein, Matteo Cameli, Antonello D'Andrea
International Guidelines consider left ventricular ejection fraction (LVEF) as an important parameter to categorize patients with heart failure (HF) and to define recommended treatments in clinical practice. However, LVEF has some technical and clinical limitations, being derived from geometric assumptions and is unable to evaluate intrinsic myocardial function and LV filling pressure (LVFP). Moreover, it has been shown to fail to predict clinical outcome in patients with end-stage HF. The analysis of LV antegrade flow derived from pulsed-wave Doppler (stroke volume index, stroke distance, cardiac output, and cardiac index) and non-invasive evaluation of LVFP have demonstrated some advantages and prognostic implications in HF patients...
March 20, 2024: Heart Failure Reviews
Yan-Bing Liu, Qian Wang, Yu-Ling Song, Xiao-Min Song, Yu-Chen Fan, Lin Kong, Jing-Sai Zhang, Sheng Li, Yi-Ju Lv, Ze-Yang Li, Jing-Yu Dai, Zhen-Kang Qiu
Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation...
March 18, 2024: Heart Failure Reviews
Abedin Teimourizad, Abdosaleh Jafari, Firooz Esmaeilzadeh
Heart failure (HF) is increasing globally and turning out to be a serious worldwide public health problem with significant morbidity and mortality. This study aims to systemically review the budget impact analysis of heart failure treatments on health care expenditure worldwide. Scientific databases such as PubMed, Web of Science, Scopus, and Google Scholar were searched for budget impact analysis and heart failure treatments, over January 2001 to August 2023. The quality assessment of the selected studies was evaluated through ISPOR practice guideline...
March 16, 2024: Heart Failure Reviews
Ravi Vazirani, Moisés Rodríguez-González, Ana Castellano-Martinez, Mireia Andrés, Aitor Uribarri, Miguel Corbí-Pascual, Fernando Alfonso, Emilia Blanco-Ponce, Carmen Lluch-Requerey, Clara Fernández-Cordón, Manuel Almendro-Delia, Oscar Vedia Cruz, Iván J Núñez-Gil
Takotsubo syndrome (TTS) in the pediatric population is an infrequent but relevant cause of morbidity and mortality, with limited studies addressing its clinical course and prognosis. We aimed to analyze the clinical features and prognosis of pediatric TTS in a nation-wide multicenter registry and considering the published literature. We included a total of 54 patients from 4 different hospitals in Spain, as well as pediatric TTS patients from the published literature. Comparisons between groups were performed in order to assess for statistically and clinically relevant prognostic differences between pediatric and adult population features...
March 14, 2024: Heart Failure Reviews
Ashraf M Anwar
Left atrium (LA) is a very important component of cardiovascular performance. The assessment of LA function has gathered the interest with expanding research supporting the utility as a biomarker for outcomes in heart failure (HF). Echocardiography is the main imaging modality which helps in a qualitative and quantitative assessment of the LA size and function. Recent advances in probe technology and software analysis have provided a better understanding of LA anatomy, physiology, pathology, and function. A variety of parameters have been defined as markers of LA function but there is no single parameter that best defines LA function...
March 11, 2024: Heart Failure Reviews
Nihar Desai, Elzbieta Olewinska, Agata Famulska, Cécile Remuzat, Clément Francois, Kerstin Folkerts
This review provides a comprehensive overview of heart failure with mildly reduced and preserved ejection fraction (HFmrEF/HFpEF), including its definition, diagnosis, and epidemiology; clinical, humanistic, and economic burdens; current pharmacologic landscape in key pharmaceutical markets; and unmet needs to identify key knowledge gaps. We conducted a targeted literature review in electronic databases and prioritized articles with valuable insights into HFmrEF/HFpEF. Overall, 27 randomized controlled trials (RCTs), 66 real-world evidence studies, 18 clinical practice guidelines, and 25 additional publications were included...
February 27, 2024: Heart Failure Reviews
George Bazoukis, Athanasios Saplaouras, Polyxeni Efthymiou, Andronicos Yiannikourides, Tong Liu, Konstantinos P Letsas, Michael Efremidis, Konstantinos Lampropoulos, Sotirios Xydonas, Gary Tse, Antonis A Armoundas
Experimental in vivo and in vitro studies showed that electric currents applied during the absolute refractory period can modulate cardiac contractility. In preclinical studies, cardiac contractility modulation (CCM) was found to improve calcium handling, reverse the foetal myocyte gene programming associated with heart failure (HF), and facilitate reverse remodeling. Randomized control trials and observational studies have provided evidence about the safety and efficacy of CCM in patients with HF. Clinically, CCM therapy is indicated to improve the 6-min hall walk, quality of life, and functional status of HF patients who remain symptomatic despite guideline-directed medical treatment without an indication for cardiac resynchronization therapy (CRT) and have a left ventricular ejection fraction (LVEF) ranging from 25 to 45%...
February 23, 2024: Heart Failure Reviews
Keivan Mohammadi, Davood Shafie, Newsha Ghomashi, Ali Abdolizadeh, Majid Sadeghpour
Heart failure (HF) is a pervasive clinical challenge characterized by compromised cardiac function and reduced quality of life. The kinin-kallikrein system (KSS), a multifaceted peptide cascade, has garnered substantial attention due to its potential role in HF. Through activation of B1 and/or B2 receptors and downstream signaling, kinins modulate various physiological processes, including inflammation, coagulation, pain, blood pressure control, and vascular permeability. Notably, aberrations in KKS components have been linked to HF risk...
February 21, 2024: Heart Failure Reviews
Dimitrios Bismpos, Jan Wintrich, Julian Hövelmann, Michael Böhm
Despite major advances in prevention and medical therapy, heart failure (HF) remains associated with high morbidity and mortality, especially in older and frailer patients. Therefore, a complete, guideline-based treatment is essential, even in HF patients with conditions traditionally associated with a problematic initiation and escalation of the medical HF therapy, such as chronic kidney disease and arterial hypotension, as the potential adverse effects are overcome by the overall decrease of the absolute risk...
February 13, 2024: Heart Failure Reviews
Kengo Z Soghoyan, Maya Guglin
The worldwide experience with mechanical circulatory support in adult patients with single ventricle and Fontan palliation is limited. We aimed to see the outcomes in such patients on durable left ventricular assist device. We systematically reviewed the English language literature found on PubMed and Google Scholar, searching the terms "Fontan," "single ventricle," "ventricular assist device," "LVAD," and "mechanical circulatory support," and selected all individual cases with reported outcomes. We identified 4 patients on pulsatile left ventricular assist device, all of whom were successfully bridged to transplant, and 15 patients on continuous flow LVAD, age 25...
February 11, 2024: Heart Failure Reviews
Carlotta Sciaccaluga, Maria Cristina Procopio, Luciano Potena, Marco Masetti, Sonia Bernazzali, Massimo Maccherini, Federico Landra, Francesca Maria Righini, Matteo Cameli, Serafina Valente
The use of left ventricular assist devices (LVAD) has significantly increased in the last years, trying to offer a therapeutic alternative to heart transplantation, in light also to the significant heart donor shortage compared to the growing advanced heart failure population. Despite technological improvements in the devices, LVAD-related mortality is still fairly high, with right heart failure being one of the predominant predictors. Therefore, many efforts have been made toward a thorough right ventricular (RV) evaluation prior to LVAD implant, considering clinical, laboratory, echocardiographic, and invasive hemodynamic parameters...
February 8, 2024: Heart Failure Reviews
Alberto Aimo, Paolo Morfino, Chiara Arzilli, Giuseppe Vergaro, Valentina Spini, Iacopo Fabiani, Vincenzo Castiglione, Claudio Rapezzi, Michele Emdin
Over the last years, there has been a growing interest in the clinical manifestations and outcomes of cardiomyopathies in women. Peripartum cardiomyopathy is the only women-specific cardiomyopathy. In cardiomyopathies with X-linked transmission, women are not simply healthy carriers of the disorder, but can show a wide spectrum of clinical manifestations ranging from mild to severe manifestations because of heterogeneous patterns of X-chromosome inactivation. In mitochondrial disorders with a matrilinear transmission, cardiomyopathy is part of a systemic disorder affecting both men and women...
February 3, 2024: Heart Failure Reviews
Taylor McKenzie, Genevieve M Hale, Amelia Miner, Jean Colón Colón, Garrett Evins, Jasmine Wade
Sodium-glucose cotransporter-2 inhibitors have been shown to have significant metabolic, renal, and atherosclerotic cardiovascular disease benefits. Recent randomized controlled trials have extended these benefits to patients with heart failure. In fact, the robust findings from these studies in patients with any type of heart failure have led to the incorporation of this drug class in currently updated evidence-based guidelines for this condition. However, given the novelty in utilizing these agents in heart failure, there is uncertainty regarding place in therapy and sequencing in treatment...
February 1, 2024: Heart Failure Reviews
Annamaria Del Franco, Giulia Iannaccone, Maria Chiara Meucci, Rosa Lillo, Francesco Cappelli, Chiara Zocchi, Maurizio Pieroni, Francesca Graziani, Iacopo Olivotto
No abstract text is available yet for this article.
January 31, 2024: Heart Failure Reviews
Gonzalo Ramírez-Guerrero, Claudio Ronco, Anna Lorenzin, Alessandra Brendolan, Luca Sgarabotto, Monica Zanella, Thiago Reis
Acute decompensated heart failure and fluid overload are the most common causes of hospitalization in heart failure patients, and often, they contribute to disease progression. Initial treatment encompasses intravenous diuretics although there might be a percentual of patients refractory to this pharmacological approach. New technologies have been developed to perform extracorporeal ultrafiltration in fluid overloaded patients. Current equipment allows to perform ultrafiltration in most hospital and acute care settings...
January 30, 2024: Heart Failure Reviews
Alberto Palazzuoli, Gaetano Ruocco, Marco Giuseppe Del Buono, Simona Pavoncelli, Elvira Delcuratolo, Antonio Abbate, Carl J Lavie
In the last decades, several classifications and definitions have been proposed for advanced heart failure (ADVHF) patients, including clinical, functional, hemodynamic, imaging, and electrocardiographic features. Despite different inclusion criteria, ADVHF is characterized by some common items, such as drug intolerance, low arterial pressure, multiple organ dysfunction, chronic kidney disease, and diuretic use dependency. Additional features include fatigue, hypotension, hyponatremia, and unintentional weight loss associated with a specific laboratory profile reflecting systemic multiorgan dysfunction...
January 29, 2024: Heart Failure Reviews
Alexandru Ababei, Luciana Andreea Hrib, Adalia Cristiana Iancu, Andra-Valeria Hadarag, Ahmad Khebbaiz, Radu Vătășescu, Ștefan Bogdan
Heart failure with preserved ejection fraction (HFpEF) has become an emerging concern. The protective effect of bradycardia in patients with reduced ejection fraction using beta-blockers or ivabradine does not improve symptoms in HFpEF. This review aims to assess current data regarding the impact of anti-bradycardia pacing in patients with HFpEF. A search was conducted on PubMed, ScienceDirect, Springer, and Wiley Online Library, selecting studies from 2013 to 2023. Relevant and eligible prospective studies and randomized controlled trials were included...
January 28, 2024: Heart Failure Reviews
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