journal
Journals Pharmaceutical Development and...

Pharmaceutical Development and Technology

https://read.qxmd.com/read/38308442/solid-self-microemulsifying-drug-delivery-system-s-smedds-prepared-by-spray-drying-to-improve-the-oral-bioavailability-of-cinnamaldehyde-ca
#21
JOURNAL ARTICLE
Yun Meng, Ye Cai, Mengyao Cui, Xu Yuhang, Wu Long, Xiang Li, Xiaoqin Chu
The aim of this study was to prepare a solid self-microemulsifying drug delivery system (S-SMEDDS) of cinnamaldehyde (CA) by spray drying technique to improve the oral bioavailability of CA. The preparation of CA S-SMEDDS with maltodextrin as the solid carrier, a core-wall material mass ratio of 1:1, a solid content of 20% (w/v), an inlet air temperature of 150 °C, an injection speed of 5.2 mL/min, and an atomization pressure of 0.1 MPa was determined by using the encapsulation rate as the index of investigation...
February 2, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38258531/fabrication-of-controlled-release-polymeric-microneedles-containing-progesterone-loaded-self-microemulsions-for-transdermal-delivery
#22
JOURNAL ARTICLE
Phuvamin Suriyaamporn, Porawan Aumklad, Theerasak Rojanarata, Prasopchai Patrojanasophon, Tanasait Ngawhirunpat, Boonnada Pamornpathomkul, Praneet Opanasopit
Progesterone (PG) has been approved for hormone replacement therapy to mitigate the risk of endometrial carcinoma. However, there has been a lack of success in oral PG due to its rapid degradation. Transdermal PG has advantages but lacks efficacy due to its poor solubility (Log P = 3.9). Therefore, this study aimed to evaluate how combining self-microemulsifying drug delivery systems (SMEDDS) and polymeric microneedles (MNs) could improve the transdermal delivery of PG in a controlled-release manner...
January 23, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38243554/preparation-and-evaluation-of-vaginal-suppo-sponges-loaded-with-benzydamine-in-vitro-in-vivo-study
#23
JOURNAL ARTICLE
Noha S El-Salamouni, Marwa A Yakout, Gihan S Labib, Ragwa M Farid
Mucoadhesive dosage forms, releasing locally administered drugs in a controlled manner for vaginal candidiasis may present distinct advantages over traditional creams, ointments, or gels. This work aimed to design a new Benzydamine HCl(BNZ), suppo-sponge intended for the treatment of vaginal candidiasis. BNZ-loaded suppo-sponges were fabricated by simple casting/freeze drying technique utilizing cross-linking of chitosan(Cs), with vanillin(V). Vaginal suppo-sponges were prepared based on different vanillin cross-linking ratios (Vn ), from 0 to 2%w/w...
January 19, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38235570/an-innovative-carrier-for-the-formulation-of-amorphous-solid-dispersion-by-hot-melt-extrusion-with-no-further-downstream-processes-a-case-study-with-indomethacin
#24
JOURNAL ARTICLE
S P Lacerda, S Del Confetto, L Haurie, M Bernard, S Faget, M I Ré
The aim of this work was to study the possibility to use SepitrapTM as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancement of poorly water - soluble drugs. SepitrapTM is a microencapsulated powder solubilizer designed to simplify the manufacture of drugs in oral solid forms, not yet tested for this purpose. The performance of SepitrapTM was evaluated in HME processing for amorphous solid dispersions of poorly-water soluble drugs with indomethacin as a model drug...
January 18, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38230653/efficient-treatment-of-colon-cancer-with-codelivery-of-trail-and-imatinib-by-liposomes
#25
JOURNAL ARTICLE
Rongrong Fu, Rui Chang, Andong Peng, Changshun Feng, Weifan Zhu, Yi Chen, Xue Tian, Rui Wang, Hui Yan, Dianlong Jia, Jun Li
Abstract:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis by interacting with death receptors. However the short half-life and the resistance of tumor cells to TRAIL limit its therapeutic effect. Imatinib has been shown to be effective against colon cancer cell lines and enhance TRAIL-induced apoptosis. However the side effects of it were unavoidable during treatment. To solve these problems, we successfully prepared a kind of multifunctional liposome that encapsulated imatinib in its internal water phase and inserted TRAIL on its membrane in this study, which named ITLPs...
January 17, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38217108/development-and-efficacy-evaluation-of-a-novel-water-in-oil-in-water-adjuvant-for-an-inactivated-foot-and-mouth-disease-vaccine
#26
JOURNAL ARTICLE
Rong, Zhang, Yanming Wei, Xuerong Liu, Yongshu Wu
To develop a novel water-in-oil-in-water (W/O/W) adjuvant and evaluate the effect on foot-and-mouth disease (FMD) inactivated vaccine, in this study, we prepared the novel nano-emulsion adjuvant based on QS-21 (BEA) which is composed of the mixture of mineral oil Marcol52, surfactant Tween80, oleate polyoxyethylene ether ester, polyoxyethylene palmitic acid ester and span80, cosurfactant polyethylene glycol and QS-21. The two-step emulsification method formed the W/O/W nano-emulsion with two films and three-phase structures...
January 12, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38190194/novel-bioequivalent-oral-disintegrating-tablet-of-aripiprazole-prepared-by-direct-compression-technique-with-shortened-disintegration-time
#27
JOURNAL ARTICLE
Do Hwan Kim, Jun Soo Park, Min Young Jeong, In Gyu Yang, Wookyung Kim, Seung Bo Shim, Hye Seon Kim, Hyun Yang Park, Myoung Jin Ho, Myung Joo Kang
Herein, we aimed to formulate a novel oral disintegrating tablet (ODT) of aripiprazole (ARP) capable of rapid disintegration using a direct compression technique. Different ODTs were fabricated with directly compressible excipients, and their disintegration time, wettability (water absorption ratio and wetting time), and mechanical properties (hardness and friability) were evaluated. The optimized ODT comprised F-Melt® type C, Prosolv® SMCC HD90, and Na croscarmellose (10 mg of ARP in a 130 mg tablet)...
January 8, 2024: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38078863/nanosized-ethosomal-dispersions-for-enhanced-transdermal-delivery-of-nebivolol-using-intradermal-transfollicular-sustained-reservoir-in-vitro-evaluation-confocal-laser-scanning-microscopy-and-in-vivo-pharmacokinetic-studies
#28
JOURNAL ARTICLE
Shahinaze A Fouad, Sara T Khatab, Mahmoud H Teaima, Mohamed A El-Nabarawi, Rehab Abdelmonem
Nebivolol (NBV), a BCS class-II anti-hypertensive drug that suffers from limited solubility and oral bioavailability. Nanosized ethosomes were adopted as an approach to solubilize and deliver NBV transdermally, as a substitute to oral route. Ethosomal dispersions were prepared employing thin film hydration method. Formulation variables were adjusted to obtain entrapment efficiency; EE > 50%, particle size; PS < 100 nm, zeta potential; ZP > ± 25 mV and polydispersity index; PDI < 0...
December 11, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38018532/-transethosome-as-a-versatile-nano-vehicle-for-various-indications-and-its-regulatory-insights
#29
REVIEW
Ramesh Joga, Bharathi Kannan, Sravani Yerram, Amruta Nandagawale, Manasi Gawai, Hitesh Kumar Behera, Neeraj Kumar, Parul Grover, Saurabh Srivastava, Gorav Monga, Sandeep Kumar
Transethosomes, classified as 3rd generation nanocarriers, have gained global acclaim due to their profound potential in addressing diverse medical conditions. Their superior dermal penetration, attributed to essential constituents such as edge activators and alcohol, sets them apart from other nanoformulations. The current review article embarks with an introduction followed by a comprehensive exploration of transethosome structures, differentiating them from fellow nanocarriers. A detailed analysis of their characteristics and the spectrum of marketed products is also provided...
November 29, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38015058/experimental-design-approach-for-development-of-carboplatin-loaded-chitosan-modified-liposomal-formulation-with-improved-topical-vaginal-therapeutic-potential
#30
JOURNAL ARTICLE
Rati Yadav, Rohit Bhawale, Deepak N Kapoor, Shashi Bala Singh, Neelesh Kumar Mehra
One of the most prevalent cancers affecting women globally is cervical cancer. Cervical cancer is thought to cause 570.000 new cases annually, and standard treatments can have serious side effects. In this work main aim is to design, fabrication and evaluation of carboplatin loaded chitosan coated liposomal formulation (CCLF-I) for vaginal delivery in treatment of cervical cancer. The particle size and polydispersity index of the CCLF-1 was observed 269.33 ± 1.15 nm and 0.40 ± 0...
November 28, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38014878/emulgels-a-promising-topical-drug-delivery-system-for-arthritis-management-and-care
#31
REVIEW
Aditi Sinha, Unnati Garg, Upendra Nagaich, Amit Chaudhary, Manisha Pandey, Neha Jain
Emulgels, hybrid formulations of emulsions and gels, offer distinct benefits viz. extended release, enhanced bioavailability, and targeted drug delivery to inflamed joints, thereby minimizing systemic side effects, and maximizing therapeutic efficacy in targeting the diseases. Oral medications and topical creams have limitations viz. limited permeation, efficacy, and side effects. Arthritis is a prevalent chronic inflammatory disorder affecting a substantial global population of about 350 million necessitating the exploration of innovative and effective treatment approaches...
November 28, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/38014703/solusomes-novel-soluplus%C3%A2-enriched-nano-vesicular-carriers-for-improving-the-oral-bioavailability-of-candesartan-cilexetil
#32
JOURNAL ARTICLE
Mohammed Abdallah, Aysha Sayed Mohamed, Mina Ibrahim Tadros, Mohamed El-Nabarawi, Mai Ahmed Tawfik
Candesartan cilexetil (CAN) is administered for treating hypertension and heart failure. CAN suffers poor oral bioavailability, owing to limited aqueous solubility, and first-pass metabolism. Solusomes (novel Soluplus® enriched nano-vesicular carriers) combine the merits of Soluplus® , and the traditional liposomes. They were explored to increase CAN solubility, allow a high drug release rate, and improve the oral drug bioavailability. Solusomes were developed via thin film hydration technique utilizing lipid (phosphatidylcholine; PC) and polymeric solubilizer (Soluplus® ; Solu)...
November 28, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37987762/effect-of-variables-on-exemestane-loaded-albumin-nanoparticles-statistical-optimization-and-anti-cancer-activity-in-mcf-7-cell-lines
#33
JOURNAL ARTICLE
Darshan Vyas, Sarika Wairkar
This research aimed to evaluate the effect of variables on exemestane-loaded bovine serum albumin nanoparticles (EXE-BSA NPs) to improve anti-breast cancer activity. EXE-BSA NPs were optimized using 32 factorial design wherein the concentration of BSA (X1) and sonication time (X2) were independent variables and particle size (Y1) and %w/w entrapment efficiency (Y2) were dependent variables. The statistical optimization revealed a significant effect of BSA concentration on both variables, whereas sonication time affected only particle size...
November 21, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37987717/fabrication-of-dissolving-microneedles-for-transdermal-delivery-of-protein-and-peptide-drugs-polymer-materials-and-solvent-casting-micromoulding-method
#34
REVIEW
Rr Kirana Andranilla, Qonita Kurnia Anjani, Pietradewi Hartrianti, Ryan F Donnelly, Delly Ramadon
Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature, their delivery is often limited to injection, with drawbacks such as pain and needle waste. To overcome these limitations, microneedle technology is developed to deliver protein and peptide drugs through the skin. One type of microneedle, known as dissolving microneedles, has been extensively studied for delivering various proteins and peptides, including ovalbumin, insulin, bovine serum albumin, polymyxin B, vancomycin, and bevacizumab...
November 21, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37975846/nose-to-brain-drug-delivery-for-the-treatment-of-glioblastoma-multiforme-nanotechnological-interventions
#35
REVIEW
Nitish Kumar, Bharat Khurana, Daisy Arora
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor with a short survival rate. Extensive research is underway for the last two decades to find an effective treatment for GBM but the tortuous pathophysiology, development of chemoresistance, and presence of BBB are the major challenges, prompting scientists to look for alternative targets and delivery strategies. Therefore, the nose to brain delivery emerged as an unorthodox and non-invasive route, which delivers the drug directly to the brain via the olfactory and trigeminal pathways and also bypasses the BBB and hepatic metabolism of the drug...
November 17, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37961995/incorporation-of-exemestane-into-ternary-nanosponge-system-for-enhanced-anti-tumor-potential-in-breast-cancer
#36
JOURNAL ARTICLE
Preeti Tanaji Mane, Balaji Sopanrao Wakure, Pravin Shridhar Wakte
The present investigation reports the potential of exemestane loaded cyclodextrin based nanosponges for the treatment of breast cancer. Fourier transform infrared, and nuclear magnetic resonance (NMR) spectroscopic analysis confirmed the encapsulation of ring B, C, and D of exemestane in the nanosponge cavity. In vitro studies demonstrated a 6.58-folds increase in the aqueous solubility and a 1.76-folds increase in the dissolution of exemestane in the optimized nanosponge formulation EF2. It also exhibited enhanced cytotoxicity in MCF-7 cell line...
November 14, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37943117/crosslinked-hydrogel-loaded-with-chitosan-supported-iron-oxide-and-silver-nanoparticles-as-burn-wound-dressing
#37
JOURNAL ARTICLE
Mina Borhani, Saba Dadpour, Atoosa Haghighizadeh, Leila Etemad, Vahid Soheili, Bahram Memar, Farzad Vafaee, Omid Rajabi
Burns can result in infection, disability, psychosocial and economic issues. Advanced wound dressings like hydrogel absorb exudate and maintain moisture. Considering the antimicrobial properties of silver nanoparticles and iron oxide nanoparticles, the efficiency of cross-linked hydrogel loaded with chitosan-supported iron oxide and silver nanoparticles for burn wounds repair was investigated in animal model. Cellulose hydrogel dressing made from carboxymethylcellulose and hydroxyethylcellulose crosslinked with different concentrations of citric acid (10%, 15%, 20% and 30%) was produced...
November 9, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37938090/effects-of-tableting-process-parameters-and-powder-lubrication-levels-on-tablet-surface-temperature-and-moisture-content
#38
JOURNAL ARTICLE
Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
Punch sticking is a recurrent problem during the pharmaceutical tableting process. Powder moisture content plays a key role in the buildup of sticking; it evaporates due to increased tablet temperature, accumulates at the punch-tablet interface, and causes sticking through capillary force. This study investigated the effects of compaction pressure (CP), compaction speed (CS), and lubrication level (magnesium stearate [MgSt] ratio) on tablet surface temperature (TST) and moisture content (TSMC). TST and TSMC were measured with an infrared thermal camera and near-infrared sensor, respectively...
November 8, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37937865/review-of-inhalable-nanoparticles-for-the-pulmonary-delivery-of-anti-tuberculosis-drugs
#39
REVIEW
Sowmya Ramachandran, Priyanka Prakash, Noratiqah Mohtar, K Sudesh Kumar, Thaigarajan Parumasivam
Tuberculosis is an airborne disease caused by the pathogen, Mycobacterium tuberculosis , which predominantly affects the lungs. World Health Organization (WHO) has reported that about 85% of TB patients are cured with the existing 6-month antibiotic regimen. However, the lengthy oral administration of high-dose anti-TB drugs is associated with significant side effects and leads to drug resistance cases. Alternatively, reformulating existing anti-tubercular drugs into inhalable nanoparticulate systems is a promising strategy to overcome the challenges associated with oral treatment as they could enhance drug retention in the pulmonary region to achieve an optimal drug concentration in the infected lungs...
November 8, 2023: Pharmaceutical Development and Technology
https://read.qxmd.com/read/37921920/in-vitro-evaluation-and-in-vivo-efficacy-studies-of-a-liposomal-doxorubicin-loaded-glycyrretinic-acid-formulation-for-the-treatment-of-hepatocellular-carcinoma
#40
JOURNAL ARTICLE
Mine Diril, Kemal Volkan Özdokur, Yeliz Yıldırım, H Yeşim Karasulu
Hepatocellular carcinoma (HCC), more than 800.000 cases reported annually, is the most common primary liver cancer globally. Doxorubicin hydrochloride (Dox-HCl) is widely used chemotherapy drug for HCC, but efficacy and tolerability are limited, thus critical to develop delivery systems that can target Dox-HCl to the tumour site. In this study, liver-targeting ligand glycyrrhetinic acid (Gly) was conjugated to polyethylene glycol (PEG) via Steglich reaction and incorporated in liposomes, which were then loaded with Dox-HCl by pH gradient method...
November 3, 2023: Pharmaceutical Development and Technology
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