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Journals Biochemia Medica : časopis ...

Biochemia Medica : časopis Hrvatskoga Društva Medicinskih Biokemičara

https://read.qxmd.com/read/38882589/antiphospholipid-antibodies-in-patients-with-antiphospholipid-syndrome
#1
REVIEW
Slavica Dodig, Ivana Čepelak
Antiphospholipid syndrome (APS) is a rare systemic autoimmune disease characterized by recurrent pregnancy morbidity or thrombosis in combination with the persistent presence of antiphospholipid antibodies (aPLs) in plasma/serum. Antiphospholipid antibodies are a heterogeneous, overlapping group of autoantibodies, of which anti-β2-glycoprotein I (aβ2GPI), anticardiolipin (aCL) antibodies and antibodies that prolong plasma clotting time in tests in vitro known as lupus anticoagulant (LAC) are included in the laboratory criteria for the diagnosis of APS...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882588/the-band-count-imprecision-a-croatian-multicentric-pilot-study
#2
MULTICENTER STUDY
Vanja Radišić Biljak, Višnja Jureša, Valentina Vidranski, Ivana Vuga, Franciska Tomić, Fran Smaić, Martina Horvat, Branka Krešić, Brankica Šimac, Ivana Lapić
INTRODUCTION: Due to high inter-observer variability the 2015 International Council for Standardization in Haematology (ICSH) recommendations state to count band neutrophils as segmented neutrophils in the white blood cell (WBC) differential. However, the inclusion of bands as a separate cell entity within the WBC differential is still widely used in hematology laboratories in Croatia. The aim of this multicentric study was to assess the degree of inter-observer variability in enumerating band neutrophils within the WBC differential among Croatian laboratories...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882587/pseudonormokalemia-case-report-what-does-it-mean-to-have-normal-blood-potassium
#3
JOURNAL ARTICLE
Tomáš Šálek, David Stejskal
This case report describes a case of pseudonormokalemia, true hypokalemia. Often, only laboratory values outside the normal range gain attention and false normal results are at risk of not being noticed. However, a disease state may be masked by another pathological process. Here, a 50-year old male was admitted to the Department of Internal Medicine due to sepsis from a dental infection. Initially, serum potassium measurement revealed a normal value of 4 mmol/L (reference interval 3.8-5.1 mmol/L). Thrombocyte number was above 500x109 /L...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882586/automated-high-throughput-igg-n-glycosylation-sample-preparation-method-development-on-the-tecan-freedom-evo-platform
#4
JOURNAL ARTICLE
Borna Rapčan, Maja Hanić, Branimir Plavša, Jelena Šimunović, Jerko Štambuk, Frano Vučković, Irena Trbojević-Akmačić, Mislav Novokmet, Gordan Lauc, Genadij Razdorov
INTRODUCTION: Glycomics, focusing on the role of glycans in biological processes, particularly their influence on the folding, stability and receptor interactions of glycoconjugates like antibodies, is vital for our understanding of biology. Changes in immunoglobulin G (IgG) N-glycosylation have been associated with various physiological and pathophysiological conditions. Nevertheless, time-consuming manual sample preparation is one of the limitations in the glycomics diagnostic implementation...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882585/preanalytical-analytical-and-postanalytical-considerations-in-circulating-micrornas-measurement
#5
REVIEW
Mustapha Zendjabil
Microribonucleic acids (miRNAs) have emerged as a new category of biomarkers for many human diseases like cancer, cardiovascular and neurodegenerative disorders. MicroRNAs can be detected in various body fluids including blood, urine and cerebrospinal fluid. However, the literature contains conflicting results for circulating miRNAs, which is the main barrier to using miRNAs as non-invasive biomarkers. This variability in results is largely due to differences between studies in sample processing methodology, miRNA quantification and result normalization...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882584/direct-and-indirect-reference-intervals-of-25-hydroxyvitamin-d-it-is-not-a-real-vitamin-d-deficiency-pandemic
#6
JOURNAL ARTICLE
Juan José Perales-Afán, Diego Aparicio-Pelaz, Sheila López-Triguero, Elena Llorente, Juan José Puente-Lanzarote, Marta Fabre
INTRODUCTION: Many studies report vitamin D (25-OH-D) deficiency, although there is no consensus among scientific societies on cut-offs and reference intervals (RI). The aim of this study is to establish and compare RI for serum 25-OH-D by direct and indirect methods. MATERIALS AND METHODS: Two studies were performed in Zaragoza (Spain). A retrospective study (N = 7222) between January 2017 and April 2019 was used for RI calculation by indirect method and a prospective study (N = 312) with healthy volunteers recruited in August 2019 and February 2020 for direct method...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882583/hairy-cell-leukemia-etiopathogenesis-diagnosis-and-modern-therapeutic-approach
#7
REVIEW
Katarzyna Maćkowiak, Magdalena Jankowiak, Karolina Szewczyk-Golec, Iga Hołyńska-Iwan
Hairy cell leukemia (HCL) represents 2% of all leukemia cases, with men aged above 55 years being the most affected. The most common symptoms of this type of leukemia include splenomegaly, monocytopenia, and neutropenia. In the basic blood count examination, leukopenia with monocytopenia and granulocytopenia, as well as aplastic anemia and/or thrombocytopenia occur. The mutation of β-rapidly accelerated fibrosarcoma ( BRAF ) proto-oncogene, which can be found in nearly 100% of patients, is an important feature of HCL...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882582/extracellular-vesicles-and-glycans-new-avenue-for-biomarker-research
#8
REVIEW
Tamara Janković, Miroslava Janković
The investigation of biomarkers is constantly evolving. New molecules and molecular assemblies, such as soluble and particulate complexes, emerged as biomarkers from basic research and investigation of different proteomes, genomes, and glycomes. Extracellular vesicles (EVs), and glycans, complex carbohydrates are ubiquitous in nature. The composition and structure of both reflect physiological state of paternal cells and are strikingly changed in diseases. The EV-associated glycans, alone or in combination with soluble glycans in related biological fluids, used as analytes, aim to capture full complex biomarker picture, enabling its use in different clinical settings...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882581/comparative-study-on-the-quality-control-effectiveness-of-ai-pbrtqc-and-traditional-pbrtqc-model-in-identifying-quality-risks
#9
COMPARATIVE STUDY
Xucai Dong, Xi Meng, Bin Li, Dongmei Wen, Xianfei Zeng
INTRODUCTION: We compared the quality control efficiency of artificial intelligence-patient-based real-time quality control (AI-PBRTQC) and traditional PBRTQC in laboratories to create favorable conditions for the broader application of PBRTQC in clinical laboratories. MATERIALS AND METHODS: In the present study, the data of patients with total thyroxine (TT4), anti-Müllerian hormone (AMH), alanine aminotransferase (ALT), total cholesterol (TC), urea, and albumin (ALB) over five months were categorized into two groups: AI-PBRTQC group and traditional PBRTQC group...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38882580/is-the-urinary-neutrophil-gelatinase-associated-lipocalin-concentration-in-children-and-adolescents-with-type-1-diabetes-mellitus-different-from-that-in-healthy-children
#10
JOURNAL ARTICLE
Bernardica Valent Morić, Ivan Šamija, Lavinia La Grasta Sabolić, Adriana Unić, Marijana Miler
INTRODUCTION: Diabetic kidney disease (DKD) is one of the major microvascular complications of type 1 diabetes mellitus (T1DM). Some studies suggest that changes of renal tubular components emerge before the glomerular lesions thus introducing the concept of diabetic tubulopathy with urinary neutrophil gelatinase-associated lipocalin (uNGAL) as a potential marker of DKD. This concept was not confirmed in all studies. MATERIALS AND METHODS: In 198 T1DM patients with median age 15 years and diabetes duration over one year, an albumin/creatinine ratio (ACR) was determined and uNGAL measured in spot urine sample...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665875/a-survey-on-the-practice-of-phlebotomy-in-lithuania-and-adherence-to-the-eflm-colabiocli-recommendations-continuous-training-and-clear-standard-operating-procedures-as-tools-for-better-quality
#11
JOURNAL ARTICLE
Ricardas Stonys, Dalius Vitkus
INTRODUCTION: The aim of this study was to determine the level of compliance of venous blood sampling (VBS) in Lithuania with the joint recommendations of the European Federation of Clinical Chemistry and Laboratory Medicine and the Latin American Confederation of Clinical Biochemistry (EFLM-COLABIOCLI) and to analyse possible causes of errors. A survey was conducted between April and September 2022. MATERIALS AND METHODS: A self-designed questionnaire was distributed to the Lithuanian National Societies...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665874/comparison-of-lipemia-interference-created-with-native-lipemic-material-and-intravenous-lipid-emulsion-in-emergency-laboratory-tests
#12
COMPARATIVE STUDY
Emel Çolak Samsum, Hatice Sürer, Serkan Bolat, Mehmet Şeneş, Doğan Yücel
INTRODUCTION: This study aimed to investigate the effects of lipemia on clinical chemistry and coagulation parameters in native ultralipemic (NULM) and intravenous lipid emulsion (IVLE) spiked samples. MATERIALS AND METHODS: The evaluation of biochemistry (photometric, ion-selective electrode, immunoturbidimetric method), cardiac (electrochemiluminescence immunoassay method) and coagulation (the viscosity-based mechanical method for prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and the immunoturbidimetric method for D-dimer) parameters were conducted...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665873/two-cases-with-discrepancy-in-the-quantitative-cytological-assessment-of-cerebrospinal-fluid-in-neonatal-samples-using-light-microscopy-in-comparison-with-sysmex-xn-1000
#13
COMPARATIVE STUDY
Pavel Broz, Simona Kukralova, Jana Palatova, Klara Kolduskova, Jana Zenkova, Daniel Rajdl, Jaroslav Racek
We present two cases from the neonatal department with cerebrospinal fluid examination. We revealed a striking discrepancy in polymorphonuclear (PMN) and mononuclear (MN) cell counts using conventional light microscopy in comparison with automated analyzer Sysmex XN-1000 (PMNs - 13 vs . 173x106 /L, MNs - 200 vs . 67x106 /L in case 1 and PMNs - 13 vs . 372x106 /L, MNs - 411 vs . 179x106 /L in case 2). We revealed the dominant presence of hemosiderophages in both cases in cytospin slide. Even though Sysmex XN-1000 offers fast examination with a low sample volume, there is possibility of misdiagnosis, with negative impact on the patient...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665872/hematological-investigations-in-a-case-of-intravascular-hemolysis-due-to-clostridium-perfringens-infection
#14
JOURNAL ARTICLE
Anamarija Beljan, Viktorija Blagec, Ana Bronic, Marina Pavić
A patient presented with fever, severe pain and edematous tight due to hip trauma and was scheduled for urgent fasciotomy. Following physical examination, laboratory analyses were requested, and results revealed anemia and severe infection. As the patient's condition was serious, a new set of samples was sent to the laboratory four hours later. Following centrifugation, severely hemolyzed dark-colored serum and plasma samples were obtained and in vitro hemolysis was suspected. The collection of samples was repeated, but a new set of samples was also hemolyzed with a significant decrease in the hemoglobin value...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665871/prediction-interval-a-powerful-statistical-tool-for-monitoring-patients-and-analytical-systems
#15
REVIEW
Abdurrahman Coskun
Monitoring is indispensable for assessing disease prognosis and evaluating the effectiveness of treatment strategies, both of which rely on serial measurements of patients' data. It also plays a critical role in maintaining the stability of analytical systems, which is achieved through serial measurements of quality control samples. Accurate monitoring can be achieved through data collection, following a strict preanalytical and analytical protocol, and the application of a suitable statistical method. In a stable process, future observations can be predicted based on historical data collected during periods when the process was deemed reliable...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665870/quality-assurance-of-add-on-testing-in-plasma-samples-stability-limit-for-29-biochemical-analytes
#16
JOURNAL ARTICLE
Francisco J Illana, Álvaro García-Osuna, María Sospedra, Rosa Ferrer, Cecília Martínez-Brú, Leonor Guiñón
INTRODUCTION: Clinical laboratories should guarantee sample stability in specific storage conditions for further analysis. The aim of this study is to evaluate the stability of plasma samples under refrigeration for 29 common biochemical analytes usually ordered within an emergency context, in order to determine the maximum allowable period for conducting add-on testing. MATERIALS AND METHODS: A total of 20 patient samples were collected in lithium heparin tubes without gel separator...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665869/corrigendum-to-negligible-effect-of-vitamin-d-supplementation-on-exacerbation-in-patients-with-chronic-obstructive-pulmonary-disease-meta-analysis
#17
Ye Hua, Ting Jiang, Jiangyi Feng, Mi Zou
[This corrects the article , PMID: 37841773.].
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665868/a-case-report-of-biclonal-immunoglobulin-d-lambda-lambda-multiple-myeloma-in-patient-with-liver-echinococcosis
#18
Andrea Prce, Željka Dunđerović, Ivanka Mikulić, Vinka Mikulić, Kristina Ljubić, Ana Ćuk, Ante Bogut, Josip Petrović, Mile Volarić, Tomislav Čolak, Fila Raguž
Less than 2% of all symptomatic multiple myeloma (MM) has immunoglobulin D (IgD) as monoclonal protein. Biclonal gammopathy is much rarer. At the time of diagnosis, disease is often in advanced stage, including renal failure, anemia, hypercalcemia and lytic bone lesions. Due to the rarity of myeloma itself, but also due to the fact that anti-IgD antisera is not used in routine practice, there are only a few reports of IgD MM described in the literature. This case report describes a patient with IgD lambda MM with anemia and renal failure...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665867/clsi-based-verification-and-de-novo-establishment-of-reference-intervals-for-common-biochemical-assays-in-croatian-newborns
#19
JOURNAL ARTICLE
Iva Friščić, Sonja Perkov, Andrea Radeljak, Jasminka Stipanović-Kastelić, Mirjana Mariana Kardum Paro
INTRODUCTION: This study aimed to examine whether the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) reference intervals for 19 commonly used biochemical assays (potassium, sodium, chloride, calcium, magnesium, inorganic phosphorous, glucose, urea, creatinine, direct and total bilirubin, C-reactive protein (CRP), total protein, albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and lactate dehydrogenase (LD)) could be applied to the newborn population of one Croatian clinical hospital...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://read.qxmd.com/read/38665866/common-p-glycoprotein-abcb1-polymorphisms-do-not-seem-to-be-associated-with-the-risk-of-rivaroxaban-related-bleeding-events-preliminary-data
#20
JOURNAL ARTICLE
Ana Marija Slišković, Jozefina Palić, Tamara Božina, Lana Ganoci, Majda Vrkić Kirhmajer, Vladimir Trkulja, Joško Bulum, Livija Šimičević
INTRODUCTION: Considering conflicting previous reports, we aimed to evaluate whether the common ABCB1 polymorphisms (rs1128503, rs2032582, rs1045642, rs4148738) affected the risk of bleeding in rivaroxaban-treated patients. MATERIALS AND METHODS: We report preliminary data from a larger nested case-control study. Consecutive adults started on rivaroxaban for any indication requiring > 6 months of treatment were followed-up to one year. Patients who experienced major or non-major clinically relevant bleeding during the initial 6 months were considered cases, whereas subjects free of bleeding over > 6 months were controls...
June 15, 2024: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
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