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Medical Science Monitor: International Medical Journal of Experimental and Clinical Research

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https://read.qxmd.com/read/30785872/diagnostic-and-management-options-of-osteoblastoma-in-the-spine
#1
Minhao Wu, Keke Xu, Yuanlong Xie, Feifei Yan, Zhouming Deng, Jun Lei, Lin Cai
BACKGROUND Osteoblastoma is a rare, benign, osteolytic neoplasm commonly found in the spine in early adulthood. Here, we review the clinical characteristics, radiographic findings, and surgical management of patients with spinal osteoblastoma. MATERIAL AND METHODS Thirteen patients with osteoblastoma who underwent surgery at our institute from June 2008 to November 2017 were enrolled in this study. The American Spinal Injury Association (ASIA) impairment scale was used to assess neurological function. All patients were treated with either total excision or intralesional piecemeal excision without postoperative radiotherapy...
February 20, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30785126/antitumor-activity-of-asiaticoside-against-multiple-myeloma-drug-resistant-cancer-cells-is-mediated-by-autophagy-induction-activation-of-effector-caspases-and-inhibition-of-cell-migration-invasion-and-stat-3-signaling-pathway
#2
Li Yingchun, Wang Huihan, Zhang Rong, Zhang Guojun, Yang Ying, Liu Zhuogang
BACKGROUND Accumulating evidence suggests that plant-derived molecules may prove extremely beneficial in the development of chemotherapy for deadly cancer types. Multiple myeloma is a rare and incurable type of cancers. Very little research has been directed towards the development of chemotherapy for the management of multiple myeloma. Here, the anticancer effects of a plant-derived triterpenoid, Asiaticoside, were examined against the drug-resistant myeloma cell line KM3/BTZ. MATERIAL AND METHODS Cell viability was determined by CCK-8 assay and autophagy was checked by transmission electron microscopy...
February 20, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30783076/long-term-outcomes-of-ligation-of-the-inter-sphincteric-fistula-tract-plus-bioprosthetic-anal-fistula-plug-lift-plug-in-the-treatment-of-trans-sphincteric-perianal-fistula
#3
Baocheng Zhao, Zhenjun Wang, Jiagang Han, Yi Zheng, Jinjie Cui, Sanshui Yu
BACKGROUND The ligation of the inter-sphincteric fistula tract plus bioprosthetic anal fistula plug (LIFT-plug) is a new procedure in the treatment of trans-sphincteric perianal fistulas. The aim of this study was to evaluate its long-term outcomes. MATERIAL AND METHODS Clinical data of 78 patients with trans-sphincteric perianal fistula who were managed by the LIFT-plug technique between March 2014 to October 2016 were analyzed retrospectively. The operation time, healing rate, postoperative complications, recurrences, and length of stay were reviewed...
February 20, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30779728/circrna-circ_0067934-overexpression-correlates-with-poor-prognosis-and-promotes-thyroid-carcinoma-progression
#4
Huihui Wang, Xiaoguang Yan, Haijun Zhang, Xiaorong Zhan
BACKGROUND Circular RNAs are important regulators in human cancers, including thyroid carcinoma. The circ_0067934 RNA is reported to participate in hepatocellular carcinoma, esophageal squamous cell carcinoma, and lung cancer. Whether it regulates thyroid carcinoma remains unclear. The purpose of this study was to research potential mechanisms of circ_0067934 in thyroid tumors to provide potential new diagnostic and treatment targets. MATERIAL AND METHODS The expression level of circ_0067934 in thyroid tumors, adjacent tissues, and cell lines was measured by qRT-PCR...
February 19, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30778023/silent-cerebral-infarcts-following-left-sided-accessory-pathway-ablation-in-wolff-parkinson-white-wpw-syndrome-a-preliminary-report
#5
Andrzej Głowniak, Marzena Janczarek, Adam Tarkowski, Anna Wysocka, Malgorzata Szczerbo-Trojanowska, Andrzej Wysokiński
BACKGROUND Catheter ablation is a routine procedure in patients with WPW syndrome. Silent cerebral infarcts (SCI) detected in magnetic resonance imaging may be a complication of the ablation procedure, but it is well documented only in atrial fibrillation ablation. Ablation of left-sided accessory pathways (L-AP) has a similar target area, but WPW patients differ from those with atrial fibrillation, due to lower initial risk of cerebral embolic events. The aim of this study was to determine whether the ablation of left-sided accessory pathways carries the risk of SCI...
February 19, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30778022/mir-34b-3p-represses-the-multidrug-chemoresistance-of-bladder-cancer-cells-by-regulating-the-ccnd2-and-p2ry1-genes
#6
Yiao Tan, Tengyue Zhang, Linyu Zhou, Shuhan Liu, Chaozhao Liang
BACKGROUND Chemoresistance is a main limitation in chemotherapy for therapeutic cancer. MicroRNA (miRNA) has been indicated in the progression and tumorigenesis of many types of cancer, but the effect of miR-34b-3p in bladder cancer (BCa) cells is still unknown. MATERIAL AND METHODS This research compared the multidrug-sensitive (5637) BCa cell line and the multidrug-resistant (EJ) BCa cell line. We found that CCND2 (G1/S-specific cyclin-D2) and P2RY1 (purinergic receptor P2Y1) were the targets of miR-34b-3p, as further validated by qRT-PCR (quantitative real-time polymerase chain reaction) and western blot analysis...
February 19, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30776287/dynamic-fixation-versus-static-fixation-for-distal-tibiofibular-syndesmosis-injuries-a-meta-analysis
#7
Kaifeng Gan, Ke Zhou, Keqi Hu, Liangjie Lu, Shirong Gu, Yandong Shen
BACKGROUND Ankle sprains with distal tibiofibular syndesmosis injuries (DTSIs) require anatomic reduction and fixation to restore the normal biomechanics of the ankle joint. In the last decade, dynamic fixation (DF) for DTSIs using a suture-button device has gained popularity because of its advantages over static fixation (SF). MATERIAL AND METHODS The present meta-analysis was conducted to compare clinical outcomes between DF and SF of DTSIs. PubMed, Cochrane Central Register of Controlled Trials, and Embase were systematically searched...
February 18, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30774116/functional-genetic-single-nucleotide-polymorphisms-snps-in-cyclin-dependent-kinase-inhibitor-2a-b-cdkn2a-b-locus-are-associated-with-risk-and-prognosis-of-osteosarcoma-in-chinese-populations
#8
Huahui Zhang, Jian-S Mao, Wei-F Hu
BACKGROUND Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) encodes several tumor suppressor proteins. Aberrant genetic alterations in CDKN2A/B were found in some malignancies, which were believed to be associated with tumor originating and progression. We hypothesized that CDKN2A/B genetic polymorphisms might be associated with the risk of poorer prognosis of osteosarcoma in Chinese populations. MATERIAL AND METHODS We included 184 validated osteosarcoma cases and 185 cancer-free healthy controls in the study...
February 18, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30773529/evaluation-of-relationship-between-occurrence-of-liver-cancer-and-methylation-of-fragile-histidine-triad-fhit-and-p16-genes
#9
Yu Bai, Yunzhi Shen, Qiang Yuan, Chengyu Lv, Qianzhe Xing
BACKGROUND We examined the level of fragile histidine triad (FHIT) and p16 gene methylation in patients with hepatocellular carcinoma and explored the relationship to liver cancer. MATERIAL AND METHODS There were 56 patients with primary liver cancer who were admitted to the hospital from July 2015 to October 2017 included in the liver cancer group, and 24 non-hepatoma patients (hepatitis A/hepatitis B/hepatitis C, liver cirrhosis, liver fibrosis, and fatty liver, alcoholic liver identified as a control group...
February 18, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30772888/phosphatase-actin-regulator-1-phactr-1-knockdown-suppresses-cell-proliferation-and-migration-and-promotes-cell-apoptosis-in-the-bend-3-mouse-brain-capillary-endothelial-cell-line
#10
Yao Jing, Lin Zhang, Zhiming Xu, Hao Chen, Shiming Ju, Jun Ding, Yan Guo, Hengli Tian
BACKGROUND The phosphatase actin regulator-1 (PHACTR-1) gene on chromosome 6 encodes an actin and protein phosphatase 1 (PP1) binding protein, Phactr-1, which is highly expressed in brain tissues. Phactr-1 expression is involved in physiological and pathological cerebral microvascular events. This study aimed to investigate the role of expression of Phactr-1 in a mouse brain capillary endothelial cell line, bEnd.3, by knockdown the PHACTR-1 gene. MATERIAL AND METHODS Three bEnd.3 cell groups were studied, CON (normal control cells), NC (control scramble transfected cells), and KD (cells with PHACTR-1 gene knockdown)...
February 17, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30772887/ursolic-acid-exhibits-potent-anticancer-effects-in-human-metastatic-melanoma-cancer-cells-sk-mel-24-via-apoptosis-induction-inhibition-of-cell-migration-and-invasion-cell-cycle-arrest-and-inhibition-of-mitogen-activated-protein-kinase-mapk-erk-signaling-pathway
#11
Pengcheng Liu, Ruili Du, Xin Yu
BACKGROUND Ursolic acid is an important bioactive triterpenoid that has been reported to be of tremendous pharmacological importance. However, the anticancer potential of ursolic acid has not been examined against metastatic melanoma cells. Therefore, in this study we examined the anticancer potential of ursolic acid and its mode of action. MATERIAL AND METHODS WST-1 and colony formation assays were used for cell viability assessment. Cell cycle analysis was performed by flow cytometry. Apoptosis was detected by AO/EB staining using fluorescence microscopy...
February 17, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30771277/association-between-activation-of-the-programmed-cell-death-1-pd-1-programmed-death-ligand-1-pd-l1-pathway-and-pain-in-patients-with-cancer
#12
Jian Zhang, Huali Zhang, Yongli Luo
BACKGROUND The aim of this study was to investigate the clinical correlation between sPD-1 (soluble programmed cell death-1) and PD-1 (programmed cell death-1) expression and cancer pain. MATERIAL AND METHODS sPD-1 content in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA). T cell surface-positive rate was determined by flow cytometry, and the correlation of clinical characteristics of patients with cancer pain was analyzed. RESULTS The positive expression rate of PD-1 in sPD-1 and T cells of patients with cancer pain was higher than that in normal patients...
February 16, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30770700/acupuncture-as-an-adjunctive-treatment-for-angina-due-to-coronary-artery-disease-a-meta-analysis
#13
Xiaolou Huang, Shuwen Guo, Fanghe Li, Xiaobo Tan, Qian Cai, Hui Wang, Panbi Chen, Guohua Wang, Xiaona Ma
BACKGROUND In traditional Chinese medicine, acupuncture has been used to treat angina due to coronary artery disease (CAD). The aim of this systematic review of the literature and meta-analysis was to identify published randomized controlled trials (RCTs) that quantified the effectiveness of adjunctive acupuncture treatment in patients with angina due to CAD who were also treated with Western or Chinese medicine. MATERIAL AND METHODS A systematic review of the literature included a search of the PubMed, Embase, Cochrane library, and China National Knowledge Infrastructure (CNKI) databases, from their inception to September 2018...
February 16, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30770526/surgical-resection-of-primary-ewing-s-sarcoma-of-bone-improves-overall-survival-in-patients-presenting-with-metastasis
#14
Yingqing Ren, Zhida Zhang, Liyong Shang, Xinmao You
BACKGROUND Metastatic Ewing's sarcoma (ES) of bone has a poor prognosis. Because there have been few previous studies on the prognostic factors and clinical outcome in patients with ES who have metastases at presentation, the aim of this study was to use the Surveillance, Epidemiology, and End Results (SEER) database to compare the clinical outcome following single and combined radiation treatment and surgery. MATERIAL AND METHODS The SEER database was used to identify patients with ES who presented with bone involvement and metastasis between 1973 to 2015...
February 16, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30768589/long-non-coding-rna-tfap2a-as1-inhibits-cell-proliferation-and-invasion-in-breast-cancer-via-mir-933-smad2
#15
Bin Zhou, Haiyan Guo, Jinhai Tang
BACKGROUND It is well documented that long non-coding RNAs (lncRNAs) are involved in the progression of multiple human tumors by sponging microRNAs (miRNAs). However, whether lncRNA TFAP2A-AS1 plays a role in the tumorigenesis of breast cancer (BC) remains undetermined. MATERIAL AND METHODS Real-time PCR (qRT-PCR) assay was performed to detect the relative mRNA expression of TFAP2A-AS1 and miR-933. Flow cytometry analysis, CCK-8 assay, and Transwell assay were applied to detect the effects of TFAP2A-AS1 overexpression on cell cycle, apoptosis, viability, and invasion of BC cells...
February 15, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30767945/simvastatin-improves-cardiac-hypertrophy-in-diabetic-rats-by-attenuation-of-oxidative-stress-and-inflammation-induced-by-calpain-1-mediated-activation-of-nuclear-factor-%C3%AE%C2%BAb-nf-%C3%AE%C2%BAb
#16
QianQian Han, QianQian Liu, Hui Zhang, Meili Lu, Hongxin Wang, Futian Tang, Yingjie Zhang
BACKGROUND Simvastatin, an HMG-CoA reductase inhibitor, has been reported to exert multiple protective effects on the cardiovascular system. However, the molecular mechanism remains to be examined. The present study was designed to study the effects of simvastatin on cardiac hypertrophy in diabetic rats and to explore its potential mechanism. MATERIAL AND METHODS Sprague-Dawley rats were assigned into a control (Con) group, a streptozotocin (STZ) group, and a STZ+simvastatin (STZ+SIM) group. The level of reactive oxygen species (ROS) was measured by using dihydroethidium (DHE) staining...
February 15, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30765684/resveratrol-reduces-oxidative-stress-and-apoptosis-in-podocytes-via-sir2-related-enzymes-sirtuins1-sirt1-peroxisome-proliferator-activated-receptor-%C3%AE-co-activator-1%C3%AE-pgc-1%C3%AE-axis
#17
Tao Zhang, Yanqing Chi, Yunzhuo Ren, Chunyang Du, Yonghong Shi, Ying Li
BACKGROUND PGC-1α can be activated by deacetylation reactions catalyzed by SIRT1. Resveratrol is currently known as a potent activator of SIRT1. However, it is unknown whether the renal-protective effect of resveratrol is further related to activation of the podocyte SIRT1/PGC-1α pathway. MATERIAL AND METHODS High glucose was used to stimulate mouse podocytes. Resveratrol and PGC-1α siRNA transfection were used to perform co-intervention treatments. The protein and mRNA expression levels of SIRT1, PGC-1α, NRF1, and TFAM were detect by immunofluorescence, Western blot analysis, and qRT-PCR in the podocytes, respectively...
February 15, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30763293/knockdown-of-long-noncoding-rna-pou5f1b-promotes-radiosensitivity-in-esophageal-carcinoma
#18
Bi Meng, Yao Xing, Hao Li, Fei Gao, Yang Chen Liu
BACKGROUND POU5F1B, serving as a carcinogen, participates in radiosensitivity of several tumors. However, in esophageal cancer, its potential mechanism and function in regulating radiosensitivity remain unclear. MATERIAL AND METHODS The expression level of POU5F1B was detected in plasma of esophageal tumor patients and cancer cell lines. The effect of POU5F1B knockdown on cell proliferation and colony formation was determined using CCK-8 assay and colony formation assay. Cell apoptosis rate was detected by flow cytometry...
February 14, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30762028/the-octamer-binding-transcription-factor-4-oct4-pseudogene-pou-domain-class-5-transcription-factor-1b-pou5f1b-is-upregulated-in-cervical-cancer-and-down-regulation-inhibits-cell-proliferation-and-migration-and-induces-apoptosis-in-cervical-cancer-cell-lines
#19
Jingwen Yu, Jingling Zhang, Liulin Zhou, Hao Li, Zhao-Qun Deng, Bi Meng
BACKGROUND The POU domain class 5 transcription factor 1B (POU5F1B), is a pseudogene that is homologous to octamer-binding transcription factor 4 (OCT4), and is located adjacent to the MYC gene on human chromosome 8q24. POU5F1B has been reported to be transcribed in several types of cancer, but its role in cervical cancer remains unclear. This study aimed to investigate the expression and function of POU5F1B in tissue samples of human cervical cancer and in cervical cancer cell lines in vitro. MATERIAL AND METHODS Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to quantify POU5F1B expression in cervical cancer tissues and in SiHa, HeLa, CaSki, and C33A human cervical cancer cell lines...
February 14, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30760696/myocardial-performance-in-elite-athletes-the-role-of-homocysteine-iron-and-lipids
#20
Serkan Duyuler
BACKGROUND The myocardial performance index (MPI) is a comprehensive measure of global systolic and diastolic function of the ventricle, and it has an inverse correlation with maximal oxygen consumption. In this study, the potential association between left ventricle MPI and biochemical biomarkers (including iron, homocysteine, and lipids) in elite athletes was investigated. MATERIAL AND METHODS This cross-sectional observational study consisted of 80 young male elite soccer and basketball players (age: 18-34 years) examined for a seasonal medical check-up...
February 14, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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