journal
https://read.qxmd.com/read/37730843/amphiregulin-normalizes-altered-circuit-connectivity-for-social-dominance-of-the-crtc3-knockout-mouse
#21
JOURNAL ARTICLE
Ji-Seon Park, Hwon Heo, Min-Seok Kim, Seung-Eun Lee, Sukyoung Park, Ki-Hyun Kim, Young-Ho Kang, Je Seong Kim, Young Hoon Sung, Woo Hyun Shim, Dong-Hou Kim, Youngsup Song, Seung-Yong Yoon
Social hierarchy has a profound impact on social behavior, reward processing, and mental health. Moreover, lower social rank can lead to chronic stress and often more serious problems such as bullying victims of abuse, suicide, or attack to society. However, its underlying mechanisms, particularly their association with glial factors, are largely unknown. In this study, we report that astrocyte-derived amphiregulin plays a critical role in the determination of hierarchical ranks. We found that astrocytes-secreted amphiregulin is directly regulated by cAMP response element-binding (CREB)-regulated transcription coactivator 3 (CRTC3) and CREB...
September 20, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37730842/the-pfc-lh-vta-pathway-contributes-to-social-deficits-in-irsp53-mutant-mice
#22
JOURNAL ARTICLE
Young Woo Noh, Yangsik Kim, Soowon Lee, Yeonghyeon Kim, Jae Jin Shin, Hyojin Kang, Il Hwan Kim, Eunjoon Kim
Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons communicate with cortical neurons. Here, we report that the medial prefrontal cortex (mPFC)-lateral hypothalamus (LH)-VTA pathway contributes to social deficits in mice with IRSp53 deletion restricted to cortical excitatory neurons (Emx1-Cre;Irsp53fl/fl mice). LH-projecting mutant mPFC neurons display abnormally increased excitability involving decreased potassium channel gene expression, leading to excessive excitatory synaptic input to LH-GABA neurons...
September 20, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37730841/brain-microvascular-endothelial-cells-and-blood-brain-barrier-dysfunction-in-psychotic-disorders
#23
JOURNAL ARTICLE
Paulo Lizano, Sovannarath Pong, Stephanie Santarriaga, Deepthi Bannai, Rakesh Karmacharya
Although there is convergent evidence for blood-brain barrier (BBB) dysfunction and peripheral inflammation in schizophrenia (SZ) and bipolar disorder (BD), it is unknown whether BBB deficits are intrinsic to brain microvascular endothelial cells (BMECs) or arise via effects of peripheral inflammatory cytokines. We examined BMEC function using stem cell-based models to identify cellular and molecular deficits associated with BBB dysfunction in SZ and BD. Induced pluripotent stem cells (iPSCs) from 4 SZ, 4 psychotic BD and 4 healthy control (HC) subjects were differentiated into BMEC-"like" cells...
September 20, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37726451/perceptual-learning-deficits-mediated-by-somatostatin-releasing-inhibitory-interneurons-of-olfactory-bulb-in-an-early-life-stress-mouse-model
#24
JOURNAL ARTICLE
Meenakshi Pardasani, Anantha Maharasi Ramakrishnan, Sarang Mahajan, Meher Kantroo, Eleanor McGowan, Susobhan Das, Priyadharshini Srikanth, Sanyukta Pandey, Nixon M Abraham
Early life adversity (ELA) causes aberrant functioning of neural circuits affecting the health of an individual. While ELA-induced behavioural disorders resulting from sensory and cognitive disabilities can be assessed clinically, the neural mechanisms need to be probed using animal models by employing multi-pronged experimental approaches. As ELA can alter sensory perception, we investigated the effect of early weaning on murine olfaction. By implementing go/no-go odour discrimination paradigm, we observed olfactory learning and memory impairments in early life stressed (ELS) male mice...
September 19, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37723284/functional-genomic-mechanisms-of-opioid-action-and-opioid-use-disorder-a-systematic-review-of-animal-models-and-human-studies
#25
Camille Falconnier, Alba Caparros-Roissard, Charles Decraene, Pierre-Eric Lutz
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a chronic relapsing disease associated with a lifetime struggle to control drug consumption, suggesting that opioids trigger long-lasting brain adaptations, notably through functional genomic and epigenomic mechanisms. Current understanding of these processes, however, remain scarce, and have not been previously reviewed systematically...
September 15, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37723283/mitochondrial-health-index-correlates-with-plasma-circulating-cell-free-mitochondrial-dna-in-bipolar-disorder
#26
JOURNAL ARTICLE
Rafaela C Cordeiro, Camila N C Lima, Gabriel R Fries, Giovana Zunta-Soares, Jair C Soares, João Quevedo, Giselli Scaini
Although mitochondrial dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial dysfunction can modulate clinical phenotypes. An emerging paradigm suggests mitochondria play an important non-energetic role in adaptation to stress, impacting cellular resilience and acting as a source of systemic allostatic load. Known as mitochondrial allostatic load, this (phenomenon) occurs when mitochondria are unable to recalibrate and maintain cell homeostasis...
September 15, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37714950/shared-and-distinct-structural-brain-networks-related-to-childhood-maltreatment-and-social-support-connectome-based-predictive-modeling
#27
JOURNAL ARTICLE
Alexandra Winter, Marius Gruber, Katharina Thiel, Kira Flinkenflügel, Susanne Meinert, Janik Goltermann, Nils R Winter, Tiana Borgers, Frederike Stein, Andreas Jansen, Katharina Brosch, Adrian Wroblewski, Florian Thomas-Odenthal, Paula Usemann, Benjamin Straube, Nina Alexander, Hamidreza Jamalabadi, Igor Nenadić, Linda M Bonnekoh, Katharina Dohm, Elisabeth J Leehr, Nils Opel, Dominik Grotegerd, Tim Hahn, Martijn P van den Heuvel, Tilo Kircher, Jonathan Repple, Udo Dannlowski
Childhood maltreatment (CM) has been associated with changes in structural brain connectivity even in the absence of mental illness. Social support, an important protective factor in the presence of childhood maltreatment, has been positively linked to white matter integrity. However, the shared effects of current social support and CM and their association with structural connectivity remain to be investigated. They might shed new light on the neurobiological basis of the protective mechanism of social support...
September 15, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37704861/overcoming-the-translational-crisis-of-contemporary-psychiatry-converging-phenomenological-and-spatiotemporal-psychopathology
#28
REVIEW
Georg Northoff, Jonas Daub, Dusan Hirjak
Despite all neurobiological/neurocomputational progress in psychiatric research, recent authors speak about a 'crisis of contemporary psychiatry'. Some argue that we do not yet know the computational mechanisms underlying the psychopathological symptoms ('crisis of mechanism') while others diagnose a neglect of subjectivity, namely first-person experience ('crisis of subjectivity'). In this perspective, we propose that Phenomenological Psychopathology, due to its focus on first-person experience of space and time, is in an ideal position to address the crisis of subjectivity and, if extended to the brain's spatiotemporal topographic-dynamic structure as key focus of Spatiotemporal Psychopathology, the crisis of mechanism...
September 13, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37696874/a-higher-dysregulation-burden-of-brain-dna-methylation-in-female-patients-implicated-in-the-sex-bias-of-schizophrenia
#29
JOURNAL ARTICLE
Jiaqi Zhou, Yan Xia, Miao Li, Yu Chen, Jiacheng Dai, Chunyu Liu, Chao Chen
Sex differences are pervasive in schizophrenia (SCZ), but the extent and magnitude of DNA methylation (DNAm) changes underlying these differences remain uncharacterized. In this study, sex-stratified differential DNAm analysis was performed in postmortem brain samples from 117 SCZ and 137 controls, partitioned into discovery and replication datasets. Three differentially methylated positions (DMPs) were identified (adj.p < 0.05) in females and 29 DMPs in males without overlap between them. Over 81% of these sex-stratified DMPs were directionally consistent between sexes but with different effect sizes...
September 11, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37696873/prefrontal-cortex-astroglia-modulate-anhedonia-like-behavior
#30
JOURNAL ARTICLE
S A Codeluppi, M Xu, Y Bansal, A E Lepack, V Duric, M Chow, J Muir, R C Bagot, P Licznerski, S L Wilber, G Sanacora, E Sibille, R S Duman, C Pittenger, M Banasr
Reductions of astroglia expressing glial fibrillary acidic protein (GFAP) are consistently found in the prefrontal cortex (PFC) of patients with depression and in rodent chronic stress models. Here, we examine the consequences of PFC GFAP+ cell depletion and cell activity enhancement on depressive-like behaviors in rodents. Using viral expression of diphtheria toxin receptor in PFC GFAP+ cells, which allows experimental depletion of these cells following diphtheria toxin administration, we demonstrated that PFC GFAP+ cell depletion induced anhedonia-like behavior within 2 days and lasting up to 8 days, but no anxiety-like deficits...
September 11, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37684322/incidence-prevalence-and-global-burden-of-adhd-from-1990-to-2019-across-204-countries-data-with-critical-re-analysis-from-the-global-burden-of-disease-study
#31
JOURNAL ARTICLE
Samuele Cortese, Minjin Song, Luis C Farhat, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Seoyeon Park, Jae Won Oh, San Lee, Keun-Ah Cheon, Lee Smith, Corentin J Gosling, Guilherme V Polanczyk, Henrik Larsson, Luis A Rohde, Stephen V Faraone, Ai Koyanagi, Elena Dragioti, Joaquim Radua, Andre F Carvalho, Jae Il Shin, Marco Solmi
Data on incidence, prevalence and burden of ADHD are crucial for clinicians, patients, and stakeholders. We present the incidence, prevalence, and burden of ADHD globally and across countries from 1990 to 2019 from the Global Burden of Disease (GBD) study. We also: (1) calculated the ADHD prevalence based on data actually collected as opposed to the prevalence estimated by the GBD with data imputation for countries without prevalence data; (2) discussed the GBD estimated ADHD burden in the light of recent meta-analytic evidence on ADHD-related mortality...
September 8, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37679472/adaptor-protein-complex-2-in-the-orbitofrontal-cortex-predicts-alcohol-use-disorder
#32
JOURNAL ARTICLE
Patrick J Mulholland, Stefano Berto, Phillip A Wilmarth, Christopher McMahan, Lauren E Ball, John J Woodward
Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that continue despite negative consequences. The inability of individuals with AUD to regulate drinking may involve functional deficits in cortical areas that normally balance actions that have aspects of both reward and risk. Among these, the orbitofrontal cortex (OFC) is critically involved in goal-directed behavior and is thought to maintain a representation of reward value that guides decision making...
September 7, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37679471/the-role-of-glial-autophagy-in-alzheimer-s-disease
#33
REVIEW
Anna Litwiniuk, Grzegorz Roman Juszczak, Adrian Mateusz Stankiewicz, Kaja Urbańska
Although Alzheimer's disease is the most pervasive neurodegenerative disorder, the mechanism underlying its development is still not precisely understood. Available data indicate that pathophysiology of this disease may involve impaired autophagy in glial cells. The dysfunction is manifested as reduced ability of astrocytes and microglia to clear abnormal protein aggregates. Consequently, excessive accumulation of amyloid beta plaques and neurofibrillary tangles activates microglia and astrocytes leading to decreased number of mature myelinated oligodendrocytes and death of neurons...
September 7, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37679470/dna-methylation-and-the-opposing-nmdar-dysfunction-in-schizophrenia-and-major-depression-disorders-a-converging-model-for-the-therapeutic-effects-of-psychedelic-compounds-in-the-treatment-of-psychiatric-illness
#34
REVIEW
L Taylor Flynn, Wen-Jun Gao
Psychedelic compounds are being increasingly explored as a potential therapeutic option for treating several psychiatric conditions, despite relatively little being known about their mechanism of action. One such possible mechanism, DNA methylation, is a process of epigenetic regulation that changes gene expression via chemical modification of nitrogenous bases. DNA methylation has been implicated in the pathophysiology of several psychiatric conditions, including schizophrenia (SZ) and major depressive disorder (MDD)...
September 7, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37674019/clinical-and-cognitive-effects-of-external-trigeminal-nerve-stimulation-etns-in-neurological-and-psychiatric-disorders-a-systematic-review-and-meta-analysis
#35
REVIEW
Samuel J Westwood, Aldo Alberto Conti, Wanjie Tang, Shuang Xue, Samuele Cortese, Katya Rubia
This pre-registered (CRD42022322038) systematic review and meta-analysis investigated clinical and cognitive outcomes of external trigeminal nerve stimulation (eTNS) in neurological and psychiatric disorders. PubMed, OVID, Web of Science, Chinese National Knowledge Infrastructure, Wanfang, and VIP database for Chinese technical periodicals were searched (until 16/03/2022) to identify trials investigating cognitive and clinical outcomes of eTNS in neurological or psychiatric disorders. The Cochrane Risk of Bias 2...
September 6, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37674018/circadian-rhythm-disruptions-associated-with-opioid-use-disorder-in-synaptic-proteomes-of-human-dorsolateral-prefrontal-cortex-and-nucleus-accumbens
#36
JOURNAL ARTICLE
Stephanie Puig, Xiangning Xue, Ryan Salisbury, Micah A Shelton, Sam-Moon Kim, Mariah A Hildebrand, Jill R Glausier, Zachary Freyberg, George C Tseng, Anastasia K Yocum, David A Lewis, Marianne L Seney, Matthew L MacDonald, Ryan W Logan
Opioid craving and relapse vulnerability is associated with severe and persistent sleep and circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian rhythms and opioid use disorder (OUD) may prove valuable for developing new treatments for opioid addiction. Previous work indicated molecular rhythm disruptions in the human brain associated with OUD, highlighting synaptic alterations in the dorsolateral prefrontal cortex (DLPFC) and nucleus accumbens (NAc)-key brain regions involved in cognition and reward, and heavily implicated in the pathophysiology of OUD...
September 6, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37674017/sounds-of-danger-and-post-traumatic-stress-responses-in-wild-rodents-ecological-validity-of-a-translational-model-of-post-traumatic-stress-disorder
#37
JOURNAL ARTICLE
Hagit Cohen, Michael A Matar, Doron Todder, Carmit Cohen, Joseph Zohar, Hadas Hawlena, Zvika Abramsky
In the wild, animals face a highly variable world full of predators. Most predator attacks are unsuccessful, and the prey survives. According to the conventional perspective, the fear responses elicited by predators are acute and transient in nature. However, the long-term, non-lethal effects of predator exposure on prey behavioral stress sequelae, such as anxiety and post-traumatic symptoms, remain poorly understood. Most experiments on animal models of anxiety-related behavior or post-traumatic stress disorder have been carried out using commercial strains of rats and mice...
September 6, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37670126/targeting-nlrp3-inflammasome-for-neurodegenerative-disorders
#38
REVIEW
Jing Yao, Zhe Wang, Weihong Song, Yun Zhang
Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing proteins (NLRs) belong to the pattern recognition receptors (PRRs) family that sense stress signals, which play an important role in inflammation. As a member of NLRs, the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) is predominantly expressed in microglia, the principal innate immune cells in the central nervous system (CNS). Microglia release proinflammatory cytokines to cause pyroptosis through activating NLRP3 inflammasome...
September 5, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37666928/genome-wide-analysis-identifies-novel-loci-influencing-plasma-apolipoprotein-e-concentration-and-alzheimer-s-disease-risk
#39
JOURNAL ARTICLE
M Muaaz Aslam, Kang-Hsien Fan, Elizabeth Lawrence, Margaret Anne Bedison, Beth E Snitz, Steven T DeKosky, Oscar L Lopez, Eleanor Feingold, M Ilyas Kamboh
The APOE 2/3/4 polymorphism is the greatest genetic risk factor for Alzheimer's disease (AD). This polymorphism is also associated with variation in plasma ApoE level; while APOE*4 lowers, APOE*2 increases ApoE level. Lower plasma ApoE level has also been suggested to be a risk factor for incident dementia. To our knowledge, no large genome-wide association study (GWAS) has been reported on plasma ApoE level. This study aimed to identify new genetic variants affecting plasma ApoE level as well as to test if baseline ApoE level is associated with cognitive function and incident dementia in a longitudinally followed cohort of the Ginkgo Evaluation of Memory (GEM) study...
September 5, 2023: Molecular Psychiatry
https://read.qxmd.com/read/37658228/a-novel-mutation-in-intron-1-of-wnt1-causes-developmental-loss-of-dopaminergic-neurons-in-midbrain-and-asd-like-behaviors-in-rats
#40
JOURNAL ARTICLE
Yongyi Li, Mingwei Zhu, Wen-Xiong Chen, Jing Luo, Xin Li, Yangyang Cao, Meng Zheng, Shanshan Ma, Zhilan Xiao, Yani Zhang, Linyan Jiang, Xiumin Wang, Ting Tan, Xia Li, Qian Gong, Xiaoli Xiong, Jun Wang, Mingxi Tang, Mingtao Li, Ya-Ping Tang
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong genetic liability. Despite extensive studies, however, the underlying pathogenic mechanism still remains elusive. In the present study, we identified a homozygous mutation in the intron 1 of Wnt1 via large-scale screening of ASD risk/causative genes and verified that this mutation created a new splicing donor site in the intron 1, and consequently, a decrease of WNT1 expression. Interestingly, humanized rat models harboring this mutation exhibited robust ASD-like behaviors including impaired ultrasonic vocalization (USV), decreased social interactions, and restricted and repetitive behaviors...
September 1, 2023: Molecular Psychiatry
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