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International Journal of Infectious Diseases: IJID

Jackson Mukonzo, Eleni Akillu, Vincent Marconi, Raymond F Schinazi
HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway-mediated drug-drug interactions and the possible effect on HIV treatment outcomes of commonly prescribed antiretroviral therapy.
April 13, 2019: International Journal of Infectious Diseases: IJID
Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Carlos Palomares-Reyes, Fernando Mazulis, Claudia Weilg, Luis J Del Valle, Jaquelin Espejo-Evaristo, Fernando Soto-Febres, Johanna Martins-Luna, Juana Del Valle-Mendoza
INTRODUCTION: Oropouche fever is an under-reported and emerging infectious disease caused by Oropouche virus (OROV). Its incidence is under-estimated mainly due to clinical similarities with other endemic arboviral diseases and the lack of specific diagnostic tests. We report the first outbreak of Oropouche fever in a western region of the Peruvian Amazon in Huanuco, Peru. METHODS: A transversal study was carried out during an outbreak in the western Region of Huanuco, Peru between January and July of 2016...
April 13, 2019: International Journal of Infectious Diseases: IJID
Muhammad Jikal, Tuan Riduan, Rosmawati Aarifin, Mohammad Saffree Jeffree, Kamruddin Ahmed
OBJECTIVES: In this study we investigated an outbreak of Vibrio cholera O1 Ogawa serotype, occurred during December 2014 in Kudat district, situated in Sabah state of the Malaysian part of Borneo. METHODS: Active case detection and contact tracing were done at respective localities by house to house survey. Passive case detection was done among acute gastroenteritis patients attended at various health facilities. To determine the source, samples from food, water and environment were taken...
April 12, 2019: International Journal of Infectious Diseases: IJID
Jessica M Stempel, Andres L Mora Carpio, Daniel Puga, Sarah Perloff
Severe malaria is an uncommon diagnosis in the United States. However, awareness of signs, symptoms, and treatment options is imperative in order to promptly initiate optimal therapy. False positive human immunodeficiency virus (HIV) results are rare in the setting of acute malaria infection and with the introduction of newer fourth-generation immunoassays. The Centers for Disease Control algorithms assist in confirming true HIV infection (Branson et al. 2014).
April 12, 2019: International Journal of Infectious Diseases: IJID
Sebastian M Heimann, Olaf Penack, Werner J Heinz, Tobias Rachow, Gerlinde Egerer, Johanna Kessel, Annika Y Claßen, Jörg Janne Vehreschild
OBJECTIVES: Novel formulations (gastro-resistant table and intravenous solution) of posaconazole (POS) have been approved in prophylaxis and therapy of invasive fungal diseases (IFDs). Study aim was to analyze treatment strategies and clinical effectiveness. METHODS: We set up a web-based registry on for documentation of comprehensive data of patients who received novel POS formulations. Data analysis was split into two groups of patients who received novel POS formulations for antifungal prophylaxis (posaconazole prophylaxis group) and antifungal therapy (posaconazole therapy group), respectively...
April 9, 2019: International Journal of Infectious Diseases: IJID
Wei Xue, Kai Liu, Ke Qiu, Yanxi Shen, Zhaojun Pan, Peng Hu, Mingli Peng, Min Chen, Hong Ren
OBJECTIVES: With the appearance of direct-acting antiviral agents (DAAs), sofosbuvir (SOF)-based DAAs are recommended for patients with hepatitis C virus (HCV) recurrence after liver transplantation (LT). Whether ribavirin (RBV) is needed by patients after LT in combination with SOF-based DAAs remains to be determined. This meta-analysis was conducted to evaluate the necessity of RBV with SOF-based DAAs for post-LT patients. METHODS: PubMed, Web of Science, Cochrane Library and EMBASE databases were systematically searched for eligible studies from the databases' inceptions until November 2018...
April 5, 2019: International Journal of Infectious Diseases: IJID
Diaa Al Rahmany, Adel Albeloushi, Iman Alreesi, Ahmed Alzaabi, Mohammed Alreesi, Laura Pontiggia, Islam M Ghazi
BACKGROUND: Increasing rate of resistant infections is a challenge to healthcare negatively impacting therapeutic and financial outcomes. Targeted antimicrobial stewardship interventions are needed to counteract this global crisis. On large scale, we sought to identify the prevalence of resistant pathogens and their susceptibility pattern in Northern Oman. MATERIAL AND METHOD: Retrospective analysis of all isolates processed by Suhar Hospital microbiology laboratory between Jan1st , 2016 and Dec31st , 2017...
April 5, 2019: International Journal of Infectious Diseases: IJID
Bin Zhang, Li Wei, M A Lin
No abstract text is available yet for this article.
April 5, 2019: International Journal of Infectious Diseases: IJID
May Yw Wong, Salman Ansari, Joo S Shin, David Koorey, John Gibson
No abstract text is available yet for this article.
April 5, 2019: International Journal of Infectious Diseases: IJID
Heun Choi, Jung Ho Kim, Hye Seong, Woonji Lee, Wooyong Jeong, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Joon Sup Yeom, Young Keun Kim, Hyo Youl Kim, Young Goo Song, June Myung Kim, Jun Yong Choi
OBJECTIVES: In 2014, South Korea expanded its national health insurance coverage to include newer antifungal agents, such as echinocandins. This study aimed to investigate the effects of policy change on the prescription patterns of antifungals, medical costs and clinical outcomes of candidemia. METHODS: This retrospective cohort enrolled hospitalized patients with candidemia at three tertiary care hospitals in South Korea from January 2012 to December 2015. The utilization of antifungal agents, medical costs, length of hospital stay (LOS), and mortality before and after the health-care benefit expansion were compared, and the factors associated with all-cause 28-day mortality during the study period were analyzed...
April 5, 2019: International Journal of Infectious Diseases: IJID
Alexandra Peters, Tcheun Borzykowski, Ermira Tartari, Claire Kilpatrick, Hwai Chuen Safiah Mai, Benedetta Allegranzi, Didier Pittet
No abstract text is available yet for this article.
April 3, 2019: International Journal of Infectious Diseases: IJID
Merav Weil, Galia Rahav, Raz Somech, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Victoria Indenbaum, Itay Bar Or, Ella Mendelson, Danit Sofer, Lester M Shulman
This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world.
April 3, 2019: International Journal of Infectious Diseases: IJID
Giovanni Battista Migliori
The World Health Organization launched a global initiative, known as aDSM (active TB drug safety monitoring and management) to better describe the safety profile of new treatment regimens for drug-resistant tuberculosis (TB) in real-world settings. However, comprehensive surveillance is difficult to implement in several countries. Aim of the aDSM project is to demonstrate the feasibility of implementing national aDSM registers and to describe the type and the frequency of adverse events (AEs) associated with exposure to the new anti-TB drugs...
April 3, 2019: International Journal of Infectious Diseases: IJID
Abi Manesh, Rohit Barnabas, Sunithi Mani, Rajiv Karthik, O C Abraham, Geeta Chacko, Rajesh Kannangai, George M Varghese
No abstract text is available yet for this article.
April 2, 2019: International Journal of Infectious Diseases: IJID
Junyang Yang, Jun Chen, Yongjia Ji, Qi Tang, Renfang Zhang, Li Liu, Yinzhong Shen, Jingna Xun, Wei Song, Yang Tang, Zhenyan Wang, Tangkai Qi, Hongzhou Lu
BACKGROUND: Tenofovir disoproxil fumarate (TDF) is an important component of antiretroviral therapy (ART) that has been widely used. The aim of this study was to observe the long-term impact of TDF-based ART on lipid metabolism profiles and renal functions in Chinese patients. METHODS: 414 and 124 HIV-infected, ART-naïve patients who initiated TDF-based regimens and non-TDF regimens respectively were retrospectively included. Demographic characteristics and clinical information of each patient was collected...
April 2, 2019: International Journal of Infectious Diseases: IJID
Oleksandr Telnov, Veronica Alvarez, Elena Gragila, Lucas Molfino, Philipp du Cros, Michael Rich
We present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function. The man was asymptomatic, with no signs of jaundice, abdominal pain, or abnormal heart rhythm...
April 2, 2019: International Journal of Infectious Diseases: IJID
Marie Blettery, Lauren Brunier, Rishika Banydeen, Christian Derancourt, Michel De Bandt
OBJECTIVE: Chikungunya (CHIKV) is an arbovirus that causes acute, debilitating polyarthritis. Its diagnosis can be difficult for clinicians not used to managing joint diseases or detecting synovitis. Joint Doppler ultrasonography (DUS) is a simple, non-invasive examination, able to visualize synovitis. Its diagnostic and prognostic value in rheumatoid arthritis is well-established. METHODS: Patients with serologically proven acute arbovirosis where included. Clinical examination and joint count were performed (DAS score)...
March 28, 2019: International Journal of Infectious Diseases: IJID
Yuhao Wu, Yuehang Zhou, Xin Jin, Yonggang Li, Hongbo Li, Jiangtao Dai, Gang Wang, Chun Wu
OBJECTIVES: The pericardial effusion (PE) caused by paragonimiasis is rarely reported. This study aims to present experience in the diagnosis and surgical management of PE due to paragonimiasis. METHODS: Medical records of 57 children who were diagnosed with PE due to paragonimiasis and underwent surgery at Children's Hospital of Chongqing Medical University between January 2012 and August 2018 were retrospectively reviewed. RESULTS: The average age of this group was 7...
March 28, 2019: International Journal of Infectious Diseases: IJID
Chioma C Dan-Nwafor, Oladipupo Ipadeola, Elizabeth Smout, Elsie Ilori, Ayodele Adeyemo, Chukwuma Umeokonkwo, Damian Nwidi, Williams Nwachukwu, Winifred Ukponu, Emeka Omabe, Uchenna Anaebonam, Nneka Igwenyi, Gordon Igbodo, Womi Eteng, Ikemefule Uzoma, Muhammed Saleh, Joseph Agboeze, Samuel Mutbam, Tanyth de Gooyer, Rosie Short, Everistus Aniaku, Robinson Onoh, Emeka Ogah, Patrick Nguku, John Oladejo, Clement Peter, Olubunmi Ojo, Chikwe Ihekweazu
BACKGROUND: Lassa fever is an acute viral haemorrhagic disease endemic in Nigeria. The 2018 Lassa fever outbreak in Nigeria was unprecedented, with 8% of all cases occurring among healthcare workers (HCWs). A disproportionately high number of these infections occurred in HCWs working in a tertiary health facility in Nigeria. This paper describes the cluster of Lassa fever infections among HCWs in a treatment centre and the lessons learnt. METHODS: We analysed clinical, epidemiological and laboratory data from surveillance and laboratory records kept during the 2018 outbreak...
March 28, 2019: International Journal of Infectious Diseases: IJID
Sharful I Khan, Reza Md Masud, Suzanne M Crowe, Mustafizur Rahman, Margaret Hellard, Md Safiullah Sarker, Ezazul Islam Chowdhury, Akm Masud Rana, Rachel Sacks-Davis, Sayera Banu, Allen G Ross
The rates of both HIV and HCV are exploding among the People Who Inject Drugs (PWID) subpopulation in the People's Republic of Bangladesh. 5,586 HIV confirmed cases have been reported since the first case of HIV was identified in 1989, of which, 865 new cases (15.5%) have been reported in the year 2017 alone. Among the new cases, 330 (38.2%) were from PWID population. The HCV prevalence is also high in Dhaka, with 40% of the PWID with unknown HIV status and 60.7% co-infected with HIV. The predominant HIV-1 strains circulating in the population are subtype C (41...
March 27, 2019: International Journal of Infectious Diseases: IJID
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