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Journals Journal of Infection and Chemo...

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy

https://read.qxmd.com/read/36933829/a-therapeutic-regimen-of-ceftazidime-avibactam-for-a-critical-patient-receiving-prolonged-intermittent-renal-replacement-therapy
#1
Yu-Ying Yan, Yi Jin, Xiang-Yuan Cao, Song-Yu Chen, Wen-Hao Liu, Chen-Rui Shen, Yu-Shuang Qiu, Fu-Ming Shen, Min Ni
The present report firstly described a critically ill patient receiving a dosing regimen of ceftazidime-avibactam (CAZ-AVI) (1.875g q24h) to eliminate multidrug-resistant Klebsiella pneumoniae and a scheduled time for prolonged intermittent renal replacement therapy (PIRRT) every 48h (6h-session beginning 12h after the previous dosage on hemodialysis day). This dosing regimen for CAZ-AVI and a scheduled time for PIRRT allowed pharmacodynamic parameters of ceftazidime and avibactam to have little difference on hemodialysis and non-hemodialysis days so that we can maintain a relatively stable drug concentration...
March 16, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36925104/viral-loads-of-parainfluenza-virus-type-3-and-severity-of-respiratory-diseases-in-children
#2
JOURNAL ARTICLE
Mami Ichinose, Keiko Soneda, Meiwa Shibata, Kazue Kinoshita, Kento Ikegawa, Hiroshi Hataya, Yuho Horikoshi
BACKGROUND: Parainfluenza virus type 3 (PIV-3) is one of the common pathogens for respiratory infections in children. Whether viral load of PIV-3 is associated with severity of respiratory diseases in children is not yet known. Our aim was to determine significance of PIV-3 viral load among infected children. METHODS: We conducted a single-center, retrospective study at Tokyo Metropolitan. Children's Medical Center, Japan, from June to August 2021. Hospitalized children were screened with a posterior nasal swab for multiplex PCR, and viral load was subsequently measured from remained samples by real-time PCR...
March 14, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36921764/dexmedetomidine-may-reduce-the-risk-of-acute-kidney-injury-development-in-critically-ill-patients-during-colistin-therapy
#3
JOURNAL ARTICLE
Murat Kucuk, Cihan Heybeli, Mehmet Celal Ozturk, Bişar Ergun, Mehmet Nuri Yakar, Ali Necati Gokmen, Bilgin Comert, Begüm Ergan
INTRODUCTION: Colistin is considered as a last resort therapy for multidrug-resistant gram-negative organisms. It is widely used despite the significant risk of nephrotoxicity. Experimental studies showed the nephroprotective effect of dexmedetomidine, a sedative agent, against colistin toxicity. This study was performed to show the possible nephroprotective effect of dexmedetomidine among critically ill patients who received colistin. METHODS: Adult (>17 years) patients who were admitted to our surgical and medical intensive care unit (ICU) from March 2018 through March 2021, and who received colistin were included...
March 13, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36921763/pulmonary-phaeohyphomycosis-due-to-exophiala-dermatitidis-in-a-patient-with-pulmonary-non-tuberculous-mycobacterial-infection
#4
Daichi Setoguchi, Naoki Iwanaga, Yuya Ito, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Shotaro Ide, Shinnosuke Takemoto, Masato Tashiro, Naoki Hosogaya, Takahiro Takazono, Noriho Sakamoto, Yasushi Obase, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae
A 65-year-old Japanese woman repeatedly withdrew and resumed antibiotics against pulmonary non-tuberculous mycobacterial infection caused by Mycobacterium intracellulare for more than 10 years. Although she continued to take medications, her respiratory symptoms and chest computed tomography indicated an enlarged infiltrative shadow in the lingular segment of the left lung that gradually worsened over the course of a year or more. Bronchoscopy was performed and mycobacterial culture of the bronchial lavage fluid was negative, whereas Exophiala dermatitidis was detected...
March 13, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36921762/evaluation-of-the-performance-of-genesoc%C3%A2-a-novel-rapid-real-time-pcr-system-to-detect-staphylococcus-aureus-and-methicillin-resistance-in-blood-cultures
#5
JOURNAL ARTICLE
Mikiko Chiba, Tetsuji Aoyagi, Makiko Yoshida, Makoto Katsumi, Shin-Ichi Fujimaki, Yoshikazu Ishii, Kazuhiro Tateda, Mitsuo Kaku
Staphylococcus aureus bacteremia results in substantial mortality. Rapid identification and the determination of methicillin susceptibility are crucial for immediate treatment with appropriate antibiotics. In the present study, we aimed to evaluate the basic assay performance of GeneSoC®, a novel rapid quantitative polymerase chain reaction (qPCR) method, for the detection of methicillin-susceptible (MS) or -resistant (MR) S. aureus in blood culture (BC) bottles. qPCR pimers and probes were desinged for femA and mecA genes to diagnose S...
March 13, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36921761/combination-of-uc-3500-and-uf-5000-as-a-quick-and-effective-method-to-exclude-bacterial-urinary-tract-infection
#6
JOURNAL ARTICLE
Yabin Chen, Zhishan Zhang, Yanjun Diao, Wanni Wang, Yan Zhu, Jiaming Li, Gangqiang Wang, Yuan Zhao, Zhenzhong Lin, Yibo Wu, Jing Jing
BACKGROUND: Our study aims to evaluate the performance of the combination of Sysmex urine dry chemistry analyzer UC-3500 and urine particle analyzer UF-5000 in screening bacterial urinary tract infection (UTI). METHODS: We analyzed 2000 urine specimens from patients with suspected UTI by using a urine dry chemistry analyzer (UC-3500) and a fully automated sediment analyzer (UF-5000). After being tested by the instrument, all specimens were sent to our clinical microbiology laboratory for culture...
March 13, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36914095/evaluation-of-residual-humoral-immune-response-against-sars-cov-2-by-a-surrogate-virus-neutralization-test-svnt-9-months-after-bnt162b2-primary-vaccination
#7
JOURNAL ARTICLE
Laura Pezzati, Laura Milazzo, Giorgia Carrozzo, Cristina Kullmann, Letizia Oreni, Martina Beltrami, Stefania Caronni, Alessia Lai, Livio Caberlotto, Cosimo Ottomano, Spinello Antinori, Anna Lisa Ridolfo
The humoral response to SARS-CoV-2 vaccination has shown to be temporary, although may be more prolonged in vaccinated individuals with a history of natural infection. We aimed to study the residual humoral response and the correlation between anti-Receptor Binding Domain (RBD) IgG levels and antibody neutralizing capacity in a population of health care workers (HCWs) after 9 months from COVID-19 vaccination. In this cross-sectional study, plasma samples were screened for anti-RBD IgG using a quantitative method...
March 11, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36914094/risk-evaluation-of-carbapenem-induced-liver-injury-based-on-machine-learning-analysis
#8
JOURNAL ARTICLE
Yuki Asai, Hayahide Ooi, Yoshiharu Sato
INTRODUCTION: Information regarding carbapenem-induced liver injury is limited, and the rate of liver injury caused by meropenem (MEPM) and doripenem (DRPM) remains unknown. Decision tree (DT) analysis, a machine learning method, has a flowchart-like model where users can easily predict the risk of liver injury. Thus, we aimed to compare the rate of liver injury between MEPM and DRPM and construct a flowchart that can be used to predict carbapenem-induced liver injury. METHODS: We investigated patients treated with MEPM (n = 310) or DRPM (n = 320) and confirmed liver injury as the primary outcome...
March 11, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36907551/risk-factors-and-pathogen-characteristics-associated-with-unfavorable-outcomes-among-adults-with-pneumococcal-meningitis-in-japan-2006-to-2016
#9
JOURNAL ARTICLE
Satoshi Iwata, Shigeo Hanada, Misako Takata, Miyuki Morozumi, Satoshi Kamei, Kimiko Ubukata
PURPOSE: In this study, we aimed to clarify the risk factors associated with unfavorable outcomes in adults with pneumococcal meningitis (PnM). METHODS: Surveillance was conducted between 2006 and 2016. Adults with PnM (n = 268) were followed up for outcomes within 28 days after admission using the Glasgow Outcome Scale (GOS). After classifying the patients into the unfavorable (GOS1-4) and favorable (GOS5) outcome groups, i) the underlying diseases, ii) biomarkers at admission, and iii) serotype, genotype, and antimicrobial susceptibility for all isolates were compared between both groups...
March 10, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36898502/verification-of-quality-assurance-for-blood-culture-surveillance-using-6%C3%A2-years-of-data-from-the-japan-infection-prevention-and-control-conference-for-national-and-public-university-hospitals
#10
JOURNAL ARTICLE
Makiko Kiyosuke, Shota Morishita, Kiyotaka Nakaie, Shuhei Kondo, Kazunari Sonobe, Miki Goto, Kazutaka Ohashi, Seiya Kashiyama
The importance of blood culture has been widely recognized, and there is a need for monitoring to evaluate the accuracy of blood culture that reflects domestic healthcare systems. In this study, we assessed 6-year trends in blood culture quality assurance data. The Japan Infection Prevention and Control Conference for National and Public University Hospitals conducted yearly blood culture surveillance at 52 national public university hospitals from 2015 to 2020. Statistical analysis showed that comparison with the previous year showed significant differences in the number of blood cultures per 1000 patient-days in all years...
March 8, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36898501/adherence-to-use-of-blood-cultures-according-to-current-national-guidelines-and-their-impact-in-patients-with-community-acquired-pneumonia-a-retrospective-cohort
#11
JOURNAL ARTICLE
Rafael Ruiz-Gaviria, Arturo Marroquin-Rivera, Maria D Pardi, Robert W Ross
BACKGROUND: Community acquired pneumonia (CAP) is the most frequent cause of mortality secondary to infectious etiologies. Recommendations about the use of blood cultures in the diagnosis and treatment of CAP has been a contentious topic of debate and ever-changing recommendations. METHODS: A cohort study was conducted in a community teaching hospital. All the patients that were admitted with a diagnosis of CAP, between January and December of 2019 were included...
March 8, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36894016/assessment-of-environmental-surface-contamination-with-sars-cov-2-in-concert-halls-and-banquet-rooms-in-japan
#12
JOURNAL ARTICLE
Hidehito Matsui, Chihiro Ueda, Eri Nakajima, Yumiko Suzuki, Harumi Endo, Miho Sugamata, Yukiko Takarabe, Yukie Yamaguchi, Masako Honsho, Rei Hokari, Aki Ishiyama, Yasuo Imoto, Hideaki Hanaki
BACKGROUND: Although crowds are considered to be a risk factor for SARS-CoV-2 transmission, little is known about the changes in environmental surface contamination with the virus when a large number of people attend an event. In this study, we evaluated the changes in environmental surface contamination with SARS-CoV-2. METHODS: Environmental samples were collected from concert halls and banquet rooms before and after events in February to April 2022 when the 7-day moving average of new COVID-19 cases in Tokyo was reported to be 5000-18000 cases per day...
March 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36894015/prospective-study-of-three-saliva-qualitative-antigen-testing-kits-for-the-detection-of-sars-cov-2-among-mainly-symptomatic-patients-in-japan
#13
JOURNAL ARTICLE
Norihiko Terada, Yusaku Akashi, Yuto Takeuchi, Atsuo Ueda, Shigeyuki Notake, Koji Nakamura, Hiromichi Suzuki
INTRODUCTION: Rapid qualitative antigen testing has been widely used for the laboratory diagnosis of COVID-19 with nasopharyngeal samples. Saliva samples have been used as alternative samples, but the analytical performance of those samples for qualitative antigen testing has not been sufficiently evaluated. METHODS: A prospective observational study evaluated the analytical performance of three In Vitro Diagnostics (IVD) approved COVID-19 rapid antigen detection kits for saliva between June 2022 and July 2022 in Japan using real-time reverse transcription polymerase chain reaction (RT-qPCR) as a reference...
March 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36894014/inactivation-of-nontuberculous-mycobacteria-by-gaseous-ozone-treatment
#14
JOURNAL ARTICLE
Kana Misawa, Tomoyasu Nishimura, Shoko Kashimura, Naoki Hasegawa
Nontuberculous mycobacteria (NTM) are environmental bacteria resistant to many common disinfectants and ultraviolet radiation. Inhalation of aerosols generated from NTM-containing water and soil causes NTM lung disease, especially in people with underlying lung diseases and decreased immunity. To prevent healthcare-acquired NTM infections, it is important to eradicate NTM living in hospital environments. Therefore, we evaluated the efficacy of gaseous ozone for the inactivation of NTM, namely Mycobacterium (M...
March 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36871825/single-center-survey-of-prescription-trends-and-appropriate-use-plans-for-macrolide-antimicrobials
#15
JOURNAL ARTICLE
Tomoyuki Kato, Masayuki Nagasawa, Ippei Tanaka, Yuka Seyama, Reiko Sekikawa, Shiori Yamada
INTRODUCTION: Macrolides (MCs) are broad-spectrum antimicrobials with activity against many microorganisms. They are widely used, and the development of MC-resistant bacteria is a serious problem in Japan. It is therefore necessary to clarify the purpose and duration of administration, with the aim of promoting appropriate use. METHODS: Patients of all ages, for whom oral MCs were prescribed between 2016 and 2020 were included. They were divided into four groups based on the number of days per prescription...
March 3, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36871824/the-combination-of-levodopa-with-levodopa-metabolizing-enzyme-inhibitors-prevents-severe-fever-with-thrombocytopenia-syndrome-virus-infection-in-vitro-more-effectively-than-single-levodopa
#16
JOURNAL ARTICLE
Motohiko Ogawa, Mana Murae, Tomoharu Mizukami, Ryutaro Gemba, Takuya Irie, Masayuki Shimojima, Hideki Ebihara, Kohji Noguchi, Masayoshi Fukasawa
Severe fever with thrombocytopenia syndrome is a hemorrhagic fever caused by a tick-borne infection. The causative agent, Dabie bandavirus, is also called the severe fever with thrombocytopenia syndrome virus (SFTSV). Ogawa et al. (2022) reported that levodopa, an antiparkinsonian drug with an o-dihydroxybenzene backbone, which is important for anti-SFTSV activity, inhibited SFTSV infection. Levodopa is metabolized by dopa decarboxylase (DDC) and catechol-O-methyltransferase (COMT) in vivo. We evaluated the anti-SFTSV efficacy of two DDC inhibitors, benserazide hydrochloride and carbidopa, and two COMT inhibitors, entacapone and nitecapone, which also have an o-dihydroxybenzene backbone...
March 3, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36871823/prognostic-factors-among-patients-with-shiga-toxin-producing-escherichia-coli-hemolytic-uremic-syndrome-a-retrospective-cohort-study-using-a-nationwide-inpatient-database-in-japan
#17
JOURNAL ARTICLE
Shota Myojin, Nobuaki Michihata, Kensuke Shoji, Jun-Ichi Takanashi, Hiroki Matsui, Kiyohide Fushimi, Isao Miyairi, Hideo Yasunaga
INTRODUCTION: Shiga toxin-producing Escherichia coli (STEC) causes hemorrhagic colitis and hemolytic uremic syndrome (STEC-HUS). Understanding its prognostic factors is essential for immediate interventions. We examined early-phase unfavorable prognostic factors among patients with STEC-HUS using a nationwide database. MATERIAL AND METHODS: This is a retrospective cohort study to analyze practice patterns and identify prognostic factors among patients with STEC-HUS...
March 3, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36868408/pharmacokinetics-of-intravenous-daptomycin-in-japanese-pediatric-patients-pharmacokinetic-comparisons-supporting-dosing-recommendations-in-japanese-pediatric-patients
#18
JOURNAL ARTICLE
Mikio Ishii, Yuji Orito, Mari Shiomi, Rebecca E Wrishko, Hiroyuki Yoshitsugu
INTRODUCTION: The pharmacokinetics (PK) of daptomycin has not been previously characterized in Japanese pediatric patients with complicated skin and soft tissue infections (cSSTI) or bacteremia. An aim of the study including evaluation of PK of daptomycin in Japanese pediatric patients and an appropriateness of the age-specific, weight-based dosing regimens in Japanese pediatric patients based on PK comparison with Japanese adult patients. METHODS: The phase 2 trial enrolled Japanese pediatric patients (age 1-17 years) with cSSTI (n = 14) or bacteremia (n = 4) caused by gram-positive cocci in order to evaluate safety, efficacy and PK...
March 1, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36849098/evaluation-of-an-immunochromatography-based-rapid-antigen-test-inspecter-kowa-sars-cov-2-using-saliva-specimens-for-the-detection-of-sars-cov-2
#19
JOURNAL ARTICLE
Masahiro Kodana, Yuta Orihara, Mariko Tezuka, Rina Takahashi, Sakiko Noguchi, Nanako Matsuzaki, Tomohito Takada, Naomi Kobari, Kana Ogane, Rieko Kawamura, Toru Kawamura, Shinichi Takeuchi, Yuki Kamiyama, Rie Shiomi, Ryutaro Aoyagi, Masaya Saito, Takeru Kusano, Nobuaki Nakaya, Satoru Kaneko, Hideo Morita, Yoshihito Uchida, Hiroaki Yazawa, Ryu Sekiya, Kazuki Katayama, Shingo Mikami, Tomoya Sato, Norihito Tarumoto, Takehito Kobayashi, Hidetomo Nakamoto, Maeda Takuya
BACKGROUND: In the context of the coronavirus disease 2019 (COVID-19) pandemic, a rapid and reliable point-of-care test is an essential tool for controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In particular, an immunochromatography test (ICT) that uses saliva specimens for rapid antigen detection not only reduces the risk of secondary infections but also reduces the burden on medical personnel. METHODS: The newly developed salivary antigen test kit "Inspecter Kowa SARS-CoV-2" is an ICT to which saliva specimens can be directly applied...
February 25, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/36841329/sahachiro-hata-1873-1938-and-his-contributions-to-the-birth-of-antimicrobial-chemotherapy
#20
JOURNAL ARTICLE
Ichiro Kawamura
Sahachiro Hata was a Japanese collaborator who helped Paul Ehrlich in his quest to develop a drug treatment for syphilis as a 'magic bullet' that specifically targets the pathogen without affecting normal host cells. Before the 1900s, syphilis was feared worldwide as a chronic contagious disease that caused major sequelae, including death. Under Ehrlich's direction, Hata screened all known synthetic arsenic derivatives for antisyphilitic properties and found 'compound 606' effective against syphilis. 'Compound 606' was the first-line drug for syphilis until the advent of penicillin...
February 23, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
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