journal
Journals Journal of Infection and Chemo...

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy

https://read.qxmd.com/read/38012984/increased-expression-of-mycobacterium-tuberculosis-rv3737-gene-associated-with-low-level-amikacin-resistance
#1
JOURNAL ARTICLE
Qiong Li, Peng Tian, Chao Xu, Zhangli Peng, Peng Xu, Hong Zhang, Ling Chen
INTRODUCTION: As an infectious disease, tuberculosis (TB) poses a serious threat to public health. Although amikacin (AMK) is an important antibiotic for the treatment of drug-resistant TB, its resistance mechanisms are not fully understood. METHODS: To investigate the role of Rv3737 gene on AMK drug susceptibility, a Mycobacterium tuberculosis (M.tb) Rv3737 knockout strain (H37Rv△Rv3737) and a Mycobacterium smegmatis (M.sm) Rv3737 overexpressing strain (Msm/pMV261-Rv3737) were used to detect their minimal inhibitory concentrations (MICs) in this study...
November 25, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38000499/toxoplasma-gondii-igg-avidity-for-the-diagnosis-of-primary-infection-in-pregnant-women-comparison-between-chemiluminescent-microparticle-immunoassay-and-enzyme-linked-immunosorbent-assay
#2
JOURNAL ARTICLE
Hajime Ota, Hideto Yamada, Shinichiro Wada, Kenji Tanimura, Masashi Deguchi, Akiko Uchida, Akira Nishikawa
INTRODUCTION: This study evaluated whether IgG avidity measured by chemiluminescent microparticle immunoassay (CMIA) compared with enzyme-linked immunosorbent assay (ELISA) was useful to detect primary T. gondii infection during pregnancy and to estimate the risk for congenital T. gondii infection. METHODS: One hundred six women with positive tests for T. gondii IgG and T. gondii IgM, comprising 21 women (19.8%) with low (<30%), 6 (5.7%) with borderline (30%-35%), and 79 (74...
November 22, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38000498/enterococcal-infective-endocarditis-post-discharge-treatment-with-continuous-benzylpenicillin-and-ceftriaxone-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
Yael Szterenlicht, Yoed Steinmetz, Ziv Dadon, Yonit Wiener-Well
BACKGROUND: Enterococcal Infective Endocarditis (EIE) is usually treated with the combination of penicillin/ampicillin with gentamicin or ampicillin with ceftriaxone. To enable prolonged outpatient treatment, a combination of benzylpenicillin and ceftriaxone has been suggested. This study aimed to describe the incidence and characteristics of EIE and to determine the outcome of EIE cases treated with benzylpenicillin and ceftriaxone. METHODS: This was a retrospective single-center study including all patients diagnosed with infective endocarditis (IE) during 2016-2021, comparing EIE with IE caused by other pathogens...
November 22, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38000497/different-immunological-responses-following-immunization-with-two-mrna-vaccines
#4
JOURNAL ARTICLE
Nakayama Tetsuo, Reiko Todaka, Akihito Sawada, Takashi Ito, Motoko Fujino, Kei Haga, Kazuhiko Katayama
INTRODUCTION: Immunological responses were investigated following immunization with two mRNA vaccines: BNT162b2 and mRNA-1273. METHODS: Neutralizing antibody (NAb) was assayed before, 2-4 weeks after, and 3 and 6 months after the primary immunization, and the same time-points after booster dose with 6- or 8-months interval. Whole-blood culture was stimulated with spike antigen, and cytokine production was assayed. RESULTS: NAb was detected after primary immunization, NAb titers began to decrease three months after primary immunization with BNT162b2, lower than those after mRNA-1273, and elevated after booster immunization...
November 22, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37992864/streptococcus-suis-meningoencephalitis-diagnosed-with-metagenomic-next-generation-sequencing-a-case-report-with-literature-review
#5
Zai-Jie Jiang, Jian-Chen Hong, Qing-Xi Tang, Bi-Wei Lin, Wei-Qing Zhang, Han Xia, Xiang-Ping Yao
Streptococcus suis is a pathogen of emerging zoonotic diseases and meningoencephalitis is the most frequent clinical symptom of S. suis infection in humans. Rapid diagnosis of S. suis meningoencephalitis is critical for the treatment of the disease. While the current routine microbiological tests including bacterial culture and gram staining are poorly sensitive, diagnosis of S. suis meningoencephalitis by metagenomic next-generation sequencing (mNGS) has been rarely reported. Here, we report a 52-year-old female pork food producer with a broken finger developed S...
November 20, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37984540/prediction-of-acute-lung-injury-assessed-by-chest-computed-tomography-oxygen-saturation-fraction-of-inspired-oxygen-ratio-and-serum-lactate-dehydrogenase-in-patients-with-covid-19
#6
JOURNAL ARTICLE
Shin Matsubara, Kazuki Sudo, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Mao Kinoshita, Kunihiko Kooguchi, Satoru Shikata, Tohru Inaba, Teiji Sawa
INTRODUCTION: In treating acute hypoxemic respiratory failure (AHRF) caused by coronavirus disease 2019 (COVID-19), clinicians choose respiratory therapies such as low-flow nasal cannula oxygenation, high-flow nasal cannula oxygenation, or mechanical ventilation after assessment of the patient's condition. Chest computed tomography (CT) imaging contributes significantly to diagnosing COVID-19 pneumonia. However, the costs and potential harm to patients from radiation exposure need to be considered...
November 19, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37981024/risk-factors-for-cefmetazole-non-susceptible-bacteremia-in-acute-cholangitis
#7
JOURNAL ARTICLE
Katsuhiro Onishi, Hiroshi Morioka, Takahiro Imaizumi, Daisuke Tsuchimoto, Mitsuru Nishio, Takuma Komiyama
INTRODUCTION: Cefmetazole (CMZ), an antibiotic with limited international distribution, is recommended by the Tokyo Guidelines 2018 (TG18) for non-severe cases of acute cholangitis (AC). However, the risk factors for CMZ-non-susceptible (CMZ-NS) bacteremia in AC remain unclear. Here, we aimed to investigate the risk factors for CMZ-NS bacteremia and evaluate mortality in patients with AC. METHODS: This single-center, retrospective, observational study included all patients diagnosed with definite bacteremic AC, based on TG18, from April 2019 to March 2023...
November 17, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37979777/epidemiology-of-endemic-human-coronavirus-infection-during-the-covid-19-pandemic
#8
JOURNAL ARTICLE
Fujio Kakuya, Ryuta Terao, Hikaru Onoda, Hitoshi Okubo, Hiroaki Fujiyasu, Fumie Inyaku, Ai Fukuura, Toshio Arai, Takahiro Kinebuchi
INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the coronavirus family that also includes endemic human coronaviruses (HCoVs) types OC43, HKU1, 229E, and NL63. HCoVs share extensive sequence homology with SARS-CoV-2. It has been assumed that HCoV infection occur primarily in winter and spring in Japan before the coronavirus disease 2019 (COVID-19) pandemic and that its frequency is the same for all age groups. METHODS: Nasopharyngeal swab samples were collected for HCoVs and SARS-CoV-2...
November 16, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37979776/predicting-mortality-in-pediatric-sepsis-a-nationwide-data-analysis-using-a-pediatric-sepsis-surveillance-method
#9
JOURNAL ARTICLE
Shinya Miura, Nobuaki Michihata
INTRODUCTION: A sepsis surveillance method using electronic health records is increasingly used to describe the epidemiology of adult sepsis. However, its application in pediatric populations has been limited, and real-world epidemiology of pediatric sepsis remains unknown. We aimed to determine whether this surveillance method could identify children with sepsis at high-risk of mortality. PATIENTS AND METHODS: From a nationwide inpatient database in Japan, we included children who underwent blood culture and received antimicrobials for ≥ 4 days between 2014 and 2021...
November 16, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37977325/the-humoral-and-cellular-immune-responses-following-booster-vaccination-with-sars-cov-2-mrna-in-people-living-with-human-immunodeficiency-virus
#10
JOURNAL ARTICLE
Yuji Matsumoto, Masayuki Murata, Azusa Ohta, Sho Yamasaki, Hiroaki Ikezaki, Kazuhiro Toyoda, Nobuyuki Shimono
INTRODUCTION: People living with human immunodeficiency virus (PLWH) have higher mortality rates from COVID-19 than those without HIV. Additionally, the seroconversion rate of antibodies following a second dose of SARS-CoV-2 vaccine is lower in PLWH than non-infected individuals, indicating the need for booster vaccination. Here, we evaluated the humoral and cellular immune responses to booster SARS-CoV-2 vaccination in PLWH. METHODS: The dynamics of anti-spike IgG titers and antigen-specific interferon (IFN)-γ levels to SARS-CoV-2 vaccination were assessed over a 6-month period following a third vaccination of 34 PLWH...
November 15, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37972691/the-covidtw2-study-role-of-covid-19-vaccination-in-intubated-patients-with-covid-19-related-acute-respiratory-distress-syndrome-in-taiwan
#11
JOURNAL ARTICLE
Kuan-Chun Wong, Chan-Yen Kuo, I-Shiang Tzeng, Ching-Fen Hsu, Chih-Wei Wu
BACKGROUND: COVID-19 vaccines have reduced the risk of disease progression to respiratory failure or death. However, in patients with breakthrough infections requiring invasive mechanical ventilation, the effect of prior COVID-19 vaccination on mortality remains inconclusive. METHOD: We retrospectively analyzed data on patients intubated due to COVID-19 pneumonia between May 1, 2022 and October 31, 2022. Receipt of two or more doses of vaccine were considered as fully vaccinated...
November 14, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37972690/prognostic-performance-of-il-6-and-il-10-in-febrile-pediatric-hematology-oncology-patients-with-normal-procalcitonin
#12
JOURNAL ARTICLE
Shu-Peng Lin, Xiao-Jun Xu, Chan Liao, Ning Zhao, Yuan-Yuan Chen, Yong-Min Tang
INTRODUCTION: It is important to predict adverse outcomes in febrile children with hematology/oncology diseases. Procalcitonin (PCT) is a promising biomarker for the prediction of infection severity, but further studies have revealed its performance in excluding adverse outcomes of infection. IL-6 and IL-10 were reported to have a close association with those infection outcomes. The aim of the study was to investigate the performance of IL-6 and IL-10 in febrile pediatric hematology/oncology patients with normal PCT...
November 14, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37956795/effects-of-probiotics-in-children-with-acute-gastroenteritis-a-systematic-review-and-meta-analysis-focusing-on-probiotics-utilized-in-japan
#13
JOURNAL ARTICLE
Toru Higuchi, Munehiro Furuichi, Naonori Maeda, Takeshi Tsugawa, Kenta Ito
BACKGROUND: Many randomized controlled trials and systematic reviews have evaluated the use of probiotics to treat acute infectious gastroenteritis. However, most probiotic species evaluated in previous large randomized controlled trials are unavailable in Japan. Our objective was to investigate the efficacy of probiotics utilized in Japan for acute gastroenteritis. METHODS: The inclusion criterion was a randomized controlled study that compared probiotics with a placebo to treat children younger than 18 years with acute infectious gastroenteritis...
November 11, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37952843/infection-prevention-measures-and-its-determinants-in-childcare-facilities-during-the-covid-19-pandemic-a-nationwide-survey-2022-2023
#14
JOURNAL ARTICLE
Yusuke Okubo, Kazuhiro Uda, Mimori Kaki, Shinobu Miyoshi, Isao Miyairi
BACKGROUND: The coronavirus disease-2019 (COVID-19) pandemic presented an unprecedented challenge to societies, necessitating adaptations in infection prevention measures. While there is ample data on infection prevention practices in workplace and healthcare settings, comprehensive data specific to childcare facilities has been lacking. METHODS: We conducted a nationwide web-based survey capturing responses from various childcare facilities (N = 549)...
November 11, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37952842/relationship-between-carbapenem-use-and-major-diagnostic-category-in-curative-care-beds-analysis-of-a-2020-japanese-national-administrative-database
#15
JOURNAL ARTICLE
Kozue Yamaguchi, Maeda Masayuki, Norio Ohmagari, Yuichi Muraki
Excessive carbapenem use has contributed to the spread of carbapenem-resistant bacteria. In response, Japan's revised National Action Plan on Antimicrobial Resistance (AMR) 2023-2027 set the goal of a 20 % reduction in carbapenem use. The aim of this study is to reveal the circumstances associated with carbapenem use in diagnosis procedure combination (DPC) community hospitals and fee-for-service hospitals, which account for the majority of the hospitals in Japan. We analyzed publicly available data from the Survey of Discharged Patients conducted by the Ministry of Health, Labour and Welfare in 2020...
November 10, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37952841/comparison-of-pneumonia-severity-scores-for-covid-19-patients-with-the-omicron-variant
#16
JOURNAL ARTICLE
Naoyuki Miyashita, Yasushi Nakamori, Makoto Ogata, Naoki Fukuda, Akihisa Yamura, Tomoki Ito
INTRODUCTION: We demonstrated that there was a significant relationship between the severity measured using the A-DROP scoring system and the mortality rate in patients with COVID-19 community-acquired pneumonia (CAP) in the ancestral strain, Alpha variant, and Delta variant. We investigated the usefulness of the A-DROP scoring system in SARS-CoV-2 Omicron variant CAP and compared it with severity scores, the Pneumonia Severity Index (PSI) and CURB-65 score. METHODS: We analyzed a total of 547 patients with COVID-19 CAP Omicron variant; 198 cases were the BA...
November 10, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37944699/autopsy-of-tetanus-with-foot-gangrene-as-portal-of-entry
#17
Miyu Wakatsuki, Kei Yamamoto, Akira Kawashima, Ayana Sakurai, Masami Kurokawa, Ryo Mizushima, Nobumasa Okumura, Gen Yamada, Hidetoshi Nomoto, Norio Ohmagari
Non-traumatic chronic skin lesions are the second most common cause of tetanus. Herein, we describe an 85-year-old woman who presented with a chronically infected skin lesion. She developed tetanus while in hospital and died of respiratory failure, after refusing mechanical ventilation. Routine immunization against tetanus began in Japan during 1968; hence many people born before 1968 are unvaccinated. Mortality due to tetanus is high and the proportion with protective antibodies is low in older adults. Therefore, we recommend tetanus vaccination for older persons in Japan who have chronic skin lesions and have never been vaccinated...
November 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37944698/a-delayed-diagnosis-of-fascioliasis-the-importance-of-appropriate-fecal-diagnostic-method
#18
Shumpei Kosaka, Shoichi Shimizu, Shingo Nakayamada, Aya Nawata, Nobuyuki Shimono, Mio Tanaka, Haruhiko Maruyama, Yoshio Osada, Yoshiya Tanaka
Fascioliasis, a zoonotic helminthiasis, occurs sporadically in Japan. In this report, we describe a case of fascioliasis that was initially difficult to diagnose because the fecal examination method was negative for the Fasciola sp. eggs. A 64-year-old man living in Shimonoseki City, Japan, presented with fatigue and anorexia. Laboratory tests showed hepatic dysfunction and eosinophilia. Abdominal dynamic contrast-enhanced computed tomography and magnetic resonance cholangiopancreatography suggested intrahepatic biliary cysts...
November 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37944697/dual-anti-viral-treatment-for-persistent-covid-19-in-immunocompromised-hemato-oncological-patients-is-associated-with-a-favorable-prognosis-and-minor-side-effects
#19
JOURNAL ARTICLE
Suzy E Meijer, Ora Halutz, Amos Adler, Katya Levytskyi, Luba Tau, Michal Dekel, Ronit Cohen-Poradosu, Evgene Katchman, David Shasha, Jacob Ablin, Guy Choshen, Giris Jacob, Asaf Wasserman, Merav Ingbir, Yael C Cohen, Chava Perry, Ron Ram, Yair Herishanu, Yael Bar On, Elma van Thijn, Natalie Rutsinsky, Sheri Harari, Adi Stern, Ronen Ben-Ami, Yael Paran
In hemato-oncological patients, COVID-19 can present as a persistent infection with ongoing symptoms and viral replication over a prolonged period of time. Data are scarce on the preferred treatment options for these patients. We describe our experience with a five-day course of dual anti-viral treatment with remdesivir and nirmatrelvir/ritonavir for hemato-oncological immunocompromised patients with persistent COVID-19. Fifteen patients with a history of lymphoma, CLL, and MM were included. Eight were male, median age was 74...
November 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/37944696/pretransplant-ribavirin-and-interferon-%C3%AE-therapy-for-rhinovirus-interstitial-pneumonia-in-a-rag1-deficient-infant
#20
Nobutaka Harada, Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Keishiro Kinoshita, Wakato Matsuoka, Yoshitomo Motomura, Noriyuki Kaku, Naoki Kawaguchi, Takami Takeuchi, Shouichi Ohga
Severe combined immunodeficiency (SCID) is one of the most serious inborn errors of immunity leading to a fatal infection in early infancy. Allogeneic hematopoietic cell transplantation (HCT) or elective gene therapy prior to infection or live-attenuated vaccination is the current standard of curative treatment. Even in the era of newborn screening for SCID, pretransplant control of severe infection is challenging for SCID. Multiple pathogens are often isolated from immunocompromised patients, and limited information is available regarding antiviral strategies to facilitate curative HCT...
November 7, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
journal
journal
32549
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.