Martina Hýžďalová, Jiřina Procházková, Nicol Straková, Kateřina Pěnčíková, Simona Strapáčová, Jana Slováčková, Simona Kajabová, Helena Líbalová, Jan Topinka, Markéta Kabátková, Jan Vondráček, Steen Mollerup, Miroslav Machala
The role of benzo[a]pyrene (BaP), a prominent genotoxic carcinogen and aryl hydrocarbon receptor (AhR) ligand, in tumor progression remains poorly characterized. We investigated the impact of BaP on the process of epithelial-mesenchymal transition (EMT) in normal human bronchial epithelial HBEC-12KT cells. Early morphological changes after 2-week exposure were accompanied with induction of SERPINB2, IL1, CDKN1A/p21 (linked with cell cycle delay) and chemokine CXCL5. After 8-week exposure, induction of cell migration and EMT-related pattern of markers/regulators led to induction of further pro-inflammatory cytokines or non-canonical Wnt pathway ligand WNT5A...
March 22, 2024: Environmental Toxicology and Pharmacology