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JOURNAL ARTICLE
Bideep Shrestha, Anni I Nieminen, Olli Matilainen
Histone H3/H4 chaperone ASF1 is a conserved factor mediating nucleosomal assembly and disassembly, playing crucial roles in processes such as replication, transcription, and DNA repair. Nevertheless, its involvement in aging has remained unclear. Here, we utilized the model organism Caenorhabditis elegans to demonstrate that the loss of UNC-85, the homolog of ASF1, leads to a shortened lifespan in a multicellular organism. Furthermore, we show that UNC-85 is required for epigenome-mediated longevity, as knockdown of the H3K4 methyltransferase ash-2 does not extend the lifespan of unc-85 mutants...
April 10, 2024: Cell Stress & Chaperones
#2
JOURNAL ARTICLE
Clinton J Belott, Oleg A Gusev, Takahiro Kikawada, Michael A Menze
Anhydrobiotic species can survive virtually complete water loss by entering a reversible ametabolic glassy state that may persist for years in ambient conditions. The Pv11 cell line was derived from egg mass of the anhydrobiotic midge, Polypedilum vanderplanki, and is currently the only available anhydrobiotic cell line. Our results demonstrate that the necessary preconditioning for Pv11 cells to enter anhydrobiosis causes autophagy and reduces mitochondrial respiration by over 70%. We speculate that reorganizing cellular bioenergetics to create and conserve energy stores may be valuable to successfully recover after rehydration...
April 10, 2024: Cell Stress & Chaperones
#3
JOURNAL ARTICLE
Ali Camara, Heerak Chugh, Alyssa George, Lukas Dolidze, Kevin Ryu, Katrina J Holly, Daniel P Flaherty, Seema Mattoo
AMPylation-the covalent transfer of an AMP from ATP onto a target protein-is catalyzed by the human enzyme HYPE/FicD to regulate its substrate, the heat shock chaperone BiP. HYPE-mediated AMPylation of BiP is critical for maintaining proteostasis in the ER (endoplasmic reticulum) and mounting an UPR (unfolded protein response) in times of proteostatic imbalance. Thus, manipulating HYPE's enzymatic activity is a key therapeutic strategy towards the treatment of various protein misfolding diseases, including neuropathy and early onset diabetes associated with two recently identified clinical mutations of HYPE...
April 8, 2024: Cell Stress & Chaperones
#4
JOURNAL ARTICLE
Yan Meng, Zhenzhen Hu, Chenyi Zhang, Hao Bai, Zhaoping Li, Xinru Guo, Liyong Chen
The role of miR-92a-3p in the ethanol-induced apoptosis of H9c2 cardiomyocytes remains unclear. In this study, we explored the role of miR-92a-3p in the ethanol-induced apoptosis of H9c2 cardiomyocytes and identified its target genes and signaling pathways. H9c2 cells were cultured with or without 100mM ethanol for 24h. The differential expression of miR-92a-3p was verified in H9c2 cells through reverse transcription-quantitative polymerase chain reaction (RT-qPCR). To manipulate the expression of miR-92a-3p, both a mimic and an inhibitor were transfected into H9c2 cells...
April 4, 2024: Cell Stress & Chaperones
#5
JOURNAL ARTICLE
Mario Fernández Comaduran, Sandra Minotti, Suleima Jacob-Tomas, Javeria Rizwan, Nancy Larochelle, Richard Robitaille, Chantelle F Sephton, M Vera, Josephine N Nalbantoglu, Heather D Durham
Protein misfolding and mislocalization are common themes in neurodegenerative disorders, including the motor neuron disease, amyotrophic lateral sclerosis (ALS). Maintaining proteostasis is a crosscutting therapeutic target, including upregulation of heat shock proteins (HSP) to increase chaperoning capacity. Motor neurons have a high threshold for upregulating stress inducible HSPA1A, but constitutively express high levels of HSPA8. This study compared expression of these HSPs in cultured motor neurons expressing three variants linked to familial ALS: TDP-43G348C , FUSR521G or SOD1G93A ...
April 1, 2024: Cell Stress & Chaperones
#6
JOURNAL ARTICLE
Mathieu E Rebeaud, Satyam Tiwari, Bruno Fauvet, Adelaïde Mohr, Paolo De Los Rios, Pierre Goloubinoff
The Hsp70 chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) co-evolved with Hsp70s to trigger ATP-hydrolysis and catalytically upload various substrate polypeptides in need to be structurally modified by the chaperone. Here, we measured the protein disaggregation and refolding activities of the main yeast cytosolic Hsp70, Ssa1, in the presence of its most abundant JDPs, Sis1 and Ydj1, and two swap mutants, in which the J-domains have been interchanged...
March 21, 2024: Cell Stress & Chaperones
#7
REVIEW
Tanveer Ahmad, Bushra A Alhammadi, Shaikha Y Almaazmi, Sahar Arafa, Gregory L Blatch, Tanima Dutta, Jason E Gestwicki, Robert A Keyzers, Addmore Shonhai, Harpreet Singh
Global efforts to eradicate malaria are threatened by multiple factors, particularly the emergence of anti-malarial drug resistant strains of Plasmodium falciparum. Heat shock proteins (HSPs), particularly P. falciparum HSPs (PfHSPs), represent promising drug targets due to their essential roles in parasite survival and virulence across the various life cycle stages. Despite structural similarities between human and malarial HSPs posing challenges, there is substantial evidence for subtle differences that could be exploited for selective drug targeting...
March 20, 2024: Cell Stress & Chaperones
#8
JOURNAL ARTICLE
Christopher Butler, Morgan Dunmire, Jaebok Choi, Gabor Szalai, Anissa Johnson, Wei Lei, Xin Chen, Liang Liu, Wei Li, Matthew J Walter, Tuoen Liu
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell malignancies characterized by abnormal hematopoietic cell maturation, increased apoptosis of bone marrow cells, and anemia. They are the most common myeloid blood cancers in American adults. The full complement of gene mutations that contribute to the phenotypes or clinical symptoms in MDS is not fully understood. Around 10%-25% of MDS patients harbor an interstitial heterozygous deletion on the long arm of chromosome 5 [del(5q)], creating haploinsufficiency for a large set of genes, including HSPA9...
March 18, 2024: Cell Stress & Chaperones
#9
JOURNAL ARTICLE
Clare K Melchiorre, Matthew D Lynes, Sadikshya Bhandari, Sheng-Chiang Su, Christian M Potts, Amy V Thees, Carol E Norris, Lucy Liaw, Yu-Hua Tseng, Michael A Lynes
Type 1 diabetes (T1D) is characterized by lymphocyte infiltration into the pancreatic islets of Langerhans, leading to the destruction of insulin-producing beta cells and uncontrolled hyperglycemia. In the non-obese diabetic (NOD) murine model of T1D, onset of this infiltration starts several weeks before glucose dysregulation and overt diabetes. Recruitment of immune cells to the islets is mediated by several chemotactic cytokines, including CXCL10, while other cytokines, including SDF-1α, can confer protective effects...
March 13, 2024: Cell Stress & Chaperones
#10
JOURNAL ARTICLE
Yunxiao Jia, Yunhao Yu, Chenxi Gao, Yuehua Li, Chuanfu Li, Zhengnian Ding, Qiuyue Kong, Li Liu
Long-term hyperglycemia can lead to diabetic cardiomyopathy (DCM), a main lethal complication of diabetes. However, the mechanisms underlying DCM development have not been fully elucidated. Heat shock protein A12A (HSPA12A) is the atypic member of HSP70 family. In the present study, we found that the expression of HSPA12A was upregulated in hearts of mice with streptozotocin (STZ)-induced diabetes, while ablation of HSPA12A improved cardiac systolic and diastolic dysfunction and increased cumulative survival of diabetic mice...
March 12, 2024: Cell Stress & Chaperones
#11
REVIEW
Tianen Wang, Guoli Xing, Tong Fu, Yanchun Ma, Qi Wang, Shuxiang Zhang, Xing Chang, Ying Tong
This comprehensive review delves into the pivotal role of mitochondria in doxorubicin-induced cardiotoxicity, a significant complication limiting the clinical use of this potent anthracycline chemotherapeutic agent. Doxorubicin, while effective against various malignancies, is associated with dose-dependent cardiotoxicity, potentially leading to irreversible cardiac damage. The review meticulously dissects the molecular mechanisms underpinning this cardiotoxicity, particularly focusing on mitochondrial dysfunction, a central player in this adverse effect...
March 12, 2024: Cell Stress & Chaperones
#12
JOURNAL ARTICLE
Jenny Joutsen, Jenny C Pessa, Otto Jokelainen, Reijo Sironen, Jaana M Hartikainen, Lea Sistonen
Heat shock factors (HSFs) are the main transcriptional regulators of the evolutionarily conserved heat shock response. Beyond cell stress, several studies have demonstrated that HSFs also contribute to a vast variety of human pathologies, ranging from metabolic diseases to cancer and neurodegeneration. Despite their evident role in mitigating cellular perturbations, the functions of HSF1 and HSF2 in physiological proteostasis have remained inconclusive. Here, we analyzed a comprehensive selection of paraffin-embedded human tissue samples with immunohistochemistry...
March 6, 2024: Cell Stress & Chaperones
#13
JOURNAL ARTICLE
Emma Lee Johnson, Yuki Ohkawa, Noriko Kanto, Reiko Fujinawa, Taiki Kuribara, Eiji Miyoshi, Naoyuki Taniguchi
Dendritic cells, macrophages, neutophils and other antigen-presenting cells express various C-type lectin receptors that function to recognize the glycans associated with pathogens. DC-SIGN (the Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) binds various pathogens such as HIV gp120, the Ebola glycoprotein, Hemagglutinin, and the dengue virus glycoprotein in addition to the SARS-CoV-2 Spike protein, and also triggers antigen presenting cell endocytosis and immune escape from systemic infections...
March 5, 2024: Cell Stress & Chaperones
#14
JOURNAL ARTICLE
Afnan Fatani, Xiangyang Wu, Yayra Gbotsyo, Thomas H MacRae, Xiaojun Song, Jiabo Tan
Females of the extremophile crustacean, Artemia franciscana, either release motile nauplii via the ovoviviparous pathway or encysted embryos (cysts) via the oviparous pathway. Cysts contain an abundant amount of the ATP-independent small heat shock protein that contributes to stress tolerance and embryo development, however, little is known of the role of ATP-dependent molecular chaperone, Hsp90 in the two processes. In this study, a hsp90 was cloned from A. franciscana. Characteristic domains of ArHsp90 were simulated from the deduced amino acid sequence, and 3D structures of ArHsp90 and Hsp90s of organisms from different groups were aligned...
February 28, 2024: Cell Stress & Chaperones
#15
REVIEW
Giulia Angelini, Sara Russo, Geltrude Mingrone
Over the past 40 years, the prevalence of obesity has risen dramatically, reaching epidemic proportions. Metabolic surgery has proven to be highly effective in treating obesity, leading to significant improvements or complete resolution of obesity-related comorbidities. Research conducted in both animals and humans suggests that the metabolic benefits achieved through metabolic surgery cannot be solely attributed to weight loss. Indeed, there has been an increasing recognition of intestinal inflammation as a novel factor influencing obesity...
February 25, 2024: Cell Stress & Chaperones
#16
JOURNAL ARTICLE
Yanjie Lu, Die Cheng, Jiayu Pang, Yuqiao Peng, Shunkang Jin, Xinyu Zhang, Yanzhen Zuo, Yuhong Li
BACKGROUND: Chronic stress is a common emotional disorder in cancer patients. Chronic stress promotes progression of gastric cancer (GC) and leads to poor outcomes. However, the underlying mechanisms remain not clear. Herein, we explored the possible mechanisms of chronic stress in GC progression. METHODS: TCGA datasets were analyzed for differentially expressed genes. Clinical data of GC were evaluated for their association with PlexinA1 using The Cancer Genome Atlas (TCGA) and Kaplan-Meier (KM)-plotter databases...
February 6, 2024: Cell Stress & Chaperones
#17
REVIEW
Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt
The heat shock response (HSR) is an ancient and evolutionarily conserved mechanism designed to restore cellular homeostasis following proteotoxic challenges. However, it has become increasingly evident that disruptions in energy metabolism also trigger the HSR. This interplay between proteostasis and energy regulation is rooted in the fundamental need for ATP to fuel protein synthesis and repair, making the HSR an essential component of cellular energy management. Recent findings suggest that the origins of proteostasis-defending systems can be traced back over 3...
February 6, 2024: Cell Stress & Chaperones
#18
EDITORIAL
Johannes Buchner, Milad J Alasady, Sarah J Backe, Brian Sj Blagg, Richard L Carpenter, Giorgio Colombo, Ioannis Gelis, Daniel T Gewirth, Lila M Gierasch, Walid A Houry, Jill L Johnson, Byoung Heon Kang, Aimee W Kao, Paul LaPointe, Seema Mattoo, Amie J McClellan, Leonard M Neckers, Chrisostomos Prodromou, Andrea Rasola, Rebecca A Sager, Maria A Theodoraki, Andrew W Truman, Matthias C Truttman, Natasha E Zachara, Dimitra Bourboulia, Mehdi Mollapour, Mark R Woodford
The 2nd International Symposium on the Chaperone Code took place on October 26-28, 2023 at the Hilton Alexandria Old Town, VA, USA. The event featured more than 100 attendees from ten countries and provided a dynamic platform for established researchers, emerging investigators, postdoctoral fellows, and students to share insights and ideas on diverse facets of molecular chaperones with a strong focus on their regulation by post-translational modifications. The format fostered discussions and collaboration among participants...
February 3, 2024: Cell Stress & Chaperones
#19
JOURNAL ARTICLE
Matthias P Mayer, Laura Blair, Gregory L Blatch, Thiago J Borges, Ahmed Chadli, Gabriela Chiosis, Aurélie de Thonel, Albena Dinkova-Kostova, Heath Ecroyd, Adrienne L Edkins, Takanori Eguchi, Monika Fleshner, Kevin P Foley, Sotirios Fragkostefanakis, Jason Gestwicki, Pierre Goloubinoff, Jennifer A Heritz, Christine M Heske, Jonathan D Hibshman, Jenny Joutsen, Wei Li, Michael Lynes, Marc L Mendillo, Nahid Mivechi, Fortunate Mokoena, Yuka Okusha, Veena Prahlad, Elizabeth Repasky, Sara Sannino, Federica Scalia, Reut Shalgi, Lea Sistonen, Emily Sontag, Patricija van Oosten-Hawle, Anniina Vihervaara, Anushka Wickramaratne, Shawn Xiang Yang Wang, Tawanda Zininga
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response (HSR), unfolded protein response (UPR) and integrated stress response (ISR), that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation...
February 2, 2024: Cell Stress & Chaperones
#20
EDITORIAL
Dimitra Bourboulia, Laura J Blair, Melody S Clark, Adrienne L Edkins, Lawrence E Hightower, Mehdi Mollapour, Veena Prahlad, Elizabeth A Repasky, Manuela Truebano, Andrew W Truman, Matthias C Truttmann, Patricija van Oosten-Hawle, Mark R Woodford
No abstract text is available yet for this article.
February 1, 2024: Cell Stress & Chaperones
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