Journal of Pediatric and Adolescent Gynecology

We performed a genetic investigation into the case of an inherited Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome. Our patients were an adolescent and her mother, both with MRKH syndrome. The delivery of a biological offspring was achieved via a gestational carrier. Karyotype and exome sequencing were used to complete a three-generation genetic analysis of the family. Both the mother and her daughter harbored a deletion of four Mb at the locus of 2q37, a syndrome rarely described in association with MRKH...

STUDY OBJECTIVE: Few studies have explored what specific outcome measures contained in assessment tools for period and pelvic pain are most relevant to adolescents. Co-design is a valuable method of ensuring input from those with lived experience. The Longitudinal Study of Teenagers with Endometriosis Periods and Pelvic Pain in Australia (LongSTEPPP) Co-Design Periods Survey comprised an anonymous online survey of adolescents' experience of menstruation to inform patient-reported outcome measures for the larger 5-year project...

BACKGROUND/PURPOSE: Hydrometrocolpos is distension of the vagina and uterus with fluid other than pus or blood. It is due to distal vaginal obstruction, one of its possible causes is agenesis of the distal vagina. Patients with distal vaginal atresia may present in the neonatal period due to stimulation of uterine and cervical glands by maternal estrogen. In this study, we presented our results in managing neonates with complicated hydrometrocolpos due to distal vaginal atresia through a single-stage abdomino-perineal pull-through vaginoplasty...

BACKGROUND: Rubinstein-Taybi syndrome (RSTS) is a multi-system neurodevelopmental condition caused by deficiency of CREBBP (16p13.3) or EP300 (22q13.2). Müllerian agenesis, or Mayer-Rokitansky-Küster-Hauser syndrome (MRKH), is defined as congenital agenesis of the uterus, cervix, and upper vagina without definite genetic cause. INDEX CASE AND CASE SERIES: We present a 14-year-old female with RSTS type 1 (CREBBP, c.4395-2A>C) and MRKH, the first documented in the literature...

STUDY OBJECTIVE: To determine the incidence of PCOS and hyperandrogenism amongst adolescent transmasculine patients presenting to a tertiary care referral center for gender affirming care. METHODS: This was a retrospective study of adolescent transmasculine patients presenting to Cleveland Clinic for gender affirming hormone therapy (GAHT). The diagnostic criteria were adolescent-specific as defined by the international evidence-based guideline for PCOS management and included oligomenorrhea and/or anovulation with clinical and/or biochemical hyperandrogenism after exclusion of other androgen excess disorders...

No abstract text is available yet for this article.

Now that ovarian tissue cryopreservation (OTC) has become standard of care for patients receiving gonadotoxic therapies, discussion has turned towards offering OTC to pediatric patients with Turner syndrome outside of research. While patients with Turner syndrome have unmet fertility needs and the authors support efforts for fertility preservation in these individuals, safety and efficacy data about OTC in this population are limited. Building on longstanding debates around offering experimental therapies as research or outside of research (as "innovative therapy"), we considered the suitability of offering OTC for Turner syndrome as innovative therapy...

STUDY OBJECTIVE: There are many videos on contraception on YouTube and TikTok, and women around the world use video platforms extensively to seek health information from videos of uncertain reliability and quality. The main objective of this research is to evaluate the scientific reliability and quality of the most popular social media videos about contraceptive subdermal implants. METHODS: TikTok and YouTube videos were assessed separately by two gynaecologists...

No abstract text is available yet for this article.

INTRODUCTION: THERE ARE SEVERAL WELL DESCRIBED PRESENTATIONS OF UTERINE DIDELPHYS (UD): : UD without vaginal septum, UD with non-obstructed longitudinal vaginal septum, or UD with duplicated vaginas and an obstructed hemivagina on one side with ipsilateral renal anomaly. STUDY OBJECTIVE: To describe another variant of UD and compare the presentation and management across different institutions. METHODS: NASPAG Fellows Research Consortium retrospective case series approved...

BACKGROUND: A longitudinal vaginal septum (LVS) is a rare congenital anomaly often identified during adolescence. Surgical removal is a mainstay in treatment of symptomatic cases; however, there is variation in the techniques used. Little is known about the risk for postoperative complications associated with novel methods. CASES: We present the cases of 2 adolescent females, ages 15 and 22, diagnosed with an LVS who elected to undergo surgical removal. A LigaSure device was used for resection, and both individuals experienced significant postoperative bleeding almost 2 weeks following resection...

BACKGROUND: Malignant phyllodes tumor (MPT) is a rare breast disease that is extremely rare in children. A few cases of pediatric malignant phyllodes tumors have been reported, including some with a poor prognosis. CASE: A 14-year-old girl presented with a growing lump on her right breast. Based on imaging tests and a core needle biopsy, MPT was diagnosed, and right mastectomy was performed. The postoperative course was uneventful. SUMMARY AND CONCLUSION: MPT is an infrequent disease in adult females and is extremely rare in pubertal females...

No abstract text is available yet for this article.

STUDY OBJECTIVE: Menstrual inequity-unequal access to menstrual healthcare or products-negatively affects wellbeing in relation to the menstrual cycle, a construct known as menstrual health. Few studies have explored menstrual inequities among adolescent and young adult populations in the United States. This multimodal qualitative research aimed to explore factors that influence the lived experience of menstruation among this population. METHODS: This qualitative study consisted of individual interviews among menstruators ages 13-24, recruited from an urban academic medical center...

STUDY OBJECTIVE: Obstructed Hemivagina with Ipsilateral Renal Agenesis (OHVIRA) is a rare congenital Müllerian anomaly. We sought to explore the impact of OHVIRA on pregnancy outcomes. METHODS: A retrospective chart review identified eight patients with an OHVIRA diagnosis and at least one documented pregnancy. Data collected included demographics, age at diagnosis and repair, gynecologic history, and pregnancy outcomes. Descriptive analysis was performed. RESULTS: Twenty-three pregnancies were identified among the eight patients (range 1-5 pregnancies per patient), resulting in nine term births, six preterm births, and eight first-trimester spontaneous abortions...

STUDY OBJECTIVE: To compare menstrual health literacy among adolescents and young adults based on family religious background and United States region. METHODS: We conducted a cross-sectional online survey of post-menarcheal U.S. adolescents and young adults aged 14-24 years who identified their family religious background, including Christian or non-religious, with recruitment via the social media platform TikTok. We asked participants several questions to assess their health literacy regarding common myths about the use of gonadal steroid hormones for menstrual suppression...

Labial size concerns are an increasingly common chief complaint by both adolescents and adults despite studies showing a wide variation in sizes of the labia minora in the prepubertal, adolescent, and adult population. A thorough history will elucidate what or whom is driving the concerns, which can then direct management. Educating the patient, caregiver, and referring physician is often all that is needed. Surgery should never be used for cosmetic reasons in a minor.

STUDY OBJECTIVE: Latino youths in the US experience disproportionately high rates of teen pregnancy. The study aim was to obtain expecting and parenting Latino adolescents' perspectives regarding factors contributing to teen pregnancy and pregnancy prevention. METHODS: Expecting/parenting Latino adolescents were recruited from high schools with high proportions of Latino youths and teen pregnancy. Participants completed a questionnaire on sociodemographic and background characteristics...

OBJECTIVE: To describe choices of transgender and gender diverse (TGD) late adolescents assigned female at birth regarding gender affirming surgery (GAS). METHODS: Participants aged 18-21 completed an online survey which included demographics, surgical history, desire for GAS, and barriers to care. RESULTS: Two hundred sixty surveys were completed. Forty-three (16.7%) underwent GAS. Of those who had not, 178 (83%) plan to do so in the future, and 15 (7%) reported no desire to undergo GAS...

OBJECTIVE: Examine the relationship between clinicians' attitudes about the appropriateness of providing sexual health services in the inpatient setting and confidence in providing services. METHODS: An online survey was emailed to pediatric hospitalists, adolescent medicine, and pediatric and adolescent gynecology societies and directors. Confidence in managing eight sexual health situations was measured on a 4-point Likert scale, summed, averaged, and dichotomized into confident and not-so-confident...