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REVIEW
Christoph Abé, Benny Liberg, Anna Luisa Klahn, Predrag Petrovic, Mikael Landén
Cross-sectional neuroimaging studies show that bipolar disorder is associated with structural brain abnormalities, predominantly observed in prefrontal and temporal cortex, cingulate gyrus, and subcortical regions. However, longitudinal studies are needed to elucidate whether these abnormalities presage disease onset or are consequences of disease processes, and to identify potential contributing factors. Here, we narratively review and summarize longitudinal structural magnetic resonance imaging studies that relate imaging outcomes to manic episodes...
May 5, 2023: Molecular Psychiatry
#22
JOURNAL ARTICLE
Dominic B Dwyer, Ganesh B Chand, Alessandro Pigoni, Adyasha Khuntia, Junhao Wen, Mathilde Antoniades, Gyujoon Hwang, Guray Erus, Jimit Doshi, Dhivya Srinivasan, Erdem Varol, Rene S Kahn, Hugo G Schnack, Eva Meisenzahl, Stephen J Wood, Chuanjun Zhuo, Aristeidis Sotiras, Russell T Shinohara, Haochang Shou, Yong Fan, Maristela Schaulfelberger, Pedro Rosa, Paris A Lalousis, Rachel Upthegrove, Antonia N Kaczkurkin, Tyler M Moore, Barnaby Nelson, Raquel E Gur, Ruben C Gur, Marylyn D Ritchie, Theodore D Satterthwaite, Robin M Murray, Marta Di Forti, Simone Ciufolini, Marcus V Zanetti, Daniel H Wolf, Christos Pantelis, Benedicto Crespo-Facorro, Geraldo F Busatto, Christos Davatzikos, Nikolaos Koutsouleris, Paola Dazzan
Using machine learning, we recently decomposed the neuroanatomical heterogeneity of established schizophrenia to discover two volumetric subgroups-a 'lower brain volume' subgroup (SG1) and an 'higher striatal volume' subgroup (SG2) with otherwise normal brain structure. In this study, we investigated whether the MRI signatures of these subgroups were also already present at the time of the first-episode of psychosis (FEP) and whether they were related to clinical presentation and clinical remission over 1-, 3-, and 5-years...
May 5, 2023: Molecular Psychiatry
#23
REVIEW
Anthony Yulin Chen, Michael C Owens, Kathy Fange Liu
Gene expression regulation is a critical process throughout the body, especially in the nervous system. One mechanism by which biological systems regulate gene expression is via enzyme-mediated RNA modifications, also known as epitranscriptomic regulation. RNA modifications, which have been found on nearly all RNA species across all domains of life, are chemically diverse covalent modifications of RNA nucleotides and represent a robust and rapid mechanism for the regulation of gene expression. Although numerous studies have been conducted regarding the impact that single modifications in single RNA molecules have on gene expression, emerging evidence highlights potential crosstalk between and coordination of modifications across RNA species...
May 3, 2023: Molecular Psychiatry
#24
REVIEW
Yi-Shuian Huang, Raul Mendez, Mercedes Fernandez, Joel D Richter
The late 1990s were banner years in molecular neuroscience; seminal studies demonstrated that local protein synthesis, at or near synapses, was necessary for synaptic plasticity, the underlying cellular basis of learning and memory [1, 2]. The newly made proteins were proposed to "tag" the stimulated synapse, distinguishing it from naive synapses, thereby forming a cellular memory [3]. Subsequent studies demonstrated that the transport of mRNAs from soma to dendrite was linked with translational unmasking at synapses upon synaptic stimulation...
May 2, 2023: Molecular Psychiatry
#25
JOURNAL ARTICLE
Tarja Weckström, Marko Elovainio, Laura Pulkki-Råback, Kimmo Suokas, Kaisla Komulainen, Sari Mullola, Petri Böckerman, Christian Hakulinen
School grades in adolescence have been linked to later psychiatric outcomes, but large-scale nationwide studies across the spectrum of mental disorders are scarce. In the present study, we examined the risk of a wide array of mental disorders in adulthood, as well as the risk of comorbidity, associated with school achievement in adolescence. We used population-based cohort data comprising all individuals born in Finland over the period 1980-2000 (N = 1,070,880) who were followed from age 15 or 16 until a diagnosis of mental disorder, emigration, death, or December 2017, whichever came first...
May 2, 2023: Molecular Psychiatry
#26
JOURNAL ARTICLE
Marisol Lavertu-Jolin, Bidisha Chattopadhyaya, Pegah Chehrazi, Denise Carrier, Florian Wünnemann, Séverine Leclerc, Félix Dumouchel, Derek Robertson, Hicham Affia, Kamal Saba, Vijaya Gopal, Anant Bahadur Patel, Gregor Andelfinger, Graçiela Pineyro, Graziella Di Cristo
While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear memory recovery in adults, but it is highly effective in juvenile rodents. Maturation of GABAergic circuits, in particular of parvalbumin-positive (PV+ ) cells, restricts plasticity in the adult brain, thus reducing PV+ cell maturation could promote the suppression of fear memories following extinction training in adults...
May 2, 2023: Molecular Psychiatry
#27
JOURNAL ARTICLE
Laiana A Quagliato, Antonio E Nardi
Although accumulating evidence suggests an interplay between child abuse and inflammatory processes and the pathophysiology of mental disorders, few studies have investigated the cellular mechanisms related to this matter. Furthermore, no studies to date have evaluated cytokine, oxidative stress, and DNA damage levels in drug-naïve panic disorder (PD) patients and their possible association with childhood trauma. The aim of the present study was to determine the levels of the proinflammatory interleukin (IL)-1B, the oxidative stress marker TBARS, and 8-hydroxy-2' -deoxyguanosine (8-OHdG; representing DNA damage) in drug-naïve PD patients compared to controls...
May 2, 2023: Molecular Psychiatry
#28
REVIEW
Jean-Charles Lambert, Alfredo Ramirez, Benjamin Grenier-Boley, Céline Bellenguez
Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge of this component has progressed over the last 10 years, thanks notably to the advent of genome-wide association studies and the establishment of large consortia that make it possible to analyze hundreds of thousands of cases and controls. The characterization of dozens of chromosomal regions associated with the risk of developing AD and (in some loci) the causal genes responsible for the observed disease signal has confirmed the involvement of major pathophysiological pathways (such as amyloid precursor protein metabolism) and opened up new perspectives (such as the central role of microglia and inflammation)...
May 2, 2023: Molecular Psychiatry
#29
JOURNAL ARTICLE
Martin Achleitner, Charlotte Steenblock, Juliane Dänhardt, Natalia Jarzebska, Romina Kardashi, Waldemar Kanczkowski, Richard Straube, Roman N Rodionov, Nitzan Bornstein, Sergey Tselmin, Frank Kaiser, Ronald Bucher, Mahmoud Barbir, Ma-Li Wong, Karin Voit-Bak, Julio Licinio, Stefan R Bornstein
In the aftermath of the COVID-19 pandemic, we are witnessing an unprecedented wave of post-infectious complications. Most prominently, millions of patients with Long-Covid complain about chronic fatigue and severe post-exertional malaise. Therapeutic apheresis has been suggested as an efficient treatment option for alleviating and mitigating symptoms in this desperate group of patients. However, little is known about the mechanisms and biomarkers correlating with treatment outcomes. Here, we have analyzed in different cohorts of Long-Covid patients specific biomarkers before and after therapeutic apheresis...
May 2, 2023: Molecular Psychiatry
#30
JOURNAL ARTICLE
Willem B Bruin, Yoshinari Abe, Pino Alonso, Alan Anticevic, Lea L Backhausen, Srinivas Balachander, Nuria Bargallo, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolin Triquell, Silvia Brem, Federico Calesella, Beatriz Couto, Damiaan A J P Denys, Marco A N Echevarria, Goi Khia Eng, Sónia Ferreira, Jamie D Feusner, Rachael G Grazioplene, Patricia Gruner, Joyce Y Guo, Kristen Hagen, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q Hoexter, Neda Jahanshad, Fern Jaspers-Fayer, Selina Kasprzak, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R Li, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, Jose M Menchon, Pedro S Moreira, Pedro Morgado, Akiko Nakagawa, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Jose C Pariente Zorrilla, John Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Janardhan Y C Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Blair H Simpson, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Jinsong Tang, Sophia I Thomopoulos, Anders L Thorsen, Yoshida Tokiko, Hirofumi Tomiyama, Benedetta Vai, Ilya M Veer, Ganesan Venkatasubramanian, Nora C Vetter, Chris Vriend, Susanne Walitza, Lea Waller, Zhen Wang, Anri Watanabe, Nicole Wolff, Je-Yeon Yun, Qing Zhao, Wieke A van Leeuwen, Hein J F van Marle, Laurens A van de Mortel, Anouk van der Straten, Ysbrand D van der Werf, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Guido A van Wingen
Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium...
May 2, 2023: Molecular Psychiatry
#31
JOURNAL ARTICLE
Eleni Siopi, Mathieu Galerne, Manon Rivagorda, Soham Saha, Carine Moigneu, Stéphanie Moriceau, Mathilde Bigot, Franck Oury, Pierre-Marie Lledo
Chronic stress constitutes a major risk factor for depression that can disrupt various aspects of homeostasis, including the gut microbiome (GM). We have recently shown that GM imbalance affects adult hippocampal (HPC) neurogenesis and induces depression-like behaviors, with the exact mechanisms being under active investigation. Here we hypothesized that the vagus nerve (VN), a key bidirectional route of communication between the gut and the brain, could relay the effects of stress-induced GM changes on HPC plasticity and behavior...
May 2, 2023: Molecular Psychiatry
#32
REVIEW
Christian P Müller, Gunter Schumann, Jürgen Rehm, Johannes Kornhuber, Bernd Lenz
Self-management includes all behavioural measures and cognitive activities aimed at coping with challenges arising throughout the lifespan. While virtually all of these challenges can be met without pharmacological means, alcohol consumption has long been instrumentalized as a supporting tool to help coping with problems arising selectively at adolescence, adulthood, and ageing. Here, we present, to our knowledge, the first systematic review of alcohol instrumentalization throughout lifespan. We searched MEDLINE, Google Scholar, PsycINFO and CINAHL (from Jan, 1990, to Dec, 2022) and analysed consumption patterns, goals and potential neurobiological mechanisms...
April 28, 2023: Molecular Psychiatry
#33
JOURNAL ARTICLE
Yang Du, Lei Chen, Mei-Chen Yan, Yan-Li Wang, Xiao-Lin Zhong, Chen-Xi Xv, Yao-Bo Li, Yong Cheng
Evidence suggests that neurometabolite alterations may be involved in the pathophysiology of autism spectrum disorders (ASDs). We performed a meta-analysis of proton magnetic resonance spectroscopy (1 H-MRS) studies to examine the neurometabolite levels in the brains of patients with ASD. A systematic search of PubMed and Web of Science identified 54 studies for the meta-analysis. A random-effects meta-analysis demonstrated that compared with the healthy controls, patients with ASD had lower N-acetyl-aspartate-containing compound (NAA) and choline-containing compound (Cho) levels and NAA/(creatine-containing compound) Cr ratios in the gray matter and lower NAA and glutamate + glutamine (Glx) levels in the white matter...
April 28, 2023: Molecular Psychiatry
#34
JOURNAL ARTICLE
Edwin J C G van den Oord, Lin Y Xie, Min Zhao, Thomas L Campbell, Gustavo Turecki, Anna K Kähler, Brian Dean, Ole Mors, Christina M Hultman, Nicklas H Staunstrup, Karolina A Aberg
Schizophrenia is a disabling disorder involving genetic predisposition in combination with environmental influences that likely act via dynamic alterations of the epigenome and the transcriptome but its detailed pathophysiology is largely unknown. We performed cell-type specific methylome-wide association study of neonatal blood (N = 333) from individuals who later in life developed schizophrenia and controls. Suggestively significant associations (P < 1.0 × 10-6 ) were detected in all cell-types and in whole blood with methylome-wide significant associations in monocytes (P = 2...
April 27, 2023: Molecular Psychiatry
#35
Liming Qiu, Casey H Halpern, Daniel A N Barbosa
No abstract text is available yet for this article.
April 27, 2023: Molecular Psychiatry
#36
Robert Yolken
No abstract text is available yet for this article.
April 27, 2023: Molecular Psychiatry
#37
JOURNAL ARTICLE
Laura A Berner, Katia M Harlé, Alan N Simmons, Angela Yu, Martin P Paulus, Amanda Bischoff-Grethe, Christina E Wierenga, Ursula F Bailer, Walter H Kaye
The neurocomputational processes underlying bulimia nervosa and its primary symptoms, out-of-control overeating and purging, are poorly understood. Research suggests that the brains of healthy individuals form a dynamic internal model to predict whether control is needed in each moment. This study tested the hypothesis that this computational process of inhibitory control is abnormally affected by metabolic state (being fasted or fed) in bulimia nervosa. A Bayesian ideal observer model was fit to behavioral data acquired from 22 women remitted from bulimia nervosa and 20 group-matched controls who completed a stop-signal task during two counterbalanced functional MRI sessions, one after a 16 h fast and one after a meal...
April 27, 2023: Molecular Psychiatry
#38
JOURNAL ARTICLE
Jason I Feinberg, Rose Schrott, Christine Ladd-Acosta, Craig J Newschaffer, Irva Hertz-Picciotto, Lisa A Croen, M Daniele Fallin, Andrew P Feinberg, Heather E Volk
There is a need to consider paternal contributions to autism spectrum disorder (ASD) more strongly. Autism etiology is complex, and heritability is not explained by genetics alone. Understanding paternal gametic epigenetic contributions to autism could help fill this knowledge gap. In the present study, we explored whether paternal autistic traits, and the sperm epigenome, were associated with autistic traits in children at 36 months enrolled in the Early Autism Risk Longitudinal Investigation (EARLI) cohort...
April 27, 2023: Molecular Psychiatry
#39
JOURNAL ARTICLE
Varsha Ramineni, Philip Millroth, Lalitha Iyadurai, Thomas Jaki, Jonathan Kingslake, Julie Highfield, Charlotte Summers, Michael B Bonsall, Emily A Holmes
Intensive care unit (ICU) staff continue to face recurrent work-related traumatic events throughout the COVID-19 pandemic. Intrusive memories (IMs) of such traumatic events comprise sensory image-based memories. Harnessing research on preventing IMs with a novel behavioural intervention on the day of trauma, here we take critical next steps in developing this approach as a treatment for ICU staff who are already experiencing IMs days, weeks, or months post-trauma. To address the urgent need to develop novel mental health interventions, we used Bayesian statistical approaches to optimise a brief imagery-competing task intervention to reduce the number of IMs...
April 26, 2023: Molecular Psychiatry
#40
REVIEW
Matthew E Peters, Constantine G Lyketsos
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of future neurodegenerative illness. This review focuses on the association between the brain-based paravascular drainage pathway known as the "glymphatic system" and TBI-related neurodegeneration. The glymphatic system is composed of cerebrospinal fluid (CSF) flowing into the brain parenchyma along paravascular spaces surrounding penetrating arterioles where it mixes with interstitial fluid (ISF) before being cleared along paravenous drainage pathways...
April 25, 2023: Molecular Psychiatry
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