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Kidney & Blood Pressure Research

Roger Gaspar Marchon, Carina Teixeira Ribeiro, Waldemar Silva Costa, Francisco José Barcellos Sampaio, Marco Aurélio Pereira-Sampaio, Diogo Benchimol de Souza
BACKGROUND/AIMS: Stress had been related to physiological and morphological alterations in different organs, however kidney morphology and function after stress conditions are not well-known. To evaluate the effects of chronic stress on renal morphology in prepubertal and adult rats, and to investigate if the effects of induced stress remain stable or worsen following removal of the stress stimuli. METHODS: Forty prepubertal rats (4 weeks old) and thirty six adult rats (10 weeks old) were used...
December 14, 2018: Kidney & Blood Pressure Research
Kai Zhu, Ting Zheng, Xinghua Chen, Huiming Wang
BACKGROUND/AIMS: To develop a novel strategy for the treatment of kidney disease, we explored potential molecular targets involved in the development of renal ischaemia-reperfusion injury (IRI). METHODS: The Gene expression profile data of GSE27274, including controls and rats subjected to renal IRI and reperfusion for 24 h (IR24) or 120 h (IR120), was obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were analysed using the limma package...
December 14, 2018: Kidney & Blood Pressure Research
Hwee-Yeong Ng, Yueh-Ting Lee, Wei-Hung Kuo, Pei-Chen Huang, Wei-Chia Lee, Chien-Te Lee
BACKGROUND/AIMS: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. METHODS: Sprague-Dawley rats were fed with high fructose diet (60%) for 3 months (FR-3) and 5 months (FR-5). At the end study, serum and urine biochemical data were compared...
December 7, 2018: Kidney & Blood Pressure Research
Xue Li, Jinsong Chen, Dongrui Cheng, Rong Wang, Wei Wang, Mingchao Zhang, Feng Xu, Jiqiu Wen, Zheng Tang
BACKGROUND/AIMS: We aimed to explore the associations between clinical parameters and long-term allograft outcomes in transplant glomerulopathy (TG) in a large retrospective cohort with long follow-up. METHODS: Clinical and laboratory data at biopsy from 180 cases of TG with an estimated glomerular filtration rate (eGFR)> 15ml/min/1.73m2 from January 2004 to December 2016 at our center were retrospectively analyzed. The main outcome of this study was initiation of replacement therapy or an eGFR declined to < 15 ml/min/1...
December 7, 2018: Kidney & Blood Pressure Research
Bo Yang, Qi Wang, Rui Wang, Tao Xu
BACKGROUND/AIMS: Cardiovascular complications are the most common cause of death in individuals with autosomal dominant polycystic kidney disease (ADPKD), yet there is no substantial data concerning the clinical characteristics of acute myocardial infarction (AMI) in this population. This study thus aimed to investigate AMI in persons with ADPKD. METHODS: A retrospective analysis of ADPKD patients admitted to our hospital over a 13 year period was conducted. Age and gender-matched control patients without ADPKD were also selected at a ratio of 1: 10...
November 30, 2018: Kidney & Blood Pressure Research
Peng Gao, Bo Xu, Panai Song, Xuejing Zhu, Shuguang Yuan, Yashipal S Kanwar, Lin Sun
BACKGROUND/AIMS: Renal tubular injury plays an important role in the progression of diabetic nephropathy (DN). However, there is a lack of specific biomarkers for tubular damage in incipient DN. We have evaluated the role of myo-inositol oxygenase (MIOX) in the tubular injury of DN, but whether it could serve as a new biomarker for the early diagnosis of DN is unclear. METHODS: Ninety patients with type 2 diabetes mellitus (T2DM) were divided into normoalbuminuria, microalbuminuria and macroalbuminuria groups...
November 30, 2018: Kidney & Blood Pressure Research
Ercilhana G B Freitas, Denis F Souza, Sebastião R Ferreira-Filho
BACKGROUND/AIMS: Elderly patients with normal systemic arterial blood pressure associated with femoral carotid pulse velocity (cf-PWV) less than 7.6 m/s and without associated comorbidities are considered to have good vascular health. The aim of the current study was to verify the probability that elderly patients with good vascular health have at least one blood pressure measurement above the different thresholds for systolic blood pressure (120, 130 and 140 mmHg) during two years of follow-up...
November 30, 2018: Kidney & Blood Pressure Research
Vojtech Kratky, Libor Kopkan, Sona Kikerlova, Zuzana Huskova, Milos Taborsky, Janusz Sadowski, Frantisek Kolar, Ludek Cervenka
BACKGROUND/AIMS: Reduction of renal blood flow (RBF) is commonly thought to be a causative factor of renal dysfunction in congestive heart failure (CHF), but the exact mechanism of the renal hypoperfusion is not clear. Apart from the activation of neurohormonal systems controlling intrarenal vascular tone, the cause might be altered reactivity of the renal vasculature to endogenous vasoactive agents. METHODS: To evaluate the role of this mechanism, we assessed by an ultrasonic transient-time flow probe maximum RBF responses to renal artery infusion of angiotensin II (ANG II), norepinephrine (NE) and acetylcholine (Ach) in healthy male rats and animals with compensated and decompensated CHF...
November 23, 2018: Kidney & Blood Pressure Research
Bruno C Silva, Erica Adelina, Benedito J Pereira, Lilian Cordeiro, Camila E Rodrigues, Ricardo J Duarte, Hugo Abensur, Rosilene M Elias
BACKGROUND/AIMS: Peritoneal dialysis (PD) has gained interest over the last decade as a viable option for early start dialysis. It is still unknown if shorter break-in periods and less time for proper patient evaluation and training could influence technique survival in comparison to planned-start PD. METHODS: A prospective and observational study that compared technique survival in a cohort of patients who started either early or planned PD. Early start PD was defined as break-in period from 3 to 14 days with no previous nephrologist follow-up or patient training...
November 23, 2018: Kidney & Blood Pressure Research
Shufen Yang, Rizwanguli Abdulla, Chen Lu, Ling Zhang
BACKGROUND/AIMS: Renal interstitial fibrosis (RIF) is a common feature that facilitates the progression of chronic kidney disease (CKD), and emerging lines of evidence suggest that microRNA-376b (miR-376b) is capable of promoting RIF. In this study, we examined collagen deposition in kidney tissues, the autophagy and mitochondrial reactive oxygen species (ROS) of macrophages, and the apoptosis of kidney fibroblasts (KFBs) after the promotion or suppression of endogenous miR-376b in cultured macrophages and renal fibroblasts obtained from mice with CKD...
November 23, 2018: Kidney & Blood Pressure Research
Shiika Watanabe, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Kazuho Inoue, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori
BACKGROUND/AIMS: Polycystic kidney disease (PKD) is a common, progressive, and heritable type of kidney disease. Although certain imaging modalities are useful for the diagnosis and staging of PKD, they cannot adequately monitor the severity of interstitial inflammation and fibrosis. Therefore, the present study evaluated the urinary level of liver-type fatty acid binding protein (L-FABP) as a marker of interstitial inflammation and fibrosis in PKD. METHODS: Male PCK/CrljCrl-Pkhd1pck/Crl (PCK) rats (n = 34) were used as an animal model of the PKD...
November 23, 2018: Kidney & Blood Pressure Research
Chia-Ter Chao, Yi-Hsuan Lee, Kuen-Cheh Yang, Jen-Kuei Peng, Chia-Ming Li, Shih-I Chen, Der-Sheng Han, Jenq-Wen Huang, Cogent Study Group
BACKGROUND/AIMS: Awareness of chronic kidney disease (CKD) has been low among affected patients, particularly the older ones. However, whether such awareness is synonymous with the presence of laboratory-diagnosed CKD among older adults is currently unclear. METHODS: We enrolled community-dwelling old adults (≥ 65 years) who received health examinations between 2013 and 2016 from a regional metropolitan hospital. Clinical information and geriatric syndromes including depression, cognitive impairment, fall, quality of life, and visual disturbance were evaluated during the medical interview...
2018: Kidney & Blood Pressure Research
John Hughes, Darren Green, Diana Y Y Chiu, Nik Abidin, Philip A Kalra
BACKGROUND/AIMS: Echocardiographic abnormalities of systolic function can be detected earlier with advancing echocardiographic technologies. Given the high prevalence of left ventricular hypertrophy in dialysis patients, we hypothesised that one such marker of strain, peak systolic strain rate (SR) would demonstrate association with cardiovascular outcome in a haemodialysis cohort. METHODS: Recruited prevalent haemodialysis patients underwent standard transthoracic echocardiography as part of a detailed cardiovascular assessment on a non-dialysis day during a short inter-dialytic midweek break...
2018: Kidney & Blood Pressure Research
Qi-Jiao Wei, Han Xu, Na Guan, Ya-Li Ren, Xiao-Ya Liu, Guo-Hong Wu, Sai-Nan Zhu
BACKGROUND/AIMS: The molecules involved in nephrotic syndrome (NS) have not been fully clarified. Mitochondrial fission proteins are found to be involved in podocyte injury in vitro. Increased glomerular expression of mitochondrial fission proteins was found in adriamycin nephropathy in our previous study. Whether or not mitochondrial fission proteins are involved in podocyte injury in NS is not clear. This study explored the glomerular expression and possible pathological significance of mitochondrial fission-associated proteins, including dynamin-related protein 1 (Drp1) and mitochondrial fission protein 1 (Fis1), in children with NS...
2018: Kidney & Blood Pressure Research
Jiachuan Xiong, Min Wang, Ying Zhang, Ling Nie, Ting He, Yiqin Wang, Yunjian Huang, Bing Feng, Jingbo Zhang, Jinghong Zhao
BACKGROUND/AIMS: Geriatric nutritional risk index (GNRI) was developed as a "nutrition-related" risk index and was reported in different populations as associated with the risk of all-cause and cardiovascular morbidity and mortality. Therefore, GNRI can be used to classify patients according to a risk of complications in relation to conditions associated with protein-energy wasting (PEW). However, not all reports pointed to the prognostic ability of the GNRI. The purpose of this study was to assess the associations of GNRI with mortality in chronic hemodialysis patients...
2018: Kidney & Blood Pressure Research
Pingping Yang, Qi Wang, Chen Xie, Gaosi Xu, Qinghua Wu
BACKGROUND/AIMS: The present network meta-analysis of randomized controlled trials (RCTs) was to explore the efficacy and safety of different pharmacologic interventions in IgA nephropathy with proteinuria more than 0.75 g/d. METHODS: We systematically searched the Cochrane Library, Embase, and PubMed database for studies compared the rate of clinical remission and/or serious adverse events in IgA nephropathy patients with proteinuria (> 0.75 g/d) up to August 1, 2018...
2018: Kidney & Blood Pressure Research
Karel Lábr, Jindřich Špinar, Jiří Pařenica, Lenka Špinarová, Filip Málek, Monika Špinarová, Ondřej Ludka, Jiří Jarkovský, Klára Benešová, Monika Goldbergová-Pávková, Růžena Lábrová
BACKGROUND/AIMS: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients...
2018: Kidney & Blood Pressure Research
Yexin Liu, Yan Zhang, Di Liu, Xia Tan, Xiaofang Tang, Fan Zhang, Ming Xia, Guochun Chen, Liyu He, Letian Zhou, Xuejing Zhu, Hong Liu
BACKGROUND/AIMS: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied. METHODS: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Demographic and clinicopathological data were obtained within 1 month of renal biopsy...
2018: Kidney & Blood Pressure Research
Zeyuan Fan, Yang Li, Hanhua Ji, Xinwen Jian
BACKGROUND/AIMS: Cardiorenal syndrome type 1(CRS1) is a serious clinical condition in patients with acute heart failure (AHF) associated with adverse clinical outcomes. Although several biomarkers for identifying CRS1 have been reported, early and accurate predicting CRS1 still remains a challenge. This study was aimed to develop and validate an individualized predictive nomogram for the risk of CRS1 in patients with AHF. METHODS: A total of 1235 AHF patients between 2013 and 2018 were included in this study...
2018: Kidney & Blood Pressure Research
Anna Tomaszuk-Kazberuk, Dimitrios Nikas, Paulina Lopatowska, Elzbieta Młodawska, Jolanta Malyszko, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Bożena Sobkowicz, Ioannis Goudevenos
BACKGROUND/AIMS: Several studies have implicated atrial fibrillation (AF) as a contributing factor in chronic kidney disease (CKD) and cardiovascular events. The prevalence of coronary artery disease (CAD) in patients with AF varies substantially from 17% to 46.5%. There are only few studies concerning renal function in population with AF undergoing coronary angiography. The aim of the present study was to assess which type of AF is dominant in CKD population scheduled for coronary angiography and if it can influence patients' outcome, the association between renal impairment and the type of coronary procedures in AF patients and the influence of renal function on in-hospital mortality...
2018: Kidney & Blood Pressure Research
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