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JOURNAL ARTICLE
Jun Young Heo, Ah Hyung Park, Min Joung Lee, Min Jeong Ryu, Yong Kyung Kim, Yun Seon Jang, Soo Jeong Kim, So Yeon Shin, Hyo Jin Son, Thor D Stein, Yang Hoon Huh, Sookja K Chung, Song Yi Choi, Jin Man Kim, Onyou Hwang, Minho Shong, Seung Jae Hyeon, Junghee Lee, Hoon Ryu, Daesoo Kim, Gi Ryang Kweon
Mitochondrial dysfunction has been implicated in Parkinson's Disease (PD) progression; however, the mitochondrial factors underlying the development of PD symptoms remain unclear. One candidate is CR6-interacting factor1 (CRIF1), which controls translation and membrane insertion of 13 mitochondrial proteins involved in oxidative phosphorylation. Here, we found that CRIF1 mRNA and protein expression were significantly reduced in postmortem brains of elderly PD patients compared to normal controls. To evaluate the effect of Crif1 deficiency, we produced mice lacking the Crif1 gene in dopaminergic neurons (DAT-CRIF1-KO mice)...
August 30, 2023: Molecular Psychiatry
#42
JOURNAL ARTICLE
Marissa A Smail, Brittany L Smith, Rammohan Shukla, Khaled Alganem, Hunter M Eby, Justin L Bollinger, Ria K Parikh, James B Chambers, James K Reigle, Rachel D Moloney, Nawshaba Nawreen, Eric S Wohleb, Harry Pantazopoulos, Robert E McCullumsmith, James P Herman
Psychological loss is a common experience that erodes well-being and negatively impacts quality of life. The molecular underpinnings of loss are poorly understood. Here, we investigate the mechanisms of loss using an environmental enrichment removal (ER) paradigm in male rats. The basolateral amygdala (BLA) was identified as a region of interest, demonstrating differential Fos responsivity to ER and having an established role in stress processing and adaptation. A comprehensive multi-omics investigation of the BLA, spanning multiple cohorts, platforms, and analyses, revealed alterations in microglia and the extracellular matrix (ECM)...
August 29, 2023: Molecular Psychiatry
#43
JOURNAL ARTICLE
Nerisa Banaj, Daniela Vecchio, Fabrizio Piras, Pietro De Rossi, Juan Bustillo, Simone Ciufolini, Paola Dazzan, Marta Di Forti, Erin W Dickie, Judith M Ford, Paola Fuentes-Claramonte, Oliver Gruber, Amalia Guerrero-Pedraza, Holly K Hamilton, Fleur M Howells, Bernd Kraemer, Stephen M Lawrie, Daniel H Mathalon, Robin Murray, Edith Pomarol-Clotet, Steven G Potkin, Adrian Preda, Joaquim Radua, Anja Richter, Raymond Salvador, Akira Sawa, Freda Scheffler, Kang Sim, Filip Spaniel, Dan J Stein, Henk S Temmingh, Sophia I Thomopoulos, David Tomecek, Anne Uhlmann, Aristotle Voineskos, Kun Yang, Neda Jahanshad, Paul M Thompson, Theo G M Van Erp, Jessica A Turner, Gianfranco Spalletta, Federica Piras
Converging evidence suggests that schizophrenia (SZ) with primary, enduring negative symptoms (i.e., Deficit SZ (DSZ)) represents a distinct entity within the SZ spectrum while the neurobiological underpinnings remain undetermined. In the largest dataset of DSZ and Non-Deficit (NDSZ), we conducted a meta-analysis of data from 1560 individuals (168 DSZ, 373 NDSZ, 1019 Healthy Controls (HC)) and a mega-analysis of a subsampled data from 944 individuals (115 DSZ, 254 NDSZ, 575 HC) collected across 9 worldwide research centers of the ENIGMA SZ Working Group (8 in the mega-analysis), to clarify whether they differ in terms of cortical morphology...
August 29, 2023: Molecular Psychiatry
#44
JOURNAL ARTICLE
Akhgar Ghassabian, Michiel van den Dries, Leonardo Trasande, Sander Lamballais, Suzanne Spaan, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W V Jaddoe, Stephanie M Engel, Anjoeka Pronk, Tonya White, Henning Tiemeier, Mònica Guxens
Exposure to phthalates, used as plasticizers and solvents in consumer products, is ubiquitous. Despite growing concerns regarding their neurotoxicity, brain differences associated with gestational exposure to phthalates are understudied. We included 775 mother-child pairs from Generation R, a population-based pediatric neuroimaging study with prenatal recruitment, who had data on maternal gestational phthalate levels and T1 -weighted magnetic resonance imaging in children at age 10 years. Maternal urinary concentrations of phthalate metabolites were measured at early, mid-, and late pregnancy...
August 29, 2023: Molecular Psychiatry
#45
JOURNAL ARTICLE
Hector E Yarur, Sanne M Casello, Valerie S Tsai, Juan Enriquez-Traba, Rufina Kore, Huikun Wang, Miguel Arenivar, Hugo A Tejeda
The medial prefrontal cortex (mPFC) controls behavior via connections with limbic excitatory afferents that engage various inhibitory motifs to shape mPFC circuit function. The dynorphin (Dyn) / kappa-opioid receptor (KOR) system is highly enriched in the mPFC, and its dysregulation is implicated in neuropsychiatric disorders. However, it is unclear how the Dyn / KOR system modulates excitatory and inhibitory circuits that are integral for mPFC information processing and behavioral control. Here, we provide a circuit-based framework wherein mPFC Dyn / KOR signaling regulates excitation-inhibition balance by toggling which afferents drive mPFC neurons...
August 29, 2023: Molecular Psychiatry
#46
JOURNAL ARTICLE
Y Saleh, I Jarratt-Barnham, P Petitet, E Fernandez-Egea, S G Manohar, M Husain
BACKGROUND: Motivational deficits are a central feature of the negative syndrome in schizophrenia. They have consistently been associated with reduced willingness to expend physical effort in return for monetary rewards on effort based decision making (EBDM) paradigms. Nevertheless, the mechanisms underlying such altered performance are not well characterised, and it remains unclear if they are driven purely by negative symptoms, or also in part by cognitive impairment, antipsychotic treatment or even positive symptoms...
August 25, 2023: Molecular Psychiatry
#47
REVIEW
Sung Eun Wang, Yong-Hui Jiang
Genomic imprinting disorders are caused by the disruption of genomic imprinting processes leading to a deficit or increase of an active allele. Their unique molecular mechanisms underlying imprinted genes offer an opportunity to investigate epigenetic-based therapy for reactivation of an inactive allele or reduction of an active allele. Current treatments are based on managing symptoms, not targeting the molecular mechanisms underlying imprinting disorders. Here, we highlight molecular approaches of therapeutic candidates in preclinical and clinical studies for individual imprinting disorders...
August 25, 2023: Molecular Psychiatry
#48
JOURNAL ARTICLE
Li Liu, Xin Qi, Shiqiang Cheng, Peilin Meng, Xuena Yang, Chuyu Pan, Na Zhang, Yujing Chen, Chune Li, Huijie Zhang, Zhen Zhang, Jingxi Zhang, Bolun Cheng, Yan Wen, Yumeng Jia, Huan Liu, Feng Zhang
The aberrant aging hypothesis of schizophrenia (SCZ) and autism spectrum disorder (ASD) has been proposed, and the DNA methylation (DNAm) clock, which is a cumulative evaluation of DNAm levels at age-related CpGs, could serve as a biological aging indicator. This study evaluated epigenetic brain aging of ASD and SCZ using Horvath's epigenetic clock, based on two public genome-wide DNA methylation datasets of post-mortem brain samples (NASD = 222; NSCZ = 142). Total subjects were further divided into subgroups by gender and age...
August 24, 2023: Molecular Psychiatry
#49
REVIEW
Masaaki Sato, Nobuhiro Nakai, Shuhei Fujima, Katrina Y Choe, Toru Takumi
Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social behaviors, and many different behavioral paradigms have been used for investigating their neural circuit bases. Social behavior is highly vulnerable to brain network dysfunction caused by neurological and neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms of abnormal social behavior and potential therapeutic targets for treatment...
August 24, 2023: Molecular Psychiatry
#50
Alessandra Borsini, Juliette Giacobbe, Gargi Mandal, Maura Boldrini
Adolescence represents a critical period for brain and behavioural health and characterised by the onset of mood, psychotic and anxiety disorders. In rodents, neurogenesis is very active during adolescence, when is particularly vulnerable to stress. Whether stress-related neurogenesis changes influence adolescence onset of psychiatric symptoms remains largely unknown. A systematic review was conducted on studies investigating changes in hippocampal neurogenesis and neuroplasticity, hippocampal-dependent cognitive functions, and behaviour, occurring after adolescence stress exposure in mice both acutely (at post-natal days 21-65) and in adulthood...
August 23, 2023: Molecular Psychiatry
#51
REVIEW
Leonidas Chouliaras, John T O'Brien
Dementia is a leading cause of disability and death worldwide. At present there is no disease modifying treatment for any of the most common types of dementia such as Alzheimer's disease (AD), Vascular dementia, Lewy Body Dementia (LBD) and Frontotemporal dementia (FTD). Early and accurate diagnosis of dementia subtype is critical to improving clinical care and developing better treatments. Structural and molecular imaging has contributed to a better understanding of the pathophysiology of neurodegenerative dementias and is increasingly being adopted into clinical practice for early and accurate diagnosis...
August 22, 2023: Molecular Psychiatry
#52
JOURNAL ARTICLE
Yiying Zhang, Yuan Shen, Ning Liufu, Ling Liu, Wei Li, Zhongyong Shi, Hailin Zheng, Xinchun Mei, Chih-Yu Chen, Zengliang Jiang, Shabnamsadat Abtahi, Yuanlin Dong, Feng Liang, Yujiang Shi, Leo L Cheng, Guang Yang, Jing X Kang, Jeremy E Wilkinson, Zhongcong Xie
Spouses of Alzheimer's disease (AD) patients are at a higher risk of developing incidental dementia. However, the causes and underlying mechanism of this clinical observation remain largely unknown. One possible explanation is linked to microbiota dysbiosis, a condition that has been associated with AD. However, it remains unclear whether gut microbiota dysbiosis can be transmitted from AD individuals to non-AD individuals and contribute to the development of AD pathogenesis and cognitive impairment. We, therefore, set out to perform both animal studies and clinical investigation by co-housing wild-type mice and AD transgenic mice, analyzing microbiota via 16S rRNA gene sequencing, measuring short-chain fatty acid amounts, and employing behavioral test, mass spectrometry, site-mutations and other methods...
August 21, 2023: Molecular Psychiatry
#53
JOURNAL ARTICLE
E Liu, Kunkun Pang, Min Liu, Xu Tan, Zhaofang Hang, Shouhong Mu, Weikai Han, Qingwei Yue, Stefano Comai, Jinhao Sun
The brain circuit projecting from the ventral tegmental area (VTA) to the nucleus accumbens lateral shell (NAcLat) has a key role in methamphetamine (MA) addiction. As different dopamine (DA) neuron subpopulations in the VTA participate in different neuronal circuits, it is a challenge to isolate these DA neuron subtypes. Using retrograde tracing and Patch-seq, we isolated DA neurons in the VTA-NAcLat circuit in MA-treated mice and performed gene expression profiling. Among the differentially expressed genes, KCNQ genes were dramatically downregulated...
August 21, 2023: Molecular Psychiatry
#54
JOURNAL ARTICLE
Hyun Kim, Xi Zhu, Yiming Zhao, Sophie A Bell, Philip R Gehrman, Daniel Cohen, D P Devanand, Terry E Goldberg, Seonjoo Lee
Sleep and related disorders could lead to changes in various brain networks, but little is known about the role of amyloid β (Aβ) burden-a key Alzheimer's disease (AD) biomarker-in the relationship between sleep disturbance and altered resting state functional connectivity (rsFC) in older adults. This cross-sectional study examined the association between sleep disturbance, Aβ burden, and rsFC using a large-scale dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Sample included 489 individuals (53...
August 18, 2023: Molecular Psychiatry
#55
JOURNAL ARTICLE
Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Naohiro Okada, Naoki Hashimoto, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Satsuki Ito, Ryuichi Yamazaki, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Jun Miyata, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-Ichiro Hashimoto, Khin K Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Reiji Yoshimura, Osamu Abe, Theo G M van Erp, Jessica A Turner, Neda Jahanshad, Paul M Thompson, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto
According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites...
August 18, 2023: Molecular Psychiatry
#56
JOURNAL ARTICLE
Thomas Desmidt, Paul-Armand Dujardin, Frédéric Andersson, Bruno Brizard, Jean-Pierre Réméniéras, Valérie Gissot, Nicolas Arlicot, Laurent Barantin, Fabien Espitalier, Catherine Belzung, Arnaud Tanti, Gabriel Robert, Samuel Bulteau, Quentin Gallet, François Kazour, Sandrine Cognet, Vincent Camus, Wissam El-Hage, Pierre Poupin, Helmet T Karim
Nitrous oxide (N2 O) has recently emerged as a potential fast-acting antidepressant but the cerebral mechanisms involved in this effect remain speculative. We hypothesized that the antidepressant response to an Equimolar Mixture of Oxygen and Nitrous Oxide (EMONO) would be associated with changes in cerebral connectivity and brain tissue pulsations (BTP). Thirty participants (20 with a major depressive episode resistant to at least one antidepressant and 10 healthy controls-HC, aged 25-50, only females) were exposed to a 1-h single session of EMONO and followed for 1 week...
August 17, 2023: Molecular Psychiatry
#57
JOURNAL ARTICLE
Rafael Campos-Martin, Katharina Bey, Björn Elsner, Benedikt Reuter, Julia Klawohn, Alexandra Philipsen, Norbert Kathmann, Michael Wagner, Alfredo Ramirez
Obsessive-compulsive disorder (OCD) is a prevalent mental disorder affecting ~2-3% of the population. This disorder involves genetic and, possibly, epigenetic risk factors. The dynamic nature of epigenetics also presents a promising avenue for identifying biomarkers associated with symptom severity, clinical progression, and treatment response in OCD. We, therefore, conducted a comprehensive case-control investigation using Illumina MethylationEPIC BeadChip, encompassing 185 OCD patients and 199 controls recruited from two distinct sites in Germany...
August 16, 2023: Molecular Psychiatry
#58
JOURNAL ARTICLE
Bin Wan, Seok-Jun Hong, Richard A I Bethlehem, Dorothea L Floris, Boris C Bernhardt, Sofie L Valk
Autism is a neurodevelopmental condition involving atypical sensory-perceptual functions together with language and socio-cognitive deficits. Previous work has reported subtle alterations in the asymmetry of brain structure and reduced laterality of functional activation in individuals with autism relative to non-autistic individuals (NAI). However, whether functional asymmetries show altered intrinsic systematic organization in autism remains unclear. Here, we examined inter- and intra-hemispheric asymmetry of intrinsic functional gradients capturing connectome organization along three axes, stretching between sensory-default, somatomotor-visual, and default-multiple demand networks, to study system-level hemispheric imbalances in autism...
August 16, 2023: Molecular Psychiatry
#59
Willem B Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A J P Denys, Marco A N Echevarria, Goi Khia Eng, Sónia Ferreira, Jamie D Feusner, Rachael G Grazioplene, Patricia Gruner, Joyce Y Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R Li, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, Jose M Menchon, Pedro S Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Jose C Pariente Zorrilla, John Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y C Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H Simpson, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Jinsong Tang, Sophia I Thomopoulos, Anders L Thorsen, Tokiko Yoshida, Hirofumi Tomiyama, Benedetta Vai, Ilya M Veer, Ganesan Venkatasubramanian, Nora C Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A van Leeuwen, Hein J F van Marle, Laurens A van de Mortel, Anouk van der Straten, Ysbrand D van der Werf, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Guido A van Wingen
No abstract text is available yet for this article.
August 15, 2023: Molecular Psychiatry
#60
JOURNAL ARTICLE
Tyler A Lesh, Ana-Maria Iosif, Costin Tanase, Roza M Vlasova, Amy M Ryan, Jeffrey Bennett, Casey E Hogrefe, Richard J Maddock, Daniel H Geschwind, Judy Van de Water, A Kimberley McAllister, Martin A Styner, Melissa D Bauman, Cameron S Carter
Maternal infection has emerged as an important environmental risk factor for neurodevelopmental disorders, including schizophrenia and autism spectrum disorders. Animal model systems of maternal immune activation (MIA) suggest that the maternal immune response plays a significant role in the offspring's neurodevelopment and behavioral outcomes. Extracellular free water is a measure of freely diffusing water in the brain that may be associated with neuroinflammation and impacted by MIA. The present study evaluates the brain diffusion characteristics of male rhesus monkeys (Macaca mulatta) born to MIA-exposed dams (n = 14) treated with a modified form of the viral mimic polyinosinic:polycytidylic acid at the end of the first trimester...
August 15, 2023: Molecular Psychiatry
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